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Items: 1 to 50 of 528

1.

DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Mäki-Nevala S, Valo S, Ristimäki A, Sarhadi V, Knuutila S, Nyström M, Renkonen-Sinisalo L, Lepistö A, Mecklin JP, Peltomäki P.

EBioMedicine. 2019 Jan;39:280-291. doi: 10.1016/j.ebiom.2018.12.018. Epub 2018 Dec 18.

2.

Different responses of colorectal cancer cells to alternative sequences of cetuximab and oxaliplatin.

Narvi E, Vaparanta K, Karrila A, Chakroborty D, Knuutila S, Pulliainen A, Sundvall M, Elenius K.

Sci Rep. 2018 Nov 8;8(1):16579. doi: 10.1038/s41598-018-34938-y.

3.

Hotspot Mutations Detectable by Next-generation Sequencing in Exhaled Breath Condensates from Patients with Lung Cancer.

Youssef O, Knuuttila A, Piirilä P, Böhling T, Sarhadi V, Knuutila S.

Anticancer Res. 2018 Oct;38(10):5627-5634. doi: 10.21873/anticanres.12897.

PMID:
30275180
4.

Stool Microbiota Composition Differs in Patients with Stomach, Colon, and Rectal Neoplasms.

Youssef O, Lahti L, Kokkola A, Karla T, Tikkanen M, Ehsan H, Carpelan-Holmström M, Koskensalo S, Böhling T, Rautelin H, Puolakkainen P, Knuutila S, Sarhadi V.

Dig Dis Sci. 2018 Jul 11. doi: 10.1007/s10620-018-5190-5. [Epub ahead of print]

5.

Gene mutations in stool from gastric and colorectal neoplasia patients by next-generation sequencing.

Youssef O, Sarhadi V, Ehsan H, Böhling T, Carpelan-Holmström M, Koskensalo S, Puolakkainen P, Kokkola A, Knuutila S.

World J Gastroenterol. 2017 Dec 21;23(47):8291-8299. doi: 10.3748/wjg.v23.i47.8291.

6.

Low Expression of miR-18a as a Characteristic of Pediatric Acute Lymphoblastic Leukemia.

Mosakhani N, Missiry ME, Vakkila E, Knuutila S, Vakkila J.

J Pediatr Hematol Oncol. 2017 Nov;39(8):585-588. doi: 10.1097/MPH.0000000000000921.

PMID:
29068867
7.

Digital Multiplex Ligation-Dependent Probe Amplification for Detection of Key Copy Number Alterations in T- and B-Cell Lymphoblastic Leukemia.

Benard-Slagter A, Zondervan I, de Groot K, Ghazavi F, Sarhadi V, Van Vlierberghe P, De Moerloose B, Schwab C, Vettenranta K, Harrison CJ, Knuutila S, Schouten J, Lammens T, Savola S.

J Mol Diagn. 2017 Sep;19(5):659-672. doi: 10.1016/j.jmoldx.2017.05.004. Epub 2017 Jul 19.

8.

Aberrant expression of ALK and EZH2 in Merkel cell carcinoma.

Veija T, Koljonen V, Bohling T, Kero M, Knuutila S, Sarhadi VK.

BMC Cancer. 2017 Mar 31;17(1):236. doi: 10.1186/s12885-017-3233-5.

9.

Narcolepsy patients' blood-based miRNA expression profiling: miRNA expression differences with Pandemrix vaccination.

Mosakhani N, Sarhadi V, Panula P, Partinen M, Knuutila S.

Acta Neurol Scand. 2017 Nov;136(5):462-469. doi: 10.1111/ane.12749. Epub 2017 Mar 1.

PMID:
28251619
10.

Presence of cancer-associated mutations in exhaled breath condensates of healthy individuals by next generation sequencing.

Youssef O, Knuuttila A, Piirilä P, Böhling T, Sarhadi V, Knuutila S.

Oncotarget. 2017 Mar 14;8(11):18166-18176. doi: 10.18632/oncotarget.15233.

11.

Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.

Ghanbari R, Rezasoltani S, Hashemi J, Mohamadkhani A, Tahmasebifar A, Arefian E, Mobarra N, Asadi J, Nazemalhosseini Mojarad E, Yazdani Y, Knuutila S, Malekzadeh R.

Arch Iran Med. 2017 Feb;20(2):92-95. doi: 0172002/AIM.006.

12.

Mitochondrial encephalomyopathy and retinoblastoma explained by compound heterozygosity of SUCLA2 point mutation and 13q14 deletion.

Matilainen S, Isohanni P, Euro L, Lönnqvist T, Pihko H, Kivelä T, Knuutila S, Suomalainen A.

Eur J Hum Genet. 2017 Feb;25(3):393. doi: 10.1038/ejhg.2016.166. No abstract available.

13.

ALK gene copy number in lung cancer: Unspecific polyploidy versus specific amplification visible as double minutes.

Caliò A, Bria E, Pilotto S, Gilioli E, Nottegar A, Eccher A, Cima L, Santo A, Pedron S, Turri G, Knuutila S, Chilosi M, Vanzo F, Bogina G, Terzi A, Tortora G, Scarpa A, Loda M, Martignoni G, Brunelli M.

Cancer Biomark. 2017;18(2):215-220. doi: 10.3233/CBM-161680.

PMID:
28009326
14.

Validation of 34betaE12 immunoexpression in clear cell papillary renal cell carcinoma as a sensitive biomarker.

Martignoni G, Brunelli M, Segala D, Munari E, Gobbo S, Cima L, Borze I, Wirtanen T, Sarhadi VK, Atanesyan L, Savola S, Barzon L, Masi G, Fassan M, Eble JN, Bohling T, Cheng L, Delahunt B, Knuutila S.

Pathology. 2017 Jan;49(1):10-18. doi: 10.1016/j.pathol.2016.05.014. Epub 2016 Dec 4.

PMID:
27923499
15.

Wide spetcrum mutational analysis of metastatic renal cell cancer: a retrospective next generation sequencing approach.

Fiorentino M, Gruppioni E, Massari F, Giunchi F, Altimari A, Ciccarese C, Bimbatti D, Scarpa A, Iacovelli R, Porta C, Virinder S, Tortora G, Artibani W, Schiavina R, Ardizzoni A, Brunelli M, Knuutila S, Martignoni G.

Oncotarget. 2017 Jan 31;8(5):7328-7335. doi: 10.18632/oncotarget.12551.

16.

Hot spot mutations in Finnish non-small cell lung cancers.

Mäki-Nevala S, Sarhadi VK, Rönty M, Kettunen E, Husgafvel-Pursiainen K, Wolff H, Knuuttila A, Knuutila S.

Lung Cancer. 2016 Sep;99:102-10. doi: 10.1016/j.lungcan.2016.06.024. Epub 2016 Jun 27.

PMID:
27565922
17.

Exhaled breath condensate as a source of biomarkers for lung carcinomas. A focus on genetic and epigenetic markers-A mini-review.

Youssef O, Sarhadi VK, Armengol G, Piirilä P, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2016 Dec;55(12):905-914. doi: 10.1002/gcc.22399. Epub 2016 Aug 13. Review.

PMID:
27480453
18.

Driver Gene Mutations in Stools of Colorectal Carcinoma Patients Detected by Targeted Next-Generation Sequencing.

Armengol G, Sarhadi VK, Ghanbari R, Doghaei-Moghaddam M, Ansari R, Sotoudeh M, Puolakkainen P, Kokkola A, Malekzadeh R, Knuutila S.

J Mol Diagn. 2016 Jul;18(4):471-9. doi: 10.1016/j.jmoldx.2016.01.008. Epub 2016 May 4.

PMID:
27155048
19.

Preeclampsia does not share common risk alleles in 9p21 with coronary artery disease and type 2 diabetes.

Kaartokallio T, Lokki AI, Peterson H, Kivinen K, Hiltunen L, Salmela E, Lappalainen T, Maanselkä P, Heino S, Knuutila S, Sayed A, Poston L, Brennecke SP, Johnson MP, Morgan L, Moses EK, Kere J, Laivuori H.

Ann Med. 2016 Aug;48(5):330-6. doi: 10.1080/07853890.2016.1174877. Epub 2016 Apr 25.

PMID:
27111527
20.

The Role of Chromosomal Instability and Epigenetics in Colorectal Cancers Lacking β-Catenin/TCF Regulated Transcription.

Abdel-Rahman WM, Lotsari-Salomaa JE, Kaur S, Niskakoski A, Knuutila S, Järvinen H, Mecklin JP, Peltomäki P.

Gastroenterol Res Pract. 2016;2016:6089658. doi: 10.1155/2016/6089658. Epub 2016 Mar 7.

21.

Simultaneous Underexpression of let-7a-5p and let-7f-5p microRNAs in Plasma and Stool Samples from Early Stage Colorectal Carcinoma.

Ghanbari R, Mosakhani N, Sarhadi VK, Armengol G, Nouraee N, Mohammadkhani A, Khorrami S, Arefian E, Paryan M, Malekzadeh R, Knuutila S.

Biomark Cancer. 2016 Jan 12;7(Suppl 1):39-48. doi: 10.4137/BIC.S25252. eCollection 2015.

22.

Hotspot mutations in polyomavirus positive and negative Merkel cell carcinomas.

Veija T, Sarhadi VK, Koljonen V, Bohling T, Knuutila S.

Cancer Genet. 2016 Jan-Feb;209(1-2):30-5. doi: 10.1016/j.cancergen.2015.11.006. Epub 2015 Dec 4.

PMID:
26725423
23.

Reprofiling Metastatic Samples for Chromosome 9p and 14q Aberrations as a Strategy to Overcome Tumor Heterogeneity in Clear-cell Renal Cell Carcinoma.

Massari F, Ciccarese C, Bria E, Porta C, La Russa F, Knuutila S, Artibani W, Porcaro AB, Bimbatti D, Modena A, Sava T, Tortora G, Cheng L, Eccher A, Cima L, Pedron S, Ghimenton C, Martignoni G, Brunelli M.

Appl Immunohistochem Mol Morphol. 2017 Jan;25(1):39-43.

PMID:
26509904
24.

Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.

Mäki-Nevala S, Sarhadi VK, Knuuttila A, Scheinin I, Ellonen P, Lagström S, Rönty M, Kettunen E, Husgafvel-Pursiainen K, Wolff H, Knuutila S.

Lung. 2016 Feb;194(1):125-35.

PMID:
26463840
25.

Downregulation of Plasma MiR-142-3p and MiR-26a-5p in Patients With Colorectal Carcinoma.

Ghanbari R, Mosakhani N, Asadi J, Nouraee N, Mowla SJ, Yazdani Y, Mohamadkhani A, Poustchi H, Knuutila S, Malekzadeh R.

Iran J Cancer Prev. 2015 May;8(3):e2329. doi: 10.17795/ijcp2329. Epub 2015 May 22.

26.

Genetic alterations in periprosthetic soft-tissue masses from patients with metal-on-metal hip replacement.

Sarhadi VK, Parkkinen J, Reito A, Nieminen J, Porkka N, Wirtanen T, Laitinen M, Eskelinen A, Knuutila S.

Mutat Res. 2015 Nov;781:1-6. doi: 10.1016/j.mrfmmm.2015.08.006. Epub 2015 Aug 29.

PMID:
26355908
27.

Monosomy of chromosome 17 in breast cancer during interpretation of HER2 gene amplification.

Brunelli M, Nottegar A, Bogina G, Caliò A, Cima L, Eccher A, Vicentini C, Marcolini L, Scarpa A, Pedron S, Brunello E, Knuutila S, Sapino A, Marchiò C, Bria E, Molino A, Carbognin L, Tortora G, Jasani B, Miller K, Merdol I, Zanatta L, Laurino L, Wirtanen T, Zamboni G, Marconi M, Chilosi M, Manfrin E, Martignoni G, Bonetti F.

Am J Cancer Res. 2015 Jun 15;5(7):2212-21. eCollection 2015.

28.

[Diagnosis of soft tissue tumors--multidisciplinary collaboration].

Söderström M, Dalin-Hirvonen N, Mattila K, Knuutila S, Kallajoki M.

Duodecim. 2015;131(8):769-80. Finnish.

PMID:
26237892
29.

Driver gene mutations of non-small-cell lung cancer are rare in primary carcinoids of the lung: NGS study by ion Torrent.

Armengol G, Sarhadi VK, Rönty M, Tikkanen M, Knuuttila A, Knuutila S.

Lung. 2015 Apr;193(2):303-8. doi: 10.1007/s00408-015-9690-1. Epub 2015 Feb 14.

PMID:
25680416
30.

Decreased expression of fecal miR-4478 and miR-1295b-3p in early-stage colorectal cancer.

Ghanbari R, Mosakhani N, Asadi J, Nouraee N, Mowla SJ, Poustchi H, Malekzadeh R, Knuutila S.

Cancer Biomark. 2015;15(2):189-95. doi: 10.3233/CBM-140453.

PMID:
25519020
31.

miRNA-34a underexpressed in Merkel cell polyomavirus-negative Merkel cell carcinoma.

Veija T, Sahi H, Koljonen V, Bohling T, Knuutila S, Mosakhani N.

Virchows Arch. 2015 Mar;466(3):289-95. doi: 10.1007/s00428-014-1700-9. Epub 2014 Dec 10.

PMID:
25491743
32.

Mitochondrial encephalomyopathy and retinoblastoma explained by compound heterozygosity of SUCLA2 point mutation and 13q14 deletion.

Matilainen S, Isohanni P, Euro L, Lönnqvist T, Pihko H, Kivelä T, Knuutila S, Suomalainen A.

Eur J Hum Genet. 2015 Mar;23(3):325-30. doi: 10.1038/ejhg.2014.128. Epub 2014 Jul 2. Review. Erratum in: Eur J Hum Genet. 2017 Feb;25(3):0-393.

33.

ALK fusion and its association with other driver gene mutations in Finnish non-small cell lung cancer patients.

Tuononen K, Kero M, Mäki-Nevala S, Sarhadi VK, Tikkanen M, Wirtanen T, Rönty M, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2014 Nov;53(11):895-901. doi: 10.1002/gcc.22198. Epub 2014 Jun 19.

PMID:
24942490
34.

Epidermal growth factor receptor mutations in 510 Finnish non--small-cell lung cancer patients.

Mäki-Nevala S, Rönty M, Morel M, Gomez M, Dawson Z, Sarhadi VK, Telaranta-Keerie A, Knuuttila A, Knuutila S.

J Thorac Oncol. 2014 Jun;9(6):886-91. doi: 10.1097/JTO.0000000000000132.

35.

Hsa-miR-31-3p expression is linked to progression-free survival in patients with KRAS wild-type metastatic colorectal cancer treated with anti-EGFR therapy.

Manceau G, Imbeaud S, Thiébaut R, Liébaert F, Fontaine K, Rousseau F, Génin B, Le Corre D, Didelot A, Vincent M, Bachet JB, Chibaudel B, Bouché O, Landi B, Bibeau F, Leroy K, Penault-Llorca F, Van Laethem JL, Demetter P, Tejpar S, Rossi S, Mosakhani N, Osterlund P, Ristamäki R, Sarhadi V, Knuutila S, Boige V, André T, Laurent-Puig P.

Clin Cancer Res. 2014 Jun 15;20(12):3338-47. doi: 10.1158/1078-0432.CCR-13-2750. Epub 2014 Apr 25.

36.

Differentiating soft tissue leiomyosarcoma and undifferentiated pleomorphic sarcoma: A miRNA analysis.

Guled M, Pazzaglia L, Borze I, Mosakhani N, Novello C, Benassi MS, Knuutila S.

Genes Chromosomes Cancer. 2014 Aug;53(8):693-702. doi: 10.1002/gcc.22179. Epub 2014 Apr 26.

PMID:
24771630
37.

Burkitt lymphoma and Ewing sarcoma in a child with Williams syndrome.

Vanhapiha N, Knuutila S, Vettenranta K, Lohi O.

Pediatr Blood Cancer. 2014 Oct;61(10):1877-9. doi: 10.1002/pbc.25055. Epub 2014 Apr 19.

PMID:
24753445
38.

RB1 gene in Merkel cell carcinoma: hypermethylation in all tumors and concurrent heterozygous deletions in the polyomavirus-negative subgroup.

Sahi H, Savola S, Sihto H, Koljonen V, Bohling T, Knuutila S.

APMIS. 2014 Dec;122(12):1157-66. doi: 10.1111/apm.12274. Epub 2014 Apr 16.

PMID:
24735260
39.

ALK/EML4 fusion gene may be found in pure squamous carcinoma of the lung.

Caliò A, Nottegar A, Gilioli E, Bria E, Pilotto S, Peretti U, Kinspergher S, Simionato F, Pedron S, Knuutila S, Tortora G, Eccher A, Santo A, Tondulli L, Inghirami G, Tabbò F, Martignoni G, Chilosi M, Scarpa A, Brunelli M.

J Thorac Oncol. 2014 May;9(5):729-32. doi: 10.1097/JTO.0000000000000109.

40.

Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.

Sarhadi VK, Lahti L, Scheinin I, Ellonen P, Kettunen E, Serra M, Scotlandi K, Picci P, Knuutila S.

Genes Chromosomes Cancer. 2014 Jul;53(7):579-88. doi: 10.1002/gcc.22168. Epub 2014 Mar 24.

PMID:
24664538
41.

Erratum to: High-resolution SNP array analysis of patients with developmental disorder and normal array CGH result.

Siggberg L, Ala-Mello S, Linnankivi T, Avela K, Scheinin I, Kristiansson K, Lahermo P, Hietala M, Metsähonkala L, Kuusinen E, Laaksonen M, Saarela J, Knuutila S.

BMC Med Genet. 2014 Nov 18;15:124. doi: 10.1186/s12881-014-0124-3. No abstract available.

42.

Renal cell carcinoma with smooth muscle stroma lacks chromosome 3p and VHL alterations.

Martignoni G, Brunelli M, Segala D, Gobbo S, Borze I, Atanesyan L, Savola S, Barzon L, Masi G, Tardanico R, Zhang S, Eble JN, Chilosi M, Böhling T, Cheng L, Delahunt B, Knuutila S.

Mod Pathol. 2014 May;27(5):765-74. doi: 10.1038/modpathol.2013.180. Epub 2013 Nov 8.

43.

Mutated ephrin receptor genes in non-small cell lung carcinoma and their occurrence with driver mutations-targeted resequencing study on formalin-fixed, paraffin-embedded tumor material of 81 patients.

Mäki-Nevala S, Kaur Sarhadi V, Tuononen K, Lagström S, Ellonen P, Rönty M, Wirtanen A, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2013 Dec;52(12):1141-9. doi: 10.1002/gcc.22109. Epub 2013 Oct 7.

PMID:
24123310
44.

[MicroRNAs and cancer].

Guled M, Knuutila S.

Duodecim. 2013;129(16):1661-9. Review. Finnish.

PMID:
24069635
45.

MicroRNA expression profiles in Kaposi's sarcoma.

Catrina Ene AM, Borze I, Guled M, Costache M, Leen G, Sajin M, Ionica E, Chitu A, Knuutila S.

Pathol Oncol Res. 2014 Jan;20(1):153-9. doi: 10.1007/s12253-013-9678-1. Epub 2013 Sep 13.

PMID:
24027049
46.

Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia.

Mosakhani N, Mustjoki S, Knuutila S.

Mol Cytogenet. 2013 Jul 16;6(1):27. doi: 10.1186/1755-8166-6-27.

47.

Report of interstitial 22q13.1q13.2 microduplication in two siblings with distinctive dysmorphic features, heart defect and mental retardation.

Rahikkala E, Forsström LM, Kokkonen H, Knuutila S, Mustonen A, Ignatius J.

Eur J Med Genet. 2013 Jul;56(7):389-96. doi: 10.1016/j.ejmg.2013.05.004. Epub 2013 May 22.

PMID:
23707653
48.

MicroRNA profiling in chemoresistant and chemosensitive acute myeloid leukemia.

Mosakhani N, Räty R, Tyybäkinoja A, Karjalainen-Lindsberg ML, Elonen E, Knuutila S.

Cytogenet Genome Res. 2013;141(4):272-6. doi: 10.1159/000351219. Epub 2013 May 16.

PMID:
23689423
49.

Targeted resequencing reveals ALK fusions in non-small cell lung carcinomas detected by FISH, immunohistochemistry, and real-time RT-PCR: a comparison of four methods.

Tuononen K, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Knuuttila A, Remes S, Telaranta-Keerie AI, Bloor S, Ellonen P, Knuutila S.

Biomed Res Int. 2013;2013:757490. doi: 10.1155/2013/757490. Epub 2013 Jan 20.

50.

Comparison of targeted next-generation sequencing (NGS) and real-time PCR in the detection of EGFR, KRAS, and BRAF mutations on formalin-fixed, paraffin-embedded tumor material of non-small cell lung carcinoma-superiority of NGS.

Tuononen K, Mäki-Nevala S, Sarhadi VK, Wirtanen A, Rönty M, Salmenkivi K, Andrews JM, Telaranta-Keerie AI, Hannula S, Lagström S, Ellonen P, Knuuttila A, Knuutila S.

Genes Chromosomes Cancer. 2013 May;52(5):503-11. doi: 10.1002/gcc.22047. Epub 2013 Jan 30.

PMID:
23362162

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