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Items: 1 to 50 of 228

1.

The structure and metal binding properties of Chlamydia trachomatis YtgA.

Luo Z, Neville SL, Campbell R, Morey JR, Menon S, Thomas M, Eijkelkamp BA, Ween MP, Huston WM, Kobe B, McDevitt CA.

J Bacteriol. 2019 Oct 14. pii: JB.00580-19. doi: 10.1128/JB.00580-19. [Epub ahead of print]

PMID:
31611288
2.

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.

Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai JS, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN, Kobe B.

Science. 2019 Aug 23;365(6455):793-799. doi: 10.1126/science.aax1911.

PMID:
31439792
3.

The Plant "Resistosome": Structural Insights into Immune Signaling.

Burdett H, Bentham AR, Williams SJ, Dodds PN, Anderson PA, Banfield MJ, Kobe B.

Cell Host Microbe. 2019 Aug 14;26(2):193-201. doi: 10.1016/j.chom.2019.07.020. Review.

PMID:
31415752
4.

Animal NLRs continue to inform plant NLR structure and function.

Burdett H, Kobe B, Anderson PA.

Arch Biochem Biophys. 2019 Jul 30;670:58-68. doi: 10.1016/j.abb.2019.05.001. Epub 2019 May 6. Review.

PMID:
31071301
5.

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses.

Dowling JK, Tate MD, Rosli S, Bourke NM, Bitto N, Lauterbach MA, Cheung S, Ve T, Kobe B, Golenbock D, Mansell A.

J Immunol. 2019 Apr 15;202(8):2384-2396. doi: 10.4049/jimmunol.1800501. Epub 2019 Feb 20.

PMID:
30787108
6.

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88.

O'Carroll A, Chauvin B, Brown JWP, Meagher A, Coyle J, Schill J, Bhumkhar A, Hunter DJB, Ve T, Kobe B, Sierecki E, Gambin Y.

BMC Biol. 2018 Dec 24;16(1):149. doi: 10.1186/s12915-018-0611-7.

7.

Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling.

Nanson JD, Kobe B, Ve T.

J Leukoc Biol. 2019 Feb;105(2):363-375. doi: 10.1002/JLB.MR0318-123R. Epub 2018 Dec 5. Review.

PMID:
30517972
8.

Autoimmunity and effector recognition in Arabidopsis thaliana can be uncoupled by mutations in the RRS1-R immune receptor.

Newman TE, Lee J, Williams SJ, Choi S, Halane MK, Zhou J, Solomon P, Kobe B, Jones JDG, Segonzac C, Sohn KH.

New Phytol. 2019 Apr;222(2):954-965. doi: 10.1111/nph.15617. Epub 2019 Feb 3.

PMID:
30500990
9.

Handling of nutrient copper in the bacterial envelope.

Stewart LJ, Thaqi D, Kobe B, McEwan AG, Waldron KJ, Djoko KY.

Metallomics. 2019 Jan 23;11(1):50-63. doi: 10.1039/c8mt00218e. Review.

PMID:
30334058
10.

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

Kummari LK, Butler MS, Furlong E, Blundell R, Nouwens A, Silva AB, Kappler U, Fraser JA, Kobe B, Cooper MA, Robertson AAB.

Bioorg Med Chem. 2018 Nov 1;26(20):5408-5419. doi: 10.1016/j.bmc.2018.09.004. Epub 2018 Sep 5.

PMID:
30322754
11.

Megahertz serial crystallography.

Wiedorn MO, Oberthür D, Bean R, Schubert R, Werner N, Abbey B, Aepfelbacher M, Adriano L, Allahgholi A, Al-Qudami N, Andreasson J, Aplin S, Awel S, Ayyer K, Bajt S, Barák I, Bari S, Bielecki J, Botha S, Boukhelef D, Brehm W, Brockhauser S, Cheviakov I, Coleman MA, Cruz-Mazo F, Danilevski C, Darmanin C, Doak RB, Domaracky M, Dörner K, Du Y, Fangohr H, Fleckenstein H, Frank M, Fromme P, Gañán-Calvo AM, Gevorkov Y, Giewekemeyer K, Ginn HM, Graafsma H, Graceffa R, Greiffenberg D, Gumprecht L, Göttlicher P, Hajdu J, Hauf S, Heymann M, Holmes S, Horke DA, Hunter MS, Imlau S, Kaukher A, Kim Y, Klyuev A, Knoška J, Kobe B, Kuhn M, Kupitz C, Küpper J, Lahey-Rudolph JM, Laurus T, Le Cong K, Letrun R, Xavier PL, Maia L, Maia FRNC, Mariani V, Messerschmidt M, Metz M, Mezza D, Michelat T, Mills G, Monteiro DCF, Morgan A, Mühlig K, Munke A, Münnich A, Nette J, Nugent KA, Nuguid T, Orville AM, Pandey S, Pena G, Villanueva-Perez P, Poehlsen J, Previtali G, Redecke L, Riekehr WM, Rohde H, Round A, Safenreiter T, Sarrou I, Sato T, Schmidt M, Schmitt B, Schönherr R, Schulz J, Sellberg JA, Seibert MM, Seuring C, Shelby ML, Shoeman RL, Sikorski M, Silenzi A, Stan CA, Shi X, Stern S, Sztuk-Dambietz J, Szuba J, Tolstikova A, Trebbin M, Trunk U, Vagovic P, Ve T, Weinhausen B, White TA, Wrona K, Xu C, Yefanov O, Zatsepin N, Zhang J, Perbandt M, Mancuso AP, Betzel C, Chapman H, Barty A.

Nat Commun. 2018 Oct 2;9(1):4025. doi: 10.1038/s41467-018-06156-7.

12.

Structural and functional insights into the modulation of the activity of a flax cytokinin oxidase by flax rust effector AvrL567-A.

Wan L, Koeck M, Williams SJ, Ashton AR, Lawrence GJ, Sakakibara H, Kojima M, Böttcher C, Ericsson DJ, Hardham AR, Jones DA, Ellis JG, Kobe B, Dodds PN.

Mol Plant Pathol. 2019 Feb;20(2):211-222. doi: 10.1111/mpp.12749. Epub 2018 Nov 15.

13.

Structural characterisation of the HT3 motif of the polyhistidine triad protein D from Streptococcus pneumoniae.

Luo Z, Pederick VG, Paton JC, McDevitt CA, Kobe B.

FEBS Lett. 2018 Jul;592(13):2341-2350. doi: 10.1002/1873-3468.13122. Epub 2018 Jun 14.

14.

Regulation of signaling by cooperative assembly formation in mammalian innate immunity signalosomes by molecular mimics.

Nanson JD, Rahaman MH, Ve T, Kobe B.

Semin Cell Dev Biol. 2018 May 23. pii: S1084-9521(17)30423-8. doi: 10.1016/j.semcdb.2018.05.002. [Epub ahead of print] Review.

PMID:
29738879
15.

Crystal structure and insights into the oligomeric state of UDP-glucose pyrophosphorylase from sugarcane.

Cotrim CA, Soares JSM, Kobe B, Menossi M.

PLoS One. 2018 Mar 1;13(3):e0193667. doi: 10.1371/journal.pone.0193667. eCollection 2018.

16.

Structural and Functional Characterization of a Cross-Reactive Dengue Virus Neutralizing Antibody that Recognizes a Cryptic Epitope.

Li J, Watterson D, Chang CW, Che XY, Li XQ, Ericsson DJ, Qiu LW, Cai JP, Chen J, Fry SR, Cheung STM, Cooper MA, Young PR, Kobe B.

Structure. 2018 Jan 2;26(1):51-59.e4. doi: 10.1016/j.str.2017.11.017. Epub 2017 Dec 14.

17.

DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.

de Barros AC, Takeda AAS, Dreyer TR, Velazquez-Campoy A, Kobe B, Fontes MRM.

Biochimie. 2018 Mar;146:87-96. doi: 10.1016/j.biochi.2017.11.013. Epub 2017 Nov 24.

18.

Crystal structure of the Melampsora lini effector AvrP reveals insights into a possible nuclear function and recognition by the flax disease resistance protein P.

Zhang X, Farah N, Rolston L, Ericsson DJ, Catanzariti AM, Bernoux M, Ve T, Bendak K, Chen C, Mackay JP, Lawrence GJ, Hardham A, Ellis JG, Williams SJ, Dodds PN, Jones DA, Kobe B.

Mol Plant Pathol. 2018 May;19(5):1196-1209. doi: 10.1111/mpp.12597. Epub 2017 Nov 16.

19.

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.

Ve T, Vajjhala PR, Hedger A, Croll T, DiMaio F, Horsefield S, Yu X, Lavrencic P, Hassan Z, Morgan GP, Mansell A, Mobli M, O'Carroll A, Chauvin B, Gambin Y, Sierecki E, Landsberg MJ, Stacey KJ, Egelman EH, Kobe B.

Nat Struct Mol Biol. 2017 Sep;24(9):743-751. doi: 10.1038/nsmb.3444. Epub 2017 Jul 31.

PMID:
28759049
20.

Emerging Insights into the Functions of Pathogenesis-Related Protein 1.

Breen S, Williams SJ, Outram M, Kobe B, Solomon PS.

Trends Plant Sci. 2017 Oct;22(10):871-879. doi: 10.1016/j.tplants.2017.06.013. Epub 2017 Jul 22. Review.

PMID:
28743380
21.

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.

Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6480-E6489. doi: 10.1073/pnas.1701868114. Epub 2017 Jul 24.

22.

The growth of peer support: an international charter.

Stratford AC, Halpin M, Phillips K, Skerritt F, Beales A, Cheng V, Hammond M, O'Hagan M, Loreto C, Tiengtom K, Kobe B, Harrington S, Fisher D, Davidson L.

J Ment Health. 2017 Jul 6:1-6. doi: 10.1080/09638237.2017.1340593. [Epub ahead of print] Erratum in: J Ment Health. 2018 Dec;27(6):605.

PMID:
28682640
23.

Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Chitty JL, Blake KL, Blundell RD, Koh YQAE, Thompson M, Robertson AAB, Butler MS, Cooper MA, Kappler U, Williams SJ, Kobe B, Fraser JA.

J Biol Chem. 2017 Jul 14;292(28):11829-11839. doi: 10.1074/jbc.M117.787994. Epub 2017 May 30.

24.

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways.

Vajjhala PR, Ve T, Bentham A, Stacey KJ, Kobe B.

Mol Immunol. 2017 Jun;86:23-37. doi: 10.1016/j.molimm.2017.02.012. Epub 2017 Feb 27. Review.

PMID:
28249680
25.

A non-uniform sampling approach enables studies of dilute and unstable proteins.

Miljenović T, Jia X, Lavrencic P, Kobe B, Mobli M.

J Biomol NMR. 2017 Jun;68(2):119-127. doi: 10.1007/s10858-017-0091-z. Epub 2017 Feb 10.

PMID:
28188517
26.

PhosphoPICK-SNP: quantifying the effect of amino acid variants on protein phosphorylation.

Patrick R, Kobe B, Lê Cao KA, Bodén M.

Bioinformatics. 2017 Jun 15;33(12):1773-1781. doi: 10.1093/bioinformatics/btx072.

PMID:
28186228
27.

Multiple functional self-association interfaces in plant TIR domains.

Zhang X, Bernoux M, Bentham AR, Newman TE, Ve T, Casey LW, Raaymakers TM, Hu J, Croll TI, Schreiber KJ, Staskawicz BJ, Anderson PA, Sohn KH, Williams SJ, Dodds PN, Kobe B.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E2046-E2052. doi: 10.1073/pnas.1621248114. Epub 2017 Feb 3.

28.

Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization.

De Oliveira DM, Hartley-Tassell L, Everest-Dass A, Day CJ, Dabbs RA, Ve T, Kobe B, Nizet V, Packer NH, Walker MJ, Jennings MP, Sanderson-Smith ML.

MBio. 2017 Jan 24;8(1). pii: e02237-16. doi: 10.1128/mBio.02237-16.

29.

Towards the structure of the TIR-domain signalosome.

Nimma S, Ve T, Williams SJ, Kobe B.

Curr Opin Struct Biol. 2017 Apr;43:122-130. doi: 10.1016/j.sbi.2016.12.014. Epub 2017 Jan 13. Review.

PMID:
28092811
30.

GMP Synthase Is Required for Virulence Factor Production and Infection by Cryptococcus neoformans.

Chitty JL, Tatzenko TL, Williams SJ, Koh YQ, Corfield EC, Butler MS, Robertson AA, Cooper MA, Kappler U, Kobe B, Fraser JA.

J Biol Chem. 2017 Feb 17;292(7):3049-3059. doi: 10.1074/jbc.M116.767533. Epub 2017 Jan 6.

31.

Structure and Function of the TIR Domain from the Grape NLR Protein RPV1.

Williams SJ, Yin L, Foley G, Casey LW, Outram MA, Ericsson DJ, Lu J, Boden M, Dry IB, Kobe B.

Front Plant Sci. 2016 Dec 8;7:1850. doi: 10.3389/fpls.2016.01850. eCollection 2016.

32.

The CC domain structure from the wheat stem rust resistance protein Sr33 challenges paradigms for dimerization in plant NLR proteins.

Casey LW, Lavrencic P, Bentham AR, Cesari S, Ericsson DJ, Croll T, Turk D, Anderson PA, Mark AE, Dodds PN, Mobli M, Kobe B, Williams SJ.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12856-12861. doi: 10.1073/pnas.1609922113. Epub 2016 Oct 17.

33.

Wheat PR-1 proteins are targeted by necrotrophic pathogen effector proteins.

Breen S, Williams SJ, Winterberg B, Kobe B, Solomon PS.

Plant J. 2016 Oct;88(1):13-25. doi: 10.1111/tpj.13228. Epub 2016 Aug 10.

34.

Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA.

ACS Infect Dis. 2016 Sep 9;2(9):651-663. Epub 2016 Aug 17.

PMID:
27759389
35.

Animal NLRs provide structural insights into plant NLR function.

Bentham A, Burdett H, Anderson PA, Williams SJ, Kobe B.

Ann Bot. 2017 Mar 1;119(5):827-702. doi: 10.1093/aob/mcw171. Review.

36.

Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence.

Patrick R, Horin C, Kobe B, Cao KA, Bodén M.

Biochim Biophys Acta. 2016 Nov;1864(11):1599-608. doi: 10.1016/j.bbapap.2016.08.001. Epub 2016 Aug 6.

PMID:
27507704
37.

Multiple Domain Associations within the Arabidopsis Immune Receptor RPP1 Regulate the Activation of Programmed Cell Death.

Schreiber KJ, Bentham A, Williams SJ, Kobe B, Staskawicz BJ.

PLoS Pathog. 2016 Jul 18;12(7):e1005769. doi: 10.1371/journal.ppat.1005769. eCollection 2016 Jul.

38.

Structural basis of thiol-based regulation of formaldehyde detoxification in H. influenzae by a MerR regulator with no sensor region.

Couñago RM, Chen NH, Chang CW, Djoko KY, McEwan AG, Kobe B.

Nucleic Acids Res. 2016 Aug 19;44(14):6981-93. doi: 10.1093/nar/gkw543. Epub 2016 Jun 15.

39.

Elevated interleukin-27 levels in human neonatal macrophages regulate indoleamine dioxygenase in a STAT-1 and STAT-3-dependent manner.

Jung JY, Gleave Parson M, Kraft JD, Lyda L, Kobe B, Davis C, Robinson J, Peña MM, Robinson CM.

Immunology. 2016 Sep;149(1):35-47. doi: 10.1111/imm.12625.

40.

Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-α.

Chang CW, Couñago RM, Williams SJ, Bodén M, Kobe B.

Traffic. 2016 Jun;17(6):704. doi: 10.1111/tra.12395. No abstract available.

41.

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target.

Ullah MO, Sweet MJ, Mansell A, Kellie S, Kobe B.

J Leukoc Biol. 2016 Jul;100(1):27-45. doi: 10.1189/jlb.2RI1115-531R. Epub 2016 May 9. Review.

PMID:
27162325
42.

Protein crystal screening and characterization for serial femtosecond nanocrystallography.

Darmanin C, Strachan J, Adda CG, Ve T, Kobe B, Abbey B.

Sci Rep. 2016 May 3;6:25345. doi: 10.1038/srep25345.

43.

Production of small cysteine-rich effector proteins in Escherichia coli for structural and functional studies.

Zhang X, Nguyen N, Breen S, Outram MA, Dodds PN, Kobe B, Solomon PS, Williams SJ.

Mol Plant Pathol. 2017 Jan;18(1):141-151. doi: 10.1111/mpp.12385. Epub 2016 Apr 12.

44.

Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery.

Lv Y, Kandale A, Wun SJ, McGeary RP, Williams SJ, Kobe B, Sieber V, Schembri MA, Schenk G, Guddat LW.

FEBS J. 2016 Apr;283(7):1184-96. doi: 10.1111/febs.13672. Epub 2016 Feb 18.

45.

Temperature-Dependent Gentamicin Resistance of Francisella tularensis is Mediated by Uptake Modulation.

Loughman K, Hall J, Knowlton S, Sindeldecker D, Gilson T, Schmitt DM, Birch JW, Gajtka T, Kobe BN, Florjanczyk A, Ingram J, Bakshi CS, Horzempa J.

Front Microbiol. 2016 Jan 28;7:37. doi: 10.3389/fmicb.2016.00037. eCollection 2016.

46.

Structural and Calorimetric Studies Demonstrate that Xeroderma Pigmentosum Type G (XPG) Can Be Imported to the Nucleus by a Classical Nuclear Import Pathway via a Monopartite NLS Sequence.

Barros AC, Takeda AA, Dreyer TR, Velazquez-Campoy A, Kobe B, Fontes MR.

J Mol Biol. 2016 May 22;428(10 Pt A):2120-31. doi: 10.1016/j.jmb.2016.01.019. Epub 2016 Jan 23.

PMID:
26812207
47.

Comparative Analysis of the Flax Immune Receptors L6 and L7 Suggests an Equilibrium-Based Switch Activation Model.

Bernoux M, Burdett H, Williams SJ, Zhang X, Chen C, Newell K, Lawrence GJ, Kobe B, Ellis JG, Anderson PA, Dodds PN.

Plant Cell. 2016 Jan;28(1):146-59. doi: 10.1105/tpc.15.00303. Epub 2016 Jan 7.

48.

Heterogeneous nucleation is required for crystallization of the ZnuA domain of pneumococcal AdcA.

Luo Z, Morey JR, McDevitt CA, Kobe B.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1459-64. doi: 10.1107/S2053230X15021330. Epub 2015 Nov 18.

49.

Structural Biology and Regulation of Protein Import into the Nucleus.

Christie M, Chang CW, Róna G, Smith KM, Stewart AG, Takeda AA, Fontes MR, Stewart M, Vértessy BG, Forwood JK, Kobe B.

J Mol Biol. 2016 May 22;428(10 Pt A):2060-90. doi: 10.1016/j.jmb.2015.10.023. Epub 2015 Oct 30. Review.

PMID:
26523678
50.

Recombinant and epitope-based vaccines on the road to the market and implications for vaccine design and production.

Oyarzún P, Kobe B.

Hum Vaccin Immunother. 2016 Mar 3;12(3):763-7. doi: 10.1080/21645515.2015.1094595.

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