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Correction to "Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine".

Waldschmidt HV, Homan KT, Cato MC, Cruz-Rodríguez O, Cannavo A, Wilson MW, Song J, Cheung JY, Koch WJ, Tesmer JJG, Larsen SD.

J Med Chem. 2019 Jun 12. doi: 10.1021/acs.jmedchem.9b00844. [Epub ahead of print] No abstract available.


G protein-coupled receptor kinases as therapeutic targets in the heart.

Pfleger J, Gresham K, Koch WJ.

Nat Rev Cardiol. 2019 Jun 11. doi: 10.1038/s41569-019-0220-3. [Epub ahead of print] Review.


Myocardial Strain and Cardiac Output are Preferable Measurements for Cardiac Dysfunction and Can Predict Mortality in Septic Mice.

Hoffman M, Kyriazis ID, Lucchese AM, de Lucia C, Piedepalumbo M, Bauer M, Schulze PC, Bonios MJ, Koch WJ, Drosatos K.

J Am Heart Assoc. 2019 May 21;8(10):e012260. doi: 10.1161/JAHA.119.012260.


Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.

LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y.

J Clin Invest. 2019 Apr 15;130:2107-2122. doi: 10.1172/JCI125014. eCollection 2019 Apr 15.


Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury.

Borden A, Kurian J, Nickoloff E, Yang Y, Troupes C, Ibetti J, Lucchese AM, Gao E, Mohsin S, Koch WJ, Houser SR, Kishore R, Khan M.

Circ Res. 2019 Apr 9. doi: 10.1161/CIRCRESAHA.118.314223. [Epub ahead of print]


Alteration of myocardial GRK2 produces a global metabolic phenotype.

Woodall BP, Gresham KS, Woodall MA, Valenti MC, Cannavo A, Pfleger J, Chuprun JK, Drosatos K, Koch WJ.

JCI Insight. 2019 Apr 4;5. pii: 123848. doi: 10.1172/jci.insight.123848.


Prior β-blocker treatment decreases leukocyte responsiveness to injury.

Grisanti LA, de Lucia C, Thomas TP, Stark A, Strony JT, Myers VD, Beretta R, Yu D, Sardu C, Marfella R, Gao E, Houser SR, Koch WJ, Hamad EA, Tilley DG.

JCI Insight. 2019 Mar 28;5. pii: 99485. doi: 10.1172/jci.insight.99485.


Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction.

Vainio LE, Szabó Z, Lin R, Ulvila J, Yrjölä R, Alakoski T, Piuhola J, Koch WJ, Ruskoaho H, Fouse SD, Seeley TW, Gao E, Signore P, Lipson KE, Magga J, Kerkelä R.

JACC Basic Transl Sci. 2019 Feb 25;4(1):83-94. doi: 10.1016/j.jacbts.2018.10.007. eCollection 2019 Feb.


Various effects of AAV9-mediated βARKct gene therapy on the heart in dystrophin-deficient (mdx) mice and δ-sarcoglycan-deficient (Sgcd-/-) mice.

Bauer R, Enns H, Jungmann A, Leuchs B, Volz C, Schinkel S, Koch WJ, Raake PW, Most P, Katus HA, Müller OJ.

Neuromuscul Disord. 2019 Mar;29(3):231-241. doi: 10.1016/j.nmd.2018.12.006. Epub 2018 Dec 20.


Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R.

Mol Ther. 2019 Mar 6;27(3):600-610. doi: 10.1016/j.ymthe.2019.01.013. Epub 2019 Jan 24.


Ethyl Pyruvate Modulates Murine Dendritic Cell Activation and Survival Through Their Immunometabolism.

Chakhtoura M, Chain RW, Sato PY, Qiu CC, Lee MH, Meissler JJ, Eisenstein TK, Koch WJ, Caricchio R, Gallucci S.

Front Immunol. 2019 Jan 28;10:30. doi: 10.3389/fimmu.2019.00030. eCollection 2019.


GRK2 and GRK5 as therapeutic targets and their role in maladaptive and pathological cardiac hypertrophy.

Lieu M, Koch WJ.

Expert Opin Ther Targets. 2019 Mar;23(3):201-214. doi: 10.1080/14728222.2019.1575363. Epub 2019 Feb 13.


Aldosterone and Myocardial Pathology.

Cannavo A, Elia A, Liccardo D, Rengo G, Koch WJ.

Vitam Horm. 2019;109:387-406. doi: 10.1016/bs.vh.2018.09.005. Epub 2018 Dec 1. Review.


Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.

de Lucia C, Piedepalumbo M, Paolisso G, Koch WJ.

Int J Biochem Cell Biol. 2019 Mar;108:29-33. doi: 10.1016/j.biocel.2019.01.004. Epub 2019 Jan 9.


Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.

Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K.

J Mol Cell Cardiol. 2019 Feb;127:232-245. doi: 10.1016/j.yjmcc.2018.12.016. Epub 2019 Jan 3.


Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J.

Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216.


Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation.

Sato PY, Chuprun JK, Grisanti LA, Woodall MC, Brown BR, Roy R, Traynham CJ, Ibetti J, Lucchese AM, Yuan A, Drosatos K, Tilley DG, Gao E, Koch WJ.

Sci Signal. 2018 Dec 11;11(560). pii: eaau0144. doi: 10.1126/scisignal.aau0144.


Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling.

Grisanti LA, Thomas TP, Carter RL, de Lucia C, Gao E, Koch WJ, Benovic JL, Tilley DG.

Theranostics. 2018 Sep 9;8(17):4664-4678. doi: 10.7150/thno.26619. eCollection 2018.


Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease.

Grisanti LA, Schumacher SM, Tilley DG, Koch WJ.

JACC Basic Transl Sci. 2018 Aug 28;3(4):550-562. doi: 10.1016/j.jacbts.2017.12.002. eCollection 2018 Aug. Review.


G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart.

Pfleger J, Gross P, Johnson J, Carter RL, Gao E, Tilley DG, Houser SR, Koch WJ.

J Mol Cell Cardiol. 2018 Oct;123:108-117. doi: 10.1016/j.yjmcc.2018.08.025. Epub 2018 Aug 29.


New Insights in Cardiac β-Adrenergic Signaling During Heart Failure and Aging.

de Lucia C, Eguchi A, Koch WJ.

Front Pharmacol. 2018 Aug 10;9:904. doi: 10.3389/fphar.2018.00904. eCollection 2018. Review.


Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging.

de Lucia C, Wallner M, Eaton DM, Zhao H, Houser SR, Koch WJ.

J Gerontol A Biol Sci Med Sci. 2019 Mar 14;74(4):455-461. doi: 10.1093/gerona/gly139.


Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration.

Cheng L, Al-Owais M, Covarrubias ML, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo NA.

J Biol Chem. 2018 Jul 13;293(28):11022-11032. doi: 10.1074/jbc.RA118.001989. Epub 2018 May 25.


S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence.

Hayashi H, Hess DT, Zhang R, Sugi K, Gao H, Tan BL, Bowles DE, Milano CA, Jain MK, Koch WJ, Stamler JS.

Mol Cell. 2018 May 3;70(3):473-487.e6. doi: 10.1016/j.molcel.2018.03.034.


PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro.

Yeh ST, Zambrano CM, Koch WJ, Purcell NH.

J Biol Chem. 2018 May 25;293(21):8056-8064. doi: 10.1074/jbc.M117.809913. Epub 2018 Apr 8.


β-arrestin2 Affects Cardiac Progenitor Cell Survival through Cell Mobility and Tube Formation in Severe Hypoxia.

Seo SK, Kim N, Lee JH, Kim SM, Lee SY, Bae JW, Hwang KK, Kim DW, Koch WJ, Cho MC.

Korean Circ J. 2018 Apr;48(4):296-309. doi: 10.4070/kcj.2017.0119.


Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure.

de Lucia C, Gambino G, Petraglia L, Elia A, Komici K, Femminella GD, D'Amico ML, Formisano R, Borghetti G, Liccardo D, Nolano M, Houser SR, Leosco D, Ferrara N, Koch WJ, Rengo G.

Circ Heart Fail. 2018 Mar;11(3):e004153. doi: 10.1161/CIRCHEARTFAILURE.117.004153.


Cardiac βarrestin2 Improves Contractility and Adverse Remodeling in Heart Failure, But Is Underexpressed in Humans.

McCrink KA, Maning J, Vu A, Jafferjee M, Marrero C, Brill A, Bathgate-Siryk A, Dabul S, Koch WJ, Lymperopoulos A.

J Am Coll Cardiol. 2017 Dec 12;70(23):2948-2949. doi: 10.1016/j.jacc.2017.10.008. No abstract available.


Structural Determinants Influencing the Potency and Selectivity of Indazole-Paroxetine Hybrid G Protein-Coupled Receptor Kinase 2 Inhibitors.

Bouley R, Waldschmidt HV, Cato MC, Cannavo A, Song J, Cheung JY, Yao XQ, Koch WJ, Larsen SD, Tesmer JJG.

Mol Pharmacol. 2017 Dec;92(6):707-717. doi: 10.1124/mol.117.110130. Epub 2017 Oct 25.


Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.

Cannavo A, Liccardo D, Komici K, Corbi G, de Lucia C, Femminella GD, Elia A, Bencivenga L, Ferrara N, Koch WJ, Paolocci N, Rengo G.

Front Pharmacol. 2017 Aug 23;8:556. doi: 10.3389/fphar.2017.00556. eCollection 2017. Review.


Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling.

Jean-Charles PY, Yu SM, Abraham D, Kommaddi RP, Mao L, Strachan RT, Zhang ZS, Bowles DE, Brian L, Stiber JA, Jones SN, Koch WJ, Rockman HA, Shenoy SK.

JCI Insight. 2017 Sep 7;2(17). pii: 95998. doi: 10.1172/jci.insight.95998. eCollection 2017 Sep 7.


β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes.

McCrink KA, Maning J, Vu A, Jafferjee M, Marrero C, Brill A, Bathgate-Siryk A, Dabul S, Koch WJ, Lymperopoulos A.

Hypertension. 2017 Nov;70(5):972-981. doi: 10.1161/HYPERTENSIONAHA.117.09817. Epub 2017 Sep 5.


G protein-coupled receptor kinase 2 promotes cardiac hypertrophy.

Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW.

PLoS One. 2017 Jul 31;12(7):e0182110. doi: 10.1371/journal.pone.0182110. eCollection 2017.


Impact of paroxetine on proximal β-adrenergic receptor signaling.

Guo S, Carter RL, Grisanti LA, Koch WJ, Tilley DG.

Cell Signal. 2017 Oct;38:127-133. doi: 10.1016/j.cellsig.2017.07.006. Epub 2017 Jul 12.


β1-Blockade Prevents Post-Ischemic Myocardial Decompensation Via β3AR-Dependent Protective Sphingosine-1 Phosphate Signaling.

Cannavo A, Rengo G, Liccardo D, Pun A, Gao E, George AJ, Gambino G, Rapacciuolo A, Leosco D, Ibanez B, Ferrara N, Paolocci N, Koch WJ.

J Am Coll Cardiol. 2017 Jul 11;70(2):182-192. doi: 10.1016/j.jacc.2017.05.020.


Interleukin-10 Inhibits Bone Marrow Fibroblast Progenitor Cell-Mediated Cardiac Fibrosis in Pressure-Overloaded Myocardium.

Verma SK, Garikipati VNS, Krishnamurthy P, Schumacher SM, Grisanti LA, Cimini M, Cheng Z, Khan M, Yue Y, Benedict C, Truongcao MM, Rabinowitz JE, Goukassian DA, Tilley D, Koch WJ, Kishore R.

Circulation. 2017 Sep 5;136(10):940-953. doi: 10.1161/CIRCULATIONAHA.117.027889. Epub 2017 Jun 30.


microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases.

de Lucia C, Komici K, Borghetti G, Femminella GD, Bencivenga L, Cannavo A, Corbi G, Ferrara N, Houser SR, Koch WJ, Rengo G.

Front Med (Lausanne). 2017 Jun 12;4:74. doi: 10.3389/fmed.2017.00074. eCollection 2017. Review.


Therapeutic inhibition of miR-375 attenuates post-myocardial infarction inflammatory response and left ventricular dysfunction via PDK-1-AKT signalling axis.

Garikipati VNS, Verma SK, Jolardarashi D, Cheng Z, Ibetti J, Cimini M, Tang Y, Khan M, Yue Y, Benedict C, Nickoloff E, Truongcao MM, Gao E, Krishnamurthy P, Goukassian DA, Koch WJ, Kishore R.

Cardiovasc Res. 2017 Jul 1;113(8):938-949. doi: 10.1093/cvr/cvx052.


Noncanonical Roles of G Protein-coupled Receptor Kinases in Cardiovascular Signaling.

Schumacher SM, Koch WJ.

J Cardiovasc Pharmacol. 2017 Sep;70(3):129-141. doi: 10.1097/FJC.0000000000000483. Review.


Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.

Waldschmidt HV, Homan KT, Cato MC, Cruz-Rodríguez O, Cannavo A, Wilson MW, Song J, Cheung JY, Koch WJ, Tesmer JJ, Larsen SD.

J Med Chem. 2017 Apr 13;60(7):3052-3069. doi: 10.1021/acs.jmedchem.7b00112. Epub 2017 Mar 29. Erratum in: J Med Chem. 2019 Jun 12;:.


GRK2 Regulates α2-Adrenergic Receptor-Dependent Catecholamine Release in Human Adrenal Chromaffin Cells.

Cannavo A, Liccardo D, Lymperopoulos A, Santangelo M, Femminella GD, Leosco D, Cittadini A, Ferrara N, Paolocci N, Koch WJ, Rengo G.

J Am Coll Cardiol. 2017 Mar 21;69(11):1515-1517. doi: 10.1016/j.jacc.2017.01.016. No abstract available.


Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade.

Cannavo A, Koch WJ.

J Cardiovasc Pharmacol. 2017 Feb;69(2):71-78. doi: 10.1097/FJC.0000000000000444. Review.


Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.

Eisner V, Cupo RR, Gao E, Csordás G, Slovinsky WS, Paillard M, Cheng L, Ibetti J, Chen SR, Chuprun JK, Hoek JB, Koch WJ, Hajnóczky G.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E859-E868. doi: 10.1073/pnas.1617288114. Epub 2017 Jan 17.


GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease.

Cannavo A, Koch WJ.

Cell Signal. 2018 Jan;41:33-40. doi: 10.1016/j.cellsig.2017.01.014. Epub 2017 Jan 7. Review.


β2-Adrenergic receptor-dependent chemokine receptor 2 expression regulates leukocyte recruitment to the heart following acute injury.

Grisanti LA, Traynham CJ, Repas AA, Gao E, Koch WJ, Tilley DG.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15126-15131. doi: 10.1073/pnas.1611023114. Epub 2016 Dec 12.


Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury.

Woodall MC, Woodall BP, Gao E, Yuan A, Koch WJ.

Circ Res. 2016 Oct 28;119(10):1116-1127. Epub 2016 Sep 6.


Vasopressin type 1A receptor deletion enhances cardiac contractility, β-adrenergic receptor sensitivity and acute cardiac injury-induced dysfunction.

Wasilewski MA, Grisanti LA, Song J, Carter RL, Repas AA, Myers VD, Gao E, Koch WJ, Cheung JY, Feldman AM, Tilley DG.

Clin Sci (Lond). 2016 Nov 1;130(22):2017-2027. doi: 10.1042/CS20160363. Epub 2016 Sep 2.


Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy.

Woodall BP, Woodall MC, Luongo TS, Grisanti LA, Tilley DG, Elrod JW, Koch WJ.

J Biol Chem. 2016 Oct 14;291(42):21913-21924. Epub 2016 Aug 26.


Leukocyte-Expressed β2-Adrenergic Receptors Are Essential for Survival After Acute Myocardial Injury.

Grisanti LA, Gumpert AM, Traynham CJ, Gorsky JE, Repas AA, Gao E, Carter RL, Yu D, Calvert JW, García AP, Ibáñez B, Rabinowitz JE, Koch WJ, Tilley DG.

Circulation. 2016 Jul 12;134(2):153-67. doi: 10.1161/CIRCULATIONAHA.116.022304. Epub 2016 Jun 30.


β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction.

Carr R 3rd, Schilling J, Song J, Carter RL, Du Y, Yoo SM, Traynham CJ, Koch WJ, Cheung JY, Tilley DG, Benovic JL.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4107-16. doi: 10.1073/pnas.1606267113. Epub 2016 Jun 27.

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