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Items: 1 to 50 of 128

1.

Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.

Colón-Thillet R, Hsieh E, Graf L, McLaughlin RN Jr, Young JM, Kochs G, Emerman M, Malik HS.

PLoS Biol. 2019 Oct 1;17(10):e3000181. doi: 10.1371/journal.pbio.3000181. eCollection 2019 Oct.

2.

Essential Role of Interferon Response in Containing Human Pathogenic Bourbon Virus.

Fuchs J, Straub T, Seidl M, Kochs G.

Emerg Infect Dis. 2019 Jul;25(7):1304-1313. doi: 10.3201/eid2507.181062.

3.

Mx1 in Hematopoietic Cells Protects against Thogoto Virus Infection.

Spitaels J, Van Hoecke L, Roose K, Kochs G, Saelens X.

J Virol. 2019 Jul 17;93(15). pii: e00193-19. doi: 10.1128/JVI.00193-19. Print 2019 Aug 1.

PMID:
31092574
4.

Equine MX2 is a restriction factor of equine infectious anemia virus (EIAV).

Meier K, Jaguva Vasudevan AA, Zhang Z, Bähr A, Kochs G, Häussinger D, Münk C.

Virology. 2018 Oct;523:52-63. doi: 10.1016/j.virol.2018.07.024. Epub 2018 Aug 3.

PMID:
30081309
5.

Human MxB Protein Is a Pan-herpesvirus Restriction Factor.

Schilling M, Bulli L, Weigang S, Graf L, Naumann S, Patzina C, Wagner V, Bauersfeld L, Goujon C, Hengel H, Halenius A, Ruzsics Z, Schaller T, Kochs G.

J Virol. 2018 Aug 16;92(17). pii: e01056-18. doi: 10.1128/JVI.01056-18. Print 2018 Sep 1.

6.

Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.

Haas DA, Meiler A, Geiger K, Vogt C, Preuss E, Kochs G, Pichlmair A.

PLoS Pathog. 2018 Apr 30;14(4):e1006980. doi: 10.1371/journal.ppat.1006980. eCollection 2018 Apr.

7.

Recombinant IFN-γ from the bank vole Myodes glareolus: a novel tool for research on rodent reservoirs of zoonotic pathogens.

Torelli F, Zander S, Ellerbrok H, Kochs G, Ulrich RG, Klotz C, Seeber F.

Sci Rep. 2018 Feb 12;8(1):2797. doi: 10.1038/s41598-018-21143-0.

8.

Effects of allelic variations in the human myxovirus resistance protein A on its antiviral activity.

Graf L, Dick A, Sendker F, Barth E, Marz M, Daumke O, Kochs G.

J Biol Chem. 2018 Mar 2;293(9):3056-3072. doi: 10.1074/jbc.M117.812784. Epub 2018 Jan 12.

9.

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection.

Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E.

Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.

10.

Molecular identification of novel phlebovirus sequences in European ticks.

Prinz M, Fuchs J, Ehrmann S, Scherer-Lorenzen M, Kochs G, Panning M.

Ticks Tick Borne Dis. 2017 Aug;8(5):795-798. doi: 10.1016/j.ttbdis.2017.06.005. Epub 2017 Jun 15.

PMID:
28641955
11.

Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET.

Chen Y, Zhang L, Graf L, Yu B, Liu Y, Kochs G, Zhao Y, Gao S.

Nat Commun. 2017 May 26;8:15744. doi: 10.1038/ncomms15744.

12.

Evolution and Antiviral Specificities of Interferon-Induced Mx Proteins of Bats against Ebola, Influenza, and Other RNA Viruses.

Fuchs J, Hölzer M, Schilling M, Patzina C, Schoen A, Hoenen T, Zimmer G, Marz M, Weber F, Müller MA, Kochs G.

J Virol. 2017 Jul 12;91(15). pii: e00361-17. doi: 10.1128/JVI.00361-17. Print 2017 Aug 1.

13.

In vivo evasion of MxA by avian influenza viruses requires human signature in the viral nucleoprotein.

Deeg CM, Hassan E, Mutz P, Rheinemann L, Götz V, Magar L, Schilling M, Kallfass C, Nürnberger C, Soubies S, Kochs G, Haller O, Schwemmle M, Staeheli P.

J Exp Med. 2017 May 1;214(5):1239-1248. doi: 10.1084/jem.20161033. Epub 2017 Apr 10.

14.

In Vivo Conditions Enable IFNAR-Independent Type I Interferon Production by Peritoneal CD11b+ Cells upon Thogoto Virus Infection.

Kochs G, Anzaghe M, Kronhart S, Wagner V, Gogesch P, Scheu S, Lienenklaus S, Waibler Z.

J Virol. 2016 Sep 29;90(20):9330-7. doi: 10.1128/JVI.00744-16. Print 2016 Oct 15.

15.

Interferon but not MxB inhibits foamy retroviruses.

Bähr A, Singer A, Hain A, Vasudevan AA, Schilling M, Reh J, Riess M, Panitz S, Serrano V, Schweizer M, König R, Chanda S, Häussinger D, Kochs G, Lindemann D, Münk C.

Virology. 2016 Jan 15;488:51-60. doi: 10.1016/j.virol.2015.10.034. Epub 2015 Nov 21.

16.

Role of nucleotide binding and GTPase domain dimerization in dynamin-like myxovirus resistance protein A for GTPase activation and antiviral activity.

Dick A, Graf L, Olal D, von der Malsburg A, Gao S, Kochs G, Daumke O.

J Biol Chem. 2015 May 15;290(20):12779-92. doi: 10.1074/jbc.M115.650325. Epub 2015 Mar 31.

17.

Influenza virus adaptation PB2-627K modulates nucleocapsid inhibition by the pathogen sensor RIG-I.

Weber M, Sediri H, Felgenhauer U, Binzen I, Bänfer S, Jacob R, Brunotte L, García-Sastre A, Schmid-Burgk JL, Schmidt T, Hornung V, Kochs G, Schwemmle M, Klenk HD, Weber F.

Cell Host Microbe. 2015 Mar 11;17(3):309-319. doi: 10.1016/j.chom.2015.01.005. Epub 2015 Feb 19.

18.

The avian-origin PB1 gene segment facilitated replication and transmissibility of the H3N2/1968 pandemic influenza virus.

Wendel I, Rubbenstroth D, Doedt J, Kochs G, Wilhelm J, Staeheli P, Klenk HD, Matrosovich M.

J Virol. 2015 Apr;89(8):4170-9. doi: 10.1128/JVI.03194-14. Epub 2015 Jan 28.

19.

Mx GTPases: dynamin-like antiviral machines of innate immunity.

Haller O, Staeheli P, Schwemmle M, Kochs G.

Trends Microbiol. 2015 Mar;23(3):154-63. doi: 10.1016/j.tim.2014.12.003. Epub 2015 Jan 6. Review.

PMID:
25572883
20.

The nucleoprotein of newly emerged H7N9 influenza A virus harbors a unique motif conferring resistance to antiviral human MxA.

Riegger D, Hai R, Dornfeld D, Mänz B, Leyva-Grado V, Sánchez-Aparicio MT, Albrecht RA, Palese P, Haller O, Schwemmle M, García-Sastre A, Kochs G, Schmolke M.

J Virol. 2015 Feb;89(4):2241-52. doi: 10.1128/JVI.02406-14. Epub 2014 Dec 10.

21.

Comparative structural and functional analysis of orthomyxovirus polymerase cap-snatching domains.

Guilligay D, Kadlec J, Crépin T, Lunardi T, Bouvier D, Kochs G, Ruigrok RW, Cusack S.

PLoS One. 2014 Jan 15;9(1):e84973. doi: 10.1371/journal.pone.0084973. eCollection 2014.

22.

Structural requirements for the antiviral activity of the human MxA protein against Thogoto and influenza A virus.

Patzina C, Haller O, Kochs G.

J Biol Chem. 2014 Feb 28;289(9):6020-7. doi: 10.1074/jbc.M113.543892. Epub 2014 Jan 21.

23.

Decrease of virus receptors during highly pathogenic H5N1 virus infection in humans and other mammals.

van Riel D, Leijten LM, Kochs G, Osterhaus ADME, Kuiken T.

Am J Pathol. 2013 Nov;183(5):1382-1389. doi: 10.1016/j.ajpath.2013.07.004. Epub 2013 Aug 27.

PMID:
23993779
24.

Emergence of a C-terminal seven-amino-acid elongation of NS1 in around 1950 conferred a minor growth advantage to former seasonal influenza A viruses.

Lohrmann F, Dijkman R, Stertz S, Thiel V, Haller O, Staeheli P, Kochs G.

J Virol. 2013 Oct;87(20):11300-3. doi: 10.1128/JVI.01271-13. Epub 2013 Aug 7.

25.

Systems to establish bunyavirus genome replication in the absence of transcription.

Klemm C, Reguera J, Cusack S, Zielecki F, Kochs G, Weber F.

J Virol. 2013 Jul;87(14):8205-12. doi: 10.1128/JVI.00371-13. Epub 2013 May 22.

26.

Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.

Mänz B, Dornfeld D, Götz V, Zell R, Zimmermann P, Haller O, Kochs G, Schwemmle M.

PLoS Pathog. 2013 Mar;9(3):e1003279. doi: 10.1371/journal.ppat.1003279. Epub 2013 Mar 28.

27.

Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling.

Weber M, Gawanbacht A, Habjan M, Rang A, Borner C, Schmidt AM, Veitinger S, Jacob R, Devignot S, Kochs G, García-Sastre A, Weber F.

Cell Host Microbe. 2013 Mar 13;13(3):336-46. doi: 10.1016/j.chom.2013.01.012.

28.

Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.

Mitchell PS, Patzina C, Emerman M, Haller O, Malik HS, Kochs G.

Cell Host Microbe. 2012 Oct 18;12(4):598-604. doi: 10.1016/j.chom.2012.09.005.

29.

Viral immune modulators perturb the human molecular network by common and unique strategies.

Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller AC, Fauster A, Holze C, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G.

Nature. 2012 Jul 26;487(7408):486-90. doi: 10.1038/nature11289.

PMID:
22810585
30.

Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus.

Koerner I, Matrosovich MN, Haller O, Staeheli P, Kochs G.

J Gen Virol. 2012 May;93(Pt 5):970-9. doi: 10.1099/vir.0.035782-0. Epub 2012 Jan 18.

PMID:
22258863
31.

Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function.

Gao S, von der Malsburg A, Dick A, Faelber K, Schröder GF, Haller O, Kochs G, Daumke O.

Immunity. 2011 Oct 28;35(4):514-25. doi: 10.1016/j.immuni.2011.07.012. Epub 2011 Sep 29.

32.

Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop.

von der Malsburg A, Abutbul-Ionita I, Haller O, Kochs G, Danino D.

J Biol Chem. 2011 Oct 28;286(43):37858-65. doi: 10.1074/jbc.M111.249037. Epub 2011 Sep 7.

33.

Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module.

Daumke O, Gao S, von der Malsburg A, Haller O, Kochs G.

Small GTPases. 2010 Jul;1(1):62-64.

34.

The viral nucleoprotein determines Mx sensitivity of influenza A viruses.

Zimmermann P, Mänz B, Haller O, Schwemmle M, Kochs G.

J Virol. 2011 Aug;85(16):8133-40. doi: 10.1128/JVI.00712-11. Epub 2011 Jun 15.

35.

Efficient influenza B virus propagation due to deficient interferon-induced antiviral activity in MDCK cells.

Frensing T, Seitz C, Heynisch B, Patzina C, Kochs G, Reichl U.

Vaccine. 2011 Sep 22;29(41):7125-9. doi: 10.1016/j.vaccine.2011.05.069. Epub 2011 Jun 7.

PMID:
21651940
36.

Highly pathogenic avian influenza viruses do not inhibit interferon synthesis in infected chickens but can override the interferon-induced antiviral state.

Penski N, Härtle S, Rubbenstroth D, Krohmann C, Ruggli N, Schusser B, Pfann M, Reuter A, Gohrbandt S, Hundt J, Veits J, Breithaupt A, Kochs G, Stech J, Summerfield A, Vahlenkamp T, Kaspers B, Staeheli P.

J Virol. 2011 Aug;85(15):7730-41. doi: 10.1128/JVI.00063-11. Epub 2011 May 25.

37.

Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity.

Haller O, Kochs G.

J Interferon Cytokine Res. 2011 Jan;31(1):79-87. doi: 10.1089/jir.2010.0076. Epub 2010 Dec 19. Review.

PMID:
21166595
38.

Singleplex real-time RT-PCR for detection of influenza A virus and simultaneous differentiation of A/H1N1v and evaluation of the RealStar influenza kit.

Panning M, Baumgarte S, Laue T, Bierbaum S, Raith S, Drexler JF, Helmer A, Falcone-Kapper V, Kochs G, Campe H, Huzly D, Eis-Hübinger AM, Drosten C.

J Clin Virol. 2011 Feb;50(2):171-4. doi: 10.1016/j.jcv.2010.10.010. Epub 2010 Nov 13.

PMID:
21075679
39.

Transcription factor redundancy ensures induction of the antiviral state.

Schmid S, Mordstein M, Kochs G, García-Sastre A, Tenoever BR.

J Biol Chem. 2010 Dec 31;285(53):42013-22. doi: 10.1074/jbc.M110.165936. Epub 2010 Oct 13.

40.

Glycine 184 in nonstructural protein NS1 determines the virulence of influenza A virus strain PR8 without affecting the host interferon response.

Steidle S, Martínez-Sobrido L, Mordstein M, Lienenklaus S, García-Sastre A, Stäheli P, Kochs G.

J Virol. 2010 Dec;84(24):12761-70. doi: 10.1128/JVI.00701-10. Epub 2010 Oct 6.

41.

Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells.

Kochs G, Bauer S, Vogt C, Frenz T, Tschopp J, Kalinke U, Waibler Z.

J Virol. 2010 Dec;84(23):12344-50. doi: 10.1128/JVI.00931-10. Epub 2010 Sep 22.

42.

Oseltamivir-resistant variants of the 2009 pandemic H1N1 influenza A virus are not attenuated in the guinea pig and ferret transmission models.

Seibert CW, Kaminski M, Philipp J, Rubbenstroth D, Albrecht RA, Schwalm F, Stertz S, Medina RA, Kochs G, García-Sastre A, Staeheli P, Palese P.

J Virol. 2010 Nov;84(21):11219-26. doi: 10.1128/JVI.01424-10. Epub 2010 Aug 25.

43.

Temporal and spatial resolution of type I and III interferon responses in vivo.

Pulverer JE, Rand U, Lienenklaus S, Kugel D, Zietara N, Kochs G, Naumann R, Weiss S, Staeheli P, Hauser H, Köster M.

J Virol. 2010 Sep;84(17):8626-38. doi: 10.1128/JVI.00303-10. Epub 2010 Jun 23.

44.

Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity.

Haller O, Gao S, von der Malsburg A, Daumke O, Kochs G.

J Biol Chem. 2010 Sep 10;285(37):28419-24. doi: 10.1074/jbc.R110.145839. Epub 2010 Jun 10. Review.

45.

Structural basis of oligomerization in the stalk region of dynamin-like MxA.

Gao S, von der Malsburg A, Paeschke S, Behlke J, Haller O, Kochs G, Daumke O.

Nature. 2010 May 27;465(7297):502-6. doi: 10.1038/nature08972. Epub 2010 Apr 28.

PMID:
20428112
46.

High yields of influenza A virus in Madin-Darby canine kidney cells are promoted by an insufficient interferon-induced antiviral state.

Seitz C, Frensing T, Höper D, Kochs G, Reichl U.

J Gen Virol. 2010 Jul;91(Pt 7):1754-63. doi: 10.1099/vir.0.020370-0. Epub 2010 Mar 31.

PMID:
20357039
47.

Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections.

Mordstein M, Neugebauer E, Ditt V, Jessen B, Rieger T, Falcone V, Sorgeloos F, Ehl S, Mayer D, Kochs G, Schwemmle M, Günther S, Drosten C, Michiels T, Staeheli P.

J Virol. 2010 Jun;84(11):5670-7. doi: 10.1128/JVI.00272-10. Epub 2010 Mar 24.

48.

Thogoto virus ML protein is a potent inhibitor of the interferon regulatory factor-7 transcription factor.

Buettner N, Vogt C, Martínez-Sobrido L, Weber F, Waibler Z, Kochs G.

J Gen Virol. 2010 Jan;91(Pt 1):220-7. doi: 10.1099/vir.0.015172-0. Epub 2009 Oct 7.

PMID:
19812269
49.

Strong interferon-inducing capacity of a highly virulent variant of influenza A virus strain PR8 with deletions in the NS1 gene.

Kochs G, Martínez-Sobrido L, Lienenklaus S, Weiss S, García-Sastre A, Staeheli P.

J Gen Virol. 2009 Dec;90(Pt 12):2990-4. doi: 10.1099/vir.0.015727-0. Epub 2009 Sep 2.

50.

Attenuated strains of influenza A viruses do not induce degradation of RNA polymerase II.

Rodriguez A, Pérez-González A, Hossain MJ, Chen LM, Rolling T, Pérez-Breña P, Donis R, Kochs G, Nieto A.

J Virol. 2009 Nov;83(21):11166-74. doi: 10.1128/JVI.01439-09. Epub 2009 Aug 19.

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