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Items: 1 to 50 of 63

1.

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.

Chow BSM, Kocan M, Shen M, Wang Y, Han L, Chew JY, Wang C, Bosnyak S, Mirabito-Colafella KM, Barsha G, Wigg B, Johnstone EKM, Hossain MA, Pfleger KDG, Denton KM, Widdop RE, Summers RJ, Bathgate RAD, Hewitson TD, Samuel CS.

J Am Soc Nephrol. 2019 Sep 11. pii: ASN.2019060597. doi: 10.1681/ASN.2019060597. [Epub ahead of print]

PMID:
31511361
2.

Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis.

Hoare BL, Kocan M, Bruell S, Scott DJ, Bathgate RAD.

Pharmacol Res Perspect. 2019 Jul 30;7(4):e00513. doi: 10.1002/prp2.513. eCollection 2019 Aug.

3.

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii.

Yang L, Uboldi AD, Seizova S, Wilde ML, Coffey MJ, Katris NJ, Yamaryo-Botté Y, Kocan M, Bathgate RAD, Stewart RJ, McConville MJ, Thompson PE, Botté CY, Tonkin CJ.

J Biol Chem. 2019 May 31;294(22):8959-8972. doi: 10.1074/jbc.RA118.005491. Epub 2019 Apr 16.

PMID:
30992368
4.

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β2-adrenoceptors without causing classical receptor desensitization.

Mukaida S, Sato M, Öberg AI, Dehvari N, Olsen JM, Kocan M, Halls ML, Merlin J, Sandström AL, Csikasz RI, Evans BA, Summers RJ, Hutchinson DS, Bengtsson T.

Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R666-R677. doi: 10.1152/ajpregu.00285.2018. Epub 2019 Mar 20.

PMID:
30892909
5.

Single chain peptide agonists of relaxin receptors.

Praveen P, Kocan M, Valkovic A, Bathgate R, Hossain MA.

Mol Cell Endocrinol. 2019 May 1;487:34-39. doi: 10.1016/j.mce.2019.01.008. Epub 2019 Jan 11. Review.

PMID:
30641102
6.

Understanding relaxin signalling at the cellular level.

Valkovic AL, Bathgate RA, Samuel CS, Kocan M.

Mol Cell Endocrinol. 2019 May 1;487:24-33. doi: 10.1016/j.mce.2018.12.017. Epub 2018 Dec 25. Review.

PMID:
30592984
7.

High magnetic field test of the ITER outer vessel steady-state magnetic field Hall sensors at ITER relevant temperature.

Entler S, Sebek J, Duran I, Vyborny K, Grover O, Kocan M, Vayakis G.

Rev Sci Instrum. 2018 Oct;89(10):10J112. doi: 10.1063/1.5038812.

PMID:
30399944
8.

Steady state magnetic sensors for ITER and beyond: Development and final design (invited).

Kocan M, Duran I, Entler S, Vayakis G, Agostinetti P, Brombin M, Carmona JM, Gambetta G, Jirman T, Marconato N, Moreau P, Peruzzo S, Spuig P, Walsh M.

Rev Sci Instrum. 2018 Oct;89(10):10J119. doi: 10.1063/1.5038871.

PMID:
30399664
9.

Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor.

Valkovic AL, Leckey MB, Whitehead AR, Hossain MA, Inoue A, Kocan M, Bathgate RAD.

Pharmacol Res Perspect. 2018 Sep 24;6(5):e00432. doi: 10.1002/prp2.432. eCollection 2018 Oct.

10.

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression.

Sampaio NG, Kocan M, Schofield L, Pfleger KDG, Eriksson EM.

PLoS One. 2018 Aug 23;13(8):e0202408. doi: 10.1371/journal.pone.0202408. eCollection 2018.

11.

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

Ang SY, Evans BA, Poole DP, Bron R, DiCello JJ, Bathgate RAD, Kocan M, Hutchinson DS, Summers RJ.

J Mol Endocrinol. 2018 Apr;60(3):213-224. doi: 10.1530/JME-17-0152.

PMID:
29535183
12.

Clinical Nurse Specialists Fostering Palliative Care Skills.

Price DM, Kocan MJ.

AACN Adv Crit Care. 2018 Spring;29(1):84-90. doi: 10.4037/aacnacc2018286. No abstract available.

PMID:
29496716
13.

The relaxin receptor as a therapeutic target - perspectives from evolution and drug targeting.

Bathgate RAD, Kocan M, Scott DJ, Hossain MA, Good SV, Yegorov S, Bogerd J, Gooley PR.

Pharmacol Ther. 2018 Jul;187:114-132. doi: 10.1016/j.pharmthera.2018.02.008. Epub 2018 Feb 17. Review.

PMID:
29458108
14.

Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.

Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T.

J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29.

15.

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

Kocan M, Sarwar M, Ang SY, Xiao J, Marugan JJ, Hossain MA, Wang C, Hutchinson DS, Samuel CS, Agoulnik AI, Bathgate RAD, Summers RJ.

Sci Rep. 2017 Jun 7;7(1):2968. doi: 10.1038/s41598-017-02916-5.

16.

A fast feedback controlled magnetic drive for the ASDEX Upgrade fast-ion loss detectors.

Ayllon-Guerola J, Gonzalez-Martin J, Garcia-Munoz M, Rivero-Rodriguez J, Herrmann A, Vorbrugg S, Leitenstern P, Zoletnik S, Galdon J, Garcia Lopez J, Rodriguez-Ramos M, Sanchis-Sanchez L, Dominguez AD, Kocan M, Gunn JP, Garcia-Vallejo D, Dominguez J.

Rev Sci Instrum. 2016 Nov;87(11):11E705.

PMID:
27910655
17.

High magnetic field test of bismuth Hall sensors for ITER steady state magnetic diagnostic.

Ďuran I, Entler S, Kohout M, Kočan M, Vayakis G.

Rev Sci Instrum. 2016 Nov;87(11):11D446.

PMID:
27910548
18.

Conceptual design of the ITER fast-ion loss detector.

Garcia-Munoz M, Kocan M, Ayllon-Guerola J, Bertalot L, Bonnet Y, Casal N, Galdon J, Garcia Lopez J, Giacomin T, Gonzalez-Martin J, Gunn JP, Jimenez-Ramos MC, Kiptily V, Pinches SD, Rodriguez-Ramos M, Reichle R, Rivero-Rodriguez JF, Sanchis-Sanchez L, Snicker A, Vayakis G, Veshchev E, Vorpahl C, Walsh M, Walton R.

Rev Sci Instrum. 2016 Nov;87(11):11D829.

PMID:
27910499
19.

Stokes-Doppler coherence imaging for ITER boundary tomography.

Howard J, Kocan M, Lisgo S, Reichle R.

Rev Sci Instrum. 2016 Nov;87(11):11E561.

PMID:
27910470
20.

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.

Ang SY, Hutchinson DS, Evans BA, Hossain MA, Patil N, Bathgate RA, Kocan M, Summers RJ.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):105-111. doi: 10.1007/s00210-016-1321-8. Epub 2016 Nov 26.

PMID:
27888281
21.

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.

Ang SY, Hutchinson DS, Patil N, Evans BA, Bathgate RAD, Halls ML, Hossain MA, Summers RJ, Kocan M.

Br J Pharmacol. 2017 May;174(10):1077-1089. doi: 10.1111/bph.13522. Epub 2016 Jul 13. Erratum in: Br J Pharmacol. 2017 Dec;174(24):4836.

22.

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1.

Hossain MA, Kocan M, Yao ST, Royce SG, Nair VB, Siwek C, Patil NA, Harrison IP, Rosengren KJ, Selemidis S, Summers RJ, Wade JD, Bathgate RAD, Samuel CS.

Chem Sci. 2016 Jun 1;7(6):3805-3819. doi: 10.1039/c5sc04754d. Epub 2016 Feb 26.

23.

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate.

Wang C, Kemp-Harper BK, Kocan M, Ang SY, Hewitson TD, Samuel CS.

Front Pharmacol. 2016 Mar 31;7:91. doi: 10.3389/fphar.2016.00091. eCollection 2016.

24.

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.

Patil NA, Hughes RA, Rosengren KJ, Kocan M, Ang SY, Tailhades J, Separovic F, Summers RJ, Grosse J, Wade JD, Bathgate RA, Hossain MA.

J Med Chem. 2016 Mar 10;59(5):2118-25. doi: 10.1021/acs.jmedchem.5b01786. Epub 2016 Feb 12.

PMID:
26824523
25.

The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.

Patil NA, Bathgate RA, Kocan M, Ang SY, Tailhades J, Separovic F, Summers R, Grosse J, Hughes RA, Wade JD, Hossain MA.

Amino Acids. 2016 Apr;48(4):987-92. doi: 10.1007/s00726-015-2144-5. Epub 2015 Dec 11.

PMID:
26661035
26.

Orthosteric, Allosteric and Biased Signalling at the Relaxin-3 Receptor RXFP3.

Kocan M, Ang SY, Summers RJ.

Neurochem Res. 2016 Mar;41(3):610-9. doi: 10.1007/s11064-015-1701-3. Epub 2015 Aug 21.

PMID:
26294284
27.

Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4.

Zhao P, Lieu T, Barlow N, Metcalf M, Veldhuis NA, Jensen DD, Kocan M, Sostegni S, Haerteis S, Baraznenok V, Henderson I, Lindström E, Guerrero-Alba R, Valdez-Morales EE, Liedtke W, McIntyre P, Vanner SJ, Korbmacher C, Bunnett NW.

J Biol Chem. 2014 Sep 26;289(39):27215-34. doi: 10.1074/jbc.M114.599712. Epub 2014 Aug 12. Erratum in: J Biol Chem. 2014 Dec 26;289(52):35858.

28.

Improving patient care through student leadership in team quality improvement projects.

Tschannen D, Aebersold M, Kocan MJ, Lundy F, Potempa K.

J Nurs Care Qual. 2015 Apr-Jun;30(2):181-6. doi: 10.1097/NCQ.0000000000000080.

PMID:
25098916
29.

Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).

Kocan M, Sarwar M, Hossain MA, Wade JD, Summers RJ.

Br J Pharmacol. 2014 Jun;171(11):2827-41. doi: 10.1111/bph.12623.

30.

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.

Chow BS, Kocan M, Bosnyak S, Sarwar M, Wigg B, Jones ES, Widdop RE, Summers RJ, Bathgate RA, Hewitson TD, Samuel CS.

Kidney Int. 2014 Jul;86(1):75-85. doi: 10.1038/ki.2013.518. Epub 2014 Jan 15.

31.

Efficacy of antibiotic-impregnated external ventricular drains in reducing ventriculostomy-associated infections.

Mikhaylov Y, Wilson TJ, Rajajee V, Thompson BG, Maher CO, Sullivan SE, Jacobs TL, Kocan MJ, Pandey AS.

J Clin Neurosci. 2014 May;21(5):765-8. doi: 10.1016/j.jocn.2013.09.002. Epub 2014 Jan 8.

PMID:
24411330
32.

Minimum active structure of insulin-like peptide 5.

Belgi A, Bathgate RA, Kocan M, Patil N, Zhang S, Tregear GW, Wade JD, Hossain MA.

J Med Chem. 2013 Dec 12;56(23):9509-16. doi: 10.1021/jm400924p. Epub 2013 Nov 21.

PMID:
24188028
33.

Stroke awareness among inpatient nursing staff at an academic medical center.

Adelman EE, Meurer WJ, Nance DK, Kocan MJ, Maddox KE, Morgenstern LB, Skolarus LE.

Stroke. 2014 Jan;45(1):271-3. doi: 10.1161/STROKEAHA.113.002905. Epub 2013 Oct 17.

34.

Tungsten injector for scrape-off layer impurity transport experiments in the Tore Supra tokamak.

Kočan M, Gunn JP, Lunt T, Meyer O, Pascal JY.

Rev Sci Instrum. 2013 Jul;84(7):073501. doi: 10.1063/1.4812341.

PMID:
23902057
35.

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

Jensen DD, Godfrey CB, Niklas C, Canals M, Kocan M, Poole DP, Murphy JE, Alemi F, Cottrell GS, Korbmacher C, Lambert NA, Bunnett NW, Corvera CU.

J Biol Chem. 2013 Aug 9;288(32):22942-60. doi: 10.1074/jbc.M113.455774. Epub 2013 Jul 1.

36.

Relaxin family peptides and their receptors.

Bathgate RA, Halls ML, van der Westhuizen ET, Callander GE, Kocan M, Summers RJ.

Physiol Rev. 2013 Jan;93(1):405-80. doi: 10.1152/physrev.00001.2012. Review.

37.

Special considerations for mobilizing patients in the neurointensive care unit.

Kocan MJ, Lietz H.

Crit Care Nurs Q. 2013 Jan-Mar;36(1):50-5. doi: 10.1097/CNQ.0b013e3182750b12. Review.

PMID:
23221441
38.

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.

Shabanpoor F, Akhter Hossain M, Ryan PJ, Belgi A, Layfield S, Kocan M, Zhang S, Samuel CS, Gundlach AL, Bathgate RA, Separovic F, Wade JD.

J Med Chem. 2012 Feb 23;55(4):1671-81. doi: 10.1021/jm201505p. Epub 2012 Feb 8.

PMID:
22257012
39.

Use of simulation in stroke unit education.

Aebersold M, Kocan MJ, Tschannen D, Michaels J.

J Neurosci Nurs. 2011 Dec;43(6):349-53. doi: 10.1097/JNN.0b013e318234e9ca. No abstract available.

PMID:
22089412
40.

β(2)-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail.

Dehvari N, Hutchinson DS, Nevzorova J, Dallner OS, Sato M, Kocan M, Merlin J, Evans BA, Summers RJ, Bengtsson T.

Br J Pharmacol. 2012 Mar;165(5):1442-56. doi: 10.1111/j.1476-5381.2011.01647.x.

41.

Implications of nurse-physician relations: report of a successful intervention.

Tschannen D, Keenan G, Aebersold M, Kocan MJ, Lundy F, Averhart V.

Nurs Econ. 2011 May-Jun;29(3):127-35.

PMID:
21736176
42.

Study of GPCR-protein interactions by BRET.

Kocan M, Pfleger KD.

Methods Mol Biol. 2011;746:357-71. doi: 10.1007/978-1-61779-126-0_20.

PMID:
21607868
43.

Application of G protein-coupled receptor-heteromer identification technology to monitor β-arrestin recruitment to G protein-coupled receptor heteromers.

See HB, Seeber RM, Kocan M, Eidne KA, Pfleger KD.

Assay Drug Dev Technol. 2011 Feb;9(1):21-30. doi: 10.1089/adt.2010.0336. Epub 2010 Dec 6.

44.

Enhanced BRET Technology for the Monitoring of Agonist-Induced and Agonist-Independent Interactions between GPCRs and β-Arrestins.

Kocan M, Dalrymple MB, Seeber RM, Feldman BJ, Pfleger KD.

Front Endocrinol (Lausanne). 2011 Jan 14;1:12. doi: 10.3389/fendo.2010.00012. eCollection 2010.

45.

Detection of GPCR/beta-arrestin interactions in live cells using bioluminescence resonance energy transfer technology.

Kocan M, Pfleger KD.

Methods Mol Biol. 2009;552:305-17. doi: 10.1007/978-1-60327-317-6_22.

PMID:
19513659
46.

Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.

Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KD.

Mol Endocrinol. 2009 Apr;23(4):559-71. doi: 10.1210/me.2008-0321. Epub 2009 Jan 29.

47.

Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells.

Kocan M, See HB, Seeber RM, Eidne KA, Pfleger KD.

J Biomol Screen. 2008 Oct;13(9):888-98. doi: 10.1177/1087057108324032. Epub 2008 Sep 23.

PMID:
18812574
48.

Improved outcomes in patients with head and neck cancer using a standardized care protocol for postoperative alcohol withdrawal.

Lansford CD, Guerriero CH, Kocan MJ, Turley R, Groves MW, Bahl V, Abrahamse P, Bradford CR, Chepeha DB, Moyer J, Prince ME, Wolf GT, Aebersold ML, Teknos TN.

Arch Otolaryngol Head Neck Surg. 2008 Aug;134(8):865-72. doi: 10.1001/archotol.134.8.865.

PMID:
18711062
49.

On the reliability of scrape-off layer ion temperature measurements by retarding field analyzers.

Kocan M, Gunn JP, Komm M, Pascal JY, Gauthier E, Bonhomme G.

Rev Sci Instrum. 2008 Jul;79(7):073502. doi: 10.1063/1.2955465.

PMID:
18681699
50.

Two-component systems of Corynebacterium glutamicum: deletion analysis and involvement of the PhoS-PhoR system in the phosphate starvation response.

Kocan M, Schaffer S, Ishige T, Sorger-Herrmann U, Wendisch VF, Bott M.

J Bacteriol. 2006 Jan;188(2):724-32.

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