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Cardiolipin-dependent mitophagy guides outcome after traumatic brain injury.

Chao H, Lin C, Zuo Q, Liu Y, Xiao M, Xu X, Li Z, Bao Z, Chen H, You Y, Kochanek PM, Yin H, Liu N, Kagan VE, Bayır H, Ji J.

J Neurosci. 2019 Jan 9. pii: 3415-17. doi: 10.1523/JNEUROSCI.3415-17.2018. [Epub ahead of print]


Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury.

Kenny EM, Fidan E, Yang Q, Anthonymuthu TS, New LA, Meyer EA, Wang H, Kochanek PM, Dixon CE, Kagan VE, Bayır H.

Crit Care Med. 2018 Dec 6. doi: 10.1097/CCM.0000000000003555. [Epub ahead of print]


Paths to successful translation of new therapies for severe TBI in the golden age of traumatic brain injury research: A Pittsburgh vision.

Kochanek PM, Jackson TC, Jha R, Clark RSB, Okonkwo DO, Bayir H, Poloyac SM, Wagner AK M.D, Empey PE, Conley YP, Bell MJ, Kline AE, Bondi CO, Simon DW, Carlson SW, Puccio AM, Horvat CM, Au A, Elmer J, Treble-Barna A, Ikonomovic M, Shutter L, Taylor DL, Stern AM, Graham SH, Kagan VE, Jackson EK, Wisniewski SR, Dixon CE.

J Neurotrauma. 2018 Dec 6. doi: 10.1089/neu.2018.6203. [Epub ahead of print]


Downstream TRPM4 Polymorphisms are associated with Intracranial Hypertension and Statistically Interact with ABCC8 Polymorphisms in a Prospective Cohort of Severe Traumatic Brain Injury.

Jha RM, Desai SM, Zusman BE, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Shutter L, Kochanek PM, Conley YP.

J Neurotrauma. 2018 Nov 28. doi: 10.1089/neu.2018.6124. [Epub ahead of print]


A Precision Medicine Approach to Cerebral Edema and Intracranial Hypertension after Severe Traumatic Brain Injury: Quo Vadis?

Jha RM, Kochanek PM.

Curr Neurol Neurosci Rep. 2018 Nov 7;18(12):105. doi: 10.1007/s11910-018-0912-9. Review.


Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain.

Jackson TC, Kotermanski SE, Kochanek PM.

Dev Neurosci. 2018;40(4):325-336. doi: 10.1159/000493637. Epub 2018 Nov 6.


Oxidative Stress Induces Release of 2'-AMP from Microglia.

Jackson TC, Kotermanski SE, Kochanek PM, Jackson EK.

Brain Res. 2018 Nov 2. pii: S0006-8993(18)30554-7. doi: 10.1016/j.brainres.2018.11.002. [Epub ahead of print]


The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.

Wallisch JS, Janesko-Feldman K, Alexander H, Jha RM, Farr GW, McGuirk PR, Kline AE, Jackson TC, Pelletier MF, Clark RSB, Kochanek PM, Manole MD.

Pediatr Res. 2018 Oct 26. doi: 10.1038/s41390-018-0215-5. [Epub ahead of print]


Quantitative and qualitative assessment of glymphatic flux using Evans blue albumin.

Wolf MS, Chen Y, Simon DW, Alexander H, Ross M, Gibson GA, Manole MD, Bayır H, Kochanek PM, Clark RSB.

J Neurosci Methods. 2019 Jan 1;311:436-441. doi: 10.1016/j.jneumeth.2018.09.031. Epub 2018 Oct 5.


Pediatric Critical Care Medicine: Serving Our Missions While Maintaining Excellence.

Kochanek PM, Kissoon N, Kudchadkar SR.

Pediatr Crit Care Med. 2018 Oct;19(10):915-916. doi: 10.1097/PCC.0000000000001711. No abstract available.


Duration of therapeutic hypothermia or targeted temperature management in pediatric cardiac arrest: Seeing through the ice.

Kochanek PM, Jackson TC, Fink EL.

Resuscitation. 2018 Dec;133:A3-A4. doi: 10.1016/j.resuscitation.2018.09.025. Epub 2018 Sep 29. No abstract available.


A Big Loss for Our Field, But an Inspiration for Passion at the Bedside.

Kochanek PM.

Pediatr Crit Care Med. 2018 Sep;19(9):799. doi: 10.1097/PCC.0000000000001663. No abstract available.


Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond.

Kochanek PM, Dixon CE, Mondello S, Wang KKK, Lafrenaye A, Bramlett HM, Dietrich WD, Hayes RL, Shear DA, Gilsdorf JS, Catania M, Poloyac SM, Empey PE, Jackson TC, Povlishock JT.

Front Neurol. 2018 Aug 7;9:640. doi: 10.3389/fneur.2018.00640. eCollection 2018. Review.


Intracranial Pressure Trajectories: A Novel Approach to Informing Severe Traumatic Brain Injury Phenotypes.

Jha RM, Elmer J, Zusman BE, Desai S, Puccio AM, Okonkwo DO, Park SY, Shutter LA, Wallisch JS, Conley YP, Kochanek PM.

Crit Care Med. 2018 Nov;46(11):1792-1802. doi: 10.1097/CCM.0000000000003361.


Pathophysiology and treatment of cerebral edema in traumatic brain injury.

Jha RM, Kochanek PM, Simard JM.

Neuropharmacology. 2019 Feb;145(Pt B):230-246. doi: 10.1016/j.neuropharm.2018.08.004. Epub 2018 Aug 4. Review.


Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury.

Aneja RK, Alcamo AM, Cummings J, Vagni V, Feldman K, Wang Q, Dixon CE, Billiar TR, Kochanek PM.

J Neurotrauma. 2019 Jan 15;36(2):360-369. doi: 10.1089/neu.2018.5664. Epub 2018 Sep 5.


Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study.

Yang Z, Zhu T, Mondello S, Akel M, Wong AT, Kothari IM, Lin F, Shear DA, Gilsdorf JS, Leung LY, Bramlett HM, Dixon CE, Dietrich WD, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Wang KKW.

J Neurotrauma. 2019 Jan 15;36(2):348-359. doi: 10.1089/neu.2017.5586. Epub 2018 Aug 30.


Systemic Estrone Production and Injury-Induced Sex Hormone Steroidogenesis after Severe Traumatic Brain Injury: A Prognostic Indicator of Traumatic Brain Injury-Related Mortality.

Rakholia MV, Kumar RG, Oh BM, Ranganathan PR, Berga SL, Kochanek PM, Wagner AK.

J Neurotrauma. 2018 Aug 24. doi: 10.1089/neu.2018.5782. [Epub ahead of print]


Pre-Clinical Testing of Therapies for Traumatic Brain Injury.

DeWitt DS, Hawkins BE, Dixon CE, Kochanek PM, Armstead W, Bass CR, Bramlett HM, Buki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds SR, LaPlaca MC, Long JB, Meaney DF, Mondello S, Noble-Haeusslein LJ, Poloyac SM, Prough DS, Robertson CS, Saatman KE, Shultz SR, Shear DA, Smith DH, Valadka AB, VandeVord P, Zhang L.

J Neurotrauma. 2018 Dec 1;35(23):2737-2754. doi: 10.1089/neu.2018.5778. Epub 2018 Aug 30.


Exploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.

Hagos FT, Empey PE, Wang P, Ma X, Poloyac SM, Bayir H, Kochanek PM, Bell MJ, Clark RSB.

Crit Care Med. 2018 Sep;46(9):1471-1479. doi: 10.1097/CCM.0000000000003203.


Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats.

Fidan E, Foley LM, New LA, Alexander H, Kochanek PM, Hitchens TK, Bayır H.

ASN Neuro. 2018 Jan-Dec;10:1759091418770543. doi: 10.1177/1759091418770543.


Acute Physiology and Neurologic Outcomes after Brain Injury in SCOP/PHLPP1 KO Mice.

Jackson TC, Dixon CE, Janesko-Feldman K, Vagni V, Kotermanski SE, Jackson EK, Kochanek PM.

Sci Rep. 2018 May 8;8(1):7158. doi: 10.1038/s41598-018-25371-2.


The role of autophagy in acute brain injury: A state of flux?

Wolf MS, Bayır H, Kochanek PM, Clark RSB.

Neurobiol Dis. 2018 Apr 26. pii: S0969-9961(18)30133-5. doi: 10.1016/j.nbd.2018.04.018. [Epub ahead of print] Review.


Regionally clustered ABCC8 polymorphisms in a prospective cohort predict cerebral oedema and outcome in severe traumatic brain injury.

Jha RM, Koleck TA, Puccio AM, Okonkwo DO, Park SY, Zusman BE, Clark RSB, Shutter LA, Wallisch JS, Empey PE, Kochanek PM, Conley YP.

J Neurol Neurosurg Psychiatry. 2018 Nov;89(11):1152-1162. doi: 10.1136/jnnp-2017-317741. Epub 2018 Apr 19.


Traumatic Brain Injury and Infectious Encephalopathy in Children From Four Resource-Limited Settings in Africa.

Fink EL, von Saint Andre-von Arnim A, Kumar R, Wilson PT, Bacha T, Aklilu AT, Teklemariam TL, Hooli S, Tuyisenge L, Otupiri E, Fabio A, Gianakas J, Kochanek PM, Angus DC, Tasker RC; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, PALISI Global Health Subgroup, and Prevalence of Acute Critical Neurological Disease in Children: A Global Epidemiological Assessment (PANGEA) Investigators.

Pediatr Crit Care Med. 2018 Jul;19(7):649-657. doi: 10.1097/PCC.0000000000001554.


Glibenclamide Produces Region-Dependent Effects on Cerebral Edema in a Combined Injury Model of Traumatic Brain Injury and Hemorrhagic Shock in Mice.

Jha RM, Molyneaux BJ, Jackson TC, Wallisch JS, Park SY, Poloyac S, Vagni VA, Janesko-Feldman KL, Hoshitsuki K, Minnigh MB, Kochanek PM.

J Neurotrauma. 2018 Sep 1;35(17):2125-2135. doi: 10.1089/neu.2016.4696. Epub 2018 Jun 6.


Operation Brain Trauma Therapy: 2016 Update.

Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA.

Mil Med. 2018 Mar 1;183(suppl_1):303-312. doi: 10.1093/milmed/usx184.


Presenting predictors and temporal trends of treatment-related outcomes in diabetic ketoacidosis.

Horvat CM, Ismail HM, Au AK, Garibaldi L, Siripong N, Kantawala S, Aneja RK, Hupp DS, Kochanek PM, Clark RS.

Pediatr Diabetes. 2018 Aug;19(5):985-992. doi: 10.1111/pedi.12663. Epub 2018 Apr 26.


Phenotyping Cardiac Arrest: Bench and Bedside Characterization of Brain and Heart Injury Based on Etiology.

Uray T, Lamade A, Elmer J, Drabek T, Stezoski JP, Missé A, Janesko-Feldman K, Garman RH, Chen N, Kochanek PM, Dezfulian C, Callaway CW, Doshi AA, Frisch A, Guyette FX, Reynolds JC, Rittenberger JC; University of Pittsburgh Post-Cardiac Arrest Service.

Crit Care Med. 2018 Jun;46(6):e508-e515. doi: 10.1097/CCM.0000000000003070.


24 vs. 72 hours of hypothermia for pediatric cardiac arrest: A pilot, randomized controlled trial.

Fink EL, Clark RSB, Berger RP, Fabio A, Angus DC, Watson RS, Gianakas JJ, Panigrahy A, Callaway CW, Bell MJ, Kochanek PM.

Resuscitation. 2018 May;126:14-20. doi: 10.1016/j.resuscitation.2018.02.008. Epub 2018 Feb 14.


A Special 50-Year Perspective on Our Field.

Kochanek PM.

Pediatr Crit Care Med. 2018 May;19(5):389. doi: 10.1097/PCC.0000000000001494. No abstract available.


Initiating Nutritional Support Before 72 Hours Is Associated With Favorable Outcome After Severe Traumatic Brain Injury in Children: A Secondary Analysis of a Randomized, Controlled Trial of Therapeutic Hypothermia.

Meinert E, Bell MJ, Buttram S, Kochanek PM, Balasubramani GK, Wisniewski SR, Adelson PD; Pediatric Traumatic Brain Injury Consortium: Hypothermia Investigators.

Pediatr Crit Care Med. 2018 Apr;19(4):345-352. doi: 10.1097/PCC.0000000000001471.


BrainPhys® increases neurofilament levels in CNS cultures, and facilitates investigation of axonal damage after a mechanical stretch-injury in vitro.

Jackson TC, Kotermanski SE, Jackson EK, Kochanek PM.

Exp Neurol. 2018 Feb;300:232-246. doi: 10.1016/j.expneurol.2017.11.013. Epub 2017 Dec 1.


Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiac arrest.

Li L, Poloyac SM, Watkins SC, St Croix CM, Alexander H, Gibson GA, Loughran PA, Kirisci L, Clark RS, Kochanek PM, Vazquez AL, Manole MD.

J Cereb Blood Flow Metab. 2017 Dec 1:271678X17744717. doi: 10.1177/0271678X17744717. [Epub ahead of print]


Pre-clinical models in pediatric traumatic brain injury-challenges and lessons learned.

Kochanek PM, Wallisch JS, Bayır H, Clark RSB.

Childs Nerv Syst. 2017 Oct;33(10):1693-1701. doi: 10.1007/s00381-017-3474-2. Epub 2017 Sep 6. Review.


Breaking Into the Top Ten.

Kochanek PM, Kissoon N.

Pediatr Crit Care Med. 2017 Oct;18(10):913-914. doi: 10.1097/PCC.0000000000001297. No abstract available.


The pharmacogenomics of severe traumatic brain injury.

Adams SM, Conley YP, Wagner AK, Jha RM, Clark RS, Poloyac SM, Kochanek PM, Empey PE.

Pharmacogenomics. 2017 Oct;18(15):1413-1425. doi: 10.2217/pgs-2017-0073. Epub 2017 Oct 4. Review.


Cell-Free Plasma Hemoglobin and Male Gender Are Risk Factors for Acute Kidney Injury in Low Risk Children Undergoing Cardiopulmonary Bypass.

Kim-Campbell N, Gretchen C, Callaway C, Felmet K, Kochanek PM, Maul T, Wearden P, Sharma M, Viegas M, Munoz R, Gladwin MT, Bayir H.

Crit Care Med. 2017 Nov;45(11):e1123-e1130. doi: 10.1097/CCM.0000000000002703.


Big Data Not Yet Big Enough to Determine the Influence of Intracranial Pressure Monitoring on Outcome in Children With Severe Traumatic Brain Injury.

Horvat CM, Kochanek PM.

JAMA Pediatr. 2017 Oct 1;171(10):942-943. doi: 10.1001/jamapediatrics.2017.2390. No abstract available.


Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons.

Jackson TC, Kotermanski SE, Kochanek PM.

Neuroscience. 2017 Oct 11;361:93-107. doi: 10.1016/j.neuroscience.2017.08.014. Epub 2017 Aug 15.


Therapeutic Hypothermia and Targeted Temperature Management With or Without the "Cold Stress" Response.

Kochanek PM, Jackson TC.

Ther Hypothermia Temp Manag. 2017 Sep;7(3):134-136. doi: 10.1089/ther.2017.0030. Epub 2017 Aug 11. No abstract available.


The far-reaching scope of neuroinflammation after traumatic brain injury.

Simon DW, McGeachy MJ, Bayır H, Clark RSB, Loane DJ, Kochanek PM.

Nat Rev Neurol. 2017 Sep;13(9):572. doi: 10.1038/nrneurol.2017.116. Epub 2017 Aug 4.


Translational Stroke Research: Vision and Opportunities.

Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H, Lo EH, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI, Schwamm LH, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W.

Stroke. 2017 Sep;48(9):2632-2637. doi: 10.1161/STROKEAHA.117.017112. Epub 2017 Jul 27. Review. No abstract available.


ABCG2 c.421C>A Is Associated with Outcomes after Severe Traumatic Brain Injury.

Adams SM, Conley YP, Ren D, Okonkwo DO, Puccio AM, Dixon CE, Clark RSB, Kochanek PM, Empey PE.

J Neurotrauma. 2018 Jan 1;35(1):48-53. doi: 10.1089/neu.2017.5000. Epub 2017 Sep 19.


Adding insight to injury: a new era in neurotrauma.

Jha RM, Kochanek PM.

Lancet Neurol. 2017 Aug;16(8):578-580. doi: 10.1016/S1474-4422(17)30225-9. Epub 2017 Jul 11. No abstract available.


Minocycline Attenuates High Mobility Group Box 1 Translocation, Microglial Activation, and Thalamic Neurodegeneration after Traumatic Brain Injury in Post-Natal Day 17 Rats.

Simon DW, Aneja RK, Alexander H, Bell MJ, Bayır H, Kochanek PM, Clark RSB.

J Neurotrauma. 2018 Jan 1;35(1):130-138. doi: 10.1089/neu.2017.5093. Epub 2017 Aug 22.


Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children.

Clark RSB, Empey PE, Bayır H, Rosario BL, Poloyac SM, Kochanek PM, Nolin TD, Au AK, Horvat CM, Wisniewski SR, Bell MJ.

PLoS One. 2017 Jul 7;12(7):e0180280. doi: 10.1371/journal.pone.0180280. eCollection 2017.


Long-Term Deficits in Cortical Circuit Function after Asphyxial Cardiac Arrest and Resuscitation in Developing Rats.

Middleton JW, Simons DJ, Simmons JW, Clark RSB, Kochanek PM, Shoykhet M.

eNeuro. 2017 Jun 30;4(3). pii: ENEURO.0319-16.2017. doi: 10.1523/ENEURO.0319-16.2017. eCollection 2017 May-Jun.


Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients.

Au AK, Bell MJ, Fink EL, Aneja RK, Kochanek PM, Clark RSB.

Neurocrit Care. 2018 Feb;28(1):26-34. doi: 10.1007/s12028-017-0414-7.


Development of the emergency preservation and resuscitation for cardiac arrest from trauma clinical trial.

Tisherman SA, Alam HB, Rhee PM, Scalea TM, Drabek T, Forsythe RM, Kochanek PM.

J Trauma Acute Care Surg. 2017 Nov;83(5):803-809. doi: 10.1097/TA.0000000000001585.


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