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Elderly Asian Patients Have Lower Revascularisation Rates and Poorer Outcomes for ST-Elevation Myocardial Infarction Compared to Younger Patients.

Cai JX, Yap J, Gao F, Koh TH, Tong KL, Ong HY, Kojodjojo P, Tan HC, Ong ME, Foo D, Ee B, Low LP, Chui P, Yeo KK.

Ann Acad Med Singapore. 2020 Jan;49(1):3-14.


Association between use of humidifier disinfectant and allergic rhinitis in Korean children: a cross-sectional study based on the eighth Panel Study on Korean Children (PSKC).

Koh TH, Park JT, Kwon D, Kwak K.

Ann Occup Environ Med. 2020 Feb 17;32:e9. doi: 10.35371/aoem.2020.32.e9. eCollection 2020.


Acquisition of Plasmid with Carbapenem-Resistance Gene blaKPC2 in Hypervirulent Klebsiella pneumoniae, Singapore.

Chen Y, Marimuthu K, Teo J, Venkatachalam I, Cherng BPZ, De Wang L, Prakki SRS, Xu W, Tan YH, Nguyen LC, Koh TH, Ng OT, Gan YH.

Emerg Infect Dis. 2020 Mar;26(3):549-559. doi: 10.3201/eid2603.191230.


Foodborne Klebsiella pneumoniae: virulence potential, antibiotic resistance and risks to food safety.

Hartantyo SHP, Chau ML, Koh TH, Yap M, Yi T, Cao DYH, Gutierrez RA, Ng LC.

J Food Prot. 2020 Jan 13. doi: 10.4315/JFP-19-520. [Epub ahead of print]


Comparative genomic analysis of Streptococcus dysgalactiae subspecies dysgalactiae, an occasional cause of zoonotic infection.

Koh TH, Binte Abdul Rahman N, Sessions OM.

Pathology. 2020 Feb;52(2):262-266. doi: 10.1016/j.pathol.2019.09.016. Epub 2019 Dec 16.


Determining the Development of Persisters in Extensively Drug-Resistant Acinetobacter baumannii upon Exposure to Polymyxin B-Based Antibiotic Combinations Using Flow Cytometry.

Wong FH, Cai Y, Leck H, Lim TP, Teo JQ, Lee W, Koh TH, Tan TT, Tan KW, Kwa AL.

Antimicrob Agents Chemother. 2020 Feb 21;64(3). pii: e01712-19. doi: 10.1128/AAC.01712-19. Print 2020 Feb 21.


Salmonella in Retail Food and Wild Birds in Singapore-Prevalence, Antimicrobial Resistance, and Sequence Types.

Aung KT, Chen HJ, Chau ML, Yap G, Lim XF, Humaidi M, Chua C, Yeo G, Yap HM, Oh JQ, Manogaran V, Hapuarachchi HC, Maiwald M, Tee NWS, Barkham T, Koh TH, Gutiérrez RA, Schlundt J, Ng LC.

Int J Environ Res Public Health. 2019 Oct 31;16(21). pii: E4235. doi: 10.3390/ijerph16214235.


Ascertainment of Silent Myocardial Infarction in Patients Undergoing Percutaneous Coronary Intervention (from the GLOBAL LEADERS Trial).

Chang CC, Spitzer E, Chichareon P, Takahashi K, Modolo R, Kogame N, Tomaniak M, Komiyama H, Yap SC, Hoole SP, Gori T, Zaman A, Frey B, Ferreira RC, Bertrand OF, Koh TH, Sousa A, Moschovitis A, van Geuns RJ, Steg PG, Hamm C, Jüni P, Vranckx P, Valgimigli M, Windecker S, Serruys PW, Soliman O, Onuma Y.

Am J Cardiol. 2019 Dec 15;124(12):1833-1840. doi: 10.1016/j.amjcard.2019.08.049. Epub 2019 Sep 26.


Oral vs Intravenous Antibiotics for Patients With Klebsiella pneumoniae Liver Abscess: A Randomized, Controlled Noninferiority Study.

Molton JS, Chan M, Kalimuddin S, Oon J, Young BE, Low JG, Salada BMA, Lee TH, Wijaya L, Fisher DA, Izharuddin E, Koh TH, Teo JWP, Krishnan PU, Tan BP, Woon WWL, Ding Y, Wei Y, Phillips R, Moorakonda R, Yuen KH, Cher BP, Yoong J, Lye DC, Archuleta S.

Clin Infect Dis. 2019 Oct 23. pii: ciz881. doi: 10.1093/cid/ciz881. [Epub ahead of print]


Candida auris in Singapore: Genomic epidemiology, antifungal drug resistance, and identification using the updated 8.01 VITEK2 system.

Tan YE, Teo JQ, Rahman NBA, Ng OT, Kalisvar M, Tan AL, Koh TH, Ong RTH.

Int J Antimicrob Agents. 2019 Dec;54(6):709-715. doi: 10.1016/j.ijantimicag.2019.09.016. Epub 2019 Oct 7.


Association between depression and cardiovascular disease risk in general population of Korea: results from the Korea National Health and Nutrition Examination Survey, 2016.

Song J, Koh TH, Park O, Kwon D, Kang S, Kwak K, Park JT.

Ann Occup Environ Med. 2019 Jun 20;31:e10. doi: 10.35371/aoem.2019.31.e10. eCollection 2019.


The higher prevalence of extended spectrum beta-lactamases among Escherichia coli ST131 in Southeast Asia is driven by expansion of a single, locally prevalent subclone.

Chen SL, Ding Y, Apisarnthanarak A, Kalimuddin S, Archuleta S, Omar SFS, De PP, Koh TH, Chew KL, Atiya N, Suwantarat N, Velayuthan RD, Wong JGX, Lye DC.

Sci Rep. 2019 Sep 13;9(1):13245. doi: 10.1038/s41598-019-49467-5.


Final results of the randomised evaluation of short-term dual antiplatelet therapy in patients with acute coronary syndrome treated with a new-generation stent (REDUCE trial).

De Luca G, Damen SA, Camaro C, Benit E, Verdoia M, Rasoul S, Liew HB, Polad J, Ahmad WA, Zambahari R, Postma S, Kedhi E, Suryapranata H; Collaborators.

EuroIntervention. 2019 Dec 6;15(11):e990-e998. doi: 10.4244/EIJ-D-19-00539.


Antecedent Carbapenem Exposure as a Risk Factor for Non-Carbapenemase-Producing Carbapenem-Resistant Enterobacteriaceae and Carbapenemase-Producing Enterobacteriaceae.

Marimuthu K, Ng OT, Cherng BPZ, Fong RKC, Pada SK, De PP, Ooi ST, Smitasin N, Thoon KC, Krishnan PU, Ang MLT, Chan DSG, Kwa ALH, Deepak RN, Chan YK, Chan YFZ, Huan X, Zaw Linn K, Tee NWS, Tan TY, Koh TH, Lin RTP, Hsu LY, Sengupta S, Paterson DL, Perencevich E, Harbarth S, Teo J, Venkatachalam I; CaPES Study Group.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e00845-19. doi: 10.1128/AAC.00845-19. Print 2019 Oct.


Independent Predictors of Cardiac Mortality and Hospitalization for Heart Failure in a Multi-Ethnic Asian ST-segment Elevation Myocardial Infarction Population Treated by Primary Percutaneous Coronary Intervention.

Bulluck H, Zheng H, Chan MY, Foin N, Foo DC, Lee CW, Lim ST, Sahlen A, Tan HC, Tan JW, Tong KL, Wong AS, Wong PE, Yeo KK, Foo LL, Chua TS, Koh TH, Hausenloy DJ.

Sci Rep. 2019 Jul 11;9(1):10072. doi: 10.1038/s41598-019-46486-0.


Seroepidemiology and genotyping of hepatitis E virus in Singapore reveal rise in number of cases and similarity of human strains to those detected in pig livers.

Wong CC, Thean SM, Ng Y, Kang JSL, Ng TY, Chau ML, Koh TH, Chan KP.

Zoonoses Public Health. 2019 Nov;66(7):773-782. doi: 10.1111/zph.12624. Epub 2019 Jul 11.


One hypervirulent clone, sequence type 283, accounts for a large proportion of invasive Streptococcus agalactiae isolated from humans and diseased tilapia in Southeast Asia.

Barkham T, Zadoks RN, Azmai MNA, Baker S, Bich VTN, Chalker V, Chau ML, Dance D, Deepak RN, van Doorn HR, Gutierrez RA, Holmes MA, Huong LNP, Koh TH, Martins E, Mehershahi K, Newton P, Ng LC, Phuoc NN, Sangwichian O, Sawatwong P, Surin U, Tan TY, Tang WY, Thuy NV, Turner P, Vongsouvath M, Zhang D, Whistler T, Chen SL.

PLoS Negl Trop Dis. 2019 Jun 27;13(6):e0007421. doi: 10.1371/journal.pntd.0007421. eCollection 2019 Jun.


A pilot study on the analytic sensitivity and accuracy of the Check-Points Check Direct CPE, Cepheid Xpert Carba-R, and ChromID CARBA SMART chromogenic agar for detecting carbapenemase-producing Enterobacteriaceae.

Vasoo S, Hon PY, Hsu JP, Koh TH, De PP.

J Glob Antimicrob Resist. 2019 Sep;18:235-237. doi: 10.1016/j.jgar.2019.06.003. Epub 2019 Jun 13. No abstract available.


Risk factors and outcomes associated with the isolation of polymyxin B and carbapenem-resistant Enterobacteriaceae spp.: A case-control study.

Teo JQ, Chang CW, Leck H, Tang CY, Lee SJ, Cai Y, Ong RT, Koh TH, Tan TT, Kwa AL.

Int J Antimicrob Agents. 2019 May;53(5):657-662. doi: 10.1016/j.ijantimicag.2019.03.011. Epub 2019 Mar 14.


First Case of Ceftriaxone-Resistant Multidrug-Resistant Neisseria gonorrhoeae in Singapore.

Ko KKK, Chio MTW, Goh SS, Tan AL, Koh TH, Abdul Rahman NB.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02624-18. doi: 10.1128/AAC.02624-18. Print 2019 May. No abstract available.


Integrated pharmacokinetic-pharmacodynamic modeling to evaluate empiric carbapenem therapy in bloodstream infections.

Lim TP, Wang R, Poh GQ, Koh TH, Tan TY, Lee W, Teo JQ, Cai Y, Tan TT, Ee PLR, Kwa AL.

Infect Drug Resist. 2018 Sep 27;11:1591-1596. doi: 10.2147/IDR.S168191. eCollection 2018.


Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial.

Vranckx P, Valgimigli M, Jüni P, Hamm C, Steg PG, Heg D, van Es GA, McFadden EP, Onuma Y, van Meijeren C, Chichareon P, Benit E, Möllmann H, Janssens L, Ferrario M, Moschovitis A, Zurakowski A, Dominici M, Van Geuns RJ, Huber K, Slagboom T, Serruys PW, Windecker S; GLOBAL LEADERS Investigators.

Lancet. 2018 Sep 15;392(10151):940-949. doi: 10.1016/S0140-6736(18)31858-0. Epub 2018 Aug 27.


Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination.

Lam MMC, Wyres KL, Duchêne S, Wick RR, Judd LM, Gan YH, Hoh CH, Archuleta S, Molton JS, Kalimuddin S, Koh TH, Passet V, Brisse S, Holt KE.

Nat Commun. 2018 Jul 13;9(1):2703. doi: 10.1038/s41467-018-05114-7.


Rapid Antibiotic Combination Testing for Carbapenem-Resistant Gram-Negative Bacteria within Six Hours Using ATP Bioluminescence.

Cai Y, Seah CL, Leck H, Lim TP, Teo JQ, Lee W, Tan TT, Koh TH, Ee PLR, Kwa AL.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00183-18. doi: 10.1128/AAC.00183-18. Print 2018 Sep.


Occurrence and characteristics of extended-spectrum β-lactamase- and carbapenemase- producing bacteria from hospital effluents in Singapore.

Haller L, Chen H, Ng C, Le TH, Koh TH, Barkham T, Sobsey M, Gin KY.

Sci Total Environ. 2018 Feb 15;615:1119-1125. doi: 10.1016/j.scitotenv.2017.09.217. Epub 2017 Oct 17.


Advanced analyses of computed tomography coronary angiography can help discriminate ischemic lesions.

Zhang JM, Shuang D, Baskaran L, Wu W, Teo SK, Huang W, Gobeawan L, Allen JC, Tan RS, Su X, Ismail NB, Wan M, Su B, Zou H, Low R, Zhao X, Chi Y, Zhou J, Su Y, Lomarda AM, Chin CY, Fam JM, Keng FYJ, Wong ASL, Tan JWC, Yeo KK, Wong PEH, Chin CT, Ho KW, Yap J, Kassab GS, Chua T, Koh TH, Tan SY, Lim ST, Zhong L.

Int J Cardiol. 2018 Sep 15;267:208-214. doi: 10.1016/j.ijcard.2018.04.020. Epub 2018 Apr 26.


Comparison of Clinical Isolates of Aeromonas from Singapore and Malaysia with Regard to Molecular Identification, Virulence, and Antimicrobial Profiles.

Khor WC, Puah SM, Koh TH, Tan JAMA, Puthucheary SD, Chua KH.

Microb Drug Resist. 2018 May;24(4):469-478. doi: 10.1089/mdr.2017.0083. Epub 2018 Feb 20.


Corrigendum: Characterization of Metagenomes in Urban Aquatic Compartments Reveals High Prevalence of Clinically Relevant Antibiotic Resistance Genes in Wastewaters.

Ng C, Tay M, Tan B, Le TH, Haller L, Chen H, Koh TH, Barkham TMS, Thompson JR, Gin KY.

Front Microbiol. 2018 Feb 5;9:175. doi: 10.3389/fmicb.2018.00175. eCollection 2018.


Draft Genome Sequence of Singapore Klebsiella pneumoniae subsp. pneumoniae Isolate DS32358_14, Which Contains the Carbapenemase Gene blaVIM-1.

Koh TH, Abdul Rahman NB, Teo JWP, La MV, Periaswamy B, Chen SL.

Genome Announc. 2018 Jan 4;6(1). pii: e01377-17. doi: 10.1128/genomeA.01377-17.


Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs.

Kale SD, Dikshit N, Kumar P, Balamuralidhar V, Khameneh HJ, Bin Abdul Malik N, Koh TH, Tan GGY, Tan TT, Mortellaro A, Sukumaran B.

Sci Rep. 2017 Dec 12;7(1):17429. doi: 10.1038/s41598-017-17653-y.


Characterization of Metagenomes in Urban Aquatic Compartments Reveals High Prevalence of Clinically Relevant Antibiotic Resistance Genes in Wastewaters.

Ng C, Tay M, Tan B, Le TH, Haller L, Chen H, Koh TH, Barkham TMS, Gin KY.

Front Microbiol. 2017 Nov 16;8:2200. doi: 10.3389/fmicb.2017.02200. eCollection 2017. Erratum in: Front Microbiol. 2018 Feb 05;9:175.


Design of a Soft Robotic Elbow Sleeve with Passive and Intent-Controlled Actuation.

Koh TH, Cheng N, Yap HK, Yeow CH.

Front Neurosci. 2017 Oct 25;11:597. doi: 10.3389/fnins.2017.00597. eCollection 2017.


Putative Integrative Mobile Elements That Exploit the Xer Recombination Machinery Carrying blaIMI-Type Carbapenemase Genes in Enterobacter cloacae Complex Isolates in Singapore.

Koh TH, Rahman NBA, Teo JWP, La MV, Periaswamy B, Chen SL.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01542-17. doi: 10.1128/AAC.01542-17. Print 2018 Jan.


Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in retail food in Singapore.

Aung KT, Hsu LY, Koh TH, Hapuarachchi HC, Chau ML, Gutiérrez RA, Ng LC.

Antimicrob Resist Infect Control. 2017 Sep 8;6:94. doi: 10.1186/s13756-017-0255-3. eCollection 2017.


Comparative analysis of recurrent events after presentation with an index myocardial infarction or ischaemic stroke.

Yeo KK, Zheng H, Chow KY, Ahmad A, Chan BPL, Chang HM, Chong E, Chua TSJ, Foo DCG, Low LP, Ong MEH, Ong HY, Koh TH, Tan HC, Tang KF, Venketasubramanian N.

Eur Heart J Qual Care Clin Outcomes. 2017 Jul 1;3(3):234-242. doi: 10.1093/ehjqcco/qcw048.


What causes the experience of discrimination in non-regular workers?

Kang SH, Song JH, Koh TH, Paek DM, Park JT, Chun H.

Ann Occup Environ Med. 2017 Aug 15;29:35. doi: 10.1186/s40557-017-0192-x. eCollection 2017.


Early clinical manifestations of vibrio necrotising fasciitis.

Koh THB, Tan JHJ, Hong CC, Wang W, Nather A.

Singapore Med J. 2018 Apr;59(4):224-227. doi: 10.11622/smedj.2017055. Epub 2017 Jul 6.


Clinical and Molecular Epidemiology of Carbapenem-Resistant Enterobacteriaceae Among Adult Inpatients in Singapore.

Marimuthu K, Venkatachalam I, Khong WX, Koh TH, Cherng BPZ, Van La M, De PP, Krishnan PU, Tan TY, Choon RFK, Pada SK, Lam CW, Ooi ST, Deepak RN, Smitasin N, Tan EL, Lee JJ, Kurup A, Young B, Sim NTW, Thoon KC, Fisher D, Ling ML, Peng BAS, Teo YY, Hsu LY, Lin RTP, Ong RT, Teo J, Ng OT; Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group.

Clin Infect Dis. 2017 May 15;64(suppl_2):S68-S75. doi: 10.1093/cid/cix113.


2015 Epidemic of Severe Streptococcus agalactiae Sequence Type 283 Infections in Singapore Associated With the Consumption of Raw Freshwater Fish: A Detailed Analysis of Clinical, Epidemiological, and Bacterial Sequencing Data.

Kalimuddin S, Chen SL, Lim CTK, Koh TH, Tan TY, Kam M, Wong CW, Mehershahi KS, Chau ML, Ng LC, Tang WY, Badaruddin H, Teo J, Apisarnthanarak A, Suwantarat N, Ip M, Holden MTG, Hsu LY, Barkham T; Singapore Group B Streptococcus Consortium.

Clin Infect Dis. 2017 May 15;64(suppl_2):S145-S152. doi: 10.1093/cid/cix021.


Simple Screening for Carbapenemase-Producing Enterobacteriaceae by Moxalactam Susceptibility Testing.

Imai W, Sasaki M, Aoki K, Ishii Y, Bonomo RA, Koh TH, Murakami H, Morita T, Tateda K.

J Clin Microbiol. 2017 Jul;55(7):2276-2279. doi: 10.1128/JCM.00606-17. Epub 2017 May 3. No abstract available.


ST3268: a geographically widespread primate MRSA clone.

Hsu LY, Holden MTG, Koh TH, Pettigrew KA, Cao D, Hon PY, Sergio DM, Pena E, Ogden BE.

J Antimicrob Chemother. 2017 Aug 1;72(8):2401-2403. doi: 10.1093/jac/dkx120. No abstract available.


Group B Streptococci in Sushi and Sashimi.

Koh TH, Cao DY, Khoo BC, Ong LH, Teo F, Tan TW.

Ann Acad Med Singapore. 2017 Feb;46(2):74-75. No abstract available.


LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.

He C, Zeng M, Dutta D, Koh TH, Chen J, van der Donk WA.

Sci Rep. 2017 Jan 20;7:40980. doi: 10.1038/srep40980.


Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Retail Chicken Meat in Singapore.

Lim EJ, Ho SX, Cao DY, Lau QC, Koh TH, Hsu LY.

Ann Acad Med Singapore. 2016 Dec;45(12):557-559. No abstract available.


Evaluating Polymyxin B-Based Combinations against Carbapenem-Resistant Escherichia coli in Time-Kill Studies and in a Hollow-Fiber Infection Model.

Cai Y, Lim TP, Teo JQ, Sasikala S, Chan EC, Hong YJ, Lee W, Tan TY, Tan TT, Koh TH, Hsu LY, Kwa AL.

Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01509-16. doi: 10.1128/AAC.01509-16. Print 2017 Jan.


Occurrences and Characterization of Antibiotic-Resistant Bacteria and Genetic Determinants of Hospital Wastewater in a Tropical Country.

Le TH, Ng C, Chen H, Yi XZ, Koh TH, Barkham TM, Zhou Z, Gin KY.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7449-7456. Print 2016 Dec.


Influence of Ethnicity, Age, and Time on Sex Disparities in Long-Term Cause-Specific Mortality After Acute Myocardial Infarction.

Gao F, Lam CS, Yeo KK, Machin D, de Carvalho LP, Sim LL, Koh TH, Foo D, Ong HY, Tong KL, Tan HC, Earnest A, Chua T, Chan MY.

J Am Heart Assoc. 2016 Oct 6;5(10). pii: e003760.


Symptom-to-door delay among patients with ST-segment elevation myocardial infarction in Singapore.

Wah W, Pek PP, Ho AF, Fook-Chong S, Zheng H, Loy EY, Chua TS, Koh TH, Chow KY, Earnest A, Pang J, Ong ME.

Emerg Med Australas. 2017 Feb;29(1):24-32. doi: 10.1111/1742-6723.12689. Epub 2016 Oct 11.


Reperfusion treatment delays amongst patients with painless ST segment elevation myocardial infarction.

Pek PP, Loy EY, Wah W, Ho AFW, Zheng H, Fook-Chong SMC, Chua TSJ, Koh TH, Chow KY, Liu N, Ong MEH.

CJEM. 2017 Sep;19(5):355-363. doi: 10.1017/cem.2016.376. Epub 2016 Sep 29.


Compression and flexural strength of bone cement mixed with blood.

Tan JH, Koh BT, Ramruttun AK, Wang W.

J Orthop Surg (Hong Kong). 2016 Aug;24(2):240-4.


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