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Items: 1 to 50 of 156

1.

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.

Czamara D, Eraslan G, Page CM, Lahti J, Lahti-Pulkkinen M, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Nystad W, Håberg SE, London SJ, O'Donnell KJ, Garg E, Meaney MJ, Entringer S, Wadhwa PD, Buss C, Jones MJ, Lin DTS, MacIsaac JL, Kobor MS, Koen N, Zar HJ, Koenen KC, Dalvie S, Stein DJ, Kondofersky I, Müller NS, Theis FJ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Räikkönen K, Binder EB.

Nat Commun. 2019 Jun 11;10(1):2548. doi: 10.1038/s41467-019-10461-0.

PMID:
31186427
2.

Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome.

Ong ML, Tuan TA, Poh J, Teh AL, Chen L, Pan H, MacIsaac JL, Kobor MS, Chong YS, Kwek K, Saw SM, Godfrey KM, Gluckman PD, Fortier MV, Karnani N, Meaney MJ, Qiu A, Holbrook JD.

Genes Brain Behav. 2019 Apr 24:e12576. doi: 10.1111/gbb.12576. [Epub ahead of print]

PMID:
31020763
3.

Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.

van Kuilenburg ABP, Tarailo-Graovac M, Richmond PA, Drögemöller BI, Pouladi MA, Leen R, Brand-Arzamendi K, Dobritzsch D, Dolzhenko E, Eberle MA, Hayward B, Jones MJ, Karbassi F, Kobor MS, Koster J, Kumari D, Li M, MacIsaac J, McDonald C, Meijer J, Nguyen C, Rajan-Babu IS, Scherer SW, Sim B, Trost B, Tseng LA, Turkenburg M, van Vugt JJFA, Veldink JH, Walia JS, Wang Y, van Weeghel M, Wright GEB, Xu X, Yuen RKC, Zhang J, Ross CJ, Wasserman WW, Geraghty MT, Santra S, Wanders RJA, Wen XY, Waterham HR, Usdin K, van Karnebeek CDM.

N Engl J Med. 2019 Apr 11;380(15):1433-1441. doi: 10.1056/NEJMoa1806627.

PMID:
30970188
4.

A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions.

Hari Dass SA, McCracken K, Pokhvisneva I, Chen LM, Garg E, Nguyen TTT, Wang Z, Barth B, Yaqubi M, McEwen LM, MacIsaac JL, Diorio J, Kobor MS, O'Donnell KJ, Meaney MJ, Silveira PP.

EBioMedicine. 2019 Apr;42:188-202. doi: 10.1016/j.ebiom.2019.03.051. Epub 2019 Mar 26.

5.

A Role of Oxytocin Receptor Gene Brain Tissue Expression Quantitative Trait Locus rs237895 in the Intergenerational Transmission of the Effects of Maternal Childhood Maltreatment.

Toepfer P, O Donnell KJ, Entringer S, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C.

J Am Acad Child Adolesc Psychiatry. 2019 Mar 8. pii: S0890-8567(19)30183-2. doi: 10.1016/j.jaac.2019.03.006. [Epub ahead of print]

PMID:
30858011
6.

Genome-wide analysis of DNA methylation in relation to socioeconomic status during development and early adulthood.

McDade TW, Ryan CP, Jones MJ, Hoke MK, Borja J, Miller GE, Kuzawa CW, Kobor MS.

Am J Phys Anthropol. 2019 May;169(1):3-11. doi: 10.1002/ajpa.23800. Epub 2019 Feb 16.

PMID:
30771258
7.

Analysis of two birth tissues provides new insights into the epigenetic landscape of neonates born preterm.

Wu Y, Lin X, Lim IY, Chen L, Teh AL, MacIsaac JL, Tan KH, Kobor MS, Chong YS, Gluckman PD, Karnani N.

Clin Epigenetics. 2019 Feb 11;11(1):26. doi: 10.1186/s13148-018-0599-4.

8.

Dynamic DNA methylation changes in the maternal oxytocin gene locus (OXT) during pregnancy predict postpartum maternal intrusiveness.

Toepfer P, O'Donnell KJ, Entringer S, Garg E, Heim CM, Lin DTS, MacIsaac JL, Kobor MS, Meaney MJ, Provençal N, Binder EB, Wadhwa PD, Buss C.

Psychoneuroendocrinology. 2019 May;103:156-162. doi: 10.1016/j.psyneuen.2019.01.013. Epub 2019 Jan 14.

9.

Budding yeast Rtt107 prevents checkpoint hyperactivation after replicative stress by limiting DNA damage.

Brown JAR, Kobor MS.

DNA Repair (Amst). 2019 Feb;74:1-16. doi: 10.1016/j.dnarep.2019.01.001. Epub 2019 Jan 6.

PMID:
30639951
10.

Integration of DNA methylation patterns and genetic variation in human pediatric tissues help inform EWAS design and interpretation.

Islam SA, Goodman SJ, MacIsaac JL, Obradović J, Barr RG, Boyce WT, Kobor MS.

Epigenetics Chromatin. 2019 Jan 2;12(1):1. doi: 10.1186/s13072-018-0245-6.

11.

Prenatal Alcohol Exposure: Profiling Developmental DNA Methylation Patterns in Central and Peripheral Tissues.

Lussier AA, Bodnar TS, Mingay M, Morin AM, Hirst M, Kobor MS, Weinberg J.

Front Genet. 2018 Dec 4;9:610. doi: 10.3389/fgene.2018.00610. eCollection 2018.

12.

Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation.

Husquin LT, Rotival M, Fagny M, Quach H, Zidane N, McEwen LM, MacIsaac JL, Kobor MS, Aschard H, Patin E, Quintana-Murci L.

Genome Biol. 2018 Dec 18;19(1):222. doi: 10.1186/s13059-018-1601-3.

13.

Early post-conception maternal cortisol, children's HPAA activity and DNA methylation profiles.

Barha CK, Salvante KG, Jones MJ, Farré P, Blais J, Kobor MS, Zeng L, Emberly E, Nepomnaschy PA.

J Dev Orig Health Dis. 2019 Feb;10(1):73-87. doi: 10.1017/S2040174418000880. Epub 2018 Nov 15.

PMID:
30428949
14.

The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

Bush NR, Edgar RD, Park M, MacIsaac JL, McEwen LM, Adler NE, Essex MJ, Kobor MS, Boyce WT.

Epigenomics. 2018 Nov;10(11):1445-1461. doi: 10.2217/epi-2018-0042. Epub 2018 Oct 23.

15.

Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array.

McEwen LM, Jones MJ, Lin DTS, Edgar RD, Husquin LT, MacIsaac JL, Ramadori KE, Morin AM, Rider CF, Carlsten C, Quintana-Murci L, Horvath S, Kobor MS.

Clin Epigenetics. 2018 Oct 16;10(1):123. doi: 10.1186/s13148-018-0556-2.

16.

Exposure to childhood abuse is associated with human sperm DNA methylation.

Roberts AL, Gladish N, Gatev E, Jones MJ, Chen Y, MacIsaac JL, Tworoger SS, Austin SB, Tanrikut C, Chavarro JE, Baccarelli AA, Kobor MS.

Transl Psychiatry. 2018 Oct 2;8(1):194. doi: 10.1038/s41398-018-0252-1.

17.

Cell type-specific DNA methylation in neonatal cord tissue and cord blood: a 850K-reference panel and comparison of cell types.

Lin X, Tan JYL, Teh AL, Lim IY, Liew SJ, MacIsaac JL, Chong YS, Gluckman PD, Kobor MS, Cheong CY, Karnani N.

Epigenetics. 2018;13(9):941-958. doi: 10.1080/15592294.2018.1522929. Epub 2018 Oct 11.

18.

Children's biobehavioral reactivity to challenge predicts DNA methylation in adolescence and emerging adulthood.

Goodman SJ, Roubinov DS, Bush NR, Park M, Farré P, Emberly E, Hertzman C, Essex MJ, Kobor MS, Boyce WT.

Dev Sci. 2019 Mar;22(2):e12739. doi: 10.1111/desc.12739. Epub 2018 Sep 21.

PMID:
30176105
19.

PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores.

Chen LM, Yao N, Garg E, Zhu Y, Nguyen TTT, Pokhvisneva I, Hari Dass SA, Unternaehrer E, Gaudreau H, Forest M, McEwen LM, MacIsaac JL, Kobor MS, Greenwood CMT, Silveira PP, Meaney MJ, O'Donnell KJ.

BMC Bioinformatics. 2018 Aug 8;19(1):295. doi: 10.1186/s12859-018-2289-9.

20.

Variability in DNA methylation at the serotonin transporter gene promoter: epigenetic mechanism or cell-type artifact?

Moore SR, Kobor MS.

Mol Psychiatry. 2018 Aug 6. doi: 10.1038/s41380-018-0121-6. [Epub ahead of print] No abstract available.

PMID:
30082839
21.

An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior.

Conradt E, Adkins DE, Crowell SE, Monk C, Kobor MS.

Dev Psychopathol. 2018 Aug;30(3):881-890. doi: 10.1017/S0954579418000688. Review.

22.

The early care environment and DNA methylome variation in childhood.

Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ; Mavan Study Team.

Dev Psychopathol. 2018 Aug;30(3):891-903. doi: 10.1017/S0954579418000627.

PMID:
30068421
23.

Comparison of DNA methylation measured by Illumina 450K and EPIC BeadChips in blood of newborns and 14-year-old children.

Solomon O, MacIsaac J, Quach H, Tindula G, Kobor MS, Huen K, Meaney MJ, Eskenazi B, Barcellos LF, Holland N.

Epigenetics. 2018;13(6):655-664. doi: 10.1080/15592294.2018.1497386. Epub 2018 Aug 15.

24.

Reproduction predicts shorter telomeres and epigenetic age acceleration among young adult women.

Ryan CP, Hayes MG, Lee NR, McDade TW, Jones MJ, Kobor MS, Kuzawa CW, Eisenberg DTA.

Sci Rep. 2018 Jul 23;8(1):11100. doi: 10.1038/s41598-018-29486-4.

25.

Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes.

Austin MK, Chen E, Ross KM, McEwen LM, Maclsaac JL, Kobor MS, Miller GE.

Psychoneuroendocrinology. 2018 Nov;97:131-134. doi: 10.1016/j.psyneuen.2018.07.007. Epub 2018 Jul 5.

PMID:
30016711
26.

Perinatally acquired HIV infection accelerates epigenetic aging in South African adolescents.

Horvath S, Stein DJ, Phillips N, Heany SJ, Kobor MS, Lin DTS, Myer L, Zar HJ, Levine AJ, Hoare J.

AIDS. 2018 Jul 17;32(11):1465-1474. doi: 10.1097/QAD.0000000000001854.

PMID:
29746298
27.

Cysteinyl Leukotriene Receptor 1 and Health Effects of Particulate Exposure in Asthma.

Rabinovitch N, Jones MJ, Faino A, Strand M, Morin AM, MacIsaac J, Reynolds PR, Singh A, Kobor MS, Gelfand EW, Carlsten C.

Ann Am Thorac Soc. 2018 Apr;15(Supplement_2):S129. doi: 10.1513/AnnalsATS.201706-469MG.

28.

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD.

Clifford RL, Fishbane N, Patel J, MacIsaac JL, McEwen LM, Fisher AJ, Brandsma CA, Nair P, Kobor MS, Hackett TL, Knox AJ.

Clin Epigenetics. 2018 Mar 5;10:32. doi: 10.1186/s13148-018-0464-5. eCollection 2018.

29.

Epigenetic analysis of human postmortem brain tissue.

Islam SA, Lussier AA, Kobor MS.

Handb Clin Neurol. 2018;150:237-261. doi: 10.1016/B978-0-444-63639-3.00017-7. Review.

PMID:
29496144
30.

Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time.

Forest M, O'Donnell KJ, Voisin G, Gaudreau H, MacIsaac JL, McEwen LM, Silveira PP, Steiner M, Kobor MS, Meaney MJ, Greenwood CMT.

Epigenetics. 2018;13(1):19-32. doi: 10.1080/15592294.2017.1411443. Epub 2018 Jan 30.

31.

DNA methylation as a predictor of fetal alcohol spectrum disorder.

Lussier AA, Morin AM, MacIsaac JL, Salmon J, Weinberg J, Reynolds JN, Pavlidis P, Chudley AE, Kobor MS.

Clin Epigenetics. 2018 Jan 12;10:5. doi: 10.1186/s13148-018-0439-6. eCollection 2018.

32.

DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up.

O'Donnell KJ, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ.

Transl Psychiatry. 2018 Jan 10;8(1):15. doi: 10.1038/s41398-017-0063-9.

33.

Choice of surrogate tissue influences neonatal EWAS findings.

Lin X, Teh AL, Chen L, Lim IY, Tan PF, MacIsaac JL, Morin AM, Yap F, Tan KH, Saw SM, Lee YS, Holbrook JD, Godfrey KM, Meaney MJ, Kobor MS, Chong YS, Gluckman PD, Karnani N.

BMC Med. 2017 Dec 5;15(1):211. doi: 10.1186/s12916-017-0970-x.

34.

Worldwide patterns of human epigenetic variation.

Carja O, MacIsaac JL, Mah SM, Henn BM, Kobor MS, Feldman MW, Fraser HB.

Nat Ecol Evol. 2017 Oct;1(10):1577-1583. doi: 10.1038/s41559-017-0299-z. Epub 2017 Aug 28.

PMID:
29185505
35.

Epigenetic correlates of neonatal contact in humans.

Moore SR, McEwen LM, Quirt J, Morin A, Mah SM, Barr RG, Boyce WT, Kobor MS.

Dev Psychopathol. 2017 Dec;29(5):1517-1538. doi: 10.1017/S0954579417001213.

PMID:
29162165
36.

DNA methylation signatures in peripheral blood mononuclear cells from a lifestyle intervention for women at midlife: a pilot randomized controlled trial.

McEwen LM, Gatev EG, Jones MJ, MacIsaac JL, McAllister MM, Goulding RE, Madden KM, Dawes MG, Kobor MS, Ashe MC.

Appl Physiol Nutr Metab. 2018 Mar;43(3):233-239. doi: 10.1139/apnm-2017-0436. Epub 2017 Oct 19.

PMID:
29049890
37.

RECQ-like helicases Sgs1 and BLM regulate R-loop-associated genome instability.

Chang EY, Novoa CA, Aristizabal MJ, Coulombe Y, Segovia R, Chaturvedi R, Shen Y, Keong C, Tam AS, Jones SJM, Masson JY, Kobor MS, Stirling PC.

J Cell Biol. 2017 Dec 4;216(12):3991-4005. doi: 10.1083/jcb.201703168. Epub 2017 Oct 17.

38.

Principles and Challenges of Applying Epigenetic Epidemiology to Psychology.

Jones MJ, Moore SR, Kobor MS.

Annu Rev Psychol. 2018 Jan 4;69:459-485. doi: 10.1146/annurev-psych-122414-033653. Epub 2017 Oct 16. Review.

PMID:
29035689
39.

DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly.

Verschoor CP, McEwen LM, Kobor MS, Loeb MB, Bowdish DME.

Exp Gerontol. 2018 May;105:47-52. doi: 10.1016/j.exger.2017.10.010. Epub 2017 Oct 12.

PMID:
29032243
40.

Birth weight and postnatal microbial exposures predict the distribution of peripheral blood leukocyte subsets in young adults in the Philippines.

McDade TW, Jones MJ, Miller G, Borja J, Kobor MS, Kuzawa CW.

J Dev Orig Health Dis. 2018 Apr;9(2):198-207. doi: 10.1017/S2040174417000794. Epub 2017 Oct 11.

PMID:
29017617
41.

Exploring genetic influences underlying acute aerobic exercise effects on motor learning.

Mang CS, McEwen LM, MacIsaac JL, Snow NJ, Campbell KL, Kobor MS, Ross CJD, Boyd LA.

Sci Rep. 2017 Sep 21;7(1):12123. doi: 10.1038/s41598-017-12422-3.

42.

Accelerated DNA methylation age in adolescent girls: associations with elevated diurnal cortisol and reduced hippocampal volume.

Davis EG, Humphreys KL, McEwen LM, Sacchet MD, Camacho MC, MacIsaac JL, Lin DTS, Kobor MS, Gotlib IH.

Transl Psychiatry. 2017 Aug 29;7(8):e1223. doi: 10.1038/tp.2017.188.

43.

Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs.

Morin AM, Gatev E, McEwen LM, MacIsaac JL, Lin DTS, Koen N, Czamara D, Räikkönen K, Zar HJ, Koenen K, Stein DJ, Kobor MS, Jones MJ.

Clin Epigenetics. 2017 Jul 25;9:75. doi: 10.1186/s13148-017-0370-2. eCollection 2017.

44.

BECon: a tool for interpreting DNA methylation findings from blood in the context of brain.

Edgar RD, Jones MJ, Meaney MJ, Turecki G, Kobor MS.

Transl Psychiatry. 2017 Aug 1;7(8):e1187. doi: 10.1038/tp.2017.171.

45.

Blood and nasal epigenetics correlate with allergic rhinitis symptom development in the environmental exposure unit.

North ML, Jones MJ, MacIsaac JL, Morin AM, Steacy LM, Gregor A, Kobor MS, Ellis AK.

Allergy. 2018 Jan;73(1):196-205. doi: 10.1111/all.13263. Epub 2017 Sep 22.

PMID:
28755526
46.

DNA methylation signatures of chronic alcohol dependence in purified CD3+ T-cells of patients undergoing alcohol treatment.

Brückmann C, Islam SA, MacIsaac JL, Morin AM, Karle KN, Di Santo A, Wüst R, Lang I, Batra A, Kobor MS, Nieratschker V.

Sci Rep. 2017 Jul 26;7(1):6605. doi: 10.1038/s41598-017-06847-z.

47.

Social and physical environments early in development predict DNA methylation of inflammatory genes in young adulthood.

McDade TW, Ryan C, Jones MJ, MacIsaac JL, Morin AM, Meyer JM, Borja JB, Miller GE, Kobor MS, Kuzawa CW.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7611-7616. doi: 10.1073/pnas.1620661114. Epub 2017 Jul 3.

48.

The relation between DNA methylation patterns and serum cytokine levels in community-dwelling adults: a preliminary study.

Verschoor CP, McEwen LM, Kohli V, Wolfson C, Bowdish DM, Raina P, Kobor MS, Balion C.

BMC Genet. 2017 Jun 21;18(1):57. doi: 10.1186/s12863-017-0525-3.

49.

Trends in DNA Methylation with Age Replicate Across Diverse Human Populations.

Gopalan S, Carja O, Fagny M, Patin E, Myrick JW, McEwen LM, Mah SM, Kobor MS, Froment A, Feldman MW, Quintana-Murci L, Henn BM.

Genetics. 2017 Jul;206(3):1659-1674. doi: 10.1534/genetics.116.195594. Epub 2017 May 22.

50.

Associations between maternal risk factors of adverse pregnancy and birth outcomes and the offspring epigenetic clock of gestational age at birth.

Girchenko P, Lahti J, Czamara D, Knight AK, Jones MJ, Suarez A, Hämäläinen E, Kajantie E, Laivuori H, Villa PM, Reynolds RM, Kobor MS, Smith AK, Binder EB, Räikkönen K.

Clin Epigenetics. 2017 May 8;9:49. doi: 10.1186/s13148-017-0349-z. eCollection 2017.

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