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Items: 1 to 50 of 78


Anti-interleukin-5 therapy (mepolizumab) in life-threatening asthma attack: A case-based discussion.

Tello K, Hoffmann A, Beutel B, Greulich T, Vogelmeier CF, Richter MJ, Kuhnert S, Böselt T, Alter P, Holland A, Idzko M, Buhl R, Koczulla AR.

Respir Med Case Rep. 2019 Aug 22;28:100927. doi: 10.1016/j.rmcr.2019.100927. eCollection 2019.


Comparison of supplemental oxygen delivery by continuous versus demand based flow systems in hypoxemic COPD patients - A randomized, single-blinded cross-over study.

Gloeckl R, Jarosch I, Schneeberger T, Fiedler C, Lausen M, Weingaertner J, Hitzl W, Kenn K, Koczulla AR.

Respir Med. 2019 Sep;156:26-32. doi: 10.1016/j.rmed.2019.08.001. Epub 2019 Aug 5.


TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.

Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E.

J Virol. 2019 Aug 7. pii: JVI.00649-19. doi: 10.1128/JVI.00649-19. [Epub ahead of print]


VOC pattern recognition of lung cancer: a comparative evaluation of different dog- and eNose-based strategies using different sampling materials.

Biehl W, Hattesohl A, Jörres RA, Duell T, Althöhn U, Koczulla AR, Schmetzer H.

Acta Oncol. 2019 Sep;58(9):1216-1224. doi: 10.1080/0284186X.2019.1634284. Epub 2019 Jul 16.


In Reply.

Koczulla AR.

Dtsch Arztebl Int. 2019 Apr 19;116(16):287-288. doi: 10.3238/arztebl.2019.0287b. No abstract available.


COPD: Rethinking Patient Management - How to Approach a Challenging Patient Group Successfully.

Jany BH, Bals R, Buhr-Schinner H, Dreher M, Koczulla AR, Jany L, Meyer A, Randerath W.

Respiration. 2019;97(4):363-368. doi: 10.1159/000493759. Epub 2019 Mar 15. Review.


Long-Term Oxygen Therapy.

Koczulla AR, Schneeberger T, Jarosch I, Kenn K, Gloeckl R.

Dtsch Arztebl Int. 2018 Dec 24;115(51-52):871-877. doi: 10.3238/arztebl.2018.0871.


Comparison of continuous flow versus demand oxygen delivery systems in patients with COPD: A systematic review and meta-analysis.

Gloeckl R, Osadnik C, Bies L, Leitl D, Koczulla AR, Kenn K.

Respirology. 2019 Apr;24(4):329-337. doi: 10.1111/resp.13457. Epub 2018 Dec 17. Review.


Longitudinal stability of blood eosinophil count strata in the COPD COSYCONET cohort.

Greulich T, Mager S, Lucke T, Koczulla AR, Bals R, Fähndrich S, Jörres RA, Alter P, Kirsten A, Vogelmeier CF, Watz H.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 28;13:2999-3002. doi: 10.2147/COPD.S165909. eCollection 2018. No abstract available.


α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1-42-stimulated murine astrocytes.

Ebrahimi T, Rust M, Kaiser SN, Slowik A, Beyer C, Koczulla AR, Schulz JB, Habib P, Bach JP.

J Neuroinflammation. 2018 Sep 27;15(1):282. doi: 10.1186/s12974-018-1319-x.


High-pressure non-invasive ventilation during exercise in COPD patients with chronic hypercapnic respiratory failure: A randomized, controlled, cross-over trial.

Gloeckl R, Andrianopoulos V, Stegemann A, Oversohl J, Schneeberger T, Schoenheit-Kenn U, Hitzl W, Dreher M, Koczulla AR, Kenn K.

Respirology. 2019 Mar;24(3):254-261. doi: 10.1111/resp.13399. Epub 2018 Sep 21.


Ondine's curse and temporal lobe seizures: anti-Hu- and Zic4-associated paraneoplastic brainstem and limbic encephalitis.

Kay L, Bauer S, Koczulla AR, Librizzi D, Vadasz D, Knake S, Rosenow F, Strzelczyk A.

Eur J Neurol. 2018 May;25(5):e59-e60. doi: 10.1111/ene.13629. No abstract available.


Alpha 1 antitrypsin to treat lung disease in alpha 1 antitrypsin deficiency: recent developments and clinical implications.

Chapman KR, Chorostowska-Wynimko J, Koczulla AR, Ferrarotti I, McElvaney NG.

Int J Chron Obstruct Pulmon Dis. 2018 Jan 31;13:419-432. doi: 10.2147/COPD.S149429. eCollection 2018. Review.


Non-invasive Detection of Bladder Tumors Through Volatile Organic Compounds: A Pilot Study with an Electronic Nose.

Heers H, Gut JM, Hegele A, Hofmann R, Boeselt T, Hattesohl A, Koczulla AR.

Anticancer Res. 2018 Feb;38(2):833-837.


Prevalence of comorbidities in COPD patients by disease severity in a German population.

Greulich T, Weist BJD, Koczulla AR, Janciauskiene S, Klemmer A, Lux W, Alter P, Vogelmeier CF.

Respir Med. 2017 Nov;132:132-138. doi: 10.1016/j.rmed.2017.10.007. Epub 2017 Oct 12.


Comparison of exercise training responses in COPD patients with and without Alpha-1 antitrypsin deficiency.

Jarosch I, Hitzl W, Koczulla AR, Wencker M, Welte T, Gloeckl R, Janciauskiene S, Kenn K.

Respir Med. 2017 Sep;130:98-101. doi: 10.1016/j.rmed.2017.07.009. Epub 2017 Jul 15.


[COPD-Management, a comprehensive review].

Gillissen A, Kähler CM, Koczulla AR, Sauer R, Paparoupa M.

MMW Fortschr Med. 2017 Nov;159(Suppl 3):32-43. doi: 10.1007/s15006-017-9594-5. German. No abstract available.


Obstructive sleep apnea patients can be identified by ion mobility spectrometry-derived smell prints of different biological materials.

Greulich T, Fischer H, Lubbe D, Nell C, Ingo Baumbach J, Koehler U, Boeselt T, Vogelmeier C, Koczulla AR.

J Breath Res. 2018 Feb 6;12(2):026006. doi: 10.1088/1752-7163/aa96e2.


Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome.

Engel M, Endesfelder D, Schloter-Hai B, Kublik S, Granitsiotis MS, Boschetto P, Stendardo M, Barta I, Dome B, Deleuze JF, Boland A, Müller-Quernheim J, Prasse A, Welte T, Hohlfeld J, Subramanian D, Parr D, Gut IG, Greulich T, Koczulla AR, Nowinski A, Gorecka D, Singh D, Gupta S, Brightling CE, Hoffmann H, Frankenberger M, Hofer TP, Burggraf D, Heiss-Neumann M, Ziegler-Heitbrock L, Schloter M, Zu Castell W.

PLoS One. 2017 Jul 13;12(7):e0180859. doi: 10.1371/journal.pone.0180859. eCollection 2017.


[COPD, an update of current management recommendations].

Gillissen A, Kähler CM, Koczulla AR, Sauer R.

MMW Fortschr Med. 2017 Jun;159(12):56-59. doi: 10.1007/s15006-017-9851-7. Review. German. No abstract available.


Feasibility and safety of whole-body vibration therapy in intensive care patients.

Alter P, Boeselt T, Nell C, Spielmanns M, Kenn K, Koczulla AR.

Crit Care. 2017 Apr 13;21(1):91. doi: 10.1186/s13054-017-1669-2. No abstract available.


Whole-Body Vibration Training During a Low Frequency Outpatient Exercise Training Program in Chronic Obstructive Pulmonary Disease Patients: A Randomized, Controlled Trial.

Spielmanns M, Gloeckl R, Gropp JM, Nell C, Koczulla AR, Boeselt T, Storre JH, Windisch W.

J Clin Med Res. 2017 May;9(5):396-402. doi: 10.14740/jocmr2763w. Epub 2017 Apr 1.


Benefits of High-Intensity Exercise Training to Patients with Chronic Obstructive Pulmonary Disease: A Controlled Study.

Boeselt T, Nell C, Lütteken L, Kehr K, Koepke J, Apelt S, Veith M, Beutel B, Spielmanns M, Greulich T, Vogelmeier CF, Kenn K, Janciauskiene S, Alter P, Koczulla AR.

Respiration. 2017;93(5):301-310. doi: 10.1159/000464139. Epub 2017 Mar 23.


[Impact of a Senso-Motoric Intervention in COPD-Patients Participating in an Outpatient Pulmonary Rehabilitation Program: A Randomized Controlled Trial].

Spielmanns M, Müller K, Schott N, Winkler A, Polanski H, Nell C, Boeselt T, Koczulla AR, Storre JH, Windisch W, Magnet FS, Baum K.

Rehabilitation (Stuttg). 2017 Jun;56(3):159-166. doi: 10.1055/s-0042-119248. Epub 2017 Feb 23. German.


Myocardial homing of mesenchymal stem cells following intrapericardial application and amplification by inflammation - an experimental pilot study.

Jung N, Rupp H, Koczulla AR, Vogelmeier CF, Alter P.

Can J Physiol Pharmacol. 2017 Sep;95(9):1064-1066. doi: 10.1139/cjpp-2016-0373. Epub 2017 Feb 23.


[Pulmonary Rehabilitation after Acute Exacerbation of COPD Reduces the Rate of Reexacerbations].

Spielmanns M, Meier A, Winkler A, Glöckl R, Nell C, Koczulla AR, Boeselt T, Alter P, Magnet F, Storre JH, Windisch W.

Dtsch Med Wochenschr. 2017 Jan;142(2):e10-e19. doi: 10.1055/s-0042-121346. Epub 2017 Jan 23. German.


Altered blood levels of vitamin D, cathelicidin and parathyroid hormone in patients with sepsis-a pilot study.

Greulich T, Regner W, Branscheidt M, Herr C, Koczulla AR, Vogelmeier CF, Bals R.

Anaesth Intensive Care. 2017 Jan;45(1):36-45.


[Outcome predictors for COPD patients hospitalized for acute exacerbation].

Spielmanns M, Axer F, Nell C, Koczulla AR, Boeselt T, Magnet F, Storre JH, Windisch W.

Med Klin Intensivmed Notfmed. 2017 Nov;112(8):708-716. doi: 10.1007/s00063-016-0245-x. Epub 2017 Jan 2. German.


Low-Volume Whole-Body Vibration Training Improves Exercise Capacity in Subjects With Mild to Severe COPD.

Spielmanns M, Boeselt T, Gloeckl R, Klutsch A, Fischer H, Polanski H, Nell C, Storre JH, Windisch W, Koczulla AR.

Respir Care. 2017 Mar;62(3):315-323. doi: 10.4187/respcare.05154. Epub 2016 Dec 6.


New concepts in asthma: clinical phenotypes and pathophysiological mechanisms.

Koczulla AR, Vogelmeier CF, Garn H, Renz H.

Drug Discov Today. 2017 Feb;22(2):388-396. doi: 10.1016/j.drudis.2016.11.008. Epub 2016 Nov 17. Review.


The prevalence of diagnosed α1-antitrypsin deficiency and its comorbidities: results from a large population-based database.

Greulich T, Nell C, Hohmann D, Grebe M, Janciauskiene S, Koczulla AR, Vogelmeier CF.

Eur Respir J. 2017 Jan 4;49(1). pii: 1600154. doi: 10.1183/13993003.00154-2016. Print 2017 Jan.


Hydrogen peroxide in exhaled air: a source of error, a paradox and its resolution.

Peters S, Kronseder A, Karrasch S, Neff PA, Haaks M, Koczulla AR, Reinhold P, Nowak D, Jörres RA.

ERJ Open Res. 2016 Jun 17;2(2). pii: 00052-2015. eCollection 2016 Apr.


[Expert Meeting on COPD: Personalized Treatment of COPD - Wishful Thinking or Reality?]

Lorenz J, Bals R, Ewert R, Jany B, Koczulla AR, Köhnlein T, Randerath WJ, Steinkamp G, Watz H, Welte T.

Pneumologie. 2016 Oct;70(10):638-650. Epub 2016 Oct 10. German.


The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.

Utiyama DM, Yoshida CT, Goto DM, de Santana Carvalho T, de Paula Santos U, Koczulla AR, Saldiva PH, Nakagawa NK.

Clinics (Sao Paulo). 2016 Jul;71(6):344-50. doi: 10.6061/clinics/2016(06)10.


Validity and Usability of Physical Activity Monitoring in Patients with Chronic Obstructive Pulmonary Disease (COPD).

Boeselt T, Spielmanns M, Nell C, Storre JH, Windisch W, Magerhans L, Beutel B, Kenn K, Greulich T, Alter P, Vogelmeier C, Koczulla AR.

PLoS One. 2016 Jun 15;11(6):e0157229. doi: 10.1371/journal.pone.0157229. eCollection 2016.


Results from a large targeted screening program for alpha-1-antitrypsin deficiency: 2003 - 2015.

Greulich T, Nell C, Herr C, Vogelmeier C, Kotke V, Wiedmann S, Wencker M, Bals R, Koczulla AR.

Orphanet J Rare Dis. 2016 Jun 10;11(1):75. doi: 10.1186/s13023-016-0453-8.


Emphysema- and airway-dominant COPD phenotypes defined by standardised quantitative computed tomography.

Subramanian DR, Gupta S, Burggraf D, Vom Silberberg SJ, Heimbeck I, Heiss-Neumann MS, Haeussinger K, Newby C, Hargadon B, Raj V, Singh D, Kolsum U, Hofer TP, Al-Shair K, Luetzen N, Prasse A, Müller-Quernheim J, Benea G, Leprotti S, Boschetto P, Gorecka D, Nowinski A, Oniszh K, Castell WZ, Hagen M, Barta I, Döme B, Strausz J, Greulich T, Vogelmeier C, Koczulla AR, Gut I, Hohlfeld J, Welte T, Lavae-Mokhtari M, Ziegler-Heitbrock L, Brightling C, Parr DG.

Eur Respir J. 2016 Jul;48(1):92-103. doi: 10.1183/13993003.01878-2015. Epub 2016 May 26.


A dual center study to compare breath volatile organic compounds from smokers and non-smokers with and without COPD.

Gaida A, Holz O, Nell C, Schuchardt S, Lavae-Mokhtari B, Kruse L, Boas U, Langejuergen J, Allers M, Zimmermann S, Vogelmeier C, Koczulla AR, Hohlfeld JM.

J Breath Res. 2016 Apr 15;10(2):026006. doi: 10.1088/1752-7155/10/2/026006.


Correction: Comparison of Two Devices and Two Breathing Patterns for Exhaled Breath Condensate Sampling.

Hüttmann EM, Greulich T, Koepke J, Nell C, Hattesohl A, Schmid S, Noeske S, Herr C, John G, Jörres RA, Müller B, Vogelmeier C, Koczulla AR.

PLoS One. 2016 Mar 28;11(3):e0152620. doi: 10.1371/journal.pone.0152620. eCollection 2016. No abstract available.


Whole-body vibration therapy in intensive care patients: A feasibility and safety study.

Boeselt T, Nell C, Kehr K, Holland A, Dresel M, Greulich T, Tackenberg B, Kenn K, Boeder J, Klapdor B, Kirschbaum A, Vogelmeier C, Alter P, Koczulla AR.

J Rehabil Med. 2016 Mar;48(3):316-21. doi: 10.2340/16501977-2052.


Reduction of glutamate-induced excitotoxicity in murine primary neurons involving calpain inhibition.

Gold M, Koczulla AR, Mengel D, Koepke J, Dodel R, Dontcheva G, Habib P, Bach JP.

J Neurol Sci. 2015 Dec 15;359(1-2):356-62. doi: 10.1016/j.jns.2015.11.016. Epub 2015 Nov 11.


Wall stress determines systolic and diastolic function--Characteristics of heart failure.

Alter P, Koczulla AR, Nell C, Figiel JH, Vogelmeier CF, Rominger MB.

Int J Cardiol. 2016 Jan 1;202:685-93. doi: 10.1016/j.ijcard.2015.09.032. Epub 2015 Sep 25.


Effect of a Three-Week Inpatient Rehabilitation Program on 544 Consecutive Patients with Very Severe COPD: A Retrospective Analysis.

Greulich T, Koczulla AR, Nell C, Kehr K, Vogelmeier CF, Stojanovic D, Wittmann M, Schultz K.

Respiration. 2015;90(4):287-92. doi: 10.1159/000436979. Epub 2015 Sep 5.


From Heart Failure to Highly Unsaturated Fatty Acid Deficiency and Vice Versa: Bidirectional Heart and Liver Interactions.

Alter P, Glück T, Figiel JH, Koczulla AR, Vogelmeier CF, Rupp H.

Can J Cardiol. 2016 Feb;32(2):217-25. doi: 10.1016/j.cjca.2015.05.019. Epub 2015 May 30.


Airflow limitation in COPD is associated with increased left ventricular wall stress in coincident heart failure.

Alter P, van de Sand K, Nell C, Figiel JH, Greulich T, Vogelmeier CF, Koczulla AR.

Respir Med. 2015 Sep;109(9):1131-7. doi: 10.1016/j.rmed.2015.07.012. Epub 2015 Jul 17.


Measuring Compounds in Exhaled Air to Detect Alzheimer's Disease and Parkinson's Disease.

Bach JP, Gold M, Mengel D, Hattesohl A, Lubbe D, Schmid S, Tackenberg B, Rieke J, Maddula S, Baumbach JI, Nell C, Boeselt T, Michelis J, Alferink J, Heneka M, Oertel W, Jessen F, Janciauskiene S, Vogelmeier C, Dodel R, Koczulla AR.

PLoS One. 2015 Jul 13;10(7):e0132227. doi: 10.1371/journal.pone.0132227. eCollection 2015.


Supporting prolonged COPD monitoring using an application for mobile devices.

Haller A, Schuerg S, Schudt F, Koczulla AR, Mursina L, Gross V, Sohrabi K.

Stud Health Technol Inform. 2015;212:154-8.


Late gadolinium enhancement in sarcoidosis: ventricular wall stress should not be overlooked.

Alter P, Vogelmeier CF, Koczulla AR.

Chest. 2015 Mar;147(3):e118. doi: 10.1378/chest.14-2740. No abstract available.


Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.

Koepke J, Dresel M, Schmid S, Greulich T, Beutel B, Schmeck B, Vogelmeier CF, Janciauskiene S, Koczulla AR.

PLoS One. 2015 Jan 30;10(1):e0117497. doi: 10.1371/journal.pone.0117497. eCollection 2015.


α1-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity.

Gold M, Dolga AM, Koepke J, Mengel D, Culmsee C, Dodel R, Koczulla AR, Bach JP.

J Neuroinflammation. 2014 Sep 23;11:165. doi: 10.1186/s12974-014-0165-8.

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