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Non-transferrin-bound iron transporters.

Knutson MD.

Free Radic Biol Med. 2019 Mar;133:101-111. doi: 10.1016/j.freeradbiomed.2018.10.413. Epub 2018 Oct 12. Review.


Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle.

Wang G, Biswas AK, Ma W, Kandpal M, Coker C, Grandgenett PM, Hollingsworth MA, Jain R, Tanji K, Lόpez-Pintado S, Borczuk A, Hebert D, Jenkitkasemwong S, Hojyo S, Davuluri RV, Knutson MD, Fukada T, Acharyya S.

Nat Med. 2018 Jun;24(6):770-781. doi: 10.1038/s41591-018-0054-2. Epub 2018 Jun 6.


SLC39A14 deficiency alters manganese homeostasis and excretion resulting in brain manganese accumulation and motor deficits in mice.

Jenkitkasemwong S, Akinyode A, Paulus E, Weiskirchen R, Hojyo S, Fukada T, Giraldo G, Schrier J, Garcia A, Janus C, Giasson B, Knutson MD.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1769-E1778. doi: 10.1073/pnas.1720739115. Epub 2018 Feb 7. Erratum in: Proc Natl Acad Sci U S A. 2018 May 7;:.


The Tumor Suppressor, P53, Decreases the Metal Transporter, ZIP14.

Zhao N, Zhang AS, Wortham AM, Jue S, Knutson MD, Enns CA.

Nutrients. 2017 Dec 8;9(12). pii: E1335. doi: 10.3390/nu9121335.


Mobilization of iron from ferritin: new steps and details.

La A, Nguyen T, Tran K, Sauble E, Tu D, Gonzalez A, Kidane TZ, Soriano C, Morgan J, Doan M, Tran K, Wang CY, Knutson MD, Linder MC.

Metallomics. 2018 Jan 24;10(1):154-168. doi: 10.1039/c7mt00284j.


Iron transport proteins: Gateways of cellular and systemic iron homeostasis.

Knutson MD.

J Biol Chem. 2017 Aug 4;292(31):12735-12743. doi: 10.1074/jbc.R117.786632. Epub 2017 Jun 14. Review.


Measurement of Transferrin- and Non-transferrin-bound Iron Uptake by Mouse Tissues.

Jenkitkasemwong S, Wang CY, Knutson MD.

Bio Protoc. 2016 Sep 5;6(17). pii: e1922. doi: 10.21769/BioProtoc.1922.


The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human β-cells.

Coffey R, Knutson MD.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C169-C175. doi: 10.1152/ajpcell.00116.2016. Epub 2016 Nov 30.


SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis.

Jenkitkasemwong S, Wang CY, Coffey R, Zhang W, Chan A, Biel T, Kim JS, Hojyo S, Fukada T, Knutson MD.

Cell Metab. 2015 Jul 7;22(1):138-50. doi: 10.1016/j.cmet.2015.05.002. Epub 2015 May 28.


Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.

Tripathi AK, Haldar S, Qian J, Beserra A, Suda S, Singh A, Hopfer U, Chen SG, Garrick MD, Turner JR, Knutson MD, Singh N.

Free Radic Biol Med. 2015 Jul;84:322-330. doi: 10.1016/j.freeradbiomed.2015.03.037. Epub 2015 Apr 8.


An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14.

Zhao N, Zhang AS, Worthen C, Knutson MD, Enns CA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9175-80. doi: 10.1073/pnas.1405355111. Epub 2014 Jun 9.


Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.

Coffey R, Nam H, Knutson MD.

PLoS One. 2014 Jan 21;9(1):e86019. doi: 10.1371/journal.pone.0086019. eCollection 2014.


Fine-mapping and genetic analysis of the loci affecting hepatic iron overload in mice.

Guo X, Zhang Z, Zhang F, Tao Y, An P, Wu Q, Wang CY, Knutson MD, Wang F.

PLoS One. 2013 May 10;8(5):e63280. doi: 10.1371/journal.pone.0063280. Print 2013.


ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders.

Nam H, Wang CY, Zhang L, Zhang W, Hojyo S, Fukada T, Knutson MD.

Haematologica. 2013 Jul;98(7):1049-57. doi: 10.3324/haematol.2012.072314. Epub 2013 Jan 24.


ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.

Wang CY, Jenkitkasemwong S, Duarte S, Sparkman BK, Shawki A, Mackenzie B, Knutson MD.

J Biol Chem. 2012 Oct 5;287(41):34032-43. doi: 10.1074/jbc.M112.367284. Epub 2012 Aug 16.


Impaired iron status in aging research.

Xu J, Jia Z, Knutson MD, Leeuwenburgh C.

Int J Mol Sci. 2012;13(2):2368-86. doi: 10.3390/ijms13022368. Epub 2012 Feb 22. Review.


Physiologic implications of metal-ion transport by ZIP14 and ZIP8.

Jenkitkasemwong S, Wang CY, Mackenzie B, Knutson MD.

Biometals. 2012 Aug;25(4):643-55. doi: 10.1007/s10534-012-9526-x. Epub 2012 Feb 9. Review.


Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy.

Xu J, Hwang JC, Lees HA, Wohlgemuth SE, Knutson MD, Judge AR, Dupont-Versteegden EE, Marzetti E, Leeuwenburgh C.

Exp Gerontol. 2012 Jan;47(1):100-8. doi: 10.1016/j.exger.2011.10.011. Epub 2011 Nov 4.


Effect of dietary iron deficiency and overload on the expression of ZIP metal-ion transporters in rat liver.

Nam H, Knutson MD.

Biometals. 2012 Feb;25(1):115-24. doi: 10.1007/s10534-011-9487-5. Epub 2011 Aug 9.


Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses.

Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, Wu Q, Zhang Y, Yu Y, Ning B, Nie G, Knutson MD, Anderson GJ, Wang F.

Blood. 2011 Aug 18;118(7):1912-22. doi: 10.1182/blood-2011-01-330324. Epub 2011 Jun 24.


Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.

Pinilla-Tenas JJ, Sparkman BK, Shawki A, Illing AC, Mitchell CJ, Zhao N, Liuzzi JP, Cousins RJ, Knutson MD, Mackenzie B.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C862-71. doi: 10.1152/ajpcell.00479.2010. Epub 2011 Jun 8.


ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.

Zhao N, Gao J, Enns CA, Knutson MD.

J Biol Chem. 2010 Oct 15;285(42):32141-50. doi: 10.1074/jbc.M110.143248. Epub 2010 Aug 3.


Iron-sensing proteins that regulate hepcidin and enteric iron absorption.

Knutson MD.

Annu Rev Nutr. 2010 Aug 21;30:149-71. doi: 10.1146/annurev.nutr.012809.104801. Review.


Metabolic crossroads of iron and copper.

Collins JF, Prohaska JR, Knutson MD.

Nutr Rev. 2010 Mar;68(3):133-47. doi: 10.1111/j.1753-4887.2010.00271.x. Review.


Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels.

Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD.

J Nutr. 2010 Apr;140(4):723-30. doi: 10.3945/jn.109.117077. Epub 2010 Feb 17.


High dietary iron reduces transporters involved in iron and manganese metabolism and increases intestinal permeability in calves.

Hansen SL, Ashwell MS, Moeser AJ, Fry RS, Knutson MD, Spears JW.

J Dairy Sci. 2010 Feb;93(2):656-65. doi: 10.3168/jds.2009-2341.


The dorsal root ganglion in Friedreich's ataxia.

Koeppen AH, Morral JA, Davis AN, Qian J, Petrocine SV, Knutson MD, Gibson WM, Cusack MJ, Li D.

Acta Neuropathol. 2009 Dec;118(6):763-76. doi: 10.1007/s00401-009-0589-x. Epub 2009 Aug 30.


Technical note: copper chaperone for copper, zinc superoxide dismutase: a potential biomarker for copper status in cattle.

Hepburn JJ, Arthington JD, Hansen SL, Spears JW, Knutson MD.

J Anim Sci. 2009 Dec;87(12):4161-6. doi: 10.2527/jas.2009-1978. Epub 2009 Aug 28.


Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level?

Genter MB, Kendig EL, Knutson MD.

Ann N Y Acad Sci. 2009 Jul;1170:623-8. doi: 10.1111/j.1749-6632.2009.03877.x. Review.


Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2.

Knutson MD.

Nutr Rev. 2009 May;67(5):284-8. doi: 10.1111/j.1753-4887.2009.00200.x. Review.


BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism.

Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL.

Nat Genet. 2009 Apr;41(4):482-7. doi: 10.1038/ng.335. Epub 2009 Mar 1.


Iron loading increases ferroportin heterogeneous nuclear RNA and mRNA levels in murine J774 macrophages.

Aydemir F, Jenkitkasemwong S, Gulec S, Knutson MD.

J Nutr. 2009 Mar;139(3):434-8. doi: 10.3945/jn.108.094052. Epub 2009 Jan 13.


Hepcidin regulation of iron transport.

Collins JF, Wessling-Resnick M, Knutson MD.

J Nutr. 2008 Nov;138(11):2284-8. doi: 10.3945/jn.108.096347.


Mitochondrial iron accumulation with age and functional consequences.

Seo AY, Xu J, Servais S, Hofer T, Marzetti E, Wohlgemuth SE, Knutson MD, Chung HY, Leeuwenburgh C.

Aging Cell. 2008 Oct;7(5):706-16.


Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases.

Knutson MD, Leeuwenburgh C.

Nutr Rev. 2008 Oct;66(10):591-6. doi: 10.1111/j.1753-4887.2008.00109.x. Review.


Iron accumulation with age, oxidative stress and functional decline.

Xu J, Knutson MD, Carter CS, Leeuwenburgh C.

PLoS One. 2008 Aug 6;3(8):e2865. doi: 10.1371/journal.pone.0002865.


The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells.

Gao J, Zhao N, Knutson MD, Enns CA.

J Biol Chem. 2008 Aug 1;283(31):21462-8. doi: 10.1074/jbc.M803150200. Epub 2008 Jun 4.


Daily supplementation with iron increases lipid peroxidation in young women with low iron stores.

King SM, Donangelo CM, Knutson MD, Walter PB, Ames BN, Viteri FE, King JC.

Exp Biol Med (Maywood). 2008 Jun;233(6):701-7. doi: 10.3181/0708-RM-233. Epub 2008 Apr 11.


Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy.

Hofer T, Marzetti E, Xu J, Seo AY, Gulec S, Knutson MD, Leeuwenburgh C, Dupont-Versteegden EE.

Exp Gerontol. 2008 Jun;43(6):563-70. doi: 10.1016/j.exger.2008.02.007. Epub 2008 Feb 29.


Steap proteins: implications for iron and copper metabolism.

Knutson MD.

Nutr Rev. 2007 Jul;65(7):335-40. Review.


The dentate nucleus in Friedreich's ataxia: the role of iron-responsive proteins.

Koeppen AH, Michael SC, Knutson MD, Haile DJ, Qian J, Levi S, Santambrogio P, Garrick MD, Lamarche JB.

Acta Neuropathol. 2007 Aug;114(2):163-73. Epub 2007 Apr 11.


Iron and iron-responsive proteins in the cardiomyopathy of Friedreich's ataxia.

Michael S, Petrocine SV, Qian J, Lamarche JB, Knutson MD, Garrick MD, Koeppen AH.

Cerebellum. 2006;5(4):257-67.


Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.

Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13612-7. Epub 2006 Sep 1.


The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.

Chlosta S, Fishman DS, Harrington L, Johnson EE, Knutson MD, Wessling-Resnick M, Cherayil BJ.

Infect Immun. 2006 May;74(5):3065-7.


Effects of iron status on transpulmonary transport and tissue distribution of Mn and Fe.

Brain JD, Heilig E, Donaghey TC, Knutson MD, Wessling-Resnick M, Molina RM.

Am J Respir Cell Mol Biol. 2006 Mar;34(3):330-7. Epub 2005 Dec 9.


Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.

Liuzzi JP, Lichten LA, Rivera S, Blanchard RK, Aydemir TB, Knutson MD, Ganz T, Cousins RJ.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6843-8. Epub 2005 Apr 29.


Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin.

Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1324-8. Epub 2005 Jan 21.


Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages.

Knutson MD, Vafa MR, Haile DJ, Wessling-Resnick M.

Blood. 2003 Dec 1;102(12):4191-7. Epub 2003 Aug 7.


Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats.

Walter PB, Knutson MD, Paler-Martinez A, Lee S, Xu Y, Viteri FE, Ames BN.

Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2264-9.

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