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Items: 1 to 50 of 168

1.

The PedBE clock accurately estimates DNA methylation age in pediatric buccal cells.

McEwen LM, O'Donnell KJ, McGill MG, Edgar RD, Jones MJ, MacIsaac JL, Lin DTS, Ramadori K, Morin A, Gladish N, Garg E, Unternaehrer E, Pokhvisneva I, Karnani N, Kee MZL, Klengel T, Adler NE, Barr RG, Letourneau N, Giesbrecht GF, Reynolds JN, Czamara D, Armstrong JM, Essex MJ, de Weerth C, Beijers R, Tollenaar MS, Bradley B, Jovanovic T, Ressler KJ, Steiner M, Entringer S, Wadhwa PD, Buss C, Bush NR, Binder EB, Boyce WT, Meaney MJ, Horvath S, Kobor MS.

Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201820843. doi: 10.1073/pnas.1820843116. [Epub ahead of print]

PMID:
31611402
2.

Airway epithelial cell isolation techniques affect DNA methylation profiles with consequences for analysis of asthma related perturbations to DNA methylation.

Clifford RL, Patel J, MacIsaac JL, McEwen LM, Johnson SR, Shaw D, Knox AJ, Hackett TL, Kobor MS.

Sci Rep. 2019 Oct 8;9(1):14409. doi: 10.1038/s41598-019-50873-y.

3.

5-Hydroxymethylcytosine in cord blood and associations of DNA methylation with sex in newborns.

Solomon O, Macisaac JL, Tindula G, Kobor MS, Eskenazi B, Holland N.

Mutagenesis. 2019 Oct 6. pii: gez023. doi: 10.1093/mutage/gez023. [Epub ahead of print]

PMID:
31587037
4.

DNA methylation of HPA-axis genes and the onset of major depressive disorder in adolescent girls: a prospective analysis.

Humphreys KL, Moore SR, Davis EG, MacIsaac JL, Lin DTS, Kobor MS, Gotlib IH.

Transl Psychiatry. 2019 Oct 3;9(1):245. doi: 10.1038/s41398-019-0582-7.

5.

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.

Chang EY, Tsai S, Aristizabal MJ, Wells JP, Coulombe Y, Busatto FF, Chan YA, Kumar A, Dan Zhu Y, Wang AY, Fournier LA, Hieter P, Kobor MS, Masson JY, Stirling PC.

Nat Commun. 2019 Sep 19;10(1):4265. doi: 10.1038/s41467-019-12271-w.

6.

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA Polymerase II-CTD phosphatase, Fcp1 and Mediator kinase subunit, Cdk8 in yeast.

Aristizabal MJ, Dever K, Negri GL, Shen M, Hawe N, Benschop JJ, Holstege FC, Krogran NJ, Sadowski I, Kobor MS.

J Biol Chem. 2019 Sep 10. pii: jbc.RA119.008515. doi: 10.1074/jbc.RA119.008515. [Epub ahead of print]

7.

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy GM, Brooke RT, Watson JP, Good Z, Vasanawala SS, Maecker H, Leipold MD, Lin DTS, Kobor MS, Horvath S.

Aging Cell. 2019 Sep 8:e13028. doi: 10.1111/acel.13028. [Epub ahead of print]

8.

Social Environment and Epigenetics.

Merrill SM, Gladish N, Kobor MS.

Curr Top Behav Neurosci. 2019 Sep 5. doi: 10.1007/7854_2019_114. [Epub ahead of print]

PMID:
31485989
9.

Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.

Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19098-19108. doi: 10.1073/pnas.1813495116. Epub 2019 Aug 30.

PMID:
31471491
10.

Prenatal exposure to traffic-related air pollution, the gestational epigenetic clock, and risk of early-life allergic sensitization.

Sbihi H, Jones MJ, MacIsaac JL, Brauer M, Allen RW, Sears MR, Subbarao P, Mandhane PJ, Moraes TJ, Azad MB, Becker AB, Brook JR, Kobor MS, Turvey SE.

J Allergy Clin Immunol. 2019 Aug 27. pii: S0091-6749(19)31101-7. doi: 10.1016/j.jaci.2019.07.047. [Epub ahead of print] No abstract available.

PMID:
31470034
11.

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data.

Gervin K, Salas LA, Bakulski KM, van Zelm MC, Koestler DC, Wiencke JK, Duijts L, Moll HA, Kelsey KT, Kobor MS, Lyle R, Christensen BC, Felix JF, Jones MJ.

Clin Epigenetics. 2019 Aug 27;11(1):125. doi: 10.1186/s13148-019-0717-y.

12.

Gestational intermittent hypoxia induces endothelial dysfunction, reduces perivascular adiponectin and causes epigenetic changes in adult male offspring.

Badran M, Yassin BA, Lin DTS, Kobor MS, Ayas N, Laher I.

J Physiol. 2019 Aug 22. doi: 10.1113/JP277936. [Epub ahead of print]

PMID:
31441069
13.

Inflammation-related genes are associated with epigenetic aging in HIV.

Sundermann EE, Hussain MA, Moore DJ, Horvath S, Lin DTS, Kobor MS, Levine A; HNRP Group.

J Neurovirol. 2019 Jul 8. doi: 10.1007/s13365-019-00777-4. [Epub ahead of print]

PMID:
31286441
14.

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O'Donnell KJ, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Räikkönen K, Binder EB.

Nat Commun. 2019 Jun 11;10(1):2548. doi: 10.1038/s41467-019-10461-0.

15.

Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome.

Ong ML, Tuan TA, Poh J, Teh AL, Chen L, Pan H, MacIsaac JL, Kobor MS, Chong YS, Kwek K, Saw SM, Godfrey KM, Gluckman PD, Fortier MV, Karnani N, Meaney MJ, Qiu A, Holbrook JD.

Genes Brain Behav. 2019 Sep;18(7):e12576. doi: 10.1111/gbb.12576. Epub 2019 May 15.

PMID:
31020763
16.

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.

van Kuilenburg ABP, Tarailo-Graovac M, Richmond PA, Drögemöller BI, Pouladi MA, Leen R, Brand-Arzamendi K, Dobritzsch D, Dolzhenko E, Eberle MA, Hayward B, Jones MJ, Karbassi F, Kobor MS, Koster J, Kumari D, Li M, MacIsaac J, McDonald C, Meijer J, Nguyen C, Rajan-Babu IS, Scherer SW, Sim B, Trost B, Tseng LA, Turkenburg M, van Vugt JJFA, Veldink JH, Walia JS, Wang Y, van Weeghel M, Wright GEB, Xu X, Yuen RKC, Zhang J, Ross CJ, Wasserman WW, Geraghty MT, Santra S, Wanders RJA, Wen XY, Waterham HR, Usdin K, van Karnebeek CDM.

N Engl J Med. 2019 Apr 11;380(15):1433-1441. doi: 10.1056/NEJMoa1806627.

PMID:
30970188
17.

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.

Hari Dass SA, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP.

EBioMedicine. 2019 Apr;42:188-202. doi: 10.1016/j.ebiom.2019.03.051. Epub 2019 Mar 26.

18.

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.

Toepfer P, O'Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C.

J Am Acad Child Adolesc Psychiatry. 2019 Mar 9. pii: S0890-8567(19)30183-2. doi: 10.1016/j.jaac.2019.03.006. [Epub ahead of print]

PMID:
30858011
19.

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.

McDade TW, Ryan CP, Jones MJ, Hoke MK, Borja J, Miller GE, Kuzawa CW, Kobor MS.

Am J Phys Anthropol. 2019 May;169(1):3-11. doi: 10.1002/ajpa.23800. Epub 2019 Feb 16.

PMID:
30771258
20.

Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.

Wu Y, Lin X, Lim IY, Chen L, Teh AL, MacIsaac JL, Tan KH, Kobor MS, Chong YS, Gluckman PD, Karnani N.

Clin Epigenetics. 2019 Feb 11;11(1):26. doi: 10.1186/s13148-018-0599-4.

21.

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness.

Toepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C.

Psychoneuroendocrinology. 2019 May;103:156-162. doi: 10.1016/j.psyneuen.2019.01.013. Epub 2019 Jan 14.

22.

Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage.

Brown JAR, Kobor MS.

DNA Repair (Amst). 2019 Feb;74:1-16. doi: 10.1016/j.dnarep.2019.01.001. Epub 2019 Jan 6.

PMID:
30639951
23.

Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation.

Islam SA, Goodman SJ, MacIsaac JL, Obradović J, Barr RG, Boyce WT, Kobor MS.

Epigenetics Chromatin. 2019 Jan 2;12(1):1. doi: 10.1186/s13072-018-0245-6.

24.

Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.

Lussier AA, Bodnar TS, Mingay M, Morin AM, Hirst M, Kobor MS, Weinberg J.

Front Genet. 2018 Dec 4;9:610. doi: 10.3389/fgene.2018.00610. eCollection 2018.

25.

Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.

Husquin LT, Rotival M, Fagny M, Quach H, Zidane N, McEwen LM, MacIsaac JL, Kobor MS, Aschard H, Patin E, Quintana-Murci L.

Genome Biol. 2018 Dec 18;19(1):222. doi: 10.1186/s13059-018-1601-3.

26.

Early post-conception maternal cortisol, children's HPAA activity and DNA methylation profiles.

Barha CK, Salvante KG, Jones MJ, Farré P, Blais J, Kobor MS, Zeng L, Emberly E, Nepomnaschy PA.

J Dev Orig Health Dis. 2019 Feb;10(1):73-87. doi: 10.1017/S2040174418000880. Epub 2018 Nov 15.

PMID:
30428949
27.

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

Bush NR, Edgar RD, Park M, MacIsaac JL, McEwen LM, Adler NE, Essex MJ, Kobor MS, Boyce WT.

Epigenomics. 2018 Nov;10(11):1445-1461. doi: 10.2217/epi-2018-0042. Epub 2018 Oct 23.

28.

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array.

McEwen LM, Jones MJ, Lin DTS, Edgar RD, Husquin LT, MacIsaac JL, Ramadori KE, Morin AM, Rider CF, Carlsten C, Quintana-Murci L, Horvath S, Kobor MS.

Clin Epigenetics. 2018 Oct 16;10(1):123. doi: 10.1186/s13148-018-0556-2.

29.

Exposure to childhood abuse is associated with human sperm DNA methylation.

Roberts AL, Gladish N, Gatev E, Jones MJ, Chen Y, MacIsaac JL, Tworoger SS, Austin SB, Tanrikut C, Chavarro JE, Baccarelli AA, Kobor MS.

Transl Psychiatry. 2018 Oct 2;8(1):194. doi: 10.1038/s41398-018-0252-1.

30.

Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types.

Lin X, Tan JYL, Teh AL, Lim IY, Liew SJ, MacIsaac JL, Chong YS, Gluckman PD, Kobor MS, Cheong CY, Karnani N.

Epigenetics. 2018;13(9):941-958. doi: 10.1080/15592294.2018.1522929. Epub 2018 Oct 11.

31.

Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood.

Goodman SJ, Roubinov DS, Bush NR, Park M, Farré P, Emberly E, Hertzman C, Essex MJ, Kobor MS, Boyce WT.

Dev Sci. 2019 Mar;22(2):e12739. doi: 10.1111/desc.12739. Epub 2018 Sep 21.

PMID:
30176105
32.

PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.

Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O'Donnell KJ.

BMC Bioinformatics. 2018 Aug 8;19(1):295. doi: 10.1186/s12859-018-2289-9.

33.

Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?

Moore SR, Kobor MS.

Mol Psychiatry. 2018 Aug 6. doi: 10.1038/s41380-018-0121-6. [Epub ahead of print] No abstract available.

PMID:
30082839
34.

An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior.

Conradt E, Adkins DE, Crowell SE, Monk C, Kobor MS.

Dev Psychopathol. 2018 Aug;30(3):881-890. doi: 10.1017/S0954579418000688. Review.

35.

The early care environment and DNA methylome variation in childhood.

Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ; Mavan Study Team.

Dev Psychopathol. 2018 Aug;30(3):891-903. doi: 10.1017/S0954579418000627.

PMID:
30068421
36.

Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children.

Solomon O, MacIsaac J, Quach H, Tindula G, Kobor MS, Huen K, Meaney MJ, Eskenazi B, Barcellos LF, Holland N.

Epigenetics. 2018;13(6):655-664. doi: 10.1080/15592294.2018.1497386. Epub 2018 Aug 15.

37.

Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women.

Ryan CP, Hayes MG, Lee NR, McDade TW, Jones MJ, Kobor MS, Kuzawa CW, Eisenberg DTA.

Sci Rep. 2018 Jul 23;8(1):11100. doi: 10.1038/s41598-018-29486-4.

38.

Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes.

Austin MK, Chen E, Ross KM, McEwen LM, Maclsaac JL, Kobor MS, Miller GE.

Psychoneuroendocrinology. 2018 Nov;97:131-134. doi: 10.1016/j.psyneuen.2018.07.007. Epub 2018 Jul 5.

PMID:
30016711
39.

Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.

Horvath S, Stein DJ, Phillips N, Heany SJ, Kobor MS, Lin DTS, Myer L, Zar HJ, Levine AJ, Hoare J.

AIDS. 2018 Jul 17;32(11):1465-1474. doi: 10.1097/QAD.0000000000001854.

40.

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, Brandsma CA, Nair P, Kobor MS, Hackett TL, Knox AJ.

Clin Epigenetics. 2018 Mar 5;10:32. doi: 10.1186/s13148-018-0464-5. eCollection 2018.

41.

Epigenetic analysis of human postmortem brain tissue.

Islam SA, Lussier AA, Kobor MS.

Handb Clin Neurol. 2018;150:237-261. doi: 10.1016/B978-0-444-63639-3.00017-7. Review.

PMID:
29496144
42.

Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.

Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT.

Epigenetics. 2018;13(1):19-32. doi: 10.1080/15592294.2017.1411443. Epub 2018 Jan 30.

43.

DNA methylation as a predictor of fetal alcohol spectrum disorder.

Lussier AA, Morin AM, MacIsaac JL, Salmon J, Weinberg J, Reynolds JN, Pavlidis P, Chudley AE, Kobor MS.

Clin Epigenetics. 2018 Jan 12;10:5. doi: 10.1186/s13148-018-0439-6. eCollection 2018.

44.

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

O'Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ.

Transl Psychiatry. 2018 Jan 10;8(1):15. doi: 10.1038/s41398-017-0063-9.

45.

Choice of surrogate tissue influences neonatal EWAS findings.

Lin X, Teh AL, Chen L, Lim IY, Tan PF, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Lee YS, Holbrook JD, Godfrey KM, Meaney MJ, Kobor MS, Chong YS, Gluckman PD, Karnani N.

BMC Med. 2017 Dec 5;15(1):211. doi: 10.1186/s12916-017-0970-x.

46.

Worldwide patterns of human epigenetic variation.

Carja O, MacIsaac JL, Mah SM, Henn BM, Kobor MS, Feldman MW, Fraser HB.

Nat Ecol Evol. 2017 Oct;1(10):1577-1583. doi: 10.1038/s41559-017-0299-z. Epub 2017 Aug 28.

PMID:
29185505
47.

Epigenetic correlates of neonatal contact in humans.

Moore SR, McEwen LM, Quirt J, Morin A, Mah SM, Barr RG, Boyce WT, Kobor MS.

Dev Psychopathol. 2017 Dec;29(5):1517-1538. doi: 10.1017/S0954579417001213.

PMID:
29162165
48.

DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.

McEwen LM, Gatev EG, Jones MJ, MacIsaac JL, McAllister MM, Goulding RE, Madden KM, Dawes MG, Kobor MS, Ashe MC.

Appl Physiol Nutr Metab. 2018 Mar;43(3):233-239. doi: 10.1139/apnm-2017-0436. Epub 2017 Oct 19.

PMID:
29049890
49.

RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.

Chang EY, Novoa CA, Aristizabal MJ, Coulombe Y, Segovia R, Chaturvedi R, Shen Y, Keong C, Tam AS, Jones SJM, Masson JY, Kobor MS, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):3991-4005. doi: 10.1083/jcb.201703168. Epub 2017 Oct 17.

50.

Principles and Challenges of Applying Epigenetic Epidemiology to Psychology.

Jones MJ, Moore SR, Kobor MS.

Annu Rev Psychol. 2018 Jan 4;69:459-485. doi: 10.1146/annurev-psych-122414-033653. Epub 2017 Oct 16. Review.

PMID:
29035689

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