Sort by
Items per page

Send to

Choose Destination

Search results

Items: 18


The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, Gaida K, Holt T, Knutson CG, Koppada N, Lanman BA, Werner J, Rapaport AS, San Miguel T, Ortiz R, Osgood T, Sun JR, Zhu X, McCarter JD, Volak LP, Houk BE, Fakih MG, O'Neil BH, Price TJ, Falchook GS, Desai J, Kuo J, Govindan R, Hong DS, Ouyang W, Henary H, Arvedson T, Cee VJ, Lipford JR.

Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30.


Application of Transmural Flow Across In Vitro Microvasculature Enables Direct Sampling of Interstitial Therapeutic Molecule Distribution.

Offeddu GS, Possenti L, Loessberg-Zahl JT, Zunino P, Roberts J, Han X, Hickman D, Knutson CG, Kamm RD.

Small. 2019 Nov;15(46):e1902393. doi: 10.1002/smll.201902393. Epub 2019 Sep 9.


An on-chip model of protein paracellular and transcellular permeability in the microcirculation.

Offeddu GS, Haase K, Gillrie MR, Li R, Morozova O, Hickman D, Knutson CG, Kamm RD.

Biomaterials. 2019 Aug;212:115-125. doi: 10.1016/j.biomaterials.2019.05.022. Epub 2019 May 13.


Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat.

Meyer JT, Sparling BA, McCarty WJ, Zhang M, Soto M, Schneider S, Chen H, Roberts J, Tan H, Kornecook T, Andrews PS, Knutson CG.

J Pharmacol Exp Ther. 2019 Nov;371(2):476-486. doi: 10.1124/jpet.119.257105. Epub 2019 May 20.


Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease.

Knutson CG, Mangerich A, Zeng Y, Raczynski AR, Liberman RG, Kang P, Ye W, Prestwich EG, Lu K, Wishnok JS, Korzenik JR, Wogan GN, Fox JG, Dedon PC, Tannenbaum SR.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):E2332-41. doi: 10.1073/pnas.1222669110. Epub 2013 Jun 10.


Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism.

Lu K, Knutson CG, Wishnok JS, Fox JG, Tannenbaum SR.

J Proteome Res. 2012 Oct 5;11(10):4916-26. doi: 10.1021/pr300429x. Epub 2012 Sep 27.


Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer.

Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, Dedon PC.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1820-9. doi: 10.1073/pnas.1207829109. Epub 2012 Jun 11.


Site-specific and redox-controlled S-nitrosation of thioredoxin.

Barglow KT, Knutson CG, Wishnok JS, Tannenbaum SR, Marletta MA.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E600-6. doi: 10.1073/pnas.1110736108. Epub 2011 Aug 17.


Oxidation and glycolytic cleavage of etheno and propano DNA base adducts.

Knutson CG, Rubinson EH, Akingbade D, Anderson CS, Stec DF, Petrova KV, Kozekov ID, Guengerich FP, Rizzo CJ, Marnett LJ.

Biochemistry. 2009 Feb 3;48(4):800-9. doi: 10.1021/bi801654j.


Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.

Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA.

Chem Res Toxicol. 2008 Oct;21(10):1933-8. doi: 10.1021/tx800073p. Epub 2008 Aug 12.


Monitoring in vivo metabolism and elimination of the endogenous DNA adduct, M1dG {3-(2-deoxy-beta-D-erythro-pentofuranosyl)pyrimido[1,2-alpha]purin-10(3H)-one}, by accelerator mass spectrometry.

Knutson CG, Skipper PL, Liberman RG, Tannenbaum SR, Marnett LJ.

Chem Res Toxicol. 2008 Jun;21(6):1290-4. doi: 10.1021/tx800049v. Epub 2008 May 8.


"One-pot" syntheses of malondialdehyde adducts of nucleosides.

Szekely J, Wang H, Peplowski KM, Knutson CG, Marnett LJ, Rizzo CJ.

Nucleosides Nucleotides Nucleic Acids. 2008 Feb;27(2):103-9. doi: 10.1080/15257770701795797.


Metabolism and elimination of the endogenous DNA adduct, 3-(2-deoxy-beta-D-erythropentofuranosyl)-pyrimido[1,2-alpha]purine-10(3H)-one, in the rat.

Knutson CG, Wang H, Rizzo CJ, Marnett LJ.

J Biol Chem. 2007 Dec 14;282(50):36257-64. Epub 2007 Oct 19.


Conformational dynamics in the F/G segment of CYP51 from Mycobacterium tuberculosis monitored by FRET.

Lepesheva GI, Seliskar M, Knutson CG, Stourman NV, Rozman D, Waterman MR.

Arch Biochem Biophys. 2007 Aug 15;464(2):221-7. Epub 2007 Jun 6.


Metabolism in vitro and in vivo of the DNA base adduct, M1G.

Knutson CG, Akingbade D, Crews BC, Voehler M, Stec DF, Marnett LJ.

Chem Res Toxicol. 2007 Mar;20(3):550-7. Epub 2007 Feb 21.


In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.

Otteneder MB, Knutson CG, Daniels JS, Hashim M, Crews BC, Remmel RP, Wang H, Rizzo C, Marnett LJ.

Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6665-9. Epub 2006 Apr 13.


Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile.

Grillo MP, Knutson CG, Sanders PE, Waldon DJ, Hua F, Ware JA.

Drug Metab Dispos. 2003 Nov;31(11):1327-36.


Supplemental Content

Loading ...
Support Center