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Re: Differential impact of FLASH versus conventional dose rate irradiation: Spitz et al.

Koch CJ.

Radiother Oncol. 2019 Oct;139:62-63. doi: 10.1016/j.radonc.2019.07.004. Epub 2019 Aug 17. No abstract available.


Intratumoral Hypoxia Reduces IFN-γ-Mediated Immunity and MHC Class I Induction in a Preclinical Tumor Model.

Murthy A, Gerber SA, Koch CJ, Lord EM.

Immunohorizons. 2019 Apr 29;3(4):149-160. doi: 10.4049/immunohorizons.1900017.


Invited editorial for the paper by Silvoniemi et al. "Repeatability of tumor hypoxia imaging using [18F]EF5 PET/CT in head and neck cancer." in this issue of EJNMMI.

Koch CJ.

Eur J Nucl Med Mol Imaging. 2018 Feb;45(2):159-160. doi: 10.1007/s00259-017-3889-8. No abstract available.


Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel.

Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M.

Int J Mol Sci. 2016 Jun 16;17(6). pii: E953. doi: 10.3390/ijms17060953.


Letter to the Editor Re: Ogawa, Y. Cancers 2016, 8, 28.

Koch CJ.

Cancers (Basel). 2016 May 24;8(6). pii: E53. doi: 10.3390/cancers8060053.


Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients.

Evans SM, Putt M, Yang XY, Lustig RA, Martinez-Lage M, Williams D, Desai A, Wolf R, Brem S, Koch CJ.

J Neurooncol. 2016 Apr;127(2):391-400. doi: 10.1007/s11060-015-2051-3. Epub 2016 Jan 8.


Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA.

Lao Z, Kelly CJ, Yang XY, Jenkins WT, Toorens E, Ganguly T, Evans SM, Koch CJ.

PLoS One. 2015 Jul 24;10(7):e0133895. doi: 10.1371/journal.pone.0133895. eCollection 2015.


Pharmacokinetic and pharmacodynamic modifiers of EF5 uptake and binding.

Koch CJ, Evans SM.

J Nucl Med. 2015 Apr;56(4):653. doi: 10.2967/jnumed.114.151662. Epub 2015 Mar 5. No abstract available.


Optimizing hypoxia detection and treatment strategies.

Koch CJ, Evans SM.

Semin Nucl Med. 2015 Mar;45(2):163-76. doi: 10.1053/j.semnuclmed.2014.10.004. Review.


Microvesicles as a Biomarker for Tumor Progression versus Treatment Effect in Radiation/Temozolomide-Treated Glioblastoma Patients.

Koch CJ, Lustig RA, Yang XY, Jenkins WT, Wolf RL, Martinez-Lage M, Desai A, Williams D, Evans SM.

Transl Oncol. 2014 Dec;7(6):752-8. doi: 10.1016/j.tranon.2014.10.004.


Single-cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry.

Chang Q, Ornatsky OI, Koch CJ, Chaudary N, Marie-Egyptienne DT, Hill RP, Tanner SD, Hedley DW.

Int J Cancer. 2015 Mar 1;136(5):1202-9. doi: 10.1002/ijc.29074. Epub 2014 Jul 16.


Androgen withdrawal fails to induce detectable tissue hypoxia in the rat prostate.

Regter S, Hedayati M, Zhang Y, Zhou H, Dalrymple S, Koch CJ, Isaacs JT, DeWeese TL.

Prostate. 2014 Jun;74(8):805-10. doi: 10.1002/pros.22803. Epub 2014 Mar 27.


Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells.

Sood N, Jenkins WT, Yang XY, Shah NN, Katz JS, Koch CJ, Frail PR, Therien MJ, Hammer DA, Evans SM.

J Pharm (Cairo). 2013;2013. pii: 932797.


Mechanisms of blood flow and hypoxia production in rat 9L-epigastric tumors.

Koch CJ, Jenkins WT, Jenkins KW, Yang XY, Shuman AL, Pickup S, Riehl CR, Paudyal R, Poptani H, Evans SM.

Tumor Microenviron Ther. 2013 Jan;1:1-13.


Radiation dosimetry and biodistribution of the hypoxia tracer (18)F-EF5 in oncologic patients.

Lin LL, Silvoniemi A, Stubbs JB, Rengan R, Suilamo S, Solin O, Divgi C, Eskola O, Sorger JM, Stabin MG, Kachur A, Hahn SM, Grönroos TJ, Forsback S, Evans SM, Koch CJ, Minn H.

Cancer Biother Radiopharm. 2012 Sep;27(7):412-9. doi: 10.1089/cbr.2011.1130. Epub 2012 Aug 16.


Re: Devic et al. (Int J Radiat Oncol Biol Phys 2010;78:1555-1562).

Evans SM, Koch CJ.

Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):902; author reply 902-3. doi: 10.1016/j.ijrobp.2011.05.020. No abstract available.


In regard to Brown et al. (Int J Radiat Oncol Biol Phys 2010;78:323-327).

Koch CJ, Evans SM.

Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1604-5; author reply 1605. doi: 10.1016/j.ijrobp.2011.04.006. No abstract available.


Sequentially-induced responses define tumour cell radiosensitivity.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Dicello JF, Little JB.

Int J Radiat Biol. 2011 Jun;87(6):628-43. doi: 10.3109/09553002.2011.568573. Epub 2011 Apr 18.


Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Dicello JF, Slater JM, Little JB.

Radiat Oncol. 2010 Aug 12;5:71. doi: 10.1186/1748-717X-5-71.


Early detection of radiation therapy response in non-Hodgkin's lymphoma xenografts by in vivo 1H magnetic resonance spectroscopy and imaging.

Lee SC, Poptani H, Pickup S, Jenkins WT, Kim S, Koch CJ, Delikatny EJ, Glickson JD.

NMR Biomed. 2010 Jul;23(6):624-32. doi: 10.1002/nbm.1505.


Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma.

Koch CJ, Scheuermann JS, Divgi C, Judy KD, Kachur AV, Freifelder R, Reddin JS, Karp J, Stubbs JB, Hahn SM, Driesbaugh J, Smith D, Prendergast S, Evans SM.

Eur J Nucl Med Mol Imaging. 2010 Nov;37(11):2048-59. doi: 10.1007/s00259-010-1517-y. Epub 2010 Jun 29.


The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study.

Evans SM, Jenkins KW, Chen HI, Jenkins WT, Judy KD, Hwang WT, Lustig RA, Judkins AR, Grady MS, Hahn SM, Koch CJ.

Transl Oncol. 2010 Jun 1;3(3):160-9.


The radiation response of cells from 9L gliosarcoma tumours is correlated with [F18]-EF5 uptake.

Koch CJ, Shuman AL, Jenkins WT, Kachur AV, Karp JS, Freifelder R, Dolbier WR Jr, Evans SM.

Int J Radiat Biol. 2009 Dec;85(12):1137-47. doi: 10.3109/09553000903242172.


Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents.

Kachur AV, Dolbier WR Jr, Xu W, Koch CJ.

Appl Radiat Isot. 2010 Feb;68(2):293-6. doi: 10.1016/j.apradiso.2009.10.005. Epub 2009 Oct 23.


pO(2)-dependent NO production determines OPPC activity in macrophages.

Robinson MA, Tuttle SW, Otto CM, Koch CJ.

Free Radic Biol Med. 2010 Jan 15;48(2):189-95. doi: 10.1016/j.freeradbiomed.2009.10.027. Epub 2009 Oct 12.


Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy.

Cerniglia GJ, Pore N, Tsai JH, Schultz S, Mick R, Choe R, Xing X, Durduran T, Yodh AG, Evans SM, Koch CJ, Hahn SM, Quon H, Sehgal CM, Lee WM, Maity A.

PLoS One. 2009 Aug 6;4(8):e6539. doi: 10.1371/journal.pone.0006539.


Tumor vascular changes mediated by inhibition of oncogenic signaling.

Qayum N, Muschel RJ, Im JH, Balathasan L, Koch CJ, Patel S, McKenna WG, Bernhard EJ.

Cancer Res. 2009 Aug 1;69(15):6347-54. doi: 10.1158/0008-5472.CAN-09-0657. Epub 2009 Jul 21.


Tumor hypoxia as a modifier of DNA strand break and cross-link repair.

Chan N, Koch CJ, Bristow RG.

Curr Mol Med. 2009 May;9(4):401-10. Review.


Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.

Evans SM, Jenkins KW, Jenkins WT, Dilling T, Judy KD, Schrlau A, Judkins A, Hahn SM, Koch CJ.

Radiat Res. 2008 Dec;170(6):677-90. doi: 10.1667/RR1207.1.


Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Slater JM, Little JB.

Int J Radiat Oncol Biol Phys. 2008 Nov 1;72(3):909-17. doi: 10.1016/j.ijrobp.2008.06.1928. Review.


Epidermal sensing of oxygen is essential for systemic hypoxic response.

Boutin AT, Weidemann A, Fu Z, Mesropian L, Gradin K, Jamora C, Wiesener M, Eckardt KU, Koch CJ, Ellies LG, Haddad G, Haase VH, Simon MC, Poellinger L, Powell FL, Johnson RS.

Cell. 2008 Apr 18;133(2):223-34. doi: 10.1016/j.cell.2008.02.038.


A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 status.

Williams JR, Zhang Y, Zhou H, Gridley DS, Koch CJ, Russell J, Slater JS, Little JB.

Int J Radiat Biol. 2008 Apr;84(4):253-64. doi: 10.1080/09553000801953342. Review.


Genotype-dependent radiosensitivity: clonogenic survival, apoptosis and cell-cycle redistribution.

Williams JR, Zhang Y, Zhou H, Russell J, Gridley DS, Koch CJ, Little JB.

Int J Radiat Biol. 2008 Feb;84(2):151-64. doi: 10.1080/09553000701797021.


Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.

Evans SM, Du KL, Chalian AA, Mick R, Zhang PJ, Hahn SM, Quon H, Lustig R, Weinstein GS, Koch CJ.

Int J Radiat Oncol Biol Phys. 2007 Nov 15;69(4):1024-31.


Quantitative comparison of tissue oxygen and motexafin lutetium uptake by ex vivo and noninvasive in vivo techniques in patients with intraperitoneal carcinomatosis.

Wang HW, Finlay JC, Lee K, Zhu TC, Putt ME, Glatstein E, Koch CJ, Evans SM, Hahn SM, Busch TM, Yodh AG.

J Biomed Opt. 2007 May-Jun;12(3):034023.


Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication.

Ayene IS, Biaglow JE, Kachur AV, Stamato TD, Koch CJ.

J Cell Biochem. 2008 Jan 1;103(1):123-35.


DNA strand breakage by bivalent metal ions and ionizing radiation.

Ayene IS, Koch CJ, Krisch RE.

Int J Radiat Biol. 2007 Mar;83(3):195-210.


In situ oxygen utilization in the rat intervertebral disc.

Lee DC, Adams CS, Albert TJ, Shapiro IM, Evans SM, Koch CJ.

J Anat. 2007 Mar;210(3):294-303.


Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F-EF5 and positron emission tomography.

Yapp DT, Woo J, Kartono A, Sy J, Oliver T, Skov KA, Koch CJ, Adomat H, Dragowska WH, Fazli L, Ruth T, Adam MJ, Green D, Gleave M.

BJU Int. 2007 May;99(5):1154-60. Epub 2007 Feb 19. Erratum in: BJU Int. 2007 May;99(5):1161. Fadzli, Ladan [corrected to Fazli, Ladan].


Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy.

Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, Sullivan D.

Int J Radiat Biol. 2006 Oct;82(10):699-757. Review.


Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.

Pore N, Gupta AK, Cerniglia GJ, Jiang Z, Bernhard EJ, Evans SM, Koch CJ, Hahn SM, Maity A.

Cancer Res. 2006 Sep 15;66(18):9252-9.


Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding.

Evans SM, Schrlau AE, Chalian AA, Zhang P, Koch CJ.

J Invest Dermatol. 2006 Dec;126(12):2596-606. Epub 2006 Jun 29.


Role of vicinal protein thiols in radiation and cytotoxic responses.

Biaglow JE, Ayene IS, Tuttle SW, Koch CJ, Donahue J, Mieyal JJ.

Radiat Res. 2006 Mar;165(3):307-17.


EF5 binding and clinical outcome in human soft tissue sarcomas.

Evans SM, Fraker D, Hahn SM, Gleason K, Jenkins WT, Jenkins K, Hwang WT, Zhang P, Mick R, Koch CJ.

Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):922-7.


Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature.

Shi Y, Lee CS, Wu J, Koch CJ, Thom SR, Maity A, Bernhard EJ.

Head Neck. 2005 May;27(5):362-9.


p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.

Grimberg A, Coleman CM, Burns TF, Himelstein BP, Koch CJ, Cohen P, El-Deiry WS.

J Clin Endocrinol Metab. 2005 Jun;90(6):3568-74. Epub 2005 Mar 15.

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