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Synthesis and screening of bead-displayed combinatorial libraries.

Doran TM, Dickson P, Ndungu JM, Ge P, Suponitsky-Kroyter I, An H, Kodadek T.

Methods Enzymol. 2019;622:91-127. doi: 10.1016/bs.mie.2019.02.005. Epub 2019 Mar 8.


Chemical composition of DNA-encoded libraries, past present and future.

Dickson P, Kodadek T.

Org Biomol Chem. 2019 May 15;17(19):4676-4688. doi: 10.1039/c9ob00581a. Review.


Sweetening the Therapeutic Pot for Type 2 Diabetes with Long Noncoding RNAs.

Dickson P, Kodadek T.

Cell Chem Biol. 2019 Mar 21;26(3):311-313. doi: 10.1016/j.chembiol.2019.02.022.


Antibody biomarker for de novo Parkinson disease: attempted validation.

Feng N, Simanski S, Islam K, Hynan LS, Kodadek T, German DC.

NPJ Parkinsons Dis. 2018 Sep 5;4:28. doi: 10.1038/s41531-018-0064-2. eCollection 2018.


A "Smart Lock" for Preventing Hepatitis B Entry into Cells.

Balzarini M, Kodadek T.

Cell Chem Biol. 2018 Jul 19;25(7):804-806. doi: 10.1016/j.chembiol.2018.06.011.


Solid-Phase Synthesis of β-Hydroxy Ketones Via DNA-Compatible Organocatalytic Aldol Reactions.

Shu K, Kodadek T.

ACS Comb Sci. 2018 May 14;20(5):277-281. doi: 10.1021/acscombsci.8b00001. Epub 2018 Apr 3.


Screening one bead one compound libraries against serum using a flow cytometer: Determination of the minimum antibody concentration required for ligand discovery.

Erharuyi O, Simanski S, McEnaney PJ, Kodadek T.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2773-2778. doi: 10.1016/j.bmcl.2018.01.033. Epub 2018 Jan 31.


Solid-Phase Synthesis of β-Amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions.

Tran-Hoang N, Kodadek T.

ACS Comb Sci. 2018 Feb 12;20(2):55-60. doi: 10.1021/acscombsci.7b00151. Epub 2018 Jan 24.


DNA-Compatible Solid-Phase Combinatorial Synthesis of β-Cyanoacrylamides and Related Electrophiles.

Pels K, Dickson P, An H, Kodadek T.

ACS Comb Sci. 2018 Feb 12;20(2):61-69. doi: 10.1021/acscombsci.7b00169. Epub 2018 Jan 17.


Another One (of the "Undruggable" Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP.

Kodadek T.

Biochemistry. 2018 Feb 13;57(6):899-900. doi: 10.1021/acs.biochem.7b01179. Epub 2017 Dec 15. No abstract available.


Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line.

Koesema E, Kodadek T.

PLoS One. 2017 Nov 16;12(11):e0188082. doi: 10.1371/journal.pone.0188082. eCollection 2017.


Asymmetric synthesis of vinylogous β-amino acids and their incorporation into mixed backbone oligomers.

Wu H, An H, Mo SC, Kodadek T.

Org Biomol Chem. 2017 Apr 11;15(15):3255-3264. doi: 10.1039/c7ob00333a.


Establishment of a suite of assays that support the discovery of proteasome stimulators.

Trader DJ, Simanski S, Dickson P, Kodadek T.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):892-899. doi: 10.1016/j.bbagen.2017.01.003. Epub 2017 Jan 5.


High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections.

Mendes KR, Malone ML, Ndungu JM, Suponitsky-Kroyter I, Cavett VJ, McEnaney PJ, MacConnell AB, Doran TM, Ronacher K, Stanley K, Utset O, Walzl G, Paegel BM, Kodadek T.

ACS Chem Biol. 2017 Jan 20;12(1):234-243. doi: 10.1021/acschembio.6b00855. Epub 2016 Dec 13.


Cell-Permeable Peptides Containing Cycloalanine Residues.

Wu H, Mousseau G, Mediouni S, Valente ST, Kodadek T.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12637-42. doi: 10.1002/anie.201605745. Epub 2016 Aug 16.


BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression.

Wu SY, Nin DS, Lee AY, Simanski S, Kodadek T, Chiang CM.

Cell Rep. 2016 Aug 9;16(6):1733-1748. doi: 10.1016/j.celrep.2016.07.001. Epub 2016 Jul 28.


Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus.

Doran TM, Morimoto J, Simanski S, Koesema EJ, Clark LF, Pels K, Stoops SL, Pugliese A, Skyler JS, Kodadek T.

Cell Chem Biol. 2016 May 19;23(5):618-628. doi: 10.1016/j.chembiol.2016.04.006. Epub 2016 May 12.


Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers.

Gearhart TL, Montelaro RC, Schurdak ME, Pilcher CD, Rinaldo CR, Kodadek T, Park Y, Islam K, Yurko R, Marques ET Jr, Burke DS.

J Immunol Methods. 2016 Aug;435:85-9. doi: 10.1016/j.jim.2016.05.001. Epub 2016 May 12.


Chemical Tools To Monitor and Manipulate Adaptive Immune Responses.

Doran TM, Sarkar M, Kodadek T.

J Am Chem Soc. 2016 May 18;138(19):6076-94. doi: 10.1021/jacs.6b02954. Epub 2016 May 3. Review.


The Immune System and Neuroinflammation as Potential Sources of Blood-Based Biomarkers for Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease.

Clark LF, Kodadek T.

ACS Chem Neurosci. 2016 May 18;7(5):520-7. doi: 10.1021/acschemneuro.6b00042. Epub 2016 Apr 14. Review.


Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.

Kodadek T, McEnaney PJ.

Chem Commun (Camb). 2016 May 4;52(36):6038-59. doi: 10.1039/c6cc00617e. Epub 2016 Mar 21.


Targeting Stereotyped B Cell Receptors from Chronic Lymphocytic Leukemia Patients with Synthetic Antigen Surrogates.

Sarkar M, Liu Y, Qi J, Peng H, Morimoto J, Rader C, Chiorazzi N, Kodadek T.

J Biol Chem. 2016 Apr 1;291(14):7558-70. doi: 10.1074/jbc.M115.701656. Epub 2016 Feb 5.


And then there were two.

Clark LF, Kodadek T.

Elife. 2015 Dec 30;4. pii: e12724. doi: 10.7554/eLife.12724.


Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and "antigen surrogates" mounted onto a liquid array.

Doran TM, Morimoto J, Simanski S, McEnaney PJ, Kodadek T.

Mol Biosyst. 2015 Nov;11(11):3156-63. doi: 10.1039/c5mb00521c.


Optimization of the Magnetic Recovery of Hits from One-Bead-One-Compound Library Screens.

Mendes K, Ndungu JM, Clark LF, Kodadek T.

ACS Comb Sci. 2015 Sep 14;17(9):506-17. doi: 10.1021/acscombsci.5b00090. Epub 2015 Aug 24.


Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues.

Li X, Patterson JT, Sarkar M, Pedzisa L, Kodadek T, Roush WR, Rader C.

Bioconjug Chem. 2015 Nov 18;26(11):2243-8. doi: 10.1021/acs.bioconjchem.5b00244. Epub 2015 Jul 24.


High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies.

Doran TM, Gao Y, Simanski S, McEnaney P, Kodadek T.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4910-4917. doi: 10.1016/j.bmcl.2015.05.046. Epub 2015 May 27.


Synthesis of a large library of macrocyclic peptides containing multiple and diverse N-alkylated residues.

Morimoto J, Kodadek T.

Mol Biosyst. 2015 Oct;11(10):2770-9. doi: 10.1039/c5mb00308c.


A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor rpn13 is toxic to multiple myeloma cells.

Trader DJ, Simanski S, Kodadek T.

J Am Chem Soc. 2015 May 20;137(19):6312-9. doi: 10.1021/jacs.5b02069. Epub 2015 May 8.


Solid-phase synthesis of diverse peptide tertiary amides by reductive amination.

Pels K, Kodadek T.

ACS Comb Sci. 2015 Mar 9;17(3):152-5. doi: 10.1021/acscombsci.5b00007. Epub 2015 Feb 25.


Direct comparison of linear and macrocyclic compound libraries as a source of protein ligands.

Gao Y, Kodadek T.

ACS Comb Sci. 2015 Mar 9;17(3):190-5. doi: 10.1021/co500161c. Epub 2015 Feb 14.


Editorial overview: Omics: Methods to monitor and manipulate biological systems: recent advances in 'omics'.

Cravatt BF, Kodadek T.

Curr Opin Chem Biol. 2015 Feb;24:v-vii. doi: 10.1016/j.cbpa.2014.12.023. Epub 2014 Dec 27. No abstract available.


Discovery of native autoantigens via antigen surrogate technology: application to type 1 diabetes.

Doran TM, Simanski S, Kodadek T.

ACS Chem Biol. 2015 Feb 20;10(2):401-12. doi: 10.1021/cb5007618. Epub 2014 Dec 17.


Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates.

Sarkar M, Liu Y, Morimoto J, Peng H, Aquino C, Rader C, Chiorazzi N, Kodadek T.

Chem Biol. 2014 Dec 18;21(12):1670-9. doi: 10.1016/j.chembiol.2014.10.010. Epub 2014 Nov 26.


Rapid lead discovery through iterative screening of one bead one compound libraries.

Gao Y, Amar S, Pahwa S, Fields G, Kodadek T.

ACS Comb Sci. 2015 Jan 12;17(1):49-59. doi: 10.1021/co500154e. Epub 2014 Dec 19.


Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides.

Sarma BK, Liu X, Wu H, Gao Y, Kodadek T.

Org Biomol Chem. 2015 Jan 7;13(1):59-63. doi: 10.1039/c4ob01883d.


Chemical tools to monitor and manipulate the adaptive immune system.

Kodadek T.

Chem Biol. 2014 Sep 18;21(9):1066-74. doi: 10.1016/j.chembiol.2014.07.009. Review.


Dextran as a generally applicable multivalent scaffold for improving immunoglobulin-binding affinities of peptide and peptidomimetic ligands.

Morimoto J, Sarkar M, Kenrick S, Kodadek T.

Bioconjug Chem. 2014 Aug 20;25(8):1479-91. doi: 10.1021/bc500226j. Epub 2014 Jul 30.


Roadblocks for integration of novel biomarker concepts into clinical routine: the peptoid approach.

Vanderstichele H, Kodadek T.

Alzheimers Res Ther. 2014 Apr 30;6(2):23. doi: 10.1186/alzrt253. eCollection 2014. Review.


Split-and-pool synthesis and characterization of peptide tertiary amide library.

Gao Y, Kodadek T.

J Vis Exp. 2014 Jun 20;(88):e51299. doi: 10.3791/51299.


Solid-phase synthesis of peptoid-like oligomers containing diverse diketopiperazine units.

Suwal S, Kodadek T.

Org Biomol Chem. 2014 Aug 21;12(31):5831-4. doi: 10.1039/c4ob00829d.


Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits.

Doran TM, Gao Y, Mendes K, Dean S, Simanski S, Kodadek T.

ACS Comb Sci. 2014 Jun 9;16(6):259-70. doi: 10.1021/co500030f. Epub 2014 Apr 21.


Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates.

Quan J, Lakhanpal A, Reddy MM, Zaman S, Li QZ, German DC, Olsen NJ, Kodadek T, Karp DR.

J Immunol Methods. 2014 Jan 15;402(1-2):23-34. doi: 10.1016/j.jim.2013.11.004. Epub 2013 Nov 20.


A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions.

Doran TM, Kodadek T.

ACS Chem Biol. 2014 Feb 21;9(2):339-46. doi: 10.1021/cb400806r. Epub 2013 Nov 20.


A jack of all trades to combat drug-resistant Gram-negative bacteria.

Kodadek T.

Chem Biol. 2013 Oct 24;20(10):1202-3. doi: 10.1016/j.chembiol.2013.10.006.


Features of modularly assembled compounds that impart bioactivity against an RNA target.

Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD.

ACS Chem Biol. 2013 Oct 18;8(10):2312-21. doi: 10.1021/cb400265y. Epub 2013 Sep 13.


Advances in blood-based protein biomarkers for Alzheimer's disease.

Clark LF, Kodadek T.

Alzheimers Res Ther. 2013 May 9;5(3):18. doi: 10.1186/alzrt172. eCollection 2013. Review.


Decoding split and pool combinatorial libraries with electron-transfer dissociation tandem mass spectrometry.

Sarkar M, Pascal BD, Steckler C, Aquino C, Micalizio GC, Kodadek T, Chalmers MJ.

J Am Soc Mass Spectrom. 2013 Jul;24(7):1026-36. doi: 10.1007/s13361-013-0633-x. Epub 2013 May 2.


Synthesis and screening of stereochemically diverse combinatorial libraries of peptide tertiary amides.

Gao Y, Kodadek T.

Chem Biol. 2013 Mar 21;20(3):360-9. doi: 10.1016/j.chembiol.2013.01.013.

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