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Items: 39

1.

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.

Zima V, Albiñana CB, Rojíková K, Pokorná J, Pachl P, Řezáčová P, Hudlicky J, Navrátil V, Majer P, Konvalinka J, Kožíšek M, Machara A.

Bioorg Med Chem. 2019 Jul 1;27(13):2935-2947. doi: 10.1016/j.bmc.2019.05.024. Epub 2019 May 17.

PMID:
31128993
2.

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.

Kožíšek M, Navrátil V, Rojíková K, Pokorná J, Berenguer Albiñana C, Pachl P, Zemanová J, Machara A, Šácha P, Hudlický J, Císařová I, Řezáčová P, Konvalinka J.

Biochem J. 2018 Dec 10;475(23):3847-3860. doi: 10.1042/BCJ20180764.

3.

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.

Pokorná J, Pachl P, Karlukova E, Hejdánek J, Řezáčová P, Machara A, Hudlický J, Konvalinka J, Kožíšek M.

Viruses. 2018 Jun 21;10(7). pii: E339. doi: 10.3390/v10070339.

4.

Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family.

Trempe JF, Šašková KG, Sivá M, Ratcliffe CD, Veverka V, Hoegl A, Ménade M, Feng X, Shenker S, Svoboda M, Kožíšek M, Konvalinka J, Gehring K.

Sci Rep. 2016 Sep 20;6:33671. doi: 10.1038/srep33671.

5.

Functional and Structural Characterization of Novel Type of Linker Connecting Capsid and Nucleocapsid Protein Domains in Murine Leukemia Virus.

Doležal M, Hadravová R, Kožíšek M, Bednárová L, Langerová H, Ruml T, Rumlová M.

J Biol Chem. 2016 Sep 23;291(39):20630-42. doi: 10.1074/jbc.M116.746461. Epub 2016 Aug 11.

6.

Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.

Sivá M, Svoboda M, Veverka V, Trempe JF, Hofmann K, Kožíšek M, Hexnerová R, Sedlák F, Belza J, Brynda J, Šácha P, Hubálek M, Starková J, Flaisigová I, Konvalinka J, Šašková KG.

Sci Rep. 2016 Jul 27;6:30443. doi: 10.1038/srep30443.

7.

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly.

Kožíšek M, Štěpánek O, Parkan K, Berenguer Albiñana C, Pávová M, Weber J, Krӓusslich HG, Konvalinka J, Machara A.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3487-90. doi: 10.1016/j.bmcl.2016.06.039. Epub 2016 Jun 16.

8.

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.

Albiñana CB, Machara A, Řezáčová P, Pachl P, Konvalinka J, Kožíšek M.

Eur J Med Chem. 2016 Oct 4;121:100-109. doi: 10.1016/j.ejmech.2016.05.016. Epub 2016 May 7.

PMID:
27236066
9.

Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds.

Machara A, Lux V, Kožíšek M, Grantz Šašková K, Štěpánek O, Kotora M, Parkan K, Pávová M, Glass B, Sehr P, Lewis J, Müller B, Kräusslich HG, Konvalinka J.

J Med Chem. 2016 Jan 28;59(2):545-58. doi: 10.1021/acs.jmedchem.5b01089. Epub 2016 Jan 6.

PMID:
26685880
10.

Preorganization of the catalytic Zn(2+)-binding site in the HNH nuclease motif--A solution study.

Németh E, Kožíšek M, Schilli GK, Gyurcsik B.

J Inorg Biochem. 2015 Oct;151:143-9. doi: 10.1016/j.jinorgbio.2015.03.017. Epub 2015 Apr 9.

PMID:
25898772
11.

Substrate binding activates the designed triple mutant of the colicin E7 metallonuclease.

Németh E, Körtvélyesi T, Kožíšek M, Thulstrup PW, Christensen HE, Asaka MN, Nagata K, Gyurcsik B.

J Biol Inorg Chem. 2014 Dec;19(8):1295-303. doi: 10.1007/s00775-014-1186-6. Epub 2014 Aug 26.

PMID:
25156149
12.

Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N-terminal mutations.

Németh E, Körtvélyesi T, Thulstrup PW, Christensen HE, Kožíšek M, Nagata K, Czene A, Gyurcsik B.

Protein Sci. 2014 Aug;23(8):1113-22. doi: 10.1002/pro.2497. Epub 2014 Jun 17.

13.

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.

Kožíšek M, Lepšík M, Grantz Šašková K, Brynda J, Konvalinka J, Rezáčová P.

FEBS J. 2014 Apr;281(7):1834-47. doi: 10.1111/febs.12743.

14.

Re-evaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.

Rozbeský D, Krejzová J, Křenek K, Prchal J, Hrabal R, Kožíšek M, Weignerová L, Fiore M, Dumy P, Křen V, Renaudet O.

Int J Mol Sci. 2014 Jan 17;15(1):1271-83. doi: 10.3390/ijms15011271.

15.

GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.

Grantz Šašková K, Kozíšek M, Stray K, de Jong D, Rezáová P, Brynda J, van Maarseveen NM, Nijhuis M, Cihlár T, Konvalinka J.

J Virol. 2014 Mar;88(6):3586-90. doi: 10.1128/JVI.02688-13. Epub 2013 Dec 26.

16.

Chasing shadows: what determines DTI metrics in gray matter regions? An in vitro and in vivo study.

Rulseh AM, Keller J, Tintěra J, Kožíšek M, Vymazal J.

J Magn Reson Imaging. 2013 Nov;38(5):1103-10. doi: 10.1002/jmri.24065. Epub 2013 Feb 25.

PMID:
23440865
17.

Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.

Schimer J, Cígler P, Veselý J, Grantz Šašková K, Lepšík M, Brynda J, Rezáčová P, Kožíšek M, Císařová I, Oberwinkler H, Kraeusslich HG, Konvalinka J.

J Med Chem. 2012 Nov 26;55(22):10130-5. doi: 10.1021/jm301249q. Epub 2012 Oct 23.

PMID:
23050738
18.

Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease.

Kozísek M, Henke S, Sasková KG, Jacobs GB, Schuch A, Buchholz B, Müller V, Kräusslich HG, Rezácová P, Konvalinka J, Bodem J.

Antimicrob Agents Chemother. 2012 Aug;56(8):4320-30. doi: 10.1128/AAC.00465-12. Epub 2012 May 29.

19.

Urea and guanidinium induced denaturation of a Trp-cage miniprotein.

Heyda J, Kožíšek M, Bednárova L, Thompson G, Konvalinka J, Vondrášek J, Jungwirth P.

J Phys Chem B. 2011 Jul 21;115(28):8910-24. doi: 10.1021/jp200790h. Epub 2011 Jun 2.

PMID:
21634379
20.

Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes.

Rezácová P, Pokorná J, Brynda J, Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezác J, Grantz Sasková K, Sieglová I, Plesek J, Sícha V, Grüner B, Oberwinkler H, Sedlácek' J, Kräusslich HG, Hobza P, Král V, Konvalinka J.

J Med Chem. 2009 Nov 26;52(22):7132-41. doi: 10.1021/jm9011388.

PMID:
19874035
21.

Backbone (1)H, (13)C, and (15)N NMR assignment for the inactive form of the retroviral protease of the murine intracisternal A-type particle, inMIA-14 PR.

Motácková V, Kubícková M, Kozísek M, Sasková KG, Svec M, Zídek L, Sklenár V.

Biomol NMR Assign. 2009 Dec;3(2):261-4. doi: 10.1007/s12104-009-9189-x.

PMID:
19856131
22.

Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir.

Sasková KG, Kozísek M, Rezácová P, Brynda J, Yashina T, Kagan RM, Konvalinka J.

J Virol. 2009 Sep;83(17):8810-8. doi: 10.1128/JVI.00451-09. Epub 2009 Jun 17.

23.

Structure-activity study of new inhibitors of human betaine-homocysteine S-methyltransferase.

Vanek V, Budesínský M, Kabeleová P, Sanda M, Kozísek M, Hanclová I, Mládková J, Brynda J, Rosenberg I, Koutmos M, Garrow TA, Jirácek J.

J Med Chem. 2009 Jun 25;52(12):3652-65. doi: 10.1021/jm8015798.

24.

Molecular design of specific metal-binding peptide sequences from protein fragments: theory and experiment.

Kozísek M, Svatos A, Budesínský M, Muck A, Bauer MC, Kotrba P, Ruml T, Havlas Z, Linse S, Rulísek L.

Chemistry. 2008;14(26):7836-46. doi: 10.1002/chem.200800178.

PMID:
18633954
25.

Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance.

Kozísek M, Cígler P, Lepsík M, Fanfrlík J, Rezácová P, Brynda J, Pokorná J, Plesek J, Grüner B, Grantz Sasková K, Václavíková J, Král V, Konvalinka J.

J Med Chem. 2008 Aug 14;51(15):4839-43. doi: 10.1021/jm8002334. Epub 2008 Jul 4.

PMID:
18598016
26.

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir.

Sasková KG, Kozísek M, Lepsík M, Brynda J, Rezácová P, Václavíková J, Kagan RM, Machala L, Konvalinka J.

Protein Sci. 2008 Sep;17(9):1555-64. doi: 10.1110/ps.036079.108. Epub 2008 Jun 17.

27.

Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates.

Rezácová P, Kozísek M, Moy SF, Sieglová I, Joachimiak A, Machius M, Otwinowski Z.

Mol Microbiol. 2008 Aug;69(4):895-910. doi: 10.1111/j.1365-2958.2008.06318.x. Epub 2008 Jun 28.

28.

Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region.

Kozísek M, Sasková KG, Rezácová P, Brynda J, van Maarseveen NM, De Jong D, Boucher CA, Kagan RM, Nijhuis M, Konvalinka J.

J Virol. 2008 Jun;82(12):5869-78. doi: 10.1128/JVI.02325-07. Epub 2008 Apr 9.

29.

Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies.

Bartonová V, Král V, Sieglová I, Brynda J, Fábry M, Horejsí M, Kozísek M, Sasková KG, Konvalinka J, Sedlácek J, Rezácová P.

Antiviral Res. 2008 Jun;78(3):275-7. doi: 10.1016/j.antiviral.2008.01.009. Epub 2008 Feb 20.

PMID:
18329737
30.

Anomalous adsorptive properties of HIV protease: indication of two-dimensional crystallization?

Cígler P, Král V, Kozísek M, Konvalinka J, Mirsky VM.

Colloids Surf B Biointerfaces. 2008 Jun 15;64(1):145-9. doi: 10.1016/j.colsurfb.2008.01.011. Epub 2008 Jan 19.

PMID:
18304786
31.

The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment.

Kozisek ME, Middlemas D, Bylund DB.

Neuropharmacology. 2008 Feb;54(2):251-7. Epub 2007 Aug 10.

PMID:
18048068
32.

Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations.

Král V, Mader P, Collard R, Fábry M, Horejsí M, Rezácová P, Kozísek M, Závada J, Sedlácek J, Rulísek L, Brynda J.

Proteins. 2008 May 15;71(3):1275-87.

PMID:
18041760
33.

Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants.

Kozísek M, Bray J, Rezácová P, Sasková K, Brynda J, Pokorná J, Mammano F, Rulísek L, Konvalinka J.

J Mol Biol. 2007 Dec 7;374(4):1005-16. Epub 2007 Oct 3.

PMID:
17977555
34.

Brain-derived neurotrophic factor and its receptor tropomyosin-related kinase B in the mechanism of action of antidepressant therapies.

Kozisek ME, Middlemas D, Bylund DB.

Pharmacol Ther. 2008 Jan;117(1):30-51. Epub 2007 Aug 15. Review.

PMID:
17949819
35.

Dispersion interactions govern the strong thermal stability of a protein.

Vondrásek J, Kubar T, Jenney FE Jr, Adams MW, Kozísek M, Cerný J, Sklenár V, Hobza P.

Chemistry. 2007;13(32):9022-7.

PMID:
17696186
36.

Today's research, tomorrow's health: focus on pharmacogenomics.

Bylund DB, Kozisek ME, Montgomery MD, Reed AL.

Per Med. 2007 Aug;4(3):363-367. doi: 10.2217/17410541.4.3.363. No abstract available.

PMID:
29788667
37.

Tetraphenylporphyrin-cobalt(III) bis(1,2-dicarbollide) conjugates: from the solution characteristics to inhibition of HIV protease.

Kubat P, Lang K, Cígler P, Kozísek M, Matejícek P, Janda P, Zelinger Z, Prochazka K, Kral V.

J Phys Chem B. 2007 May 3;111(17):4539-46. Epub 2007 Apr 11.

PMID:
17425351
38.

Appropriate dosing regimens for treating juvenile rats with desipramine for neuropharmacological and behavioral studies.

Kozisek ME, Deupree JD, Burke WJ, Bylund DB.

J Neurosci Methods. 2007 Jun 15;163(1):83-91. Epub 2007 Feb 22.

39.

From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease.

Cígler P, Kozísek M, Rezácová P, Brynda J, Otwinowski Z, Pokorná J, Plesek J, Grüner B, Dolecková-Maresová L, Mása M, Sedlácek J, Bodem J, Kräusslich HG, Král V, Konvalinka J.

Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15394-9. Epub 2005 Oct 14.

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