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Items: 1 to 50 of 78

1.

Lysophosphatidylcholine in Platelet Microvesicles: The Grease for Cardiovascular Disease.

Koenen RR.

Thromb Haemost. 2019 Aug;119(8):1202-1204. doi: 10.1055/s-0039-1693024. Epub 2019 Jul 2. No abstract available.

PMID:
31266081
2.

Tick saliva protein Evasin-3 modulates chemotaxis by disrupting CXCL8 interactions with glycosaminoglycans and CXCR2.

Denisov SS, Ippel JH, Heinzmann ACA, Koenen RR, Ortega-Gomez A, Soehnlein O, Hackeng TM, Dijkgraaf I.

J Biol Chem. 2019 Aug 16;294(33):12370-12379. doi: 10.1074/jbc.RA119.008902. Epub 2019 Jun 24.

3.

Proteomic analysis reveals procoagulant properties of cigarette smoke-induced extracellular vesicles.

Benedikter BJ, Bouwman FG, Heinzmann ACA, Vajen T, Mariman EC, Wouters EFM, Savelkoul PHM, Koenen RR, Rohde GGU, van Oerle R, Spronk HM, Stassen FRM.

J Extracell Vesicles. 2019 Mar 5;8(1):1585163. doi: 10.1080/20013078.2019.1585163. eCollection 2019.

4.

Chemokines as Therapeutic Targets in Cardiovascular Disease.

Noels H, Weber C, Koenen RR.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):583-592. doi: 10.1161/ATVBAHA.118.312037.

PMID:
30760014
5.

No hearty reception: infusion of CXCL4 impedes tissue repair by macrophages after myocardial infarction.

Koenen RR.

Cardiovasc Res. 2019 Feb 1;115(2):264-265. doi: 10.1093/cvr/cvy241. No abstract available.

PMID:
30295755
6.

Editorial: Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases.

Koenen RR, Aikawa E.

Front Cardiovasc Med. 2018 Sep 19;5:133. doi: 10.3389/fcvm.2018.00133. eCollection 2018. No abstract available.

7.

Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks.

Dickhout A, Koenen RR.

Front Cardiovasc Med. 2018 Aug 22;5:113. doi: 10.3389/fcvm.2018.00113. eCollection 2018. Review.

8.

Blocking CCL5-CXCL4 heteromerization preserves heart function after myocardial infarction by attenuating leukocyte recruitment and NETosis.

Vajen T, Koenen RR, Werner I, Staudt M, Projahn D, Curaj A, Sönmez TT, Simsekyilmaz S, Schumacher D, Möllmann J, Hackeng TM, Hundelshausen PV, Weber C, Liehn EA.

Sci Rep. 2018 Jul 13;8(1):10647. doi: 10.1038/s41598-018-29026-0.

9.

Laminar Flow-based Assays to Investigate Leukocyte Recruitment on Cultured Vascular Cells and Adherent Platelets.

Vajen T, Heinzmann ACA, Dickhout A, Zhao Z, Nagy M, Heemskerk JWM, Koenen RR.

J Vis Exp. 2018 Apr 9;(134). doi: 10.3791/57009.

PMID:
29683452
10.

Initiation and Propagation of Vascular Calcification Is Regulated by a Concert of Platelet- and Smooth Muscle Cell-Derived Extracellular Vesicles.

Schurgers LJ, Akbulut AC, Kaczor DM, Halder M, Koenen RR, Kramann R.

Front Cardiovasc Med. 2018 Apr 6;5:36. doi: 10.3389/fcvm.2018.00036. eCollection 2018.

11.

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, Vajen T, Alshaikh NA, Wolberg AS, Macrae FL, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers JCM, Heestermans M, Renné T, Dólleman S, Chayouâ W, Ariëns RAS, Baaten CC, Nagy M, Kuliopulos A, Posma JJ, Harrison P, Vries MJ, Crijns HJGM, Dudink EAMP, Buller HR, Henskens YMC, Själander A, Zwaveling S, Erküner O, Eikelboom JW, Gulpen A, Peeters FECM, Douxfils J, Olie RH, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom HMM, Mosnier LO, van der Vorm L, Declerck P, Visser M, Dippel DWJ, Strijbis VJ, Pertiwi K, Ten Cate-Hoek AJ, Ten Cate H.

Thromb Haemost. 2018 Feb;118(2):229-250. doi: 10.1160/TH17-07-0492. Epub 2018 Jan 29.

12.

Molecular Ultrasound Imaging of Junctional Adhesion Molecule A Depicts Acute Alterations in Blood Flow and Early Endothelial Dysregulation.

Curaj A, Wu Z, Rix A, Gresch O, Sternkopf M, Alampour-Rajabi S, Lammers T, van Zandvoort M, Weber C, Koenen RR, Liehn EA, Kiessling F.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):40-48. doi: 10.1161/ATVBAHA.117.309503. Epub 2017 Nov 30.

PMID:
29191926
13.

Ultrafiltration combined with size exclusion chromatography efficiently isolates extracellular vesicles from cell culture media for compositional and functional studies.

Benedikter BJ, Bouwman FG, Vajen T, Heinzmann ACA, Grauls G, Mariman EC, Wouters EFM, Savelkoul PH, Lopez-Iglesias C, Koenen RR, Rohde GGU, Stassen FRM.

Sci Rep. 2017 Nov 10;7(1):15297. doi: 10.1038/s41598-017-15717-7.

14.

Platelet extracellular vesicles induce a pro-inflammatory smooth muscle cell phenotype.

Vajen T, Benedikter BJ, Heinzmann ACA, Vasina EM, Henskens Y, Parsons M, Maguire PB, Stassen FR, Heemskerk JWM, Schurgers LJ, Koenen RR.

J Extracell Vesicles. 2017 May 16;6(1):1322454. doi: 10.1080/20013078.2017.1322454. eCollection 2017.

15.

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

von Hundelshausen P, Agten SM, Eckardt V, Blanchet X, Schmitt MM, Ippel H, Neideck C, Bidzhekov K, Leberzammer J, Wichapong K, Faussner A, Drechsler M, Grommes J, van Geffen JP, Li H, Ortega-Gomez A, Megens RT, Naumann R, Dijkgraaf I, Nicolaes GA, Döring Y, Soehnlein O, Lutgens E, Heemskerk JW, Koenen RR, Mayo KH, Hackeng TM, Weber C.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaah6650. doi: 10.1126/scitranslmed.aah6650.

PMID:
28381538
16.

Deletion of junctional adhesion molecule A from platelets increases early-stage neointima formation after wire injury in hyperlipidemic mice.

Zhao Z, Vajen T, Karshovska E, Dickhout A, Schmitt MM, Megens RTA, von Hundelshausen P, Koeppel TA, Hackeng TM, Weber C, Koenen RR.

J Cell Mol Med. 2017 Aug;21(8):1523-1531. doi: 10.1111/jcmm.13083. Epub 2017 Feb 17.

17.

Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation.

Agten SM, Koenen RR, Ippel H, Eckardt V, von Hundelshausen P, Mayo KH, Weber C, Hackeng TM.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14963-14966. doi: 10.1002/anie.201607036. Epub 2016 Oct 27.

18.

Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium.

Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S.

J Mol Cell Cardiol. 2016 Oct;99:57-64. doi: 10.1016/j.yjmcc.2016.08.010. Epub 2016 Aug 15.

19.

The prowess of platelets in immunity and inflammation.

Koenen RR.

Thromb Haemost. 2016 Sep 27;116(4):605-12. doi: 10.1160/TH16-04-0300. Epub 2016 Jul 7. Review.

PMID:
27384503
20.

Hck/Fgr Kinase Deficiency Reduces Plaque Growth and Stability by Blunting Monocyte Recruitment and Intraplaque Motility.

Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, Bot I, de Jager S, Weber C, Cleutjens J, van Berkel TJC, Sikkink KJ, Mócsai A, Maridonneau-Parini I, Soehnlein O, Biessen EAL.

Circulation. 2015 Aug 11;132(6):490-501. doi: 10.1161/CIRCULATIONAHA.114.012316. Epub 2015 Jun 11.

21.

Microvesicles from platelets: novel drivers of vascular inflammation.

Vajen T, Mause SF, Koenen RR.

Thromb Haemost. 2015 Aug;114(2):228-36. doi: 10.1160/TH14-11-0962. Epub 2015 May 21. Review.

22.

Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice.

Karshovska E, Zhao Z, Blanchet X, Schmitt MM, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JM, Megens RT, Koeppel TA, Schober A, Hackeng TM, Weber C, Koenen RR.

Circ Res. 2015 Feb 13;116(4):587-99. doi: 10.1161/CIRCRESAHA.116.304035. Epub 2014 Dec 3.

PMID:
25472975
23.

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome.

Blanchet X, Cesarek K, Brandt J, Herwald H, Teupser D, Küchenhoff H, Karshovska E, Mause SF, Siess W, Wasmuth H, Soehnlein O, Koenen RR, Weber C, von Hundelshausen P.

Thromb Haemost. 2014 Dec;112(6):1277-87. doi: 10.1160/TH14-02-0139. Epub 2014 Aug 28.

PMID:
25183015
24.

CXCR4 blockade induces atherosclerosis by affecting neutrophil function.

Bot I, Daissormont IT, Zernecke A, van Puijvelde GH, Kramp B, de Jager SC, Sluimer JC, Manca M, Hérias V, Westra MM, Bot M, van Santbrink PJ, van Berkel TJ, Su L, Skjelland M, Gullestad L, Kuiper J, Halvorsen B, Aukrust P, Koenen RR, Weber C, Biessen EA.

J Mol Cell Cardiol. 2014 Sep;74:44-52. doi: 10.1016/j.yjmcc.2014.04.021. Epub 2014 May 8.

25.

Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution.

Schmitt MM, Fraemohs L, Hackeng TM, Weber C, Koenen RR.

Atherosclerosis. 2014 Jun;234(2):254-64. doi: 10.1016/j.atherosclerosis.2014.03.014. Epub 2014 Mar 25.

PMID:
24704627
26.

CX3CL1, a special deputy at the intersection of platelets and the vessel wall.

Koenen RR.

Thromb Haemost. 2014 Apr 1;111(4):567. doi: 10.1160/TH14-02-0173. Epub 2014 Mar 13. No abstract available.

PMID:
24633475
27.

Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction.

Projahn D, Simsekyilmaz S, Singh S, Kanzler I, Kramp BK, Langer M, Burlacu A, Bernhagen J, Klee D, Zernecke A, Hackeng TM, Groll J, Weber C, Liehn EA, Koenen RR.

J Cell Mol Med. 2014 May;18(5):790-800. doi: 10.1111/jcmm.12225. Epub 2014 Feb 6.

28.

Bone marrow-specific knock-in of a non-activatable Ikkα kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice.

Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Döring Y, Drechsler M, Pawig L, Simsekyilmaz S, Koenen RR, de Winther MP, Lawrence T, Bernhagen J, Zernecke A, Weber C, Noels H.

PLoS One. 2014 Feb 3;9(2):e87452. doi: 10.1371/journal.pone.0087452. eCollection 2014.

29.

Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue.

Li X, Zhu M, Penfold ME, Koenen RR, Thiemann A, Heyll K, Akhtar S, Koyadan S, Wu Z, Gremse F, Kiessling F, van Zandvoort M, Schall TJ, Weber C, Schober A.

Circulation. 2014 Mar 18;129(11):1244-53. doi: 10.1161/CIRCULATIONAHA.113.006840. Epub 2013 Dec 27.

PMID:
24374972
30.

Chemoselective oxime reactions in proteins and peptides by using an optimized oxime strategy: the demise of levulinic acid.

Agten SM, Suylen D, Ippel H, Kokozidou M, Tans G, van de Vijver P, Koenen RR, Hackeng TM.

Chembiochem. 2013 Dec 16;14(18):2431-4. doi: 10.1002/cbic.201300598. Epub 2013 Oct 22. No abstract available.

PMID:
24151209
31.

CCR6 selectively promotes monocyte mediated inflammation and atherogenesis in mice.

Manthey HD, Cochain C, Barnsteiner S, Karshovska E, Pelisek J, Koch M, Chaudhari SM, Busch M, Eckstein HH, Weber C, Koenen RR, Zernecke A.

Thromb Haemost. 2013 Dec;110(6):1267-77. doi: 10.1160/TH13-01-0017. Epub 2013 Oct 10.

PMID:
24114205
32.

TNF-α and IFN-γ promote lymphocyte adhesion to endothelial junctional regions facilitating transendothelial migration.

Jaczewska J, Abdulreda MH, Yau CY, Schmitt MM, Schubert I, Berggren PO, Weber C, Koenen RR, Moy VT, Wojcikiewicz EP.

J Leukoc Biol. 2014 Feb;95(2):265-74. doi: 10.1189/jlb.0412205. Epub 2013 Sep 26.

33.

Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis.

Schmitt MM, Megens RT, Zernecke A, Bidzhekov K, van den Akker NM, Rademakers T, van Zandvoort MA, Hackeng TM, Koenen RR, Weber C.

Circulation. 2014 Jan 7;129(1):66-76. doi: 10.1161/CIRCULATIONAHA.113.004149. Epub 2013 Sep 24.

PMID:
24065611
34.

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment.

Kramp BK, Megens RT, Sarabi A, Winkler S, Projahn D, Weber C, Koenen RR, von Hundelshausen P.

Thromb Haemost. 2013 Oct;110(4):795-806. doi: 10.1160/TH13-05-0420. Epub 2013 Aug 8.

PMID:
23925484
35.

Aging- and activation-induced platelet microparticles suppress apoptosis in monocytic cells and differentially signal to proinflammatory mediator release.

Vasina EM, Cauwenberghs S, Staudt M, Feijge MA, Weber C, Koenen RR, Heemskerk JW.

Am J Blood Res. 2013 May 5;3(2):107-23. Print 2013.

36.

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes.

Soehnlein O, Drechsler M, Döring Y, Lievens D, Hartwig H, Kemmerich K, Ortega-Gómez A, Mandl M, Vijayan S, Projahn D, Garlichs CD, Koenen RR, Hristov M, Lutgens E, Zernecke A, Weber C.

EMBO Mol Med. 2013 Mar;5(3):471-81. doi: 10.1002/emmm.201201717. Epub 2013 Feb 18.

37.

Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S.

Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM.

J Am Chem Soc. 2012 Nov 28;134(47):19318-21. doi: 10.1021/ja306993t. Epub 2012 Nov 13.

PMID:
23066897
38.

MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages.

Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A.

J Clin Invest. 2012 Nov;122(11):4190-202. doi: 10.1172/JCI61716. Epub 2012 Oct 8.

39.

Platelets: key players in vascular inflammation.

Projahn D, Koenen RR.

J Leukoc Biol. 2012 Dec;92(6):1167-75. doi: 10.1189/jlb.0312151. Epub 2012 Aug 24. Review.

PMID:
22923486
40.

Touch of chemokines.

Blanchet X, Langer M, Weber C, Koenen RR, von Hundelshausen P.

Front Immunol. 2012 Jul 12;3:175. doi: 10.3389/fimmu.2012.00175. eCollection 2012.

41.

Hematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice.

Döring Y, Soehnlein O, Drechsler M, Shagdarsuren E, Chaudhari SM, Meiler S, Hartwig H, Hristov M, Koenen RR, Hieronymus T, Zenke M, Weber C, Zernecke A.

Arterioscler Thromb Vasc Biol. 2012 Jul;32(7):1613-23. doi: 10.1161/ATVBAHA.111.236539. Epub 2012 May 3.

PMID:
22556330
42.

Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.

Döring Y, Manthey HD, Drechsler M, Lievens D, Megens RT, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J, Daemen MJ, Lutgens E, Zenke M, Binder CJ, Weber C, Zernecke A.

Circulation. 2012 Apr 3;125(13):1673-83. doi: 10.1161/CIRCULATIONAHA.111.046755. Epub 2012 Mar 2.

PMID:
22388324
43.

Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia.

Postea O, Vasina EM, Cauwenberghs S, Projahn D, Liehn EA, Lievens D, Theelen W, Kramp BK, Butoi ED, Soehnlein O, Heemskerk JW, Ludwig A, Weber C, Koenen RR.

Arterioscler Thromb Vasc Biol. 2012 May;32(5):1186-93. doi: 10.1161/ATVBAHA.111.243485. Epub 2012 Mar 1.

PMID:
22383701
44.

Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.

Grommes J, Alard JE, Drechsler M, Wantha S, Mörgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O.

Am J Respir Crit Care Med. 2012 Mar 15;185(6):628-36. doi: 10.1164/rccm.201108-1533OC. Epub 2012 Jan 12.

45.

Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction.

Liehn EA, Tuchscheerer N, Kanzler I, Drechsler M, Fraemohs L, Schuh A, Koenen RR, Zander S, Soehnlein O, Hristov M, Grigorescu G, Urs AO, Leabu M, Bucur I, Merx MW, Zernecke A, Ehling J, Gremse F, Lammers T, Kiessling F, Bernhagen J, Schober A, Weber C.

J Am Coll Cardiol. 2011 Nov 29;58(23):2415-23. doi: 10.1016/j.jacc.2011.08.033.

46.

Chemokines: established and novel targets in atherosclerosis.

Koenen RR, Weber C.

EMBO Mol Med. 2011 Dec;3(12):713-25. doi: 10.1002/emmm.201100183. Epub 2011 Oct 28. Review.

47.

Microparticles from apoptotic platelets promote resident macrophage differentiation.

Vasina EM, Cauwenberghs S, Feijge MA, Heemskerk JW, Weber C, Koenen RR.

Cell Death Dis. 2011 Sep 29;2:e211. doi: 10.1038/cddis.2011.94.

48.

Cross talk between smooth muscle cells and monocytes/activated monocytes via CX3CL1/CX3CR1 axis augments expression of pro-atherogenic molecules.

Butoi ED, Gan AM, Manduteanu I, Stan D, Calin M, Pirvulescu M, Koenen RR, Weber C, Simionescu M.

Biochim Biophys Acta. 2011 Dec;1813(12):2026-35. doi: 10.1016/j.bbamcr.2011.08.009. Epub 2011 Aug 22.

49.

Anti-inflammatory therapeutic approaches to reduce acute atherosclerotic complications.

Kanzler I, Liehn EA, Koenen RR, Weber C.

Curr Pharm Biotechnol. 2012 Jan;13(1):37-45. Review.

PMID:
21470163
50.

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis.

de Jager SC, Bermúdez B, Bot I, Koenen RR, Bot M, Kavelaars A, de Waard V, Heijnen CJ, Muriana FJ, Weber C, van Berkel TJ, Kuiper J, Lee SJ, Abia R, Biessen EA.

J Exp Med. 2011 Feb 14;208(2):217-25. doi: 10.1084/jem.20100370. Epub 2011 Jan 17.

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