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Items: 32


Pharmacological Profile of the Bradycardic Agent Ivabradine on Human Cardiac Ion Channels.

Haechl N, Ebner J, Hilber K, Todt H, Koenig X.

Cell Physiol Biochem. 2019;53(1):36-48. doi: 10.33594/000000119.


Mechanistic insights into store-operated Ca2+ entry during excitation-contraction coupling in skeletal muscle.

Koenig X, Choi RH, Schicker K, Singh DP, Hilber K, Launikonis BS.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1239-1248. doi: 10.1016/j.bbamcr.2019.02.014. Epub 2019 Feb 27.


Voltage-Dependent Sarcolemmal Ion Channel Abnormalities in the Dystrophin-Deficient Heart.

Koenig X, Ebner J, Hilber K.

Int J Mol Sci. 2018 Oct 23;19(11). pii: E3296. doi: 10.3390/ijms19113296. Review.


Store-operated Ca2+ entry is activated by every action potential in skeletal muscle.

Koenig X, Choi RH, Launikonis BS.

Commun Biol. 2018 Apr 19;1:31. doi: 10.1038/s42003-018-0033-7. eCollection 2018.


Calcium current properties in dystrophin-deficient ventricular cardiomyocytes from aged mdx mice.

Rubi L, Todt H, Kubista H, Koenig X, Hilber K.

Physiol Rep. 2018 Jan;6(1). doi: 10.14814/phy2.13567.


Distinct modulation of inactivation by a residue in the pore domain of voltage-gated Na+ channels: mechanistic insights from recent crystal structures.

Cervenka R, Lukacs P, Gawali VS, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Sandtner W, Stary-Weinzinger A, Todt H.

Sci Rep. 2018 Jan 12;8(1):631. doi: 10.1038/s41598-017-18919-1.


Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.

Mills RJ, Titmarsh DM, Koenig X, Parker BL, Ryall JG, Quaife-Ryan GA, Voges HK, Hodson MP, Ferguson C, Drowley L, Plowright AT, Needham EJ, Wang QD, Gregorevic P, Xin M, Thomas WG, Parton RG, Nielsen LK, Launikonis BS, James DE, Elliott DA, Porrello ER, Hudson JE.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8372-E8381. doi: 10.1073/pnas.1707316114. Epub 2017 Sep 15.


Modulation of the heart's electrical properties by the anticonvulsant drug retigabine.

Rubi L, Kovar M, Zebedin-Brandl E, Koenig X, Dominguez-Rodriguez M, Todt H, Kubista H, Boehm S, Hilber K.

Toxicol Appl Pharmacol. 2017 Aug 15;329:309-317. doi: 10.1016/j.taap.2017.06.018. Epub 2017 Jun 20.


Dantrolene requires Mg2+ to arrest malignant hyperthermia.

Choi RH, Koenig X, Launikonis BS.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4811-4815. doi: 10.1073/pnas.1619835114. Epub 2017 Apr 3.


Phosphorylation regulates the sensitivity of voltage-gated Kv7.2 channels towards phosphatidylinositol-4,5-bisphosphate.

Salzer I, Erdem FA, Chen WQ, Heo S, Koenig X, Schicker KW, Kubista H, Lubec G, Boehm S, Yang JW.

J Physiol. 2017 Feb 1;595(3):759-776. doi: 10.1113/JP273274. Epub 2016 Nov 7.


Decreased inward rectifier potassium current IK1 in dystrophin-deficient ventricular cardiomyocytes.

Rubi L, Koenig X, Kubista H, Todt H, Hilber K.

Channels (Austin). 2017 Mar 4;11(2):101-108. doi: 10.1080/19336950.2016.1228498. Epub 2016 Aug 25.


Anti-addiction Drug Ibogaine Prolongs the Action Potential in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Rubi L, Eckert D, Boehm S, Hilber K, Koenig X.

Cardiovasc Toxicol. 2017 Apr;17(2):215-218. doi: 10.1007/s12012-016-9366-y.


Mechanism of Modification, by Lidocaine, of Fast and Slow Recovery from Inactivation of Voltage-Gated Na⁺ Channels.

Gawali VS, Lukacs P, Cervenka R, Koenig X, Rubi L, Hilber K, Sandtner W, Todt H.

Mol Pharmacol. 2015 Nov;88(5):866-79. doi: 10.1124/mol.115.099580. Epub 2015 Sep 10.


δ Subunit-containing GABAA receptors are preferred targets for the centrally acting analgesic flupirtine.

Klinger F, Bajric M, Salzer I, Dorostkar MM, Khan D, Pollak DD, Kubista H, Boehm S, Koenig X.

Br J Pharmacol. 2015 Oct;172(20):4946-58. doi: 10.1111/bph.13262. Epub 2015 Oct 18.


Proper Voltage-Dependent Ion Channel Function in Dysferlin-Deficient Cardiomyocytes.

Rubi L, Gawali VS, Kubista H, Todt H, Hilber K, Koenig X.

Cell Physiol Biochem. 2015;36(3):1049-58. doi: 10.1159/000430278. Epub 2015 Jun 18.


Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.


The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.

Treven M, Koenig X, Assadpour E, Gantumur E, Meyer C, Hilber K, Boehm S, Kubista H.

Epilepsia. 2015 Apr;56(4):647-57. doi: 10.1111/epi.12950. Epub 2015 Mar 16.


The anti-addiction drug ibogaine and the heart: a delicate relation.

Koenig X, Hilber K.

Molecules. 2015 Jan 29;20(2):2208-28. doi: 10.3390/molecules20022208. Review.


VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes.

Koley M, Mike AK, Heher P, Koenig X, Schön M, Schnürch M, Hilber K, Weitzer G, Mihovilovic MD.

Medchemcomm. 2013 Aug 1;4(8):1189-1195. doi: 10.1039/C3MD00101F.


Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics.

Lukacs P, Gawali VS, Cervenka R, Ke S, Koenig X, Rubi L, Zarrabi T, Hilber K, Stary-Weinzinger A, Todt H.

J Biol Chem. 2014 Aug 1;289(31):21770-81. doi: 10.1074/jbc.M113.541763. Epub 2014 Jun 19.


The conservative view: is it necessary to implant a stent into the dopamine transporter?

Schmid D, Koenig X, Bulusu S, Schicker K, Freissmuth M, Sitte HH, Sandtner W.

Br J Pharmacol. 2015 Oct;172(19):4775-8. doi: 10.1111/bph.12766. No abstract available.


Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells.

Mike AK, Koenig X, Koley M, Heher P, Wahl G, Rubi L, Schnürch M, Mihovilovic MD, Weitzer G, Hilber K.

Cell Physiol Biochem. 2014;33(1):205-21. doi: 10.1159/000356663. Epub 2014 Jan 24.


Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.

Koenig X, Rubi L, Obermair GJ, Cervenka R, Dang XB, Lukacs P, Kummer S, Bittner RE, Kubista H, Todt H, Hilber K.

Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H564-H573. doi: 10.1152/ajpheart.00441.2013. Epub 2013 Dec 13.


Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine.

Thurner P, Stary-Weinzinger A, Gafar H, Gawali VS, Kudlacek O, Zezula J, Hilber K, Boehm S, Sandtner W, Koenig X.

J Pharmacol Exp Ther. 2014 Feb;348(2):346-58. doi: 10.1124/jpet.113.209643. Epub 2013 Dec 4.


A quantitative model of amphetamine action on the 5-HT transporter.

Sandtner W, Schmid D, Schicker K, Gerstbrein K, Koenig X, Mayer FP, Boehm S, Freissmuth M, Sitte HH.

Br J Pharmacol. 2014 Feb;171(4):1007-18. doi: 10.1111/bph.12520.


Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profile.

Koenig X, Kovar M, Rubi L, Mike AK, Lukacs P, Gawali VS, Todt H, Hilber K, Sandtner W.

Toxicol Appl Pharmacol. 2013 Dec 1;273(2):259-68. doi: 10.1016/j.taap.2013.05.012. Epub 2013 May 22.


PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.

Putz EM, Prchal-Murphy M, Simma OA, Forster F, Koenig X, Stockinger H, Piekorz RP, Freissmuth M, Müller M, Sexl V, Zebedin-Brandl E.

PLoS One. 2012;7(7):e40852. doi: 10.1371/journal.pone.0040852. Epub 2012 Jul 13.


Anti-addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk.

Koenig X, Kovar M, Boehm S, Sandtner W, Hilber K.

Addict Biol. 2014 Mar;19(2):237-239. doi: 10.1111/j.1369-1600.2012.00447.x. Epub 2012 Mar 28.


Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

Koenig X, Dysek S, Kimbacher S, Mike AK, Cervenka R, Lukacs P, Nagl K, Dang XB, Todt H, Bittner RE, Hilber K.

PLoS One. 2011;6(5):e20300. doi: 10.1371/journal.pone.0020300. Epub 2011 May 23.


A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel.

Zarrabi T, Cervenka R, Sandtner W, Lukacs P, Koenig X, Hilber K, Mille M, Lipkind GM, Fozzard HA, Todt H.

J Biol Chem. 2010 Dec 10;285(50):39458-70. doi: 10.1074/jbc.M110.132886. Epub 2010 Oct 6.


Sodium current properties of primary skeletal myocytes and cardiomyocytes derived from different mouse strains.

Mille M, Koenig X, Zebedin E, Uhrin P, Cervenka R, Todt H, Hilber K.

Pflugers Arch. 2009 Mar;457(5):1023-33. doi: 10.1007/s00424-008-0570-x. Epub 2008 Aug 13.


Effects of duramycin on cardiac voltage-gated ion channels.

Zebedin E, Koenig X, Radenkovic M, Pankevych H, Todt H, Freissmuth M, Hilber K.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):87-100. doi: 10.1007/s00210-007-0248-5. Epub 2008 Jan 5.


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