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Items: 1 to 50 of 279

1.

The relative resistance of children to sepsis mortality: from pathways to drug candidates.

Joachim RB, Altschuler GM, Hutchinson JN, Wong HR, Hide WA, Kobzik L.

Mol Syst Biol. 2018 May 17;14(5):e7998. doi: 10.15252/msb.20177998.

2.

Future Research Directions in Pneumonia: NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Mar 16. doi: 10.1164/rccm.201801-0139WS. [Epub ahead of print]

PMID:
29546996
3.

Machine learning and deep analytics for biocomputing: call for better explainability.

Petkovic D, Kobzik L, Re C.

Pac Symp Biocomput. 2018;23:623-627.

4.

Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach.

Gregory DJ, Kramnik I, Kobzik L.

FEBS J. 2018 Jan;285(2):244-260. doi: 10.1111/febs.14348. Epub 2017 Dec 26.

5.

Characterising Pre-pubertal Resistance to Death from Endotoxemia.

Joachim R, Suber F, Kobzik L.

Sci Rep. 2017 Nov 29;7(1):16541. doi: 10.1038/s41598-017-16743-1.

6.

The fetal programming effect of prenatal smoking on Igf1r and Igf1 methylation is organ- and sex-specific.

Meyer KF, Verkaik-Schakel RN, Timens W, Kobzik L, Plösch T, Hylkema MN.

Epigenetics. 2017;12(12):1076-1091. doi: 10.1080/15592294.2017.1403691.

7.

Childhood tolerance of severe influenza: a mortality analysis in mice.

Suber F, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1087-L1095. doi: 10.1152/ajplung.00364.2017. Epub 2017 Sep 7.

PMID:
28882815
8.

Correction: The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes.

Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Högler S, Kovarik P, Decker T, Jamieson AM.

PLoS Pathog. 2017 Aug 30;13(8):e1006591. doi: 10.1371/journal.ppat.1006591. eCollection 2017 Aug.

9.

All That Wheezes….

Divakaran S, Dellaripa P, Kobzik L, Levy B, Loscalzo J.

N Engl J Med. 2017 Aug 3;377(5):477-484. doi: 10.1056/NEJMcps1607526. No abstract available.

PMID:
28767340
10.

All That Wheezes...

Divakaran S, Vaidya A, Kobzik L, Dellaripa P.

N Engl J Med. 2017 Jul 27;377(4):e6. doi: 10.1056/NEJMimc1613182. No abstract available.

11.

Phagocytic Receptors Activate Syk and Src Signaling during Borrelia burgdorferi Phagocytosis.

Killpack TL, Ballesteros M, Bunnell SC, Bedugnis A, Kobzik L, Hu LT, Petnicki-Ocwieja T.

Infect Immun. 2017 Sep 20;85(10). pii: e00004-17. doi: 10.1128/IAI.00004-17. Print 2017 Oct.

12.

Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy.

Gregory DJ, Kobzik L, Yang Z, McGuire CC, Fedulov AV.

Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L395-L405. doi: 10.1152/ajplung.00035.2017. Epub 2017 May 11.

PMID:
28495853
13.

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

PrabhuDas MR, Baldwin CL, Bollyky PL, Bowdish DME, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, McVicker B, Means TK, Moestrup SK, Post SR, Sawamura T, Silverstein S, Speth RC, Telfer JC, Thiele GM, Wang XY, Wright SD, El Khoury J.

J Immunol. 2017 May 15;198(10):3775-3789. doi: 10.4049/jimmunol.1700373.

14.

Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.

Wu M, Gibbons JG, DeLoid GM, Bedugnis AS, Thimmulappa RK, Biswal S, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L138-L153. doi: 10.1152/ajplung.00075.2017. Epub 2017 Apr 13.

PMID:
28408365
15.

Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.

Ordija CM, Chiou TT, Yang Z, Deloid GM, de Oliveira Valdo M, Wang Z, Bedugnis A, Noah TL, Jones S, Koziel H, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L1018-L1028. doi: 10.1152/ajplung.00067.2017. Epub 2017 Apr 6.

16.

Searching for a Lifeline: Transcriptome Profiling Studies of Influenza Susceptibility and Resistance.

Kobzik L.

J Innate Immun. 2017;9(3):232-242. doi: 10.1159/000457902. Epub 2017 Mar 1. Review.

17.

Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring.

Meyer KF, Krauss-Etschmann S, Kooistra W, Reinders-Luinge M, Timens W, Kobzik L, Plösch T, Hylkema MN.

Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L542-L555. doi: 10.1152/ajplung.00271.2016. Epub 2017 Jan 27.

18.

The Influence of Programmed Cell Death in Myeloid Cells on Host Resilience to Infection with Legionella pneumophila or Streptococcus pyogenes.

Gamradt P, Xu Y, Gratz N, Duncan K, Kobzik L, Högler S, Kovarik P, Decker T, Jamieson AM.

PLoS Pathog. 2016 Dec 14;12(12):e1006032. doi: 10.1371/journal.ppat.1006032. eCollection 2016 Dec. Erratum in: PLoS Pathog. 2017 Aug 30;13(8):e1006591.

19.

Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants.

High M, Cho HY, Marzec J, Wiltshire T, Verhein KC, Caballero MT, Acosta PL, Ciencewicki J, McCaw ZR, Kobzik L, Miller-DeGraff L, Gladwell W, Peden DB, Serra ME, Shi M, Weinberg C, Suzuki O, Wang X, Bell DA, Polack FP, Kleeberger SR.

EBioMedicine. 2016 Sep;11:73-84. doi: 10.1016/j.ebiom.2016.08.011. Epub 2016 Aug 6.

20.

IL-10-dependent Tr1 cells attenuate astrocyte activation and ameliorate chronic central nervous system inflammation.

Mayo L, Cunha AP, Madi A, Beynon V, Yang Z, Alvarez JI, Prat A, Sobel RA, Kobzik L, Lassmann H, Quintana FJ, Weiner HL.

Brain. 2016 Jul;139(Pt 7):1939-57. doi: 10.1093/brain/aww113. Epub 2016 May 31.

21.

Fine-tuning of macrophage activation using synthetic rocaglate derivatives.

Bhattacharya B, Chatterjee S, Devine WG, Kobzik L, Beeler AB, Porco JA Jr, Kramnik I.

Sci Rep. 2016 Apr 18;6:24409. doi: 10.1038/srep24409.

22.

Effects of engineered nanomaterial exposure on macrophage innate immune function.

DeLoid G, Casella B, Pirela S, Filoramo R, Pyrgiotakis G, Demokritou P, Kobzik L.

NanoImpact. 2016 Apr;2:70-81. doi: 10.1016/j.impact.2016.07.001. Epub 2016 Jul 25.

23.

Gene control of tyrosine kinase TIE2 and vascular manifestations of infections.

Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):2472-7. doi: 10.1073/pnas.1519467113. Epub 2016 Feb 16.

24.

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

Jiang Z, Lao T, Qiu W, Polverino F, Gupta K, Guo F, Mancini JD, Naing ZZ, Cho MH, Castaldi PJ, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AM, Perrella MA, Owen CA, Silverman EK, Zhou X.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):185-97. doi: 10.1164/rccm.201505-0999OC.

25.

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity.

Puchta A, Naidoo A, Verschoor CP, Loukov D, Thevaranjan N, Mandur TS, Nguyen PS, Jordana M, Loeb M, Xing Z, Kobzik L, Larché MJ, Bowdish DM.

PLoS Pathog. 2016 Jan 14;12(1):e1005368. doi: 10.1371/journal.ppat.1005368. eCollection 2016 Jan.

26.

Influenza lung injury: mechanisms and therapeutic opportunities.

Gregory DJ, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1041-6. doi: 10.1152/ajplung.00283.2015. Epub 2015 Sep 25. Review.

27.

Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts.

Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P.

Environ Health Perspect. 2016 Feb;124(2):210-9. doi: 10.1289/ehp.1409582. Epub 2015 Jun 16.

28.

Plasma gelsolin improves lung host defense against pneumonia by enhancing macrophage NOS3 function.

Yang Z, Chiou TT, Stossel TP, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L11-6. doi: 10.1152/ajplung.00094.2015. Epub 2015 May 8.

29.

Alternative activation of macrophages and pulmonary fibrosis are modulated by scavenger receptor, macrophage receptor with collagenous structure.

Murthy S, Larson-Casey JL, Ryan AJ, He C, Kobzik L, Carter AB.

FASEB J. 2015 Aug;29(8):3527-36. doi: 10.1096/fj.15-271304. Epub 2015 May 7.

30.

Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target.

Yang Z, Huang YC, Koziel H, de Crom R, Ruetten H, Wohlfart P, Thomsen RW, Kahlert JA, Sørensen HT, Jozefowski S, Colby A, Kobzik L.

Elife. 2014 Oct 15;3. doi: 10.7554/eLife.03711.

31.

The scavenger receptor MARCO modulates TLR-induced responses in dendritic cells.

Kissick HT, Dunn LK, Ghosh S, Nechama M, Kobzik L, Arredouani MS.

PLoS One. 2014 Aug 4;9(8):e104148. doi: 10.1371/journal.pone.0104148. eCollection 2014.

32.

Arterial stiffness, oxidative stress, and smoke exposure in wildland firefighters.

Gaughan DM, Siegel PD, Hughes MD, Chang CY, Law BF, Campbell CR, Richards JC, Kales SF, Chertok M, Kobzik L, Nguyen PS, O'Donnell CR, Kiefer M, Wagner GR, Christiani DC.

Am J Ind Med. 2014 Jul;57(7):748-56. doi: 10.1002/ajim.22331. Epub 2014 Jun 6.

33.

Prenatal maternal stress predicts childhood asthma in girls: project ice storm.

Turcotte-Tremblay AM, Lim R, Laplante DP, Kobzik L, Brunet A, King S.

Biomed Res Int. 2014;2014:201717. doi: 10.1155/2014/201717. Epub 2014 May 8.

34.

Maternal stress during pregnancy increases neonatal allergy susceptibility: role of glucocorticoids.

Lim R, Fedulov AV, Kobzik L.

Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15;307(2):L141-8. doi: 10.1152/ajplung.00250.2013. Epub 2014 May 16.

35.

Estrogen-mediated impairment of macrophageal uptake of environmental TiO2 particles to explain inflammatory effect of TiO2 on airways during pregnancy.

Zhang Y, Mikhaylova L, Kobzik L, Fedulov AV.

J Immunotoxicol. 2015 Jan-Mar;12(1):81-91. doi: 10.3109/1547691X.2014.899411. Epub 2014 May 13.

PMID:
24825546
36.

NO turning back.

Kobzik L.

Am J Respir Cell Mol Biol. 2014 May;50(5):843. doi: 10.1165/rcmb.2014-0106PS. No abstract available.

PMID:
24783955
37.

Exposures and cross-shift lung function declines in wildland firefighters.

Gaughan DM, Piacitelli CA, Chen BT, Law BF, Virji MA, Edwards NT, Enright PL, Schwegler-Berry DE, Leonard SS, Wagner GR, Kobzik L, Kales SN, Hughes MD, Christiani DC, Siegel PD, Cox-Ganser JM, Hoover MD.

J Occup Environ Hyg. 2014;11(9):591-603. doi: 10.1080/15459624.2014.895372.

PMID:
24568319
38.

Standardizing scavenger receptor nomenclature.

Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J.

J Immunol. 2014 Mar 1;192(5):1997-2006. doi: 10.4049/jimmunol.1490003. Review.

39.

Tracking translocation of industrially relevant engineered nanomaterials (ENMs) across alveolar epithelial monolayers in vitro.

Cohen JM, Derk R, Wang L, Godleski J, Kobzik L, Brain J, Demokritou P.

Nanotoxicology. 2014 Aug;8 Suppl 1:216-25. doi: 10.3109/17435390.2013.879612. Epub 2014 Jan 30.

40.

MARCOing monocytes for elimination.

Kobzik L, Swirski FK.

Sci Transl Med. 2014 Jan 15;6(219):219fs4. doi: 10.1126/scitranslmed.3008448.

41.

High hsCRP is associated with reduced lung function in structural firefighters.

Gaughan DM, Christiani DC, Hughes MD, Baur DM, Kobzik L, Wagner GR, Kales SN.

Am J Ind Med. 2014 Jan;57(1):31-7. doi: 10.1002/ajim.22260. Epub 2013 Sep 20.

PMID:
24115029
42.

Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation.

Gregory DJ, Zhang Y, Kobzik L, Fedulov AV.

Epigenetics. 2013 Nov;8(11):1205-12. doi: 10.4161/epi.26267. Epub 2013 Sep 5.

43.

Link between epigenomic alterations and genome-wide aberrant transcriptional response to allergen in dendritic cells conveying maternal asthma risk.

Mikhaylova L, Zhang Y, Kobzik L, Fedulov AV.

PLoS One. 2013 Aug 12;8(8):e70387. doi: 10.1371/journal.pone.0070387. eCollection 2013.

44.

Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone.

Kasahara DI, Williams AS, Benedito LA, Ranscht B, Kobzik L, Hug C, Shore SA.

PLoS One. 2013 Jun 6;8(6):e65829. doi: 10.1371/journal.pone.0065829. Print 2013.

45.

HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection.

MacLeod DT, Nakatsuji T, Yamasaki K, Kobzik L, Gallo RL.

Nat Commun. 2013;4:1963. doi: 10.1038/ncomms2963.

46.

Adam8 limits the development of allergic airway inflammation in mice.

Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA.

J Immunol. 2013 Jun 15;190(12):6434-49. doi: 10.4049/jimmunol.1202329. Epub 2013 May 13.

47.

Role of macrophage receptor with collagenous structure in innate immune tolerance.

Jing J, Yang IV, Hui L, Patel JA, Evans CM, Prikeris R, Kobzik L, O'Connor BP, Schwartz DA.

J Immunol. 2013 Jun 15;190(12):6360-7. doi: 10.4049/jimmunol.1202942. Epub 2013 May 10.

48.

Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice.

Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow J, Drazen JM.

Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L701-7. doi: 10.1152/ajplung.00259.2012. Epub 2013 Apr 5.

49.

Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury.

Craig VJ, Quintero PA, Fyfe SE, Patel AS, Knolle MD, Kobzik L, Owen CA.

J Immunol. 2013 Apr 15;190(8):4283-96. doi: 10.4049/jimmunol.1201043. Epub 2013 Mar 13.

50.

TRIF mediates Toll-like receptor 2-dependent inflammatory responses to Borrelia burgdorferi.

Petnicki-Ocwieja T, Chung E, Acosta DI, Ramos LT, Shin OS, Ghosh S, Kobzik L, Li X, Hu LT.

Infect Immun. 2013 Feb;81(2):402-10. doi: 10.1128/IAI.00890-12. Epub 2012 Nov 19.

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