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Items: 1 to 50 of 83

1.

Communication between human macrophages and epithelial cancer cell lines dictates lipid mediator biosynthesis.

Werner M, Pace S, Czapka A, Jordan PM, Gerstmeier J, Koeberle A, Werz O.

Cell Mol Life Sci. 2020 Jan 1. doi: 10.1007/s00018-019-03413-w. [Epub ahead of print]

PMID:
31894359
2.

Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanisms.

Koeberle SC, Gollowitzer A, Laoukili J, Kranenburg O, Werz O, Koeberle A, Kipp AP.

Redox Biol. 2020 Jan;28:101388. doi: 10.1016/j.redox.2019.101388. Epub 2019 Nov 16.

3.

Aneuploidy-inducing gene knockdowns overlap with cancer mutations and identify Orp3 as a B-cell lymphoma suppressor.

Njeru SN, Kraus J, Meena JK, Lechel A, Katz SF, Kumar M, Knippschild U, Azoitei A, Wezel F, Bolenz C, Leithäuser F, Gollowitzer A, Omrani O, Hoischen C, Koeberle A, Kestler HA, Günes C, Rudolph KL.

Oncogene. 2020 Feb;39(7):1445-1465. doi: 10.1038/s41388-019-1073-2. Epub 2019 Oct 28.

PMID:
31659255
4.

Ginkgolic Acid is a Multi-Target Inhibitor of Key Enzymes in Pro-Inflammatory Lipid Mediator Biosynthesis.

Gerstmeier J, Seegers J, Witt F, Waltenberger B, Temml V, Rollinger JM, Stuppner H, Koeberle A, Schuster D, Werz O.

Front Pharmacol. 2019 Jul 17;10:797. doi: 10.3389/fphar.2019.00797. eCollection 2019.

5.

Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death.

Bartel K, Pein H, Popper B, Schmitt S, Janaki-Raman S, Schulze A, Lengauer F, Koeberle A, Werz O, Zischka H, Müller R, Vollmar AM, von Schwarzenberg K.

Cell Commun Signal. 2019 Jul 29;17(1):87. doi: 10.1186/s12964-019-0399-2.

6.

The standardized herbal combination BNO 2103 contained in Canephron® N alleviates inflammatory pain in experimental cystitis and prostatitis.

Nausch B, Pace S, Pein H, Koeberle A, Rossi A, Künstle G, Werz O.

Phytomedicine. 2019 Jul;60:152987. doi: 10.1016/j.phymed.2019.152987. Epub 2019 Jun 10.

PMID:
31257118
7.

The vitamin E derivative garcinoic acid from Garcinia kola nut seeds attenuates the inflammatory response.

Wallert M, Bauer J, Kluge S, Schmölz L, Chen YC, Ziegler M, Searle AK, Maxones A, Schubert M, Thürmer M, Pein H, Koeberle A, Werz O, Birringer M, Peter K, Lorkowski S.

Redox Biol. 2019 Jun;24:101166. doi: 10.1016/j.redox.2019.101166. Epub 2019 Mar 12.

8.

Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol.

Lauro G, Cantone V, Potenza M, Fischer K, Koeberle A, Werz O, Riccio R, Bifulco G.

Medchemcomm. 2018 Nov 20;9(12):2028-2036. doi: 10.1039/c8md00497h. eCollection 2018 Dec 1.

9.

Targeting biosynthetic networks of the proinflammatory and proresolving lipid metabolome.

Werner M, Jordan PM, Romp E, Czapka A, Rao Z, Kretzer C, Koeberle A, Garscha U, Pace S, Claesson HE, Serhan CN, Werz O, Gerstmeier J.

FASEB J. 2019 May;33(5):6140-6153. doi: 10.1096/fj.201802509R. Epub 2019 Feb 8.

10.

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor.

Rodrigues T, Werner M, Roth J, da Cruz EHG, Marques MC, Akkapeddi P, Lobo SA, Koeberle A, Corzana F, da Silva Júnior EN, Werz O, Bernardes GJL.

Chem Sci. 2018 Jul 17;9(34):6899-6903. doi: 10.1039/c8sc02634c. eCollection 2018 Sep 14.

11.

Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase.

Pein H, Ville A, Pace S, Temml V, Garscha U, Raasch M, Alsabil K, Viault G, Dinh CP, Guilet D, Troisi F, Neukirch K, König S, Bilancia R, Waltenberger B, Stuppner H, Wallert M, Lorkowski S, Weinigel C, Rummler S, Birringer M, Roviezzo F, Sautebin L, Helesbeux JJ, Séraphin D, Mosig AS, Schuster D, Rossi A, Richomme P, Werz O, Koeberle A.

Nat Commun. 2018 Sep 20;9(1):3834. doi: 10.1038/s41467-018-06158-5.

12.

Discovery of a benzenesulfonamide-based dual inhibitor of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase that favorably modulates lipid mediator biosynthesis in inflammation.

Cheung SY, Werner M, Esposito L, Troisi F, Cantone V, Liening S, König S, Gerstmeier J, Koeberle A, Bilancia R, Rizza R, Rossi A, Roviezzo F, Temml V, Schuster D, Stuppner H, Schubert-Zsilavecz M, Werz O, Hanke T, Pace S.

Eur J Med Chem. 2018 Aug 5;156:815-830. doi: 10.1016/j.ejmech.2018.07.031. Epub 2018 Jul 25.

PMID:
30053720
13.

Protective Effect of Casperome®, an Orally Bioavailable Frankincense Extract, on Lipopolysaccharide- Induced Systemic Inflammation in Mice.

Loeser K, Seemann S, König S, Lenhardt I, Abdel-Tawab M, Koeberle A, Werz O, Lupp A.

Front Pharmacol. 2018 Apr 20;9:387. doi: 10.3389/fphar.2018.00387. eCollection 2018.

14.

Lipophilic extracts of Leucas zeylanica, a multi-purpose medicinal plant in the tropics, inhibit key enzymes involved in inflammation and gout.

Napagoda M, Gerstmeier J, Butschek H, Lorenz S, Kanatiwela D, Qader M, Nagahawatte A, De Soyza S, Wijayaratne GB, Svatoš A, Jayasinghe L, Koeberle A, Werz O.

J Ethnopharmacol. 2018 Oct 5;224:474-481. doi: 10.1016/j.jep.2018.04.042. Epub 2018 May 1.

PMID:
29727733
15.

Triterpene Acids from Frankincense and Semi-Synthetic Derivatives That Inhibit 5-Lipoxygenase and Cathepsin G.

Koeberle A, Henkel A, Verhoff M, Tausch L, König S, Fischer D, Kather N, Seitz S, Paul M, Jauch J, Werz O.

Molecules. 2018 Feb 24;23(2). pii: E506. doi: 10.3390/molecules23020506.

16.

Natural products as inhibitors of prostaglandin E2 and pro-inflammatory 5-lipoxygenase-derived lipid mediator biosynthesis.

Koeberle A, Werz O.

Biotechnol Adv. 2018 Nov 1;36(6):1709-1723. doi: 10.1016/j.biotechadv.2018.02.010. Epub 2018 Feb 15. Review.

PMID:
29454981
17.

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition.

Glatzel DK, Koeberle A, Pein H, Löser K, Stark A, Keksel N, Werz O, Müller R, Bischoff I, Fürst R.

J Lipid Res. 2018 Feb;59(2):298-311. doi: 10.1194/jlr.M080101. Epub 2017 Dec 5.

18.

Discovery of new potent molecular entities able to inhibit mPGES-1.

Di Micco S, Terracciano S, Cantone V, Fischer K, Koeberle A, Foglia A, Riccio R, Werz O, Bruno I, Bifulco G.

Eur J Med Chem. 2018 Jan 1;143:1419-1427. doi: 10.1016/j.ejmech.2017.10.039. Epub 2017 Oct 23.

PMID:
29133047
19.

Targeting de novo lipogenesis as a novel approach in anti-cancer therapy.

Stoiber K, Nagło O, Pernpeintner C, Zhang S, Koeberle A, Ulrich M, Werz O, Müller R, Zahler S, Lohmüller T, Feldmann J, Braig S.

Br J Cancer. 2018 Jan;118(1):43-51. doi: 10.1038/bjc.2017.374. Epub 2017 Nov 7.

20.

Developmental stage-dependent regulation of spine formation by calcium-calmodulin-dependent protein kinase IIα and Rap1.

Cornelia Koeberle S, Tanaka S, Kuriu T, Iwasaki H, Koeberle A, Schulz A, Helbing DL, Yamagata Y, Morrison H, Okabe S.

Sci Rep. 2017 Oct 17;7(1):13409. doi: 10.1038/s41598-017-13728-y.

21.

Structure-Function Relationship Studies In Vitro Reveal Distinct and Specific Effects of Long-Chain Metabolites of Vitamin E.

Schmölz L, Wallert M, Rozzino N, Cignarella A, Galli F, Glei M, Werz O, Koeberle A, Birringer M, Lorkowski S.

Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700562. Epub 2017 Nov 3.

PMID:
28960703
22.

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males.

Pace S, Pergola C, Dehm F, Rossi A, Gerstmeier J, Troisi F, Pein H, Schaible AM, Weinigel C, Rummler S, Northoff H, Laufer S, Maier TJ, Rådmark O, Samuelsson B, Koeberle A, Sautebin L, Werz O.

J Clin Invest. 2017 Aug 1;127(8):3167-3176. doi: 10.1172/JCI92885. Epub 2017 Jul 24.

23.

Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.

Pein H, Koeberle SC, Voelkel M, Schneider F, Rossi A, Thürmer M, Loeser K, Sautebin L, Morrison H, Werz O, Koeberle A.

FASEB J. 2017 Oct;31(10):4566-4577. doi: 10.1096/fj.201700078R. Epub 2017 Jul 7.

PMID:
28687611
24.

Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.

Siemoneit U, Tausch L, Poeckel D, Paul M, Northoff H, Koeberle A, Jauch J, Werz O.

Planta Med. 2017 Aug;83(12-13):1020-1027. doi: 10.1055/s-0043-107884. Epub 2017 Apr 12.

PMID:
28403501
25.

Docosahexaenoic acid in the treatment of rheumatoid arthritis: A double-blind, placebo-controlled, randomized cross-over study with microalgae vs. sunflower oil.

Dawczynski C, Dittrich M, Neumann T, Goetze K, Welzel A, Oelzner P, Völker S, Schaible AM, Troisi F, Thomas L, Pace S, Koeberle A, Werz O, Schlattmann P, Lorkowski S, Jahreis G.

Clin Nutr. 2018 Apr;37(2):494-504. doi: 10.1016/j.clnu.2017.02.021. Epub 2017 Mar 6.

PMID:
28302406
26.

The Bibenzyl Canniprene Inhibits the Production of Pro-Inflammatory Eicosanoids and Selectively Accumulates in Some Cannabis sativa Strains.

Allegrone G, Pollastro F, Magagnini G, Taglialatela-Scafati O, Seegers J, Koeberle A, Werz O, Appendino G.

J Nat Prod. 2017 Mar 24;80(3):731-734. doi: 10.1021/acs.jnatprod.6b01126. Epub 2017 Feb 6.

PMID:
28165233
27.

Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy.

Pergola C, Schubert K, Pace S, Ziereisen J, Nikels F, Scherer O, Hüttel S, Zahler S, Vollmar AM, Weinigel C, Rummler S, Müller R, Raasch M, Mosig A, Koeberle A, Werz O.

Sci Rep. 2017 Jan 30;7:41434. doi: 10.1038/srep41434.

28.

V-ATPase inhibition increases cancer cell stiffness and blocks membrane related Ras signaling - a new option for HCC therapy.

Bartel K, Winzi M, Ulrich M, Koeberle A, Menche D, Werz O, Müller R, Guck J, Vollmar AM, von Schwarzenberg K.

Oncotarget. 2017 Feb 7;8(6):9476-9487. doi: 10.18632/oncotarget.14339.

29.

Target identification and lead discovery by functional lipidomics.

Koeberle A.

Future Med Chem. 2016 Dec;8(18):2169-2171. Epub 2016 Nov 15. No abstract available.

30.

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.

Park EB, Kim KJ, Jeong HR, Lee JK, Kim HJ, Lee HH, Lim JW, Shin JS, Koeberle A, Werz O, Lee KT, Lee JY.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5193-5197. doi: 10.1016/j.bmcl.2016.09.070. Epub 2016 Sep 29.

PMID:
27720548
31.

Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening.

Grisoni F, Reker D, Schneider P, Friedrich L, Consonni V, Todeschini R, Koeberle A, Werz O, Schneider G.

Mol Inform. 2017 Jan;36(1-2). doi: 10.1002/minf.201600091. Epub 2016 Sep 21.

PMID:
27650559
32.

Stearoyl-CoA desaturase-1 and adaptive stress signaling.

Koeberle A, Löser K, Thürmer M.

Biochim Biophys Acta. 2016 Nov;1861(11):1719-1726. doi: 10.1016/j.bbalip.2016.08.009. Epub 2016 Aug 24. Review.

PMID:
27550503
33.

Anti-inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions.

Maione F, Cantone V, Pace S, Chini MG, Bisio A, Romussi G, Pieretti S, Werz O, Koeberle A, Mascolo N, Bifulco G.

Br J Pharmacol. 2017 Jun;174(11):1497-1508. doi: 10.1111/bph.13545. Epub 2016 Aug 8.

34.

Semisynthetic and Natural Garcinoic Acid Isoforms as New mPGES-1 Inhibitors.

Alsabil K, Suor-Cherer S, Koeberle A, Viault G, Lavaud A, Temml V, Waltenberger B, Schuster D, Litaudon M, Lorkowski S, de Vaumas R, Helesbeux JJ, Guilet D, Stuppner H, Werz O, Seraphin D, Richomme P.

Planta Med. 2016 Jul;82(11-12):1110-6. doi: 10.1055/s-0042-108739. Epub 2016 Jun 10.

PMID:
27286327
35.

Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action.

Chindo BA, Schröder H, Koeberle A, Werz O, Becker A.

J Ethnopharmacol. 2016 May 26;184:101-6. doi: 10.1016/j.jep.2016.03.003. Epub 2016 Mar 3.

PMID:
26945978
36.

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme.

Lauro G, Tortorella P, Bertamino A, Ostacolo C, Koeberle A, Fischer K, Bruno I, Terracciano S, Gomez-Monterrey IM, Tauro M, Loiodice F, Novellino E, Riccio R, Werz O, Campiglia P, Bifulco G.

ChemMedChem. 2016 Mar 17;11(6):612-9. doi: 10.1002/cmdc.201500598. Epub 2016 Feb 24.

PMID:
26915684
37.

Predictive Bioinformatic Assignment of Methyl-Bearing Stereocenters, Total Synthesis, and an Additional Molecular Target of Ajudazol B.

Essig S, Schmalzbauer B, Bretzke S, Scherer O, Koeberle A, Werz O, Müller R, Menche D.

J Org Chem. 2016 Feb 19;81(4):1333-57. doi: 10.1021/acs.joc.5b02844. Epub 2016 Feb 2.

PMID:
26796481
38.

Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions.

Koeberle A, Laufer SA, Werz O.

J Med Chem. 2016 Jul 14;59(13):5970-86. doi: 10.1021/acs.jmedchem.5b01750. Epub 2016 Feb 24.

PMID:
26791385
39.

2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors.

Di Micco S, Spatafora C, Cardullo N, Riccio R, Fischer K, Pergola C, Koeberle A, Werz O, Chalal M, Vervandier-Fasseur D, Tringali C, Bifulco G.

Bioorg Med Chem. 2016 Feb 15;24(4):820-6. doi: 10.1016/j.bmc.2016.01.002. Epub 2016 Jan 4.

PMID:
26777299
40.

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study.

Kim M, Lee S, Park EB, Kim KJ, Lee HH, Shin JS, Fischer K, Koeberle A, Werz O, Lee KT, Lee JY.

Bioorg Med Chem Lett. 2016 Jan 1;26(1):94-9. doi: 10.1016/j.bmcl.2015.11.024. Epub 2015 Nov 10.

PMID:
26602278
41.

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

Iranshahi M, Chini MG, Masullo M, Sahebkar A, Javidnia A, Chitsazian Yazdi M, Pergola C, Koeberle A, Werz O, Pizza C, Terracciano S, Piacente S, Bifulco G.

J Nat Prod. 2015 Dec 24;78(12):2867-79. doi: 10.1021/acs.jnatprod.5b00700. Epub 2015 Nov 20.

PMID:
26588603
42.

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.

De Lucia D, Lucio OM, Musio B, Bender A, Listing M, Dennhardt S, Koeberle A, Garscha U, Rizzo R, Manfredini S, Werz O, Ley SV.

Eur J Med Chem. 2015 Aug 28;101:573-83. doi: 10.1016/j.ejmech.2015.07.011. Epub 2015 Jul 15. Erratum in: Eur J Med Chem. 2015 Oct 20;103:223-5.

PMID:
26197161
43.

Perspective of microsomal prostaglandin E2 synthase-1 as drug target in inflammation-related disorders.

Koeberle A, Werz O.

Biochem Pharmacol. 2015 Nov 1;98(1):1-15. doi: 10.1016/j.bcp.2015.06.022. Epub 2015 Jun 27. Review.

PMID:
26123522
44.

Discovery of novel, non-acidic mPGES-1 inhibitors by virtual screening with a multistep protocol.

Noha SM, Fischer K, Koeberle A, Garscha U, Werz O, Schuster D.

Bioorg Med Chem. 2015 Aug 1;23(15):4839-45. doi: 10.1016/j.bmc.2015.05.045. Epub 2015 Jun 1.

45.

α-Tocopherol long-chain metabolite α-13'-COOH affects the inflammatory response of lipopolysaccharide-activated murine RAW264.7 macrophages.

Wallert M, Schmölz L, Koeberle A, Krauth V, Glei M, Galli F, Werz O, Birringer M, Lorkowski S.

Mol Nutr Food Res. 2015 Aug;59(8):1524-34. doi: 10.1002/mnfr.201400737. Epub 2015 Jun 12.

PMID:
25943249
46.

Myxochelins target human 5-lipoxygenase.

Schieferdecker S, König S, Koeberle A, Dahse HM, Werz O, Nett M.

J Nat Prod. 2015 Feb 27;78(2):335-8. doi: 10.1021/np500909b. Epub 2015 Feb 16.

PMID:
25686392
47.

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis.

Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O.

FASEB J. 2015 Jun;29(6):2439-49. doi: 10.1096/fj.14-268474. Epub 2015 Feb 12.

PMID:
25678624
48.

Revealing the macromolecular targets of complex natural products.

Reker D, Perna AM, Rodrigues T, Schneider P, Reutlinger M, Mönch B, Koeberle A, Lamers C, Gabler M, Steinmetz H, Müller R, Schubert-Zsilavecz M, Werz O, Schneider G.

Nat Chem. 2014 Dec;6(12):1072-8. doi: 10.1038/nchem.2095. Epub 2014 Nov 2.

PMID:
25411885
49.

Multi-target approach for natural products in inflammation.

Koeberle A, Werz O.

Drug Discov Today. 2014 Dec;19(12):1871-82. doi: 10.1016/j.drudis.2014.08.006. Epub 2014 Aug 27. Review.

PMID:
25172801
50.

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

Koeberle A, Muñoz E, Appendino GB, Minassi A, Pace S, Rossi A, Weinigel C, Barz D, Sautebin L, Caprioglio D, Collado JA, Werz O.

J Med Chem. 2014 Jul 10;57(13):5638-48. doi: 10.1021/jm500308c. Epub 2014 Jun 24.

PMID:
24920381

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