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Items: 1 to 50 of 69

1.
2.

5-[(3-nitropyrid-2-yl)amino]indoles: novel serotonin agonists with selectivity for the 5-HT1D receptor. Variation of the C3 substituent on the indole template leads to increased 5-HT1D receptor selectivity.

Macor JE, Blank DH, Fox CB, Lebel LA, Newman ME, Post RJ, Ryan K, Schmidt AW, Schulz DW, Koe BK.

J Med Chem. 1994 Aug 5;37(16):2509-12. No abstract available.

PMID:
8057297
3.

Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin.

Macor JE, Blake J, Fox CB, Johnson C, Koe BK, Lebel LA, Morrone JM, Ryan K, Schmidt AW, Schulz DW, et al.

J Med Chem. 1992 Nov 13;35(23):4503-5. No abstract available.

PMID:
1447752
5.
6.

Separation of alpha 1 adrenergic and N-methyl-D-aspartate antagonist activity in a series of ifenprodil compounds.

Chenard BL, Shalaby IA, Koe BK, Ronau RT, Butler TW, Prochniak MA, Schmidt AW, Fox CB.

J Med Chem. 1991 Oct;34(10):3085-90.

PMID:
1681106
7.

Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase.

Lowe JA 3rd, Archer RL, Chapin DS, Chen JB, Helweg D, Johnson JL, Koe BK, Lebel LA, Moore PF, Nielsen JA, et al.

J Med Chem. 1991 Feb;34(2):624-8.

PMID:
1995886
8.

Nicotinamide ethers: novel inhibitors of calcium-independent phosphodiesterase and [3H]rolipram binding.

Vinick FJ, Saccomano NA, Koe BK, Nielsen JA, Williams IH, Thadeio PF, Jung S, Meltz M, Johnson J Jr, Lebel LA, et al.

J Med Chem. 1991 Jan;34(1):86-9.

PMID:
1825116
9.

Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones.

Saccomano NA, Vinick FJ, Koe BK, Nielsen JA, Whalen WM, Meltz M, Phillips D, Thadieo PF, Jung S, Chapin DS, et al.

J Med Chem. 1991 Jan;34(1):291-8.

PMID:
1992129
10.

Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake.

Koe BK.

J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7. Review.

PMID:
2175308
11.

4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.

Sarges R, Howard HR, Browne RG, Lebel LA, Seymour PA, Koe BK.

J Med Chem. 1990 Aug;33(8):2240-54.

PMID:
2374150
12.

[3H] sertraline binding to rat brain membranes.

Koe BK, Lebel LA, Welch WM.

Psychopharmacology (Berl). 1990;100(4):470-6.

PMID:
2138796
13.

Sertraline potently displaces (+)-[3H]3-PPP binding to sigma sites in rat brain.

Schmidt A, Lebel L, Koe BK, Seeger T, Heym J.

Eur J Pharmacol. 1989 Jun 20;165(2-3):335-6. No abstract available.

PMID:
2550252
14.

(+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)-piperidine binding to sigma receptors in mouse brain in vivo.

Koe BK, Burkhart CA, Lebel LA.

Eur J Pharmacol. 1989 Feb 28;161(2-3):263-6.

PMID:
2566491
15.

A novel class of "GABAergic" agents: 1-aryl-3-(aminoalkylidene)oxindoles.

Sarges R, Howard HR, Koe BK, Weissman A.

J Med Chem. 1989 Feb;32(2):437-44.

PMID:
2536440
16.
17.

Pharmacology of sertraline: a review.

Heym J, Koe BK.

J Clin Psychiatry. 1988 Aug;49 Suppl:40-5. Review.

PMID:
3045112
18.
19.

Sertraline, a selective inhibitor of serotonin uptake, induces subsensitivity of beta-adrenoceptor system of rat brain.

Koe BK, Koch SW, Lebel LA, Minor KW, Page MG.

Eur J Pharmacol. 1987 Sep 11;141(2):187-94.

PMID:
2824215
20.

Neuroleptics from the 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 3. Carboxamidoalkyl derivatives.

Welch WM, Harbert CA, Sarges R, Weissman A, Koe BK.

J Med Chem. 1986 Oct;29(10):2108-11.

PMID:
2876105
21.

Neuroleptics from the 4a,9b-cis- and 4a,9b-trans-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole series. 2.

Welch WM, Harbert CA, Weissman A, Koe BK.

J Med Chem. 1986 Oct;29(10):2093-9.

PMID:
2876102
22.

Neuroleptic activity of chiral trans-hexahydro-gamma-carbolines.

Sarges R, Howard HR, Donahue KM, Welch WM, Dominy BW, Weissman A, Koe BK, Bordner J.

J Med Chem. 1986 Jan;29(1):8-19. Erratum in: J Med Chem 1986 May;29(5):876.

PMID:
3941416
24.

Enhancement of brain [3H]flunitrazepam binding and analgesic activity of synthetic cannabimimetics.

Koe BK, Milne GM, Weissman A, Johnson MR, Melvin LS.

Eur J Pharmacol. 1985 Feb 26;109(2):201-12.

PMID:
2986995
25.

Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.

Welch WM, Kraska AR, Sarges R, Koe BK.

J Med Chem. 1984 Nov;27(11):1508-15.

PMID:
6492080
26.
27.
29.

GABA-like actions of levonantradol.

Leader JP, Koe BK, Weissman A.

J Clin Pharmacol. 1981 Aug-Sep;21(S1):262S-270S.

PMID:
6271832
30.

Facilitation of benzodiazepine binding by levonantradol.

Koe BK, Weissman A.

J Clin Pharmacol. 1981 Aug-Sep;21(S1):397S-405S.

PMID:
6117577
32.

Dopamine receptor blockade by imidoline and its proposed active conformation.

Koe BK, Koch SW, Dominy BW.

Eur J Pharmacol. 1980 Nov 21;68(2):139-46.

PMID:
6110542
33.
34.

Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines.

Harbert CA, Plattner JJ, Welch WM, Weissman A, Koe BK.

J Med Chem. 1980 Jun;23(6):635-43.

PMID:
6104732
35.

Neuroleptic activity of the 5-aryltetrahydro-gamma-carboline series. Conformational requirements for interaction with central dopamine receptors.

Harbert CA, Plattner JJ, Welch WM, Weissman A, Koe BK.

Mol Pharmacol. 1980 Jan;17(1):38-42. No abstract available.

PMID:
6104285
36.

Stereospecific and potent analgetic activity for nantradol--a structurally novel, cannabinoid-related analgetic.

Milne GM, Koe BK, Johnson MR.

NIDA Res Monogr. 1979;27:84-92. No abstract available.

PMID:
121368
38.

Inhibition of rat brain tryptophan hydroxylation with p-chloroamphetamine.

Koe BK, Corkey RF Jr.

Biochem Pharmacol. 1976 Jan;25(1):31-5. No abstract available.

PMID:
1252254
40.

Blockade of hepatic aldehyde dehydrogenase in mice on chronic ingestion of 4-bromopyrazole and 4-iodopyrazole.

Koe BK, Tenen SS.

Biochem Pharmacol. 1975 Mar 15;24(6):723-7. No abstract available.

PMID:
1125074
41.

Blockade of heart 3H-norepinephrine up-take by 4-phenyl-1-aminotetralines: implications for the active conformation of imipramine-like drugs.

Sarges R, Koe BK, Weissman A, Schaefer JP.

J Pharmacol Exp Ther. 1974 Dec;191(3):393-402. No abstract available.

PMID:
4427286
42.

Saccharin preference of butyraldoxime-treated C57BL mice.

Tenen SS, Koe BK.

Experientia. 1972 Oct 15;28(10):1194-5. No abstract available.

PMID:
5087035
43.

Blocking H 3 -Norepinephrine uptake and some guanethidine-induced effects with tricyclic psychotherapeutic drugs.

Koe BK, Constantine JW.

Arch Int Pharmacodyn Ther. 1972 Jan;195(1):71-80. No abstract available.

PMID:
5010834
44.

Tryptophan hydroxylase inhibitors.

Koe BK.

Fed Proc. 1971 May-Jun;30(3):886-96. No abstract available.

PMID:
4252531
45.

Inhibiting action of n-butyraldoxime on ethanol metabolism and on natural ethanol preference of C57BL mice.

Koe BK, Tenen SS.

J Pharmacol Exp Ther. 1970 Sep;174(3):434-49. No abstract available.

PMID:
5456176
46.

Clinical and biochemical effects of fenclonine: a serotonin depletor.

Cremata VY Jr, Koe BK.

Dis Nerv Syst. 1968 May;29(5):Suppl:147-52. No abstract available.

PMID:
5673619
47.

The pharmacology of para-chlorophenylalanine, a selective depletor of serotonin stores.

Koe BK, Weissman A.

Adv Pharmacol. 1968;6(Pt B):Suppl 1:29-47. No abstract available.

PMID:
4968786
48.

Dependence of m-fluorophenylalanine toxicity on phenylalanine hydroxylase activity.

Koe BK, Weissman A.

J Pharmacol Exp Ther. 1967 Sep;157(3):565-73. No abstract available.

PMID:
6048017
49.

Contrasting locomotor effects of catecholamine releasers and tyrosine hydroxylase inhibitors in MAO-inhibited mice.

Weissman A, Koe BK.

Psychopharmacologia. 1967 Aug 4;11(3):282-6. No abstract available.

PMID:
6055527
50.

m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism.

Weissman A, Koe BK.

J Pharmacol Exp Ther. 1967 Jan;155(1):135-44. No abstract available.

PMID:
5297377

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