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Items: 1 to 50 of 175

1.

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

Schütze K, Petry K, Hambach J, Schuster N, Fumey W, Schriewer L, Röckendorf J, Menzel S, Albrecht B, Haag F, Stortelers C, Bannas P, Koch-Nolte F.

Front Immunol. 2018 Nov 19;9:2553. doi: 10.3389/fimmu.2018.02553. eCollection 2018.

PMID:
30524421
2.

Perspectives for the Development of CD38-Specific Heavy Chain Antibodies as Therapeutics for Multiple Myeloma.

Bannas P, Koch-Nolte F.

Front Immunol. 2018 Nov 6;9:2559. doi: 10.3389/fimmu.2018.02559. eCollection 2018. Review.

3.

Disease-Linked Glutarylation Impairs Function and Interactions of Mitochondrial Proteins and Contributes to Mitochondrial Heterogeneity.

Schmiesing J, Storch S, Dörfler AC, Schweizer M, Makrypidi-Fraune G, Thelen M, Sylvester M, Gieselmann V, Meyer-Schwesinger C, Koch-Nolte F, Tidow H, Mühlhausen C, Waheed A, Sly WS, Braulke T.

Cell Rep. 2018 Sep 11;24(11):2946-2956. doi: 10.1016/j.celrep.2018.08.014.

4.

Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.

Leutert M, Menzel S, Braren R, Rissiek B, Hopp AK, Nowak K, Bisceglie L, Gehrig P, Li H, Zolkiewska A, Koch-Nolte F, Hottiger MO.

Cell Rep. 2018 Aug 14;24(7):1916-1929.e5. doi: 10.1016/j.celrep.2018.07.048.

5.

Monitoring the Sensitivity of T Cell Populations Towards NAD+ Released During Cell Preparation.

Rissiek B, Lukowiak M, Haag F, Magnus T, Koch-Nolte F.

Methods Mol Biol. 2018;1813:317-326. doi: 10.1007/978-1-4939-8588-3_22.

PMID:
30097878
6.

Monitoring Expression and Enzyme Activity of Ecto-ARTCs.

Menzel S, Adriouch S, Bannas P, Haag F, Koch-Nolte F.

Methods Mol Biol. 2018;1813:167-186. doi: 10.1007/978-1-4939-8588-3_11.

PMID:
30097867
7.

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody.

Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A.

Elife. 2018 Aug 3;7. pii: e36217. doi: 10.7554/eLife.36217.

8.

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells.

Rissiek B, Lukowiak M, Raczkowski F, Magnus T, Mittrücker HW, Koch-Nolte F.

Front Immunol. 2018 Jul 9;9:1580. doi: 10.3389/fimmu.2018.01580. eCollection 2018.

9.

P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis.

Zabala A, Vazquez-Villoldo N, Rissiek B, Gejo J, Martin A, Palomino A, Perez-Samartín A, Pulagam KR, Lukowiak M, Capetillo-Zarate E, Llop J, Magnus T, Koch-Nolte F, Rassendren F, Matute C, Domercq M.

EMBO Mol Med. 2018 Aug;10(8). pii: e8743. doi: 10.15252/emmm.201708743.

10.

CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes.

Raczkowski F, Rissiek A, Ricklefs I, Heiss K, Schumacher V, Wundenberg K, Haag F, Koch-Nolte F, Tolosa E, Mittrücker HW.

PLoS One. 2018 May 9;13(5):e0197151. doi: 10.1371/journal.pone.0197151. eCollection 2018.

11.

Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity.

Menzel S, Schwarz N, Haag F, Koch-Nolte F.

Front Pharmacol. 2018 Mar 27;9:266. doi: 10.3389/fphar.2018.00266. eCollection 2018. Review.

12.

Modulating ion channel function with antibodies and nanobodies.

Stortelers C, Pinto-Espinoza C, Van Hoorick D, Koch-Nolte F.

Curr Opin Immunol. 2018 Jun;52:18-26. doi: 10.1016/j.coi.2018.02.003. Epub 2018 Mar 23. Review.

PMID:
29579624
13.

The Most N-Terminal Region of THSD7A Is the Predominant Target for Autoimmunity in THSD7A-Associated Membranous Nephropathy.

Seifert L, Hoxha E, Eichhoff AM, Zahner G, Dehde S, Reinhard L, Koch-Nolte F, Stahl RAK, Tomas NM.

J Am Soc Nephrol. 2018 May;29(5):1536-1548. doi: 10.1681/ASN.2017070805. Epub 2018 Mar 19.

PMID:
29555830
14.

CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism.

García-Rodríguez S, Rosal-Vela A, Botta D, Cumba Garcia LM, Zumaquero E, Prados-Maniviesa V, Cerezo-Wallis D, Lo Buono N, Robles-Guirado JÁ, Guerrero S, González-Paredes E, Andrés-León E, Corbí Á, Mack M, Koch-Nolte F, Merino R, Zubiaur M, Lund FE, Sancho J.

Sci Rep. 2018 Feb 20;8(1):3357. doi: 10.1038/s41598-018-21337-6.

15.

A cDNA Immunization Strategy to Generate Nanobodies against Membrane Proteins in Native Conformation.

Eden T, Menzel S, Wesolowski J, Bergmann P, Nissen M, Dubberke G, Seyfried F, Albrecht B, Haag F, Koch-Nolte F.

Front Immunol. 2018 Jan 23;8:1989. doi: 10.3389/fimmu.2017.01989. eCollection 2017.

16.

Nanobodies and Nanobody-Based Human Heavy Chain Antibodies As Antitumor Therapeutics.

Bannas P, Hambach J, Koch-Nolte F.

Front Immunol. 2017 Nov 22;8:1603. doi: 10.3389/fimmu.2017.01603. eCollection 2017. Review.

17.

Ecto-ADP-ribosyltransferase ARTC2.1 functionally modulates FcγR1 and FcγR2B on murine microglia.

Rissiek B, Menzel S, Leutert M, Cordes M, Behr S, Jank L, Ludewig P, Gelderblom M, Rissiek A, Adriouch S, Haag F, Hottiger MO, Koch-Nolte F, Magnus T.

Sci Rep. 2017 Nov 28;7(1):16477. doi: 10.1038/s41598-017-16613-w.

18.

Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.

Fumey W, Koenigsdorf J, Kunick V, Menzel S, Schütze K, Unger M, Schriewer L, Haag F, Adam G, Oberle A, Binder M, Fliegert R, Guse A, Zhao YJ, Cheung Lee H, Malavasi F, Goldbaum F, van Hegelsom R, Stortelers C, Bannas P, Koch-Nolte F.

Sci Rep. 2017 Oct 30;7(1):14289. doi: 10.1038/s41598-017-14112-6.

19.

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers.

Koch K, Kalusche S, Torres JL, Stanfield RL, Danquah W, Khazanehdari K, von Briesen H, Geertsma ER, Wilson IA, Wernery U, Koch-Nolte F, Ward AB, Dietrich U.

Sci Rep. 2017 Aug 21;7(1):8390. doi: 10.1038/s41598-017-08273-7.

20.

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy.

Tomas NM, Meyer-Schwesinger C, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK.

J Am Soc Nephrol. 2017 Nov;28(11):3262-3277. doi: 10.1681/ASN.2017010030. Epub 2017 Aug 16.

21.

Identification of the ectoenzyme CD38 as a marker of committed preadipocytes.

Carrière A, Jeanson Y, Côté JA, Dromard C, Galinier A, Menzel S, Barreau C, Dupuis-Coronas S, Arnaud E, Girousse A, Cuminetti V, Paupert J, Cousin B, Sengenes C, Koch-Nolte F, Tchernof A, Casteilla L.

Int J Obes (Lond). 2017 Oct;41(10):1539-1546. doi: 10.1038/ijo.2017.140. Epub 2017 Jun 14.

PMID:
28611394
22.

Long-term CD38 saturation by daratumumab interferes with diagnostic myeloma cell detection.

Oberle A, Brandt A, Alawi M, Langebrake C, Janjetovic S, Wolschke C, Schütze K, Bannas P, Kröger N, Koch-Nolte F, Bokemeyer C, Binder M.

Haematologica. 2017 Sep;102(9):e368-e370. doi: 10.3324/haematol.2017.169235. Epub 2017 May 18. No abstract available.

23.

Nanobodies that block gating of the P2X7 ion channel ameliorate inflammation.

Danquah W, Meyer-Schwesinger C, Rissiek B, Pinto C, Serracant-Prat A, Amadi M, Iacenda D, Knop JH, Hammel A, Bergmann P, Schwarz N, Assunção J, Rotthier W, Haag F, Tolosa E, Bannas P, Boué-Grabot E, Magnus T, Laeremans T, Stortelers C, Koch-Nolte F.

Sci Transl Med. 2016 Nov 23;8(366):366ra162.

PMID:
27881823
24.

Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection.

Fernandez-Ruiz D, Ng WY, Holz LE, Ma JZ, Zaid A, Wong YC, Lau LS, Mollard V, Cozijnsen A, Collins N, Li J, Davey GM, Kato Y, Devi S, Skandari R, Pauley M, Manton JH, Godfrey DI, Braun A, Tay SS, Tan PS, Bowen DG, Koch-Nolte F, Rissiek B, Carbone FR, Crabb BS, Lahoud M, Cockburn IA, Mueller SN, Bertolino P, McFadden GI, Caminschi I, Heath WR.

Immunity. 2016 Oct 18;45(4):889-902. doi: 10.1016/j.immuni.2016.08.011. Epub 2016 Sep 27.

25.

The binary toxin CDT enhances Clostridium difficile virulence by suppressing protective colonic eosinophilia.

Cowardin CA, Buonomo EL, Saleh MM, Wilson MG, Burgess SL, Kuehne SA, Schwan C, Eichhoff AM, Koch-Nolte F, Lyras D, Aktories K, Minton NP, Petri WA Jr.

Nat Microbiol. 2016 Jul 11;1(8):16108. doi: 10.1038/nmicrobiol.2016.108.

26.

Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells.

Rauch L, Hennings K, Trasak C, Röder A, Schröder B, Koch-Nolte F, Rivera-Molina F, Toomre D, Aepfelbacher M.

J Cell Sci. 2016 Aug 1;129(15):2937-49. doi: 10.1242/jcs.186213. Epub 2016 Jun 16.

27.

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells.

Berneking L, Schnapp M, Rumm A, Trasak C, Ruckdeschel K, Alawi M, Grundhoff A, Kikhney AG, Koch-Nolte F, Buck F, Perbandt M, Betzel C, Svergun DI, Hentschke M, Aepfelbacher M.

PLoS Pathog. 2016 Jun 14;12(6):e1005660. doi: 10.1371/journal.ppat.1005660. eCollection 2016 Jun.

28.

Immuno-targeting the multifunctional CD38 using nanobody.

Li T, Qi S, Unger M, Hou YN, Deng QW, Liu J, Lam CM, Wang XW, Xin D, Zhang P, Koch-Nolte F, Hao Q, Zhang H, Lee HC, Zhao YJ.

Sci Rep. 2016 Jun 2;6:27055. doi: 10.1038/srep27055.

29.

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy.

Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.

J Clin Invest. 2016 Jul 1;126(7):2519-32. doi: 10.1172/JCI85265. Epub 2016 May 23.

30.

A transplant "immunome" screening platform defines a targetable epitope fingerprint of multiple myeloma.

Schieferdecker A, Oberle A, Thiele B, Hofmann F, Göthel M, Miethe S, Hust M, Braig F, Voigt M, von Pein UM, Koch-Nolte F, Haag F, Alawi M, Indenbirken D, Grundhoff A, Bokemeyer C, Bacher U, Kröger N, Binder M.

Blood. 2016 Jun 23;127(25):3202-14. doi: 10.1182/blood-2015-10-676536. Epub 2016 Mar 31.

31.

The European antibody network's practical guide to finding and validating suitable antibodies for research.

Roncador G, Engel P, Maestre L, Anderson AP, Cordell JL, Cragg MS, Šerbec VČ, Jones M, Lisnic VJ, Kremer L, Li D, Koch-Nolte F, Pascual N, Rodríguez-Barbosa JI, Torensma R, Turley H, Pulford K, Banham AH.

MAbs. 2016;8(1):27-36. doi: 10.1080/19420862.2015.1100787. Epub 2015 Sep 29.

32.

Nucleotide-Induced Membrane-Proximal Proteolysis Controls the Substrate Specificity of T Cell Ecto-ADP-Ribosyltransferase ARTC2.2.

Menzel S, Rissiek B, Bannas P, Jakoby T, Miksiewicz M, Schwarz N, Nissen M, Haag F, Tholey A, Koch-Nolte F.

J Immunol. 2015 Sep 1;195(5):2057-66. doi: 10.4049/jimmunol.1401677. Epub 2015 Jul 24.

33.

P2X7 on Mouse T Cells: One Channel, Many Functions.

Rissiek B, Haag F, Boyer O, Koch-Nolte F, Adriouch S.

Front Immunol. 2015 May 19;6:204. doi: 10.3389/fimmu.2015.00204. eCollection 2015. Review.

34.

CD38 is expressed on inflammatory cells of the intestine and promotes intestinal inflammation.

Schneider M, Schumacher V, Lischke T, Lücke K, Meyer-Schwesinger C, Velden J, Koch-Nolte F, Mittrücker HW.

PLoS One. 2015 May 4;10(5):e0126007. doi: 10.1371/journal.pone.0126007. eCollection 2015.

35.

Molecular imaging of tumors with nanobodies and antibodies: Timing and dosage are crucial factors for improved in vivo detection.

Bannas P, Lenz A, Kunick V, Well L, Fumey W, Rissiek B, Haag F, Schmid J, Schütze K, Eichhoff A, Trepel M, Adam G, Ittrich H, Koch-Nolte F.

Contrast Media Mol Imaging. 2015 Sep-Oct;10(5):367-78. doi: 10.1002/cmmi.1637. Epub 2015 Apr 27.

PMID:
25925493
36.

Validation of nanobody and antibody based in vivo tumor xenograft NIRF-imaging experiments in mice using ex vivo flow cytometry and microscopy.

Bannas P, Lenz A, Kunick V, Fumey W, Rissiek B, Schmid J, Haag F, Leingärtner A, Trepel M, Adam G, Koch-Nolte F.

J Vis Exp. 2015 Apr 6;(98):e52462. doi: 10.3791/52462.

37.

Tuning IL-2 signaling by ADP-ribosylation of CD25.

Teege S, Hann A, Miksiewicz M, MacMillan C, Rissiek B, Buck F, Menzel S, Nissen M, Bannas P, Haag F, Boyer O, Seman M, Adriouch S, Koch-Nolte F.

Sci Rep. 2015 Mar 10;5:8959. doi: 10.1038/srep08959.

38.

The expression of CD39 on regulatory T cells is genetically driven and further upregulated at sites of inflammation.

Rissiek A, Baumann I, Cuapio A, Mautner A, Kolster M, Arck PC, Dodge-Khatami A, Mittrücker HW, Koch-Nolte F, Haag F, Tolosa E.

J Autoimmun. 2015 Apr;58:12-20. doi: 10.1016/j.jaut.2014.12.007. Epub 2015 Jan 29.

PMID:
25640206
39.

Blockade of P2X7 receptors or pannexin-1 channels similarly attenuates postischemic damage.

Cisneros-Mejorado A, Gottlieb M, Cavaliere F, Magnus T, Koch-Nolte F, Scemes E, Pérez-Samartín A, Matute C.

J Cereb Blood Flow Metab. 2015 May;35(5):843-50. doi: 10.1038/jcbfm.2014.262. Epub 2015 Jan 21.

40.

Selection of nanobodies that block the enzymatic and cytotoxic activities of the binary Clostridium difficile toxin CDT.

Unger M, Eichhoff AM, Schumacher L, Strysio M, Menzel S, Schwan C, Alzogaray V, Zylberman V, Seman M, Brandner J, Rohde H, Zhu K, Haag F, Mittrücker HW, Goldbaum F, Aktories K, Koch-Nolte F.

Sci Rep. 2015 Jan 19;5:7850. doi: 10.1038/srep07850.

41.

Nanobodies as modulators of inflammation: potential applications for acute brain injury.

Rissiek B, Koch-Nolte F, Magnus T.

Front Cell Neurosci. 2014 Oct 21;8:344. doi: 10.3389/fncel.2014.00344. eCollection 2014.

42.

ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.

Fabrizio G, Di Paola S, Stilla A, Giannotta M, Ruggiero C, Menzel S, Koch-Nolte F, Sallese M, Di Girolamo M.

Cell Mol Life Sci. 2015 Mar;72(6):1209-25. doi: 10.1007/s00018-014-1745-6. Epub 2014 Oct 8.

PMID:
25292337
43.

ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells.

Rissiek B, Haag F, Boyer O, Koch-Nolte F, Adriouch S.

Curr Top Microbiol Immunol. 2015;384:107-26. doi: 10.1007/82_2014_420. Review.

PMID:
25048544
44.

In vivo near-infrared fluorescence targeting of T cells: comparison of nanobodies and conventional monoclonal antibodies.

Bannas P, Well L, Lenz A, Rissiek B, Haag F, Schmid J, Hochgräfe K, Trepel M, Adam G, Ittrich H, Koch-Nolte F.

Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):135-42. doi: 10.1002/cmmi.1548.

PMID:
24523058
45.

Clostridium difficile toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence.

Schwan C, Kruppke AS, Nölke T, Schumacher L, Koch-Nolte F, Kudryashev M, Stahlberg H, Aktories K.

Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2313-8. doi: 10.1073/pnas.1311589111. Epub 2014 Jan 27.

46.

Evidence of promiscuous endothelial binding by Plasmodium falciparum-infected erythrocytes.

Esser C, Bachmann A, Kuhn D, Schuldt K, Förster B, Thiel M, May J, Koch-Nolte F, Yáñez-Mó M, Sánchez-Madrid F, Schinkel AH, Jalkanen S, Craig AG, Bruchhaus I, Horstmann RD.

Cell Microbiol. 2014 May;16(5):701-8. doi: 10.1111/cmi.12270. Epub 2014 Feb 24.

47.

Mucolipidosis II-related mutations inhibit the exit from the endoplasmic reticulum and proteolytic cleavage of GlcNAc-1-phosphotransferase precursor protein (GNPTAB).

De Pace R, Coutinho MF, Koch-Nolte F, Haag F, Prata MJ, Alves S, Braulke T, Pohl S.

Hum Mutat. 2014 Mar;35(3):368-76. doi: 10.1002/humu.22502. Epub 2014 Jan 15.

PMID:
24375680
48.

Technical Advance: a new cell preparation strategy that greatly improves the yield of vital and functional Tregs and NKT cells.

Rissiek B, Danquah W, Haag F, Koch-Nolte F.

J Leukoc Biol. 2014 Mar;95(3):543-9. doi: 10.1189/jlb.0713407. Epub 2013 Nov 8.

PMID:
24212099
49.

Short-term TNFα shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17.

Schwarz J, Broder C, Helmstetter A, Schmidt S, Yan I, Müller M, Schmidt-Arras D, Becker-Pauly C, Koch-Nolte F, Mittrücker HW, Rabe B, Rose-John S, Chalaris A.

Biochim Biophys Acta. 2013 Dec;1833(12):3355-3367. doi: 10.1016/j.bbamcr.2013.10.005. Epub 2013 Oct 14.

50.

CD38 controls the innate immune response against Listeria monocytogenes.

Lischke T, Heesch K, Schumacher V, Schneider M, Haag F, Koch-Nolte F, Mittrücker HW.

Infect Immun. 2013 Nov;81(11):4091-9. doi: 10.1128/IAI.00340-13. Epub 2013 Aug 26.

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