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Cytotoxic T cell depletion with increasing epithelial abnormality in women with benign breast disease.

Adhikary S, Hoskin TL, Stallings-Mann ML, Arshad M, Frost MH, Winham SJ, Peña A, Lee DJ, Murphy LM, Rakoff M, Denison LA, Knutson KL, Radisky DC, Visscher DW, Degnim AC.

Breast Cancer Res Treat. 2020 Jan 13. doi: 10.1007/s10549-019-05493-5. [Epub ahead of print]


Longitudinal relationships between rheumatoid factor and cytokine expression by immunostimulated peripheral blood lymphocytes from patients with rheumatoid arthritis: New insights into B-cell activation.

Davis JM 3rd, Crowson CS, Knutson KL, Achenbach SJ, Strausbauch MA, Therneau TM, Matteson EL, Gabriel SE, Wettstein PJ.

Clin Immunol. 2020 Jan 8:108342. doi: 10.1016/j.clim.2020.108342. [Epub ahead of print]


Rapid generation of sustainable HER2-specific T cell immunity in HER2 breast cancer patients using a degenerate HLA class II epitope vaccine.

Knutson KL, Block MS, Norton N, Erskine CL, Hobday TJ, Dietz AB, Padley D, Gustafson MP, Puglisi-Knutson D, Mangskau TK, Chumsri S, Dueck AC, Karyampudi L, Wilson G, Degnim AC.

Clin Cancer Res. 2019 Nov 22. pii: clincanres.2123.2019. doi: 10.1158/1078-0432.CCR-19-2123. [Epub ahead of print]


The Association of Optimism with Sleep Duration and Quality: Findings from the Coronary Artery Risk and Development in Young Adults (CARDIA) Study.

Hernandez R, Vu TT, Kershaw KN, Boehm JK, Kubzansky LD, Carnethon M, Trudel-Fitzgerald C, Knutson KL, Colangelo LA, Liu K.

Behav Med. 2019 Jul 24:1-12. doi: 10.1080/08964289.2019.1575179. [Epub ahead of print]


Sleep and activity patterns in older patients discharged from the hospital.

Kessler R, Knutson KL, Mokhlesi B, Anderson SL, Shah M, Meltzer DO, Arora VM.

Sleep. 2019 Oct 21;42(11). pii: zsz153. doi: 10.1093/sleep/zsz153.


Genome-wide association study of breakfast skipping links clock regulation with food timing.

Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena R.

Am J Clin Nutr. 2019 Aug 1;110(2):473-484. doi: 10.1093/ajcn/nqz076.


Sleep myths: an expert-led study to identify false beliefs about sleep that impinge upon population sleep health practices.

Robbins R, Grandner MA, Buxton OM, Hale L, Buysse DJ, Knutson KL, Patel SR, Troxel WM, Youngstedt SD, Czeisler CA, Jean-Louis G.

Sleep Health. 2019 Aug;5(4):409-417. doi: 10.1016/j.sleh.2019.02.002. Epub 2019 Apr 17.


Hypereosinophilia in a patient with metastatic non-small-cell lung cancer treated with antiprogrammed cell death 1 (anti-PD-1) therapy.

Lou Y, Marin-Acevedo JA, Vishnu P, Manochakian R, Dholaria B, Soyano A, Luo Y, Zhang Y, Knutson KL.

Immunotherapy. 2019 May;11(7):577-584. doi: 10.2217/imt-2018-0128.


Poor sleep quality and lipid profile in a rural cohort (The Baependi Heart Study).

Geovanini GR, Lorenzi-Filho G, de Paula LK, Oliveira CM, de Oliveira Alvim R, Beijamini F, Negrão AB, von Schantz M, Knutson KL, Krieger JE, Pereira AC.

Sleep Med. 2019 May;57:30-35. doi: 10.1016/j.sleep.2018.12.028. Epub 2019 Jan 30.


Effects of Age and Immune Landscape on Outcome in HER2-Positive Breast Cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) Trials.

Chumsri S, Serie DJ, Li Z, Pogue-Geile KL, Soyano-Muller AE, Mashadi-Hossein A, Warren S, Lou Y, Colon-Otero G, Knutson KL, Perez EA, Moreno-Aspitia A, Thompson EA.

Clin Cancer Res. 2019 Jul 15;25(14):4422-4430. doi: 10.1158/1078-0432.CCR-18-2206. Epub 2019 Feb 26.


The evolving clinical landscape for dendritic cell vaccines and cancer immunotherapy.

Cannon MJ, Block MS, Morehead LC, Knutson KL.

Immunotherapy. 2019 Feb;11(2):75-79. doi: 10.2217/imt-2018-0129. No abstract available.


Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association.

Benjamin EJ, Muntner P, Alonso A, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Das SR, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Jordan LC, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, O'Flaherty M, Pandey A, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Spartano NL, Stokes A, Tirschwell DL, Tsao CW, Turakhia MP, VanWagner LB, Wilkins JT, Wong SS, Virani SS; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee.

Circulation. 2019 Mar 5;139(10):e56-e528. doi: 10.1161/CIR.0000000000000659. No abstract available. Erratum in: Circulation. 2020 Jan 14;141(2):e33.


Effectiveness of SIESTA on Objective and Subjective Metrics of Nighttime Hospital Sleep Disruptors.

Arora VM, Machado N, Anderson SL, Desai N, Marsack W, Blossomgame S, Tuvilleja A, Ramos J, Francisco MA, LaFond C, Leung EK, Valencia A, Martin SK, Meltzer DO, Farnan JM, Balachandran J, Knutson KL, Mokhlesi B.

J Hosp Med. 2019 Jan;14(1):38-41. doi: 10.12788/jhm.3091.


Peripheral blood biomarkers correlate with outcomes in advanced non-small cell lung Cancer patients treated with anti-PD-1 antibodies.

Soyano AE, Dholaria B, Marin-Acevedo JA, Diehl N, Hodge D, Luo Y, Manochakian R, Chumsri S, Adjei A, Knutson KL, Lou Y.

J Immunother Cancer. 2018 Nov 23;6(1):129. doi: 10.1186/s40425-018-0447-2.


Generation of HER2-specific antibody immunity during trastuzumab adjuvant therapy associates with reduced relapse in resected HER2 breast cancer.

Norton N, Fox N, McCarl CA, Tenner KS, Ballman K, Erskine CL, Necela BM, Northfelt D, Tan WW, Calfa C, Pegram M, Colon-Otero G, Perez EA, Clynes R, Knutson KL.

Breast Cancer Res. 2018 Jun 14;20(1):52. doi: 10.1186/s13058-018-0989-8.


Associations between chronotype, morbidity and mortality in the UK Biobank cohort.

Knutson KL, von Schantz M.

Chronobiol Int. 2018 Aug;35(8):1045-1053. doi: 10.1080/07420528.2018.1454458. Epub 2018 Apr 11.


Folate Receptor Alpha Peptide Vaccine Generates Immunity in Breast and Ovarian Cancer Patients.

Kalli KR, Block MS, Kasi PM, Erskine CL, Hobday TJ, Dietz A, Padley D, Gustafson MP, Shreeder B, Puglisi-Knutson D, Visscher DW, Mangskau TK, Wilson G, Knutson KL.

Clin Cancer Res. 2018 Jul 1;24(13):3014-3025. doi: 10.1158/1078-0432.CCR-17-2499. Epub 2018 Mar 15.


Next generation of immune checkpoint therapy in cancer: new developments and challenges.

Marin-Acevedo JA, Dholaria B, Soyano AE, Knutson KL, Chumsri S, Lou Y.

J Hematol Oncol. 2018 Mar 15;11(1):39. doi: 10.1186/s13045-018-0582-8. Review.


Cancer immunotherapy beyond immune checkpoint inhibitors.

Marin-Acevedo JA, Soyano AE, Dholaria B, Knutson KL, Lou Y.

J Hematol Oncol. 2018 Jan 12;11(1):8. doi: 10.1186/s13045-017-0552-6. Review.


Health implications of sleep and circadian rhythm research in 2017.

Abbott SM, Knutson KL, Zee PC.

Lancet Neurol. 2018 Jan;17(1):17-18. doi: 10.1016/S1474-4422(17)30410-6. Epub 2017 Dec 16. No abstract available.


Macrophagic "Crown-like Structures" Are Associated with an Increased Risk of Breast Cancer in Benign Breast Disease.

Carter JM, Hoskin TL, Pena MA, Brahmbhatt R, Winham SJ, Frost MH, Stallings-Mann M, Radisky DC, Knutson KL, Visscher DW, Degnim AC.

Cancer Prev Res (Phila). 2018 Feb;11(2):113-119. doi: 10.1158/1940-6207.CAPR-17-0245. Epub 2017 Nov 22.


Downregulation of TAP1 and TAP2 in early stage breast cancer.

Henle AM, Nassar A, Puglisi-Knutson D, Youssef B, Knutson KL.

PLoS One. 2017 Nov 1;12(11):e0187323. doi: 10.1371/journal.pone.0187323. eCollection 2017.


CD56+ immune cell infiltration and MICA are decreased in breast lobules with fibrocystic changes.

Kerekes D, Visscher DW, Hoskin TL, Radisky DC, Brahmbhatt RD, Pena A, Frost MH, Arshad M, Stallings-Mann M, Winham SJ, Murphy L, Denison L, Carter JM, Knutson KL, Degnim AC.

Breast Cancer Res Treat. 2018 Feb;167(3):649-658. doi: 10.1007/s10549-017-4558-0. Epub 2017 Nov 1.


Immune checkpoint inhibition by anti-PDCD1 (anti-PD1) monoclonal antibody has significant therapeutic activity against central nervous system lymphoma in an immunocompetent preclinical model.

Qiu Y, Li Z, Pouzoulet F, Vishnu P, Copland JA 3rd, Knutson KL, Soussain C, Tun HW.

Br J Haematol. 2018 Nov;183(4):674-678. doi: 10.1111/bjh.15009. Epub 2017 Oct 26. No abstract available.


IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer.

Lamichhane P, Karyampudi L, Shreeder B, Krempski J, Bahr D, Daum J, Kalli KR, Goode EL, Block MS, Cannon MJ, Knutson KL.

Cancer Res. 2017 Dec 1;77(23):6667-6678. doi: 10.1158/0008-5472.CAN-17-0740. Epub 2017 Oct 9.


Comparison between an African town and a neighbouring village shows delayed, but not decreased, sleep during the early stages of urbanisation.

Beale AD, Pedrazzoli M, Gonçalves BDSB, Beijamini F, Duarte NE, Egan KJ, Knutson KL, Schantz MV, Roden LC.

Sci Rep. 2017 Jul 18;7(1):5697. doi: 10.1038/s41598-017-05712-3.


The National Sleep Foundation's Sleep Health Index.

Knutson KL, Phelan J, Paskow MJ, Roach A, Whiton K, Langer G, Hillygus DS, Mokrzycki M, Broughton WA, Chokroverty S, Lichstein KL, Weaver TE, Hirshkowitz M.

Sleep Health. 2017 Aug;3(4):234-240. doi: 10.1016/j.sleh.2017.05.011. Epub 2017 Jun 20.


Habitual sleep and kidney function in chronic kidney disease: the Chronic Renal Insufficiency Cohort study.

Knutson KL, Lash J, Ricardo AC, Herdegen J, Thornton JD, Rahman M, Turek N, Cohan J, Appel LJ, Bazzano LA, Tamura MK, Steigerwalt SP, Weir MR, Van Cauter E; Cric Study Investigators.

J Sleep Res. 2018 Apr;27(2):281-289. doi: 10.1111/jsr.12573. Epub 2017 Jun 23.


Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy.

Yuan H, Jiang W, von Roemeling CA, Qie Y, Liu X, Chen Y, Wang Y, Wharen RE, Yun K, Bu G, Knutson KL, Kim BYS.

Nat Nanotechnol. 2017 Aug;12(8):763-769. doi: 10.1038/nnano.2017.69. Epub 2017 May 1.


Association of sleep characteristics with cardiovascular and metabolic risk factors in a population sample: the Chicago Area Sleep Study.

Montag SE, Knutson KL, Zee PC, Goldberger JJ, Ng J, Kim KA, Carnethon MR.

Sleep Health. 2017 Apr;3(2):107-112. doi: 10.1016/j.sleh.2017.01.003. Epub 2017 Feb 10.


Association Between Sleep Timing, Obesity, Diabetes: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Cohort Study.

Knutson KL, Wu D, Patel SR, Loredo JS, Redline S, Cai J, Gallo LC, Mossavar-Rahmani Y, Ramos AR, Teng Y, Daviglus ML, Zee PC.

Sleep. 2017 Apr 1;40(4). doi: 10.1093/sleep/zsx014.


Sleep-apnea risk and subclinical atherosclerosis in early-middle-aged retired National Football League players.

Luyster FS, Dunn RE, Lauderdale DS, Carnethon MR, Tucker AM, Vogel RA, Lincoln AE, Knutson KL, Pellman EJ, Strollo PJ Jr.

Nat Sci Sleep. 2017 Feb 21;9:31-38. doi: 10.2147/NSS.S125228. eCollection 2017.


Later chronotype is associated with higher hemoglobin A1c in prediabetes patients.

Anothaisintawee T, Lertrattananon D, Thamakaison S, Knutson KL, Thakkinstian A, Reutrakul S.

Chronobiol Int. 2017;34(3):393-402. doi: 10.1080/07420528.2017.1279624. Epub 2017 Jan 27.


Alterations in the Immune Cell Composition in Premalignant Breast Tissue that Precede Breast Cancer Development.

Degnim AC, Hoskin TL, Arshad M, Frost MH, Winham SJ, Brahmbhatt RA, Pena A, Carter JM, Stallings-Mann ML, Murphy LM, Miller EE, Denison LA, Vachon CM, Knutson KL, Radisky DC, Visscher DW.

Clin Cancer Res. 2017 Jul 15;23(14):3945-3952. doi: 10.1158/1078-0432.CCR-16-2026. Epub 2017 Jan 26.


Cytokine and neuropeptide levels are associated with pain relief in patients with chronically painful total knee arthroplasty: a pilot study.

Singh JA, Noorbaloochi S, Knutson KL.

BMC Musculoskelet Disord. 2017 Jan 14;18(1):17. doi: 10.1186/s12891-016-1375-2.


Amerindian (but not African or European) ancestry is significantly associated with diurnal preference within an admixed Brazilian population.

Egan KJ, Campos Santos H, Beijamini F, Duarte NE, Horimoto AR, Taporoski TP, Vallada H, Negrão AB, Krieger JE, Pedrazzoli M, Knutson KL, Pereira AC, von Schantz M.

Chronobiol Int. 2017;34(2):269-272. doi: 10.1080/07420528.2016.1265979. Epub 2017 Jan 5.


Timing and quality of sleep in a rural Brazilian family-based cohort, the Baependi Heart Study.

Beijamini F, Knutson KL, Lorenzi-Filho G, Egan KJ, Taporoski TP, De Paula LK, Negrão AB, Horimoto AR, Duarte NE, Vallada H, Krieger JE, Pedrazzoli M, Pereira AC, von Schantz M.

Sci Rep. 2016 Dec 23;6:39283. doi: 10.1038/srep39283.


The role of race and ethnicity in sleep, circadian rhythms and cardiovascular health.

Egan KJ, Knutson KL, Pereira AC, von Schantz M.

Sleep Med Rev. 2017 Jun;33:70-78. doi: 10.1016/j.smrv.2016.05.004. Epub 2016 Jun 3. Review.


Association Between Inpatient Sleep Loss and Hyperglycemia of Hospitalization.

DePietro RH, Knutson KL, Spampinato L, Anderson SL, Meltzer DO, Van Cauter E, Arora VM.

Diabetes Care. 2017 Feb;40(2):188-193. doi: 10.2337/dc16-1683. Epub 2016 Nov 30.


Sleep characteristics in type 1 diabetes and associations with glycemic control: systematic review and meta-analysis.

Reutrakul S, Thakkinstian A, Anothaisintawee T, Chontong S, Borel AL, Perfect MM, Janovsky CC, Kessler R, Schultes B, Harsch IA, van Dijk M, Bouhassira D, Matejko B, Lipton RB, Suwannalai P, Chirakalwasan N, Schober AK, Knutson KL.

Sleep Med. 2016 Jul;23:26-45. doi: 10.1016/j.sleep.2016.03.019. Epub 2016 Jun 8. Review.


The Mediation of Racial Differences in Hypertension by Sleep Characteristics: Chicago Area Sleep Study.

Rasmussen-Torvik LJ, De Chavez PJD, Kershaw KN, Montag SE, Knutson KL, Kim KA, Zee PC, Carnethon MR.

Am J Hypertens. 2016 Dec 1;29(12):1353-1357. doi: 10.1093/ajh/hpw093.


Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.

Hampras SS, Sucheston-Campbell LE, Cannioto R, Chang-Claude J, Modugno F, Dörk T, Hillemanns P, Preus L, Knutson KL, Wallace PK, Hong CC, Friel G, Davis W, Nesline M, Pearce CL, Kelemen LE, Goodman MT, Bandera EV, Terry KL, Schoof N, Eng KH, Clay A, Singh PK, Joseph JM, Aben KK, Anton-Culver H, Antonenkova N, Baker H, Bean Y, Beckmann MW, Bisogna M, Bjorge L, Bogdanova N, Brinton LA, Brooks-Wilson A, Bruinsma F, Butzow R, Campbell IG, Carty K, Cook LS, Cramer DW, Cybulski C, Dansonka-Mieszkowska A, Dennis J, Despierre E, Dicks E, Doherty JA, du Bois A, Dürst M, Easton D, Eccles D, Edwards RP, Ekici AB, Fasching PA, Fridley BL, Gao YT, Gentry-Maharaj A, Giles GG, Glasspool R, Gronwald J, Harrington P, Harter P, Hasmad HN, Hein A, Heitz F, Hildebrandt MA, Hogdall C, Hogdall E, Hosono S, Iversen ES, Jakubowska A, Jensen A, Ji BT, Karlan BY, Kellar M, Kelley JL, Kiemeney LA, Klapdor R, Kolomeyevskaya N, Krakstad C, Kjaer SK, Kruszka B, Kupryjanczyk J, Lambrechts D, Lambrechts S, Le ND, Lee AW, Lele S, Leminen A, Lester J, Levine DA, Liang D, Lissowska J, Liu S, Lu K, Lubinski J, Lundvall L, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, McNeish I, Menon U, Moes-Sosnowska J, Narod SA, Nedergaard L, Nevanlinna H, Nickels S, Olson SH, Orlow I, Weber RP, Paul J, Pejovic T, Pelttari LM, Perkins B, Permuth-Wey J, Pike MC, Plisiecka-Halasa J, Poole EM, Risch HA, Rossing MA, Rothstein JH, Rudolph A, Runnebaum IB, Rzepecka IK, Salvesen HB, Schernhammer E, Schmitt K, Schwaab I, Shu XO, Shvetsov YB, Siddiqui N, Sieh W, Song H, Southey MC, Tangen IL, Teo SH, Thompson PJ, Timorek A, Tsai YY, Tworoger SS, Tyrer J, van Altena AM, Vergote I, Vierkant RA, Walsh C, Wang-Gohrke S, Wentzensen N, Whittemore AS, Wicklund KG, Wilkens LR, Wu AH, Wu X, Woo YL, Yang H, Zheng W, Ziogas A, Gayther SA, Ramus SJ, Sellers TA, Schildkraut JM, Phelan CM, Berchuck A, Chenevix-Trench G, Cunningham JM, Pharoah PP, Ness RB, Odunsi K, Goode EL, Moysich KB.

Oncotarget. 2016 Oct 25;7(43):69097-69110. doi: 10.18632/oncotarget.10215.


The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease.

Hieken TJ, Chen J, Hoskin TL, Walther-Antonio M, Johnson S, Ramaker S, Xiao J, Radisky DC, Knutson KL, Kalari KR, Yao JZ, Baddour LM, Chia N, Degnim AC.

Sci Rep. 2016 Aug 3;6:30751. doi: 10.1038/srep30751.


Sleep Duration and White Matter Quality in Middle-Aged Adults.

Yaffe K, Nasrallah I, Hoang TD, Lauderdale DS, Knutson KL, Carnethon MR, Launer LJ, Lewis CE, Sidney S.

Sleep. 2016 Sep 1;39(9):1743-7. doi: 10.5665/sleep.6104.


Retraction Note: Targeted immune therapy of ovarian cancer.

Knutson KL, Karyampudi L, Lamichhane P, Preston C.

Cancer Metastasis Rev. 2016 Sep;35(3):489. No abstract available.


Improved Survival of HER2+ Breast Cancer Patients Treated with Trastuzumab and Chemotherapy Is Associated with Host Antibody Immunity against the HER2 Intracellular Domain.

Knutson KL, Clynes R, Shreeder B, Yeramian P, Kemp KP, Ballman K, Tenner KS, Erskine CL, Norton N, Northfelt D, Tan W, Calfa C, Pegram M, Mittendorf EA, Perez EA.

Cancer Res. 2016 Jul 1;76(13):3702-10. doi: 10.1158/0008-5472.CAN-15-3091. Epub 2016 Apr 20.


Sleep in the modern family: protective family routines for child and adolescent sleep.

Buxton OM, Chang AM, Spilsbury JC, Bos T, Emsellem H, Knutson KL.

Sleep Health. 2015 May 1;1(1):15-27.


Consequences of Circadian Disruption on Cardiometabolic Health.

Reutrakul S, Knutson KL.

Sleep Med Clin. 2015 Dec;10(4):455-68. doi: 10.1016/j.jsmc.2015.07.005. Epub 2015 Sep 15. Review.


PD-1 Blunts the Function of Ovarian Tumor-Infiltrating Dendritic Cells by Inactivating NF-κB.

Karyampudi L, Lamichhane P, Krempski J, Kalli KR, Behrens MD, Vargas DM, Hartmann LC, Janco JM, Dong H, Hedin KE, Dietz AB, Goode EL, Knutson KL.

Cancer Res. 2016 Jan 15;76(2):239-50. doi: 10.1158/0008-5472.CAN-15-0748. Epub 2015 Nov 13.


Disparities in sleep characteristics by race/ethnicity in a population-based sample: Chicago Area Sleep Study.

Carnethon MR, De Chavez PJ, Zee PC, Kim KY, Liu K, Goldberger JJ, Ng J, Knutson KL.

Sleep Med. 2016 Feb;18:50-5. doi: 10.1016/j.sleep.2015.07.005. Epub 2015 Jul 26.

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