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An ex vivo bladder model with detrusor smooth muscle removed to analyse biologically active mediators released from the suburothelium.

Durnin L, Kwok B, Kukadia P, McAvera R, Corrigan RD, Ward SM, Zhang Y, Chen Q, Koh SD, Sanders KM, Mutafova-Yambolieva VN.

J Physiol. 2018 Oct 5. doi: 10.1113/JP276924. [Epub ahead of print]


The Functional Role of Protease-Activated Receptors on Contractile Responses by Activation of Ca2+ Sensitization Pathways in Simian Colonic Muscles.

Sung TS, Lu H, Sung J, Yeom JH, Perrino BA, Koh SD.

Am J Physiol Gastrointest Liver Physiol. 2018 Sep 27. doi: 10.1152/ajpgi.00255.2018. [Epub ahead of print]


SOCE mediated by STIM and Orai is essential for pacemaker activity in the interstitial cells of Cajal in the gastrointestinal tract.

Zheng H, Drumm BT, Earley S, Sung TS, Koh SD, Sanders KM.

Sci Signal. 2018 Jun 12;11(534). pii: eaaq0918. doi: 10.1126/scisignal.aaq0918.


The effects of mitochondrial inhibitors on Ca2+ signalling and electrical conductances required for pacemaking in interstitial cells of Cajal in the mouse small intestine.

Drumm BT, Sung TS, Zheng H, Baker SA, Koh SD, Sanders KM.

Cell Calcium. 2018 Jun;72:1-17. doi: 10.1016/j.ceca.2018.01.003. Epub 2018 Feb 1.


The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach.

Sung TS, Hwang SJ, Koh SD, Bayguinov Y, Peri LE, Blair PJ, Webb TI, Pardo DM, Rock JR, Sanders KM, Ward SM.

J Physiol. 2018 May 1;596(9):1549-1574. doi: 10.1113/JP275478. Epub 2018 Mar 23.


Molecular and functional characterization of inwardly rectifying K+ currents in murine proximal colon.

Huang X, Lee SH, Lu H, Sanders KM, Koh SD.

J Physiol. 2018 Feb 1;596(3):379-391. doi: 10.1113/JP275234. Epub 2017 Dec 27.


The Mystery of the Interstitial Cells in the Urinary Bladder.

Koh SD, Lee H, Ward SM, Sanders KM.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:603-623. doi: 10.1146/annurev-pharmtox-010617-052615. Epub 2017 Oct 6.


Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFRα+ cells.

Lee H, Koh BH, Peri LE, Corrigan RD, Lee HT, George NE, Bhetwal BP, Xie Y, Perrino BA, Chai TC, Sanders KM, Koh SD.

Sci Rep. 2017 Sep 25;7(1):12245. doi: 10.1038/s41598-017-12561-7.


A model of the enteric neural circuitry underlying the generation of rhythmic motor patterns in the colon: the role of serotonin.

Smith TK, Koh SD.

Am J Physiol Gastrointest Liver Physiol. 2017 Jan 1;312(1):G1-G14. doi: 10.1152/ajpgi.00337.2016. Epub 2016 Oct 27. Review.


Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal.

Zhu MH, Sung TS, Kurahashi M, O'Kane LE, O'Driscoll K, Koh SD, Sanders KM.

Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1037-G1046. doi: 10.1152/ajpgi.00277.2016. Epub 2016 Oct 13.


Urothelial purine release during filling of murine and primate bladders.

Durnin L, Hayoz S, Corrigan RD, Yanez A, Koh SD, Mutafova-Yambolieva VN.

Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F708-F716. doi: 10.1152/ajprenal.00387.2016. Epub 2016 Jul 27.


Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels.

Sung TS, O'Driscoll K, Zheng H, Yapp NJ, Leblanc N, Koh SD, Sanders KM.

Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C437-51. doi: 10.1152/ajpcell.00070.2016. Epub 2016 Jul 13.


Use of Genetically Encoded Calcium Indicators (GECIs) Combined with Advanced Motion Tracking Techniques to Examine the Behavior of Neurons and Glia in the Enteric Nervous System of the Intact Murine Colon.

Hennig GW, Gould TW, Koh SD, Corrigan RD, Heredia DJ, Shonnard MC, Smith TK.

Front Cell Neurosci. 2015 Nov 10;9:436. doi: 10.3389/fncel.2015.00436. eCollection 2015.


UTP activates small-conductance Ca2+-activated K+ channels in murine detrusor PDGFRα+ cells.

Lee H, Koh BH, Yamasaki E, George NE, Sanders KM, Koh SD.

Am J Physiol Renal Physiol. 2015 Sep 15;309(6):F569-74. doi: 10.1152/ajprenal.00156.2015. Epub 2015 Jul 22.


Reply to O'Grady et al.

Sanders KM, Ward SM, Koh SD.

Physiol Rev. 2015 Apr;95(2):693-4. doi: 10.1152/physrev.00006.2015. No abstract available.


Protease-activated receptors modulate excitability of murine colonic smooth muscles by differential effects on interstitial cells.

Sung TS, Kim HU, Kim JH, Lu H, Sanders KM, Koh SD.

J Physiol. 2015 Mar 1;593(5):1169-81. doi: 10.1113/jphysiol.2014.285148. Epub 2015 Feb 4.


Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.

Zhu MH, Sung TS, O'Driscoll K, Koh SD, Sanders KM.

Am J Physiol Cell Physiol. 2015 Apr 15;308(8):C608-20. doi: 10.1152/ajpcell.00360.2014. Epub 2015 Jan 28.


Calcium signalling in Cajal-like interstitial cells of the lower urinary tract.

Drumm BT, Koh SD, Andersson KE, Ward SM.

Nat Rev Urol. 2014 Oct;11(10):555-64. doi: 10.1038/nrurol.2014.241. Epub 2014 Sep 16. Review.


Platelet-derived growth factor receptor-α-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles.

Kurahashi M, Mutafova-Yambolieva V, Koh SD, Sanders KM.

Am J Physiol Cell Physiol. 2014 Sep 15;307(6):C561-70. doi: 10.1152/ajpcell.00080.2014. Epub 2014 Jul 23.


Interstitial cells: regulators of smooth muscle function.

Sanders KM, Ward SM, Koh SD.

Physiol Rev. 2014 Jul;94(3):859-907. doi: 10.1152/physrev.00037.2013. Review.


Responses to enteric motor neurons in the gastric fundus of mice with reduced intramuscular interstitial cells of cajal.

Sanders KM, Salter AK, Hennig GW, Koh SD, Perrino BA, Ward SM, Baker SA.

J Neurogastroenterol Motil. 2014 Apr 30;20(2):171-84. doi: 10.5056/jnm.2014.20.2.171.


Expression and function of a T-type Ca2+ conductance in interstitial cells of Cajal of the murine small intestine.

Zheng H, Park KS, Koh SD, Sanders KM.

Am J Physiol Cell Physiol. 2014 Apr 1;306(7):C705-13. doi: 10.1152/ajpcell.00390.2013. Epub 2014 Jan 29.


Extensive projections of myenteric serotonergic neurons suggest they comprise the central processing unit in the colon.

Okamoto T, Barton MJ, Hennig GW, Birch GC, Grainger N, Corrigan RD, Koh SD, Sanders KM, Smith TK.

Neurogastroenterol Motil. 2014 Apr;26(4):556-70. doi: 10.1111/nmo.12302. Epub 2014 Jan 26.


Purinergic inhibitory regulation of murine detrusor muscles mediated by PDGFRα+ interstitial cells.

Lee H, Koh BH, Peri LE, Sanders KM, Koh SD.

J Physiol. 2014 Mar 15;592(6):1283-93. doi: 10.1113/jphysiol.2013.267989. Epub 2014 Jan 6.


Comparison of skeletal anchored facemask and tooth-borne facemask according to vertical skeletal pattern and growth stage.

Koh SD, Chung DH.

Angle Orthod. 2014 Jul;84(4):628-33. doi: 10.2319/060313-421.1. Epub 2013 Nov 25.


Ionic Conductance(s) in Response to Post-junctional Potentials.

Koh SD, Rhee PL.

J Neurogastroenterol Motil. 2013 Oct;19(4):426-32. doi: 10.5056/jnm.2013.19.4.426. Epub 2013 Oct 7. Review.


Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: in vitro analyses in mice lacking tryptophan hydroxylase 1.

Heredia DJ, Gershon MD, Koh SD, Corrigan RD, Okamoto T, Smith TK.

J Physiol. 2013 Dec 1;591(23):5939-57. doi: 10.1113/jphysiol.2013.256230. Epub 2013 Oct 14.


Laminar shear stress upregulates endothelial Ca²⁺-activated K⁺ channels KCa2.3 and KCa3.1 via a Ca²⁺/calmodulin-dependent protein kinase kinase/Akt/p300 cascade.

Takai J, Santu A, Zheng H, Koh SD, Ohta M, Filimban LM, Lemaître V, Teraoka R, Jo H, Miura H.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H484-93. doi: 10.1152/ajpheart.00642.2012. Epub 2013 Jun 21.


Functional expression of SK channels in murine detrusor PDGFR+ cells.

Lee H, Koh BH, Peri LE, Sanders KM, Koh SD.

J Physiol. 2013 Jan 15;591(2):503-13. doi: 10.1113/jphysiol.2012.241505. Epub 2012 Nov 12.


Regulation of gastrointestinal motility--insights from smooth muscle biology.

Sanders KM, Koh SD, Ro S, Ward SM.

Nat Rev Gastroenterol Hepatol. 2012 Nov;9(11):633-45. doi: 10.1038/nrgastro.2012.168. Epub 2012 Sep 11. Review.


Ionic conductances regulating the excitability of colonic smooth muscles.

Koh SD, Ward SM, Sanders KM.

Neurogastroenterol Motil. 2012 Aug;24(8):705-18. doi: 10.1111/j.1365-2982.2012.01956.x. Epub 2012 Jun 24. Review.


Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells.

Koh BH, Roy R, Hollywood MA, Thornbury KD, McHale NG, Sergeant GP, Hatton WJ, Ward SM, Sanders KM, Koh SD.

J Cell Mol Med. 2012 Apr;16(4):691-700. doi: 10.1111/j.1582-4934.2011.01506.x.


Analysis of pacemaker activity in the human stomach.

Rhee PL, Lee JY, Son HJ, Kim JJ, Rhee JC, Kim S, Koh SD, Hwang SJ, Sanders KM, Ward SM.

J Physiol. 2011 Dec 15;589(Pt 24):6105-18. doi: 10.1113/jphysiol.2011.217497. Epub 2011 Oct 17.


Anoctamins and gastrointestinal smooth muscle excitability.

Sanders KM, Zhu MH, Britton F, Koh SD, Ward SM.

Exp Physiol. 2012 Feb;97(2):200-6. doi: 10.1113/expphysiol.2011.058248. Epub 2011 Oct 14. Review.


Identification of histamine receptors and effects of histamine on murine and simian colonic excitability.

Kim H, Dwyer L, Song JH, Martin-Cano FE, Bahney J, Peri L, Britton FC, Sanders KM, Koh SD.

Neurogastroenterol Motil. 2011 Oct;23(10):949-e409. doi: 10.1111/j.1365-2982.2011.01760.x. Epub 2011 Aug 1.


Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal.

Zhu MH, Sung IK, Zheng H, Sung TS, Britton FC, O'Driscoll K, Koh SD, Sanders KM.

J Physiol. 2011 Sep 15;589(Pt 18):4565-82. doi: 10.1113/jphysiol.2011.211094. Epub 2011 Jul 18.


Basally activated nonselective cation currents regulate the resting membrane potential in human and monkey colonic smooth muscle.

Dwyer L, Rhee PL, Lowe V, Zheng H, Peri L, Ro S, Sanders KM, Koh SD.

Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G287-96. doi: 10.1152/ajpgi.00415.2010. Epub 2011 May 12.


Contribution of Rho-kinase to membrane excitability of murine colonic smooth muscle.

Bayguinov O, Dwyer L, Kim H, Marklew A, Sanders KM, Koh SD.

Br J Pharmacol. 2011 Jun;163(3):638-48. doi: 10.1111/j.1476-5381.2011.01241.x.


The stretch-dependent potassium channel TREK-1 and its function in murine myometrium.

Monaghan K, Baker SA, Dwyer L, Hatton WC, Sik Park K, Sanders KM, Koh SD.

J Physiol. 2011 Mar 1;589(Pt 5):1221-33. doi: 10.1113/jphysiol.2010.203869. Epub 2011 Jan 10.


The clue of Interstitial Cell of Cajalopathy (ICCpathy) in human diabetic gastropathy: the ultrastructural and electrical clues of ICCpathy in human diabetic gastropathy.

Kim ER, Kim KM, Lee JY, Joo M, Kim S, Noh JH, Ward SM, Koh SD, Rhee PL.

Exp Toxicol Pathol. 2012 Jul;64(5):521-6. doi: 10.1016/j.etp.2010.11.008. Epub 2010 Dec 23.


A functional role for the 'fibroblast-like cells' in gastrointestinal smooth muscles.

Kurahashi M, Zheng H, Dwyer L, Ward SM, Koh SD, Sanders KM.

J Physiol. 2011 Feb 1;589(Pt 3):697-710. doi: 10.1113/jphysiol.2010.201129. Epub 2010 Dec 20.


β-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons.

Hwang SJ, Durnin L, Dwyer L, Rhee PL, Ward SM, Koh SD, Sanders KM, Mutafova-Yambolieva VN.

Gastroenterology. 2011 Feb;140(2):608-617.e6. doi: 10.1053/j.gastro.2010.09.039. Epub 2010 Sep 25.


Role of TREK-1 potassium channel in bladder overactivity after partial bladder outlet obstruction in mouse.

Baker SA, Hatton WJ, Han J, Hennig GW, Britton FC, Koh SD.

J Urol. 2010 Feb;183(2):793-800. doi: 10.1016/j.juro.2009.09.079.


Phospholipase C-independent effects of 3M3FBS in murine colon.

Dwyer L, Kim HJ, Koh BH, Koh SD.

Eur J Pharmacol. 2010 Feb 25;628(1-3):187-94. doi: 10.1016/j.ejphar.2009.11.029. Epub 2009 Nov 18.


CaM kinase II in colonic smooth muscle contributes to dysmotility in murine DSS-colitis.

Qureshi S, Song J, Lee HT, Koh SD, Hennig GW, Perrino BA.

Neurogastroenterol Motil. 2010 Feb;22(2):186-95, e64. doi: 10.1111/j.1365-2982.2009.01406.x. Epub 2009 Sep 7.


A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity.

Zhu MH, Kim TW, Ro S, Yan W, Ward SM, Koh SD, Sanders KM.

J Physiol. 2009 Oct 15;587(Pt 20):4905-18. doi: 10.1113/jphysiol.2009.176206. Epub 2009 Aug 24.


Caffeine inhibits nonselective cationic currents in interstitial cells of Cajal from the murine jejunum.

Jin NG, Koh SD, Sanders KM.

Am J Physiol Cell Physiol. 2009 Oct;297(4):C971-8. doi: 10.1152/ajpcell.00155.2009. Epub 2009 Jul 22.


Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.

Faville RA, Pullan AJ, Sanders KM, Koh SD, Lloyd CM, Smith NP.

Biophys J. 2009 Jun 17;96(12):4834-52. doi: 10.1016/j.bpj.2009.03.058.


Modulation of murine gastric antrum smooth muscle STOC activity and excitability by phospholamban.

Kim M, Hennig GW, Park K, Han IS, Smith TK, Koh SD, Perrino BA.

J Physiol. 2008 Oct 15;586(20):4977-91. doi: 10.1113/jphysiol.2008.156836. Epub 2008 Aug 28.


Functional and molecular identification of pH-sensitive K+ channels in murine urinary bladder smooth muscle.

Beckett EA, Han I, Baker SA, Han J, Britton FC, Koh SD.

BJU Int. 2008 Jul;102(1):113-24. doi: 10.1111/j.1464-410X.2008.07541.x. Epub 2008 Apr 3.

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