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Items: 1 to 50 of 51

1.

The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation.

Zhou H, Zeng Z, Koentgen F, Khan M, Mombaerts P.

Genesis. 2019 Jun;57(6):e23295. doi: 10.1002/dvg.23295. Epub 2019 Apr 19.

2.

Targeting the CDA1/CDA1BP1 Axis Retards Renal Fibrosis in Experimental Diabetic Nephropathy.

Chai Z, Wu T, Dai A, Huynh P, Koentgen F, Krippner G, Ren S, Cooper ME.

Diabetes. 2019 Feb;68(2):395-408. doi: 10.2337/db18-0712. Epub 2018 Nov 13.

3.

Generation and phenotypic characterisation of a cytochrome P450 4x1 knockout mouse.

Kharkwal H, Batool F, Koentgen F, Bell DR, Kendall DA, Ebling FJP, Duce IR.

PLoS One. 2017 Dec 11;12(12):e0187959. doi: 10.1371/journal.pone.0187959. eCollection 2017.

4.

Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice.

Barman-Aksözen J, C Wiek P, Bansode VB, Koentgen F, Trüb J, Pelczar P, Cinelli P, Schneider-Yin X, Schümperli D, Minder EI.

Dis Model Mech. 2017 Mar 1;10(3):225-233. doi: 10.1242/dmm.027755. Epub 2017 Jan 12.

5.

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy.

Altmann C, Hardt S, Fischer C, Heidler J, Lim HY, Häussler A, Albuquerque B, Zimmer B, Möser C, Behrends C, Koentgen F, Wittig I, Schmidt MHH, Clement AM, Deller T, Tegeder I.

Neurobiol Dis. 2016 Dec;96:294-311. doi: 10.1016/j.nbd.2016.09.010. Epub 2016 Sep 11.

PMID:
27629805
6.

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation.

Segerer G, Hadamek K, Zundler M, Fekete A, Seifried A, Mueller MJ, Koentgen F, Gessler M, Jeanclos E, Gohla A.

Sci Rep. 2016 Oct 12;6:35160. doi: 10.1038/srep35160.

7.

The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis.

Ifrim DC, Quintin J, Courjol F, Verschueren I, van Krieken JH, Koentgen F, Fradin C, Gow NA, Joosten LA, van der Meer JW, van de Veerdonk F, Netea MG.

J Interferon Cytokine Res. 2016 Apr;36(4):267-76. doi: 10.1089/jir.2015.0040. Epub 2016 Jan 27.

8.

Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline.

Koentgen F, Lin J, Katidou M, Chang I, Khan M, Watts J, Mombaerts P.

Genesis. 2016 Jun;54(6):326-33. doi: 10.1002/dvg.22938. Epub 2016 May 18.

9.

Response to Heard et al.

Moulin M, Voss AK, Thomas T, Wong WW, Cook WD, Koentgen F, Vince J, Silke J, Vaux DL.

EMBO J. 2015 Oct 1;34(19):2396-7. doi: 10.15252/embj.201592761. No abstract available.

10.

Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent.

Oosting M, Buffen K, Cheng SC, Verschueren IC, Koentgen F, van de Veerdonk FL, Netea MG, Joosten LAB.

Cytokine. 2015 Dec;76(2):465-472. doi: 10.1016/j.cyto.2015.08.005. Epub 2015 Aug 18.

PMID:
26297607
11.

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.

Ooms LM, Binge LC, Davies EM, Rahman P, Conway JR, Gurung R, Ferguson DT, Papa A, Fedele CG, Vieusseux JL, Chai RC, Koentgen F, Price JT, Tiganis T, Timpson P, McLean CA, Mitchell CA.

Cancer Cell. 2015 Aug 10;28(2):155-69. doi: 10.1016/j.ccell.2015.07.003.

12.

The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.

Hughes CE, Finney BA, Koentgen F, Lowe KL, Watson SP.

Blood. 2015 Jan 1;125(1):144-54. doi: 10.1182/blood-2014-05-579375. Epub 2014 Oct 28.

13.

A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism.

Hasan S, van der Veen DR, Winsky-Sommerer R, Hogben A, Laing EE, Koentgen F, Dijk DJ, Archer SN.

FASEB J. 2014 Jun;28(6):2441-54. doi: 10.1096/fj.13-240135. Epub 2014 Feb 27.

14.

Role of Dectin-2 for host defense against systemic infection with Candida glabrata.

Ifrim DC, Bain JM, Reid DM, Oosting M, Verschueren I, Gow NA, van Krieken JH, Brown GD, Kullberg BJ, Joosten LA, van der Meer JW, Koentgen F, Erwig LP, Quintin J, Netea MG.

Infect Immun. 2014 Mar;82(3):1064-73. doi: 10.1128/IAI.01189-13. Epub 2013 Dec 16.

15.

The error-prone DNA polymerase ι provides quantitative resistance to lung tumorigenesis and mutagenesis in mice.

Iguchi M, Osanai M, Hayashi Y, Koentgen F, Lee GH.

Oncogene. 2014 Jul 3;33(27):3612-7. doi: 10.1038/onc.2013.331. Epub 2013 Aug 19.

PMID:
23955086
16.

Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury.

Chai Z, Dai A, Tu Y, Li J, Wu T, Wang Y, Hale LJ, Koentgen F, Thomas MC, Cooper ME.

J Am Soc Nephrol. 2013 Nov;24(11):1782-92. doi: 10.1681/ASN.2013010060. Epub 2013 Aug 8.

17.

Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.

Fang CM, Roy S, Nielsen E, Paul M, Maul R, Paun A, Koentgen F, Raval FM, Szomolanyi-Tsuda E, Pitha PM.

Genes Immun. 2012 Jul;13(5):421-30. doi: 10.1038/gene.2012.10. Epub 2012 Apr 26.

18.

Distinct APCs explain the cytokine bias of α-galactosylceramide variants in vivo.

Bai L, Constantinides MG, Thomas SY, Reboulet R, Meng F, Koentgen F, Teyton L, Savage PB, Bendelac A.

J Immunol. 2012 Apr 1;188(7):3053-61. doi: 10.4049/jimmunol.1102414. Epub 2012 Mar 5.

19.

Preclinical development of CAT-354, an IL-13 neutralizing antibody, for the treatment of severe uncontrolled asthma.

May RD, Monk PD, Cohen ES, Manuel D, Dempsey F, Davis NH, Dodd AJ, Corkill DJ, Woods J, Joberty-Candotti C, Conroy LA, Koentgen F, Martin EC, Wilson R, Brennan N, Powell J, Anderson IK.

Br J Pharmacol. 2012 May;166(1):177-93. doi: 10.1111/j.1476-5381.2011.01659.x.

20.

Lung-specific loss of the laminin α3 subunit confers resistance to mechanical injury.

Urich D, Eisenberg JL, Hamill KJ, Takawira D, Chiarella SE, Soberanes S, Gonzalez A, Koentgen F, Manghi T, Hopkinson SB, Misharin AV, Perlman H, Mutlu GM, Budinger GR, Jones JC.

J Cell Sci. 2011 Sep 1;124(Pt 17):2927-37. doi: 10.1242/jcs.080911.

21.

Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.

Duysen EG, Koentgen F, Williams GR, Timperley CM, Schopfer LM, Cerasoli DM, Lockridge O.

Chem Res Toxicol. 2011 Nov 21;24(11):1891-8. doi: 10.1021/tx200237a. Epub 2011 Sep 7.

22.

Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice.

Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, Koentgen F, Ridgway WM, Todd JA, Bluestone JA, Peterson LB, Mattner J, Wicker LS.

J Immunol. 2011 Jul 1;187(1):325-36. doi: 10.4049/jimmunol.1003523. Epub 2011 May 25.

23.

Alcohol and aldehyde dehydrogenases: retinoid metabolic effects in mouse knockout models.

Kumar S, Sandell LL, Trainor PA, Koentgen F, Duester G.

Biochim Biophys Acta. 2012 Jan;1821(1):198-205. doi: 10.1016/j.bbalip.2011.04.004. Epub 2011 Apr 15. Review.

24.

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.

Boase NA, Rychkov GY, Townley SL, Dinudom A, Candi E, Voss AK, Tsoutsman T, Semsarian C, Melino G, Koentgen F, Cook DI, Kumar S.

Nat Commun. 2011;2:287. doi: 10.1038/ncomms1284.

25.

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.

Gardam S, Turner VM, Anderton H, Limaye S, Basten A, Koentgen F, Vaux DL, Silke J, Brink R.

Blood. 2011 Apr 14;117(15):4041-51. doi: 10.1182/blood-2010-10-312793. Epub 2011 Feb 7.

PMID:
21300983
26.

Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice.

Zhang Y, Cheng Y, Hansen GH, Niels-Christiansen LL, Koentgen F, Ohlsson L, Nilsson A, Duan RD.

J Lipid Res. 2011 Apr;52(4):771-81. doi: 10.1194/jlr.M012880. Epub 2010 Dec 21.

27.

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

Steinberg GR, O'Neill HM, Dzamko NL, Galic S, Naim T, Koopman R, Jørgensen SB, Honeyman J, Hewitt K, Chen ZP, Schertzer JD, Scott JW, Koentgen F, Lynch GS, Watt MJ, van Denderen BJ, Campbell DJ, Kemp BE.

J Biol Chem. 2010 Nov 26;285(48):37198-209. doi: 10.1074/jbc.M110.102434. Epub 2010 Sep 20.

28.

c-Cbl promotes T cell receptor-induced thymocyte apoptosis by activating the phosphatidylinositol 3-kinase/Akt pathway.

Thien CB, Dagger SA, Steer JH, Koentgen F, Jansen ES, Scott CL, Langdon WY.

J Biol Chem. 2010 Apr 2;285(14):10969-81. doi: 10.1074/jbc.M109.094920. Epub 2010 Feb 4.

29.

Engineering the mouse genome to model human disease for drug discovery.

Koentgen F, Suess G, Naf D.

Methods Mol Biol. 2010;602:55-77. doi: 10.1007/978-1-60761-058-8_4.

PMID:
20012392
30.

Effects of presynaptic mutations on a postsynaptic Cacna1s calcium channel colocalized with mGluR6 at mouse photoreceptor ribbon synapses.

Specht D, Wu SB, Turner P, Dearden P, Koentgen F, Wolfrum U, Maw M, Brandstätter JH, tom Dieck S.

Invest Ophthalmol Vis Sci. 2009 Feb;50(2):505-15. doi: 10.1167/iovs.08-2758. Epub 2008 Oct 24.

PMID:
18952919
31.

Conditional activation of a single-copy L1 transgene in mice by Cre.

An W, Han JS, Schrum CM, Maitra A, Koentgen F, Boeke JD.

Genesis. 2008 Jul;46(7):373-83. doi: 10.1002/dvg.20407.

32.

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.

Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU, Benetatos CA, Chunduru SK, Condon SM, McKinlay M, Brink R, Leverkus M, Tergaonkar V, Schneider P, Callus BA, Koentgen F, Vaux DL, Silke J.

Cell. 2007 Nov 16;131(4):682-93.

33.

A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent.

Robinson C, van Bruggen I, Segal A, Dunham M, Sherwood A, Koentgen F, Robinson BW, Lake RA.

Cancer Res. 2006 Nov 15;66(22):10786-94.

34.

Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies.

Lee H, Zahra D, Vogelzang A, Newton R, Thatcher J, Quan A, So T, Zwirner J, Koentgen F, Padkjaer SB, Mackay F, Whitfeld PL, Mackay CR.

Nat Biotechnol. 2006 Oct;24(10):1279-84. Epub 2006 Sep 17.

PMID:
16980974
35.

The murine stanniocalcin 1 gene is not essential for growth and development.

Chang AC, Cha J, Koentgen F, Reddel RR.

Mol Cell Biol. 2005 Dec;25(23):10604-10.

36.

Lentiviral vector-based models of amyloid pathology: from cells to animals.

Shaughnessy L, Thomas MB, Wakefield J, Chamblin B, Nair A, Koentgen F, Ramabhadran R.

Curr Alzheimer Res. 2005 Apr;2(2):239-47.

PMID:
15974924
37.

Novel approaches to models of Alzheimer's disease pathology for drug screening and development.

Shaughnessy L, Chamblin B, McMahon L, Nair A, Thomas MB, Wakefield J, Koentgen F, Ramabhadran R.

J Mol Neurosci. 2004;24(1):23-32. Review.

PMID:
15314246
38.

All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain.

Corcoran LM, Koentgen F, Dietrich W, Veale M, Humbert PO.

J Immunol. 2004 Mar 1;172(5):2962-9.

39.

The magnitude and encephalogenic potential of autoimmune response to MOG is enhanced in MOG deficient mice.

Liñares D, Mañá P, Goodyear M, Chow AM, Clavarino C, Huntington ND, Barnett L, Koentgen F, Tomioka R, Bernard CC, Freire-Garabal M, Reid HH.

J Autoimmun. 2003 Dec;21(4):339-51.

PMID:
14624757
40.

Role of the polymeric Ig receptor in mucosal B cell homeostasis.

Uren TK, Johansen FE, Wijburg OL, Koentgen F, Brandtzaeg P, Strugnell RA.

J Immunol. 2003 Mar 1;170(5):2531-9.

41.

Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5.

Stanley EG, Biben C, Elefanty A, Barnett L, Koentgen F, Robb L, Harvey RP.

Int J Dev Biol. 2002;46(4):431-9.

42.

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses.

Barnes N, Gavin AL, Tan PS, Mottram P, Koentgen F, Hogarth PM.

Immunity. 2002 Mar;16(3):379-89.

43.

A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice.

Chen Z, Dudek N, Wijburg O, Strugnell R, Brown L, Deliyannis G, Jackson D, Koentgen F, Gordon T, McCluskey J.

J Immunol. 2002 Mar 15;168(6):3050-6.

44.

Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland.

Zammit DJ, Berzins SP, Gill JW, Randle-Barrett ES, Barnett L, Koentgen F, Lambert GW, Harvey RP, Boyd RL, Classon BJ.

Mol Cell Biol. 2002 Feb;22(3):946-52.

45.

The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.

Palmer S, Groves N, Schindeler A, Yeoh T, Biben C, Wang CC, Sparrow DB, Barnett L, Jenkins NA, Copeland NG, Koentgen F, Mohun T, Harvey RP.

J Cell Biol. 2001 May 28;153(5):985-98.

46.

Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5.

Biben C, Weber R, Kesteven S, Stanley E, McDonald L, Elliott DA, Barnett L, Köentgen F, Robb L, Feneley M, Harvey RP.

Circ Res. 2000 Nov 10;87(10):888-95.

PMID:
11073884
47.

Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.

Wang CC, Biben C, Robb L, Nassir F, Barnett L, Davidson NO, Koentgen F, Tarlinton D, Harvey RP.

Dev Biol. 2000 Aug 15;224(2):152-67.

48.

Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis.

Stanley EG, Biben C, Allison J, Hartley L, Wicks IP, Campbell IK, McKinley M, Barnett L, Koentgen F, Robb L, Harvey RP.

Genesis. 2000 Apr;26(4):259-64.

PMID:
10748464
49.

A direct method for the formation of peptide and carbohydrate dendrimers.

Mitchell JP, Roberts KD, Langley J, Koentgen F, Lambert JN.

Bioorg Med Chem Lett. 1999 Oct 4;9(19):2785-8.

PMID:
10522691
50.

Infertility in female mice lacking the receptor for interleukin 11 is due to a defective uterine response to implantation.

Robb L, Li R, Hartley L, Nandurkar HH, Koentgen F, Begley CG.

Nat Med. 1998 Mar;4(3):303-8.

PMID:
9500603

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