Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 151

1.

Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation.

Eichler HG, Koenig F, Arlett P, Enzmann H, Humphreys A, Pétavy F, Schwarzer-Daum B, Sepodes B, Vamvakas S, Rasi G.

Clin Pharmacol Ther. 2019 Oct 1. doi: 10.1002/cpt.1638. [Epub ahead of print]

PMID:
31574163
2.

Group sequential adaptive designs in series of time-to-event randomised trials in rare diseases: A simulation study.

Bayar MA, Le Teuff G, Koenig F, Le Deley MC, Michiels S.

Stat Methods Med Res. 2019 Jul 29:962280219862313. doi: 10.1177/0962280219862313. [Epub ahead of print]

PMID:
31354106
3.

Composite Outcome Improves Feasibility of Clinical Trials in Peritoneal Dialysis.

Boehm M, Niewczas J, Herkner H, Koenig F, Kratochwill K, Rutherford P, Aufricht C, Vychytil A.

Perit Dial Int. 2019 Sep-Oct;39(5):479-485. doi: 10.3747/pdi.2018.00214. Epub 2019 May 23.

PMID:
31123075
4.

Response to comments on Jaki et al., A proposal for a new PhD level curriculum on quantitative methods for drug development. Pharm Stat 17(5):593-606, Sep/Oct 2018., DOI: https://doi.org/10.1002/pst.1873.

Jaki T, Gordon A, Forster P, Bijnens L, Bornkamp B, Brannath W, Fontana R, Gasparini M, Hampson LV, Jacobs T, Jones B, Paoletti X, Posch M, Titman A, Vonk R, Koenig F.

Pharm Stat. 2019 May;18(3):284-286. doi: 10.1002/pst.1942. Epub 2019 Mar 14. No abstract available.

PMID:
30868716
5.

Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak.

Kafetzopoulou LE, Pullan ST, Lemey P, Suchard MA, Ehichioya DU, Pahlmann M, Thielebein A, Hinzmann J, Oestereich L, Wozniak DM, Efthymiadis K, Schachten D, Koenig F, Matjeschk J, Lorenzen S, Lumley S, Ighodalo Y, Adomeh DI, Olokor T, Omomoh E, Omiunu R, Agbukor J, Ebo B, Aiyepada J, Ebhodaghe P, Osiemi B, Ehikhametalor S, Akhilomen P, Airende M, Esumeh R, Muoebonam E, Giwa R, Ekanem A, Igenegbale G, Odigie G, Okonofua G, Enigbe R, Oyakhilome J, Yerumoh EO, Odia I, Aire C, Okonofua M, Atafo R, Tobin E, Asogun D, Akpede N, Okokhere PO, Rafiu MO, Iraoyah KO, Iruolagbe CO, Akhideno P, Erameh C, Akpede G, Isibor E, Naidoo D, Hewson R, Hiscox JA, Vipond R, Carroll MW, Ihekweazu C, Formenty P, Okogbenin S, Ogbaini-Emovon E, Günther S, Duraffour S.

Science. 2019 Jan 4;363(6422):74-77. doi: 10.1126/science.aau9343.

6.

A feasibility study of a multimodal stimulation bioreactor for the conditioning of stem cell seeded cardiac patches via electrical impulses and pulsatile perfusion.

Herrmann FEM, Lehner A, Koenig F, Hollweck T, Fano C, Dauner M, Eissner G, Hagl C, Akra B.

Biomed Mater Eng. 2019;30(1):37-48. doi: 10.3233/BME-181031.

PMID:
30530957
7.

Adaptive designs in clinical trials: from scientific advice to marketing authorisation to the European Medicine Agency.

Collignon O, Koenig F, Koch A, Hemmings RJ, Pétavy F, Saint-Raymond A, Papaluca-Amati M, Posch M.

Trials. 2018 Nov 20;19(1):642. doi: 10.1186/s13063-018-3012-x.

8.

Development process of a consensus-driven CONSORT extension for randomised trials using an adaptive design.

Dimairo M, Coates E, Pallmann P, Todd S, Julious SA, Jaki T, Wason J, Mander AP, Weir CJ, Koenig F, Walton MK, Biggs K, Nicholl J, Hamasaki T, Proschan MA, Scott JA, Ando Y, Hind D, Altman DG.

BMC Med. 2018 Nov 16;16(1):210. doi: 10.1186/s12916-018-1196-2.

9.

Successful decellularization of thick-walled tissue: Highlighting pitfalls and the need for a multifactorial approach.

Koenig F, Kilzer M, Hagl C, Thierfelder N.

Int J Artif Organs. 2019 Jan;42(1):17-24. doi: 10.1177/0391398818805624. Epub 2018 Nov 16.

PMID:
30442045
10.

Abbreviated MRI Protocols in Breast Cancer Diagnostics.

Deike-Hofmann K, Koenig F, Paech D, Dreher C, Delorme S, Schlemmer HP, Bickelhaupt S.

J Magn Reson Imaging. 2019 Mar;49(3):647-658. doi: 10.1002/jmri.26525. Epub 2018 Oct 16. Review.

PMID:
30328180
11.

Design and estimation in clinical trials with subpopulation selection.

Chiu YD, Koenig F, Posch M, Jaki T.

Stat Med. 2018 Dec 20;37(29):4335-4352. doi: 10.1002/sim.7925. Epub 2018 Aug 7.

12.

A proposal for a new PhD level curriculum on quantitative methods for drug development.

Jaki T, Gordon A, Forster P, Bijnens L, Bornkamp B, Brannath W, Fontana R, Gasparini M, Hampson LV, Jacobs T, Jones B, Paoletti X, Posch M, Titman A, Vonk R, Koenig F.

Pharm Stat. 2018 Sep;17(5):593-606. doi: 10.1002/pst.1873. Epub 2018 Jul 9.

13.

Flexible alpha allocation strategies for confirmatory adaptive enrichment clinical trials with a prespecified subgroup.

Sugitani T, Posch M, Bretz F, Koenig F.

Stat Med. 2018 Oct 30;37(24):3387-3402. doi: 10.1002/sim.7851. Epub 2018 Jun 26.

PMID:
29945304
14.

An update on the clinical evidence that supports biosimilar approvals in Europe.

Mielke J, Jilma B, Jones B, Koenig F.

Br J Clin Pharmacol. 2018 Jul;84(7):1415-1431. doi: 10.1111/bcp.13586. Epub 2018 Apr 27.

15.

Marketing authorisation of orphan medicines in Europe from 2000 to 2013.

Hofer MP, Hedman H, Mavris M, Koenig F, Vetter T, Posch M, Vamvakas S, Regnstrom J, Aarum S.

Drug Discov Today. 2018 Feb;23(2):424-433. doi: 10.1016/j.drudis.2017.10.012. Epub 2017 Oct 23. Review.

16.

Many-to-one comparisons after safety selection in multi-arm clinical trials.

Hlavin G, Hampson LV, Koenig F.

PLoS One. 2017 Jun 26;12(6):e0180131. doi: 10.1371/journal.pone.0180131. eCollection 2017.

17.

"Threshold-crossing": A Useful Way to Establish the Counterfactual in Clinical Trials?

Eichler HG, Bloechl-Daum B, Bauer P, Bretz F, Brown J, Hampson LV, Honig P, Krams M, Leufkens H, Lim R, Lumpkin MM, Murphy MJ, Pignatti F, Posch M, Schneeweiss S, Trusheim M, Koenig F.

Clin Pharmacol Ther. 2016 Dec;100(6):699-712. doi: 10.1002/cpt.515. Epub 2016 Oct 19.

18.

Clinical trials for authorized biosimilars in the European Union: a systematic review.

Mielke J, Jilma B, Koenig F, Jones B.

Br J Clin Pharmacol. 2016 Dec;82(6):1444-1457. doi: 10.1111/bcp.13076. Epub 2016 Sep 5. Review.

19.

Is Transcatheter Aortic Valve Implantation of Living Tissue-Engineered Valves Feasible? An In Vitro Evaluation Utilizing a Decellularized and Reseeded Biohybrid Valve.

Koenig F, Lee JS, Akra B, Hollweck T, Wintermantel E, Hagl C, Thierfelder N.

Artif Organs. 2016 Aug;40(8):727-37. doi: 10.1111/aor.12683. Epub 2016 May 17.

PMID:
27187768
20.

Hematogenous Tumor Cell Spread Following Standard Transurethral Resection of Bladder Carcinoma.

Blaschke S, Koenig F, Schostak M.

Eur Urol. 2016 Sep;70(3):544-5. doi: 10.1016/j.eururo.2016.03.051. Epub 2016 Apr 14. No abstract available.

PMID:
27086503
21.

Sample Size Reassessment and Hypothesis Testing in Adaptive Survival Trials.

Magirr D, Jaki T, Koenig F, Posch M.

PLoS One. 2016 Feb 10;11(2):e0146465. doi: 10.1371/journal.pone.0146465. eCollection 2016.

22.

Evidence, eminence and extrapolation.

Hlavin G, Koenig F, Male C, Posch M, Bauer P.

Stat Med. 2016 Jun 15;35(13):2117-32. doi: 10.1002/sim.6865. Epub 2016 Jan 11.

23.

Adaptive designs for subpopulation analysis optimizing utility functions.

Graf AC, Posch M, Koenig F.

Biom J. 2015 Jan;57(1):76-89. doi: 10.1002/bimj.201300257. Epub 2014 Nov 14.

24.

Adaptive graph-based multiple testing procedures.

Klinglmueller F, Posch M, Koenig F.

Pharm Stat. 2014 Nov-Dec;13(6):345-56. doi: 10.1002/pst.1640. Epub 2014 Oct 16.

25.

Adaptive clinical trial designs for European marketing authorization: a survey of scientific advice letters from the European Medicines Agency.

Elsäßer A, Regnstrom J, Vetter T, Koenig F, Hemmings RJ, Greco M, Papaluca-Amati M, Posch M.

Trials. 2014 Oct 2;15:383. doi: 10.1186/1745-6215-15-383. Review.

26.

Sharing clinical trial data on patient level: opportunities and challenges.

Koenig F, Slattery J, Groves T, Lang T, Benjamini Y, Day S, Bauer P, Posch M.

Biom J. 2015 Jan;57(1):8-26. doi: 10.1002/bimj.201300283. Epub 2014 Jun 18. Review.

27.

Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications.

Graf AC, Bauer P, Glimm E, Koenig F.

Biom J. 2014 Jul;56(4):614-30. doi: 10.1002/bimj.201300153. Epub 2014 Apr 22.

28.

Cephalometric assessment of craniofacial dysmorphologies in relation with Msx2 mutations in mouse.

Simon Y, Marchadier A, Riviere MK, Vandamme K, Koenig F, Lezot F, Trouve A, Benhamou CL, Saffar JL, Berdal A, Nefussi JR.

Orthod Craniofac Res. 2014 May;17(2):92-105. doi: 10.1111/ocr.12035. Epub 2014 Jan 6.

PMID:
24387797
29.

In vitro comparison of novel polyurethane aortic valves and homografts after seeding and conditioning.

Thierfelder N, Koenig F, Bombien R, Fano C, Reichart B, Wintermantel E, Schmitz C, Akra B.

ASAIO J. 2013 May-Jun;59(3):309-16. doi: 10.1097/MAT.0b013e318289b95e.

PMID:
23644620
30.

Joint EMA, ISBS, and DR-IBS International Symposium on Biopharmaceutical Statistics: bridging drug development from research to marketing.

Koenig F, Bretz F.

Stat Med. 2013 May 10;32(10):1619-20. doi: 10.1002/sim.5739. No abstract available.

PMID:
23592410
31.

Use of a special bioreactor for the cultivation of a new flexible polyurethane scaffold for aortic valve tissue engineering.

Aleksieva G, Hollweck T, Thierfelder N, Haas U, Koenig F, Fano C, Dauner M, Wintermantel E, Reichart B, Schmitz C, Akra B.

Biomed Eng Online. 2012 Dec 4;11:92. doi: 10.1186/1475-925X-11-92.

32.

Are there risk factors for acute renal failure in adult patients using deoxycholate amphotericin B?

Tuon FF, Koenig F, Jacometto D, Rocha JL.

Rev Iberoam Micol. 2013 Jan 3;30(1):21-4. doi: 10.1016/j.riam.2012.09.003. Epub 2012 Sep 17.

PMID:
22995903
33.

[The role of the nurse in the changing healthcare system].

Hébert R, Salois R, McVey L, Rocher M, Koenig F.

Perspect Infirm. 2012 Jul-Aug;9(4):17. French. No abstract available.

PMID:
22812066
34.

Unique properties vs. common themes: the atypical cyanobacterium Gloeobacter violaceus PCC 7421 is capable of state transitions and blue-light-induced fluorescence quenching.

Bernát G, Schreiber U, Sendtko E, Stadnichuk IN, Rexroth S, Rögner M, Koenig F.

Plant Cell Physiol. 2012 Mar;53(3):528-42. doi: 10.1093/pcp/pcs009. Epub 2012 Feb 1.

PMID:
22302714
35.

The plasma membrane of the cyanobacterium Gloeobacter violaceus contains segregated bioenergetic domains.

Rexroth S, Mullineaux CW, Ellinger D, Sendtko E, Rögner M, Koenig F.

Plant Cell. 2011 Jun;23(6):2379-90. doi: 10.1105/tpc.111.085779. Epub 2011 Jun 3.

36.

Comparison of three separate antiadhesive barriers for intraperitoneal onlay mesh hernia repair in an experimental model.

Gruber-Blum S, Petter-Puchner AH, Brand J, Fortelny RH, Walder N, Oehlinger W, Koenig F, Redl H.

Br J Surg. 2011 Mar;98(3):442-9. doi: 10.1002/bjs.7334. Epub 2010 Nov 16.

PMID:
21254024
37.

Role of modeling and simulation in pediatric investigation plans.

Manolis E, Osman TE, Herold R, Koenig F, Tomasi P, Vamvakas S, Saint Raymond A.

Paediatr Anaesth. 2011 Mar;21(3):214-21. doi: 10.1111/j.1460-9592.2011.03523.x. Epub 2011 Jan 18. Review.

PMID:
21244569
38.

Factors associated with success of market authorisation applications for pharmaceutical drugs submitted to the European Medicines Agency.

Regnstrom J, Koenig F, Aronsson B, Reimer T, Svendsen K, Tsigkos S, Flamion B, Eichler HG, Vamvakas S.

Eur J Clin Pharmacol. 2010 Jan;66(1):39-48. doi: 10.1007/s00228-009-0756-y. Epub 2009 Nov 20.

PMID:
19936724
39.

Selection and bias--two hostile brothers.

Bauer P, Koenig F, Brannath W, Posch M.

Stat Med. 2010 Jan 15;29(1):1-13. doi: 10.1002/sim.3716.

PMID:
19844944
40.

The distillation of "VISCI": towards a better identification of suicidal inmates.

Frottier P, Koenig F, Seyringer M, Matschnig T, Fruehwald S.

Suicide Life Threat Behav. 2009 Aug;39(4):376-85. doi: 10.1521/suli.2009.39.4.376.

PMID:
19792979
41.

Optimal choice of the number of treatments to be included in a clinical trial.

Stallard N, Posch M, Friede T, Koenig F, Brannath W.

Stat Med. 2009 Apr 30;28(9):1321-38. doi: 10.1002/sim.3551. Erratum in: Stat Med. 2010 Feb 28;29(5):614-5.

PMID:
19243083
42.

Adaptive designs for confirmatory clinical trials.

Bretz F, Koenig F, Brannath W, Glimm E, Posch M.

Stat Med. 2009 Apr 15;28(8):1181-217. doi: 10.1002/sim.3538.

PMID:
19206095
43.

Functional recovery at a minimum of 2 years after multiple injury-development of an outcome score.

Weninger P, Aldrian S, Koenig F, Vécsei V, Nau T.

J Trauma. 2008 Oct;65(4):799-808; discussion 808. doi: 10.1097/TA.0b013e3181820dae.

PMID:
18849794
44.

Anti-Ma and anti-Ta associated paraneoplastic neurological syndromes: 22 newly diagnosed patients and review of previous cases.

Hoffmann LA, Jarius S, Pellkofer HL, Schueller M, Krumbholz M, Koenig F, Johannis W, la Fougere C, Newman T, Vincent A, Voltz R.

J Neurol Neurosurg Psychiatry. 2008 Jul;79(7):767-73. doi: 10.1136/jnnp.2007.118588. Epub 2008 Jan 25. Review.

PMID:
18223018
45.

Adaptive Dunnett tests for treatment selection.

Koenig F, Brannath W, Bretz F, Posch M.

Stat Med. 2008 May 10;27(10):1612-25.

PMID:
17876763
46.

Characteristics of polytrauma patients between 1992 and 2002: what is changing?

Aldrian S, Koenig F, Weninger P, Vécsei V, Nau T.

Injury. 2007 Sep;38(9):1059-64. Epub 2007 Aug 15.

PMID:
17706653
47.

Multiplicity and flexibility in clinical trials.

Brannath W, Koenig F, Bauer P.

Pharm Stat. 2007 Jul-Sep;6(3):205-16.

PMID:
17674349
48.

An integrated MELD model including serum sodium and age improves the prediction of early mortality in patients with cirrhosis.

Luca A, Angermayr B, Bertolini G, Koenig F, Vizzini G, Ploner M, Peck-Radosavljevic M, Gridelli B, Bosch J.

Liver Transpl. 2007 Aug;13(8):1174-80.

49.

Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering.

Lardi-Studler B, Smolinsky B, Petitjean CM, Koenig F, Sidler C, Meier JC, Fritschy JM, Schwarz G.

J Cell Sci. 2007 Apr 15;120(Pt 8):1371-82. Epub 2007 Mar 20.

50.

Supplemental Content

Loading ...
Support Center