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Items: 1 to 50 of 82

1.

The Hemimelic extra toes mouse mutant: Historical perspective on unraveling mechanisms of dysmorphogenesis.

Knudsen TB, Kochhar DM.

Birth Defects Res C Embryo Today. 2010 Jun;90(2):155-62. doi: 10.1002/bdrc.20181. Review.

PMID:
20544697
2.

Cellular anomalies underlying retinoid-induced phocomelia.

Zhou J, Kochhar DM.

Reprod Toxicol. 2004 Nov;19(1):103-10.

PMID:
15336718
3.

Retinoid-induced limb malformations.

Lee GS, Kochhar DM, Collins MD.

Curr Pharm Des. 2004;10(22):2657-99. Review.

PMID:
15320736
4.

Regulation of AP-2 and apoptosis in developing eye in a vitamin A-deficiency model.

Zhou J, Kochhar DM.

Birth Defects Res A Clin Mol Teratol. 2003 Jan;67(1):41-53.

PMID:
12749383
5.

PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.

Qin P, Cimildoro R, Kochhar DM, Soprano KJ, Soprano DR.

Teratology. 2002 Nov;66(5):224-34.

PMID:
12397630
6.

The synthetic retinoid AGN 193109 but not retinoic acid elevates CYP1A1 levels in mouse embryos and Hepa-1c1c7 cells.

Soprano DR, Gambone CJ, Sheikh SN, Gabriel JL, Chandraratna RA, Soprano KJ, Kochhar DM.

Toxicol Appl Pharmacol. 2001 Jul 15;174(2):153-9.

PMID:
11446831
7.

Teratogenicity of retinoic acid.

Kochhar DM.

Teratology. 2000 Oct;62(4):178-80. No abstract available.

PMID:
10992258
8.

The use of a retinoid receptor antagonist in a new model to study vitamin A-dependent developmental events.

Kochhar DM, Jiang H, Penner JD, Johnson AT, Chandraratna RA.

Int J Dev Biol. 1998 May;42(4):601-8.

9.

Tretinoin: a review of the nonclinical developmental toxicology experience.

Kochhar DM, Christian MS.

J Am Acad Dermatol. 1997 Mar;36(3 Pt 2):S47-59. Review.

PMID:
9091508
10.

Synthesis and structure-activity relationships of retinoid X receptor selective diaryl sulfide analogs of retinoic acid.

Beard RL, Colon DF, Song TK, Davies PJ, Kochhar DM, Chandraratna RA.

J Med Chem. 1996 Aug 30;39(18):3556-63.

PMID:
8784454
11.

Murine toxicology and pharmacology of UAB-8, a conformationally constrained analog of retinoic acid.

Lin TH, Rogers TS, Hill DL, Simpson-Herren L, Farnell DR, Kochhar DM, Alam M, Brouillette WJ, Muccio DD.

Toxicol Appl Pharmacol. 1996 Aug;139(2):310-6.

PMID:
8806847
12.

Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid.

Kochhar DM, Jiang H, Penner JD, Beard RL, ChandraratnaAS.

Chem Biol Interact. 1996 Mar 8;100(1):1-12.

PMID:
8599851
13.

Diminished teratogenicity of retinoid X receptor-selective synthetic retinoids.

Jiang H, Penner JD, Beard RL, Chandraratna RA, Kochhar DM.

Biochem Pharmacol. 1995 Aug 25;50(5):669-76.

PMID:
7669070
14.

Modulation of limb bud chondrogenesis by retinoic acid and retinoic acid receptors.

Jiang H, Soprano DR, Li SW, Soprano KJ, Penner JD, Gyda M 3rd, Kochhar DM.

Int J Dev Biol. 1995 Aug;39(4):617-27.

15.

Placental transfer and developmental effects of 9-cis retinoic acid in mice.

Kochhar DM, Jiang H, Penner JD, Heyman RA.

Teratology. 1995 Apr;51(4):257-65.

PMID:
7570368
16.

Teratogenesis by retinoic acid analogs positively correlates with elevation of retinoic acid receptor-beta 2 mRNA levels in treated embryos.

Jiang H, Gyda M 3rd, Harnish DC, Chandraratna RA, Soprano KJ, Kochhar DM, Soprano DR.

Teratology. 1994 Jul;50(1):38-43.

PMID:
7974253
17.

A sustained elevation in retinoic acid receptor-beta 2 mRNA and protein occurs during retinoic acid-induced fetal dysmorphogenesis.

Soprano DR, Gyda M 3rd, Jiang H, Harnish DC, Ugen K, Satre M, Chen L, Soprano KJ, Kochhar DM.

Mech Dev. 1994 Mar;45(3):243-53.

PMID:
8011556
18.

Induction of RAR-beta 2 gene expression in embryos and RAR-beta 2 transactivation by the synthetic retinoid Ro 13-6307 correlates with its high teratogenic potency.

Soprano DR, Tairis N, Gyda M 3rd, Harnish DC, Jiang H, Soprano KJ, Kochhar DM.

Toxicol Appl Pharmacol. 1993 Sep;122(1):159-63.

PMID:
8397452
19.

Correlations of RAR isoforms and cellular retinoid-binding proteins mRNA levels with retinoid-induced teratogenesis.

Soprano DR, Harnish DC, Soprano KJ, Kochhar DM, Jiang H.

J Nutr. 1993 Feb;123(2 Suppl):367-71. doi: 10.1093/jn/123.suppl_2.367. Review.

PMID:
8381482
20.

Evidence that retinoic acid-induced apoptosis in the mouse limb bud core mesenchymal cells is gene-mediated.

Kochhar DM, Jiang H, Harnish DC, Soprano DR.

Prog Clin Biol Res. 1993;383B:815-25.

PMID:
7906884
21.

Induction of tissue transglutaminase and apoptosis by retinoic acid in the limb bud.

Jiang H, Kochhar DM.

Teratology. 1992 Oct;46(4):333-40.

PMID:
1357767
22.

Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid-gestation mouse embryos.

Harnish DC, Jiang H, Soprano KJ, Kochhar DM, Soprano DR.

Dev Dyn. 1992 Jul;194(3):239-46.

23.
24.

Developmental changes in endogenous retinoids during pregnancy and embryogenesis in the mouse.

Satre MA, Ugen KE, Kochhar DM.

Biol Reprod. 1992 May;46(5):802-10.

PMID:
1591336
25.

Retinamides: hydrolytic conversion of retinoylglycine to retinoic acid in pregnant mice contributes to teratogenicity.

Kochhar DM, Shealy YF, Penner JD, Jiang H.

Teratology. 1992 Feb;45(2):175-85.

PMID:
1615427
26.

Isotretinoin (13-cis-retinoic acid) metabolism, cis-trans isomerization, glucuronidation, and transfer to the mouse embryo: consequences for teratogenicity.

Creech Kraft J, Eckhoff C, Kochhar DM, Bochert G, Chahoud I, Nau H.

Teratog Carcinog Mutagen. 1991;11(1):21-30.

PMID:
1677495
27.

Effects of exposure to high concentrations of ribavirin in developing embryos.

Kochhar DM.

Pediatr Infect Dis J. 1990 Sep;9(9 Suppl):S88-90. No abstract available.

PMID:
1700362
28.

Computer-automated structure evaluation (CASE) of retinoids in teratogenesis bioassays.

Frierson MR, Mielach FA, Kochhar DM.

Fundam Appl Toxicol. 1990 Feb;14(2):408-28.

PMID:
2318362
29.

Quantification of embryonic retinoic acid derived from maternally administered retinol.

Kochhar DM.

Methods Enzymol. 1990;190:317-25. No abstract available.

PMID:
2087183
30.

Biotransformation of etretinate and developmental toxicity of etretin and other aromatic retinoids in teratogenesis bioassays.

Kochhar DM, Penner JD, Minutella LM.

Drug Metab Dispos. 1989 Nov-Dec;17(6):618-24.

PMID:
2575497
32.
33.
34.

Derivation of retinoic acid and metabolites from a teratogenic dose of retinol (vitamin A) in mice.

Kochhar DM, Penner JD, Satre MA.

Toxicol Appl Pharmacol. 1988 Dec;96(3):429-41.

PMID:
3206525
35.

Transplacental pharmacokinetics of teratogenic doses of etretinate and other aromatic retinoids in mice.

Reiners J, Löfberg B, Kraft JC, Kochhar DM, Nau H.

Reprod Toxicol. 1988;2(1):19-29.

PMID:
2980988
36.
37.
38.
40.
41.

Skeletal morphogenesis: comparative effects of a mutant gene and a teratogen.

Kochhar DM.

Prog Clin Biol Res. 1985;171:267-81. Review.

PMID:
3157194
43.

Comparative teratogenic activities of two retinoids: effects on palate and limb development.

Kochhar DM, Penner JD, Tellone CI.

Teratog Carcinog Mutagen. 1984;4(4):377-87.

PMID:
6149630
44.

A selection of candidate compounds for in vitro teratogenesis test validation.

Smith MK, Kimmel GL, Kochhar DM, Shepard TH, Spielberg SP, Wilson JG.

Teratog Carcinog Mutagen. 1983;3(6):461-80.

PMID:
6140767
45.

Differentiation of cartilage and bone in a mutant mouse deficient in cartilage-specific proteoglycans.

Kochhar DM, Penner JD.

Prog Clin Biol Res. 1982;110 Pt B:203-13. No abstract available.

PMID:
7167573
46.

Embryonic limb bud organ culture in assessment of teratogenicity of environmental agents.

Kochhar DM.

Teratog Carcinog Mutagen. 1982;2(3-4):303-12.

PMID:
6130629
47.

Overview of In Vitro Teratogenicity Testing: aspects of validation and application to screening.

Kimmel GL, Smith K, Kochhar DM, Pratt RM.

Teratog Carcinog Mutagen. 1982;2(3-4):221-9. No abstract available.

PMID:
6130622
50.

Vitamin A alters the internal viscosity of fragments of limb-bud mesenchyme.

Kwasigroch TE, Kochhar DM.

J Embryol Exp Morphol. 1980 Oct;59:325-39.

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