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PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence.

Klein ME, Dickson MA, Antonescu C, Qin LX, Dooley SJ, Barlas A, Manova K, Schwartz GK, Crago AM, Singer S, Koff A, Tap WD.

Oncogene. 2018 Sep;37(37):5066-5078. doi: 10.1038/s41388-018-0332-y. Epub 2018 May 23.


CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought.

Klein ME, Kovatcheva M, Davis LE, Tap WD, Koff A.

Cancer Cell. 2018 Jul 9;34(1):9-20. doi: 10.1016/j.ccell.2018.03.023. Epub 2018 May 3. Review.


Mechanistic understanding of the role of ATRX in senescence provides new insight for combinatorial therapies with CDK4 inhibitors.

Kovatcheva M, Klein ME, Tap WD, Koff A.

Mol Cell Oncol. 2017 Nov 7;5(1):e1384882. doi: 10.1080/23723556.2017.1384882. eCollection 2018.


ATRX is a regulator of therapy induced senescence in human cells.

Kovatcheva M, Liao W, Klein ME, Robine N, Geiger H, Crago AM, Dickson MA, Tap WD, Singer S, Koff A.

Nat Commun. 2017 Aug 30;8(1):386. doi: 10.1038/s41467-017-00540-5.


Implementation of clinical effectiveness guidelines for solid organ injury after trauma: 10-year experience at a level 1 pediatric trauma center.

Leeper CM, Nasr I, Koff A, McKenna C, Gaines BA.

J Pediatr Surg. 2018 Apr;53(4):775-779. doi: 10.1016/j.jpedsurg.2017.05.025. Epub 2017 Jun 6.


Condomless sex and HIV transmission among serodifferent couples: current evidence and recommendations.

Koff A, Goldberg C, Ogbuagu O.

Ann Med. 2017 Sep;49(6):534-544. doi: 10.1080/07853890.2017.1320423. Epub 2017 May 3. Review.


Progression-Free Survival Among Patients With Well-Differentiated or Dedifferentiated Liposarcoma Treated With CDK4 Inhibitor Palbociclib: A Phase 2 Clinical Trial.

Dickson MA, Schwartz GK, Keohan ML, D'Angelo SP, Gounder MM, Chi P, Antonescu CR, Landa J, Qin LX, Crago AM, Singer S, Koff A, Tap WD.

JAMA Oncol. 2016 Jul 1;2(7):937-40. doi: 10.1001/jamaoncol.2016.0264.


Application of molecular biology to individualize therapy for patients with liposarcoma.

Abbas Manji G, Singer S, Koff A, Schwartz GK.

Am Soc Clin Oncol Educ Book. 2015:213-8. doi: 10.14694/EdBook_AM.2015.35.213. Review.


MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition.

Kovatcheva M, Liu DD, Dickson MA, Klein ME, O'Connor R, Wilder FO, Socci ND, Tap WD, Schwartz GK, Singer S, Crago AM, Koff A.

Oncotarget. 2015 Apr 10;6(10):8226-43.


The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity.

Raheja R, Liu Y, Hukkelhoven E, Yeh N, Koff A.

Biochem J. 2014 Mar 15;458(3):537-45. doi: 10.1042/BJ20131288.


TRIM3, a tumor suppressor linked to regulation of p21(Waf1/Cip1.).

Liu Y, Raheja R, Yeh N, Ciznadija D, Pedraza AM, Ozawa T, Hukkelhoven E, Erdjument-Bromage H, Tempst P, Gauthier NP, Brennan C, Holland EC, Koff A.

Oncogene. 2014 Jan 16;33(3):308-15. doi: 10.1038/onc.2012.596. Epub 2013 Jan 14.


Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells.

Pérez-Sanz J, Arluzea J, Matorras R, González-Santiago N, Bilbao J, Yeh N, Barlas A, Romin Y, Manova-Todorova K, Koff A, de la Hoz C.

Hum Reprod. 2013 Apr;28(4):1023-30. doi: 10.1093/humrep/des436. Epub 2013 Jan 8.


Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.

Hukkelhoven E, Liu Y, Yeh N, Ciznadija D, Blain SW, Koff A.

J Biol Chem. 2012 Nov 9;287(46):38523-30. doi: 10.1074/jbc.M112.366542. Epub 2012 Sep 24.


The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer.

Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, Porcu L, Bussani C, D'Incalci M, Erba E, Romano M, Cattoretti G, Katsaros D, Koff A, Luzzatto L.

Clin Cancer Res. 2012 Aug 15;18(16):4313-24. Epub 2012 Jun 25.


p27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.

Miller JP, Yeh N, Hofstetter CP, Keskin D, Goldstein AS, Koff A.

J Biol Chem. 2012 Jun 8;287(24):19775-85. doi: 10.1074/jbc.M112.361972. Epub 2012 Apr 17.


Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma.

Ciznadija D, Liu Y, Pyonteck SM, Holland EC, Koff A.

Cancer Res. 2011 Oct 1;71(19):6174-83. doi: 10.1158/0008-5472.CAN-11-1031. Epub 2011 Aug 15.


Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase.

Ciznadija D, Zhu XH, Koff A.

Cell Cycle. 2011 Aug 15;10(16):2714-23. Epub 2011 Aug 15.


ZIC1 overexpression is oncogenic in liposarcoma.

Brill E, Gobble R, Angeles C, Lagos-Quintana M, Crago A, Laxa B, Decarolis P, Zhang L, Antonescu C, Socci ND, Taylor BS, Sander C, Koff A, Singer S.

Cancer Res. 2010 Sep 1;70(17):6891-901. doi: 10.1158/0008-5472.CAN-10-0745. Epub 2010 Aug 16.


Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas.

See WL, Miller JP, Squatrito M, Holland E, Resh MD, Koff A.

Oncogene. 2010 Mar 25;29(12):1720-31. doi: 10.1038/onc.2009.465. Epub 2010 Jan 11.


The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior.

Liu Y, Elf SE, Asai T, Miyata Y, Liu Y, Sashida G, Huang G, Di Giandomenico S, Koff A, Nimer SD.

Cell Cycle. 2009 Oct 1;8(19):3120-4. Review.


PRP with subcorneal acantholysis: case report and review.

Sebastian A, Koff AB, Goldberg LJ.

J Cutan Pathol. 2010 Jan;37(1):99-101. doi: 10.1111/j.1600-0560.2009.01279.x. Epub 2009 Jul 7.


CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis.

Liu L, Lee S, Zhang J, Peters SB, Hannah J, Zhang Y, Yin Y, Koff A, Ma L, Zhou P.

Mol Cell. 2009 May 14;34(4):451-60. doi: 10.1016/j.molcel.2009.04.020.


Sclerotic bodies in nephrogenic systemic fibrosis: a new histopathologic finding.

Bhawan J, Swick BL, Koff AB, Stone MS.

J Cutan Pathol. 2009 May;36(5):548-52. doi: 10.1111/j.1600-0560.2008.01111.x. Epub 2009 Mar 30.


p53 regulates hematopoietic stem cell quiescence.

Liu Y, Elf SE, Miyata Y, Sashida G, Liu Y, Huang G, Di Giandomenico S, Lee JM, Deblasio A, Menendez S, Antipin J, Reva B, Koff A, Nimer SD.

Cell Stem Cell. 2009 Jan 9;4(1):37-48. doi: 10.1016/j.stem.2008.11.006.


Overview of the cell cycle.

Park MS, Koff A.

Curr Protoc Cell Biol. 2001 May;Chapter 8:Unit 8.1. doi: 10.1002/0471143030.cb0801s00.


Interweaving the cell cycle machinery with cell differentiation.

Miller JP, Yeh N, Vidal A, Koff A.

Cell Cycle. 2007 Dec 1;6(23):2932-8. Epub 2007 Sep 11. Review.


Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1).

Liu Y, Yeh N, Zhu XH, Leversha M, Cordon-Cardo C, Ghossein R, Singh B, Holland E, Koff A.

EMBO J. 2007 Nov 14;26(22):4683-93. Epub 2007 Oct 18.


p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia.

Smartt HJ, Guilmeau S, Nasser SV, Nicholas C, Bancroft L, Simpson SA, Yeh N, Yang W, Mariadason JM, Koff A, Augenlicht LH.

Gastroenterology. 2007 Jul;133(1):232-43. Epub 2007 Apr 25.


Cooperation between p27 and p107 during endochondral ossification suggests a genetic pathway controlled by p27 and p130.

Yeh N, Miller JP, Gaur T, Capellini TD, Nikolich-Zugich J, de la Hoz C, Selleri L, Bromage TG, van Wijnen AJ, Stein GS, Lian JB, Vidal A, Koff A.

Mol Cell Biol. 2007 Jul;27(14):5161-71. Epub 2007 May 14.


p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling.

Hulit J, Lee RJ, Li Z, Wang C, Katiyar S, Yang J, Quong AA, Wu K, Albanese C, Russell R, Di Vizio D, Koff A, Thummala S, Zhang H, Harrell J, Sun H, Muller WJ, Inghirami G, Lisanti MP, Pestell RG.

Cancer Res. 2006 Sep 1;66(17):8529-41.


Misexpression of cyclin B3 leads to aberrant spermatogenesis.

Refik-Rogers J, Manova K, Koff A.

Cell Cycle. 2006 Sep;5(17):1966-73. Epub 2006 Sep 1.


Functional interaction of the retinoblastoma and Ini1/Snf5 tumor suppressors in cell growth and pituitary tumorigenesis.

Guidi CJ, Mudhasani R, Hoover K, Koff A, Leav I, Imbalzano AN, Jones SN.

Cancer Res. 2006 Aug 15;66(16):8076-82.


The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2.

Liu Y, Hedvat CV, Mao S, Zhu XH, Yao J, Nguyen H, Koff A, Nimer SD.

Mol Cell Biol. 2006 Apr;26(8):3114-23.


p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice.

Kuzushita N, Rogers AB, Monti NA, Whary MT, Park MJ, Aswad BI, Shirin H, Koff A, Eguchi H, Moss SF.

Gastroenterology. 2005 Nov;129(5):1544-56.


Glomerular aging in females is a multi-stage reversible process mediated by phenotypic changes in progenitors.

Feng Z, Plati AR, Cheng QL, Berho M, Banerjee A, Potier M, Jy WC, Koff A, Striker LJ, Striker GE.

Am J Pathol. 2005 Aug;167(2):355-63.


PDGF-BB regulates p27 expression through ERK-dependent RNA turn-over in vascular smooth muscle cells.

Sakakibara K, Kubota K, Worku B, Ryer EJ, Miller JP, Koff A, Kent KC, Liu B.

J Biol Chem. 2005 Jul 8;280(27):25470-7. Epub 2005 May 14.


p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow.

Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley AH, de la Hoz C, Jensen KK, Kato D, MacDonald DD, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D, Koff A.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6890-5. Epub 2005 May 2.


Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.

Shaffer DR, Viale A, Ishiwata R, Leversha M, Olgac S, Manova K, Satagopan J, Scher H, Koff A.

Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):210-5. Epub 2004 Dec 22.


Noncatalytic requirement for cyclin A-cdk2 in p27 turnover.

Zhu XH, Nguyen H, Halicka HD, Traganos F, Koff A.

Mol Cell Biol. 2004 Jul;24(13):6058-66.


p27 as a target for cancer therapeutics.

Blain SW, Scher HI, Cordon-Cardo C, Koff A.

Cancer Cell. 2003 Feb;3(2):111-5. Review. No abstract available.


p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development.

Carneiro C, Jiao MS, Hu M, Shaffer D, Park M, Pandolfi PP, Cordon-Cardo C, Koff A.

Oncogene. 2003 Jan 23;22(3):361-9.


Characterization and expression of mammalian cyclin b3, a prepachytene meiotic cyclin.

Nguyen TB, Manova K, Capodieci P, Lindon C, Bottega S, Wang XY, Refik-Rogers J, Pines J, Wolgemuth DJ, Koff A.

J Biol Chem. 2002 Nov 1;277(44):41960-9. Epub 2002 Aug 15.


Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.

Vidal A, Millard SS, Miller JP, Koff A.

J Biol Chem. 2002 May 10;277(19):16433-40. Epub 2002 Mar 1.


The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.

Mahoney JA, Odin JA, White SM, Shaffer D, Koff A, Casciola-Rosen L, Rosen A.

Biochem J. 2002 Feb 1;361(Pt 3):587-95.


Cdk pathway: cyclin-dependent kinases and cyclin-dependent kinase inhibitors.

Gitig DM, Koff A.

Mol Biotechnol. 2001 Oct;19(2):179-88.


Inhibin and p27 interact to regulate gonadal tumorigenesis.

Cipriano SC, Chen L, Burns KH, Koff A, Matzuk MM.

Mol Endocrinol. 2001 Jun;15(6):985-96.


p21cip1 is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal.

Zezula J, Casaccia-Bonnefil P, Ezhevsky SA, Osterhout DJ, Levine JM, Dowdy SF, Chao MV, Koff A.

EMBO Rep. 2001 Jan;2(1):27-34.


Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse.

Di Cristofano A, De Acetis M, Koff A, Cordon-Cardo C, Pandolfi PP.

Nat Genet. 2001 Feb;27(2):222-4.


A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.

Millard SS, Vidal A, Markus M, Koff A.

Mol Cell Biol. 2000 Aug;20(16):5947-59.

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