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Items: 1 to 50 of 299

1.

Conformational Plasticity of Human Protease-Activated Receptor 1 upon Antagonist- and Agonist-Binding.

Spoerri PM, Sapra KT, Zhang C, Mari SA, Kato HE, Kobilka BK, Müller DJ.

Structure. 2019 Oct 1;27(10):1517-1526.e3. doi: 10.1016/j.str.2019.07.014. Epub 2019 Aug 15.

PMID:
31422910
2.

Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs.

Jain MK, Cheung VG, Utz PJ, Kobilka BK, Yamada T, Lefkowitz R.

N Engl J Med. 2019 Aug 1;381(5):399-402. doi: 10.1056/NEJMp1904482. No abstract available.

PMID:
31365796
3.

Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability.

Sadaf A, Ramos M, Mortensen JS, Du Y, Bae HE, Munk CF, Hariharan P, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS.

ACS Chem Biol. 2019 Aug 16;14(8):1717-1726. doi: 10.1021/acschembio.9b00166. Epub 2019 Jul 29.

PMID:
31305987
4.

Mechanism of β2AR regulation by an intracellular positive allosteric modulator.

Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B.

Science. 2019 Jun 28;364(6447):1283-1287. doi: 10.1126/science.aaw8981. Epub 2019 Jun 27.

5.

Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability.

Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chemistry. 2019 Sep 2;25(49):11545-11554. doi: 10.1002/chem.201902468. Epub 2019 Aug 5.

PMID:
31243822
6.

Conformational transitions of a neurotensin receptor 1-Gi1 complex.

Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G.

Nature. 2019 Aug;572(7767):80-85. doi: 10.1038/s41586-019-1337-6. Epub 2019 Jun 26.

PMID:
31243364
7.

Selective modulation of the cannabinoid type 1 (CB1) receptor as an emerging platform for the treatment of neuropathic pain.

Banister SD, Krishna Kumar K, Kumar V, Kobilka BK, Malhotra SV.

Medchemcomm. 2019 Mar 18;10(5):647-659. doi: 10.1039/c8md00595h. eCollection 2019 May 1. Review.

PMID:
31191856
8.

Local membrane charge regulates β2 adrenergic receptor coupling to Gi3.

Strohman MJ, Maeda S, Hilger D, Masureel M, Du Y, Kobilka BK.

Nat Commun. 2019 May 20;10(1):2234. doi: 10.1038/s41467-019-10108-0.

9.

Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy.

Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Maeda S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK.

Mol Cell. 2019 Jul 11;75(1):53-65.e7. doi: 10.1016/j.molcel.2019.04.028. Epub 2019 May 15.

PMID:
31103421
10.

Structural Insights into the Process of GPCR-G Protein Complex Formation.

Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixà-González R, Mathiesen JM, Hildebrand PW, Kobilka BK.

Cell. 2019 May 16;177(5):1243-1251.e12. doi: 10.1016/j.cell.2019.04.021. Epub 2019 May 9.

PMID:
31080070
11.

Assembly of a GPCR-G Protein Complex.

Du Y, Duc NM, Rasmussen SGF, Hilger D, Kubiak X, Wang L, Bohon J, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee J, Chance MR, Lodowski DT, Kobilka BK, Chung KY.

Cell. 2019 May 16;177(5):1232-1242.e11. doi: 10.1016/j.cell.2019.04.022. Epub 2019 May 9.

PMID:
31080064
12.

Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK.

Science. 2019 May 10;364(6440):552-557. doi: 10.1126/science.aaw5188.

PMID:
31073061
13.

Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability.

Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Seok Chae P.

Org Biomol Chem. 2019 May 15;17(19):4919-4920. doi: 10.1039/c9ob90075f.

PMID:
31062815
14.

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study.

Ehsan M, Kumar A, Mortensen JS, Du Y, Hariharan P, Kumar KK, Ha B, Byrne B, Guan L, Kobilka BK, Loland CJ, Chae PS.

Chem Asian J. 2019 Jun 3;14(11):1926-1931. doi: 10.1002/asia.201900224. Epub 2019 Apr 10.

PMID:
30969484
15.

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability.

Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Chae PS.

Org Biomol Chem. 2019 Mar 20;17(12):3249-3257. doi: 10.1039/c8ob03153c. Erratum in: Org Biomol Chem. 2019 May 15;17(19):4919-4920.

PMID:
30843907
16.

Author Correction: Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Mar;567(7747):E10. doi: 10.1038/s41586-019-0983-z.

PMID:
30814739
17.

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability.

Bae HE, Du Y, Hariharan P, Mortensen JS, Kumar KK, Ha B, Das M, Lee HS, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chem Sci. 2018 Nov 5;10(4):1107-1116. doi: 10.1039/c8sc02560f. eCollection 2019 Jan 28.

18.

Diverse GPCRs exhibit conserved water networks for stabilization and activation.

Venkatakrishnan AJ, Ma AK, Fonseca R, Latorraca NR, Kelly B, Betz RM, Asawa C, Kobilka BK, Dror RO.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3288-3293. doi: 10.1073/pnas.1809251116. Epub 2019 Feb 6.

19.

Structural insights into the activation of metabotropic glutamate receptors.

Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK.

Nature. 2019 Feb;566(7742):79-84. doi: 10.1038/s41586-019-0881-4. Epub 2019 Jan 23. Erratum in: Nature. 2019 Mar;567(7747):E10.

20.

An improved yeast surface display platform for the screening of nanobody immune libraries.

Uchański T, Zögg T, Yin J, Yuan D, Wohlkönig A, Fischer B, Rosenbaum DM, Kobilka BK, Pardon E, Steyaert J.

Sci Rep. 2019 Jan 23;9(1):382. doi: 10.1038/s41598-018-37212-3.

21.

Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.

Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G.

Cell. 2019 Jan 24;176(3):448-458.e12. doi: 10.1016/j.cell.2018.11.040. Epub 2019 Jan 10.

PMID:
30639101
22.

Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations.

Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ.

Cell. 2019 Jan 24;176(3):468-478.e11. doi: 10.1016/j.cell.2018.12.005. Epub 2019 Jan 10.

PMID:
30639099
23.

Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2019 Feb;15(2):205. doi: 10.1038/s41589-018-0182-5.

PMID:
30504785
24.

Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor.

Suno R, Lee S, Maeda S, Yasuda S, Yamashita K, Hirata K, Horita S, Tawaramoto MS, Tsujimoto H, Murata T, Kinoshita M, Yamamoto M, Kobilka BK, Vaidehi N, Iwata S, Kobayashi T.

Nat Chem Biol. 2018 Dec;14(12):1150-1158. doi: 10.1038/s41589-018-0152-y. Epub 2018 Nov 12.

25.

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.

Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):12046-12050. doi: 10.1073/pnas.1813988115. Epub 2018 Nov 7.

26.

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability.

Hussain H, Helton T, Du Y, Mortensen JS, Hariharan P, Ehsan M, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS.

Analyst. 2018 Nov 19;143(23):5702-5710. doi: 10.1039/c8an01408f.

PMID:
30334564
27.

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.

Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK.

Nat Chem Biol. 2018 Nov;14(11):1059-1066. doi: 10.1038/s41589-018-0145-x. Epub 2018 Oct 16. Erratum in: Nat Chem Biol. 2019 Feb;15(2):205.

28.

Development of an antibody fragment that stabilizes GPCR/G-protein complexes.

Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK.

Nat Commun. 2018 Sep 13;9(1):3712. doi: 10.1038/s41467-018-06002-w.

29.

Structural mechanisms of selectivity and gating in anion channelrhodopsins.

Kato HE, Kim YS, Paggi JM, Evans KE, Allen WE, Richardson C, Inoue K, Ito S, Ramakrishnan C, Fenno LE, Yamashita K, Hilger D, Lee SY, Berndt A, Shen K, Kandori H, Dror RO, Kobilka BK, Deisseroth K.

Nature. 2018 Sep;561(7723):349-354. doi: 10.1038/s41586-018-0504-5. Epub 2018 Aug 29.

30.

Crystal structure of the natural anion-conducting channelrhodopsin GtACR1.

Kim YS, Kato HE, Yamashita K, Ito S, Inoue K, Ramakrishnan C, Fenno LE, Evans KE, Paggi JM, Dror RO, Kandori H, Kobilka BK, Deisseroth K.

Nature. 2018 Sep;561(7723):343-348. doi: 10.1038/s41586-018-0511-6. Epub 2018 Aug 29.

31.

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy.

Das M, Du Y, Mortensen JS, Hariharan P, Lee HS, Byrne B, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chembiochem. 2018 Oct 18;19(20):2225-2232. doi: 10.1002/cbic.201800388. Epub 2018 Sep 21.

PMID:
30070754
32.

Single Proteoliposome High-Content Analysis Reveals Differences in the Homo-Oligomerization of GPCRs.

Walsh SM, Mathiasen S, Christensen SM, Fay JF, King C, Provasi D, Borrero E, Rasmussen SGF, Fung JJ, Filizola M, Hristova K, Kobilka B, Farrens DL, Stamou D.

Biophys J. 2018 Jul 17;115(2):300-312. doi: 10.1016/j.bpj.2018.05.036.

33.

The Molecular Basis of G Protein-Coupled Receptor Activation.

Weis WI, Kobilka BK.

Annu Rev Biochem. 2018 Jun 20;87:897-919. doi: 10.1146/annurev-biochem-060614-033910. Review.

34.

Structure of the µ-opioid receptor-Gi protein complex.

Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK.

Nature. 2018 Jun;558(7711):547-552. doi: 10.1038/s41586-018-0219-7. Epub 2018 Jun 13.

35.

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.

Das M, Du Y, Mortensen JS, Bae HE, Byrne B, Loland CJ, Kobilka BK, Chae PS.

Chemistry. 2018 Jul 11;24(39):9860-9868. doi: 10.1002/chem.201801141. Epub 2018 Jun 13.

PMID:
29741269
36.

Structural Properties of the Human Protease-Activated Receptor 1 Changing by a Strong Antagonist.

Spoerri PM, Kato HE, Pfreundschuh M, Mari SA, Serdiuk T, Thoma J, Sapra KT, Zhang C, Kobilka BK, Müller DJ.

Structure. 2018 Jun 5;26(6):829-838.e4. doi: 10.1016/j.str.2018.03.020. Epub 2018 May 3.

37.

Steroid-Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability.

Ehsan M, Das M, Stern V, Du Y, Mortensen JS, Hariharan P, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS.

Chembiochem. 2018 Jul 4;19(13):1433-1443. doi: 10.1002/cbic.201800106. Epub 2018 May 29.

PMID:
29660780
38.

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.

Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS.

Chem Sci. 2017 Dec 1;8(12):8315-8324. doi: 10.1039/c7sc03700g. Epub 2017 Oct 25.

39.

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

Org Biomol Chem. 2018 Apr 4;16(14):2489-2498. doi: 10.1039/C8OB00270C.

40.

Structure-based discovery of selective positive allosteric modulators of antagonists for the M2 muscarinic acetylcholine receptor.

Korczynska M, Clark MJ, Valant C, Xu J, Moo EV, Albold S, Weiss DR, Torosyan H, Huang W, Kruse AC, Lyda BR, May LT, Baltos JA, Sexton PM, Kobilka BK, Christopoulos A, Shoichet BK, Sunahara RK.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2419-E2428. doi: 10.1073/pnas.1718037115. Epub 2018 Feb 16.

41.

Structure and dynamics of GPCR signaling complexes.

Hilger D, Masureel M, Kobilka BK.

Nat Struct Mol Biol. 2018 Jan;25(1):4-12. doi: 10.1038/s41594-017-0011-7. Epub 2018 Jan 8. Review.

42.

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.

Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Analyst. 2017 Oct 9;142(20):3889-3898. doi: 10.1039/c7an01168g.

43.

Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure.

Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK.

Nature. 2017 Aug 24;548(7668):480-484. doi: 10.1038/nature23652. Epub 2017 Aug 16.

44.

The cubicon method for concentrating membrane proteins in the cubic mesophase.

Ma P, Weichert D, Aleksandrov LA, Jensen TJ, Riordan JR, Liu X, Kobilka BK, Caffrey M.

Nat Protoc. 2017 Sep;12(9):1745-1762. doi: 10.1038/nprot.2017.057. Epub 2017 Aug 3.

PMID:
28771236
45.

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies.

Hussain H, Mortensen JS, Du Y, Santillan C, Ribeiro O, Go J, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Sci Rep. 2017 Jun 21;7(1):3963. doi: 10.1038/s41598-017-03809-3.

46.

Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC.

Nature. 2017 Jul 6;547(7661):68-73. doi: 10.1038/nature22354. Epub 2017 Jun 7.

47.

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.

Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G.

Nature. 2017 Jun 8;546(7657):248-253. doi: 10.1038/nature22394. Epub 2017 May 24.

48.

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.

Das M, Du Y, Mortensen JS, Ribeiro O, Hariharan P, Guan L, Loland CJ, Kobilka BK, Byrne B, Chae PS.

Chem Sci. 2017 Feb 1;8(2):1169-1177. doi: 10.1039/c6sc02981g. Epub 2016 Oct 5.

49.

Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM.

Nature. 2017 Jun 1;546(7656):118-123. doi: 10.1038/nature22327. Epub 2017 Apr 24.

50.

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

Komolov KE, Du Y, Duc NM, Betz RM, Rodrigues JPGLM, Leib RD, Patra D, Skiniotis G, Adams CM, Dror RO, Chung KY, Kobilka BK, Benovic JL.

Cell. 2017 Apr 20;169(3):407-421.e16. doi: 10.1016/j.cell.2017.03.047.

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