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Items: 1 to 50 of 52

1.

A bone model to study the role of triggering receptor expressed on myeloid cells-2 (TREM-2).

Rossi E, Mracsko E, Papadimitropoulos A, Allafi N, Reinhardt D, Mehrkens A, Martin I, Knuesel I, Scherberich A.

Tissue Eng Part C Methods. 2018 Jun 13. doi: 10.1089/ten.TEC.2018.0061. [Epub ahead of print]

PMID:
29897015
2.

NF-κB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS.

Ouali Alami N, Schurr C, Olde Heuvel F, Tang L, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver S, Rogers-Evans M, Rothenhäusler B, Ullmer C, Fingerle J, Grether U, Knuesel I, Boeckers TM, Ludolph A, Wirth T, Roselli F, Baumann B.

EMBO J. 2018 Jun 6. pii: e98697. doi: 10.15252/embj.201798697. [Epub ahead of print]

3.

Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy.

Gschwind T, Lafourcade C, Gfeller T, Zaichuk M, Rambousek L, Knuesel I, Fritschy JM.

Eur J Neurosci. 2018 Jun 4. doi: 10.1111/ejn.13983. [Epub ahead of print]

PMID:
29862588
4.

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, Mueggler T, Arzberger T, Knuesel I, Rominger A, Haass C.

EMBO J. 2017 Jul 3;36(13):1837-1853. doi: 10.15252/embj.201796516. Epub 2017 May 30.

PMID:
28559417
5.

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.

Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C.

EMBO Mol Med. 2016 Sep 1;8(9):992-1004. doi: 10.15252/emmm.201606370. Print 2016 Sep.

6.

Maternal immune activation and abnormal brain development across CNS disorders.

Knuesel I, Chicha L, Britschgi M, Schobel SA, Bodmer M, Hellings JA, Toovey S, Prinssen EP.

Nat Rev Neurol. 2014 Nov;10(11):643-60. doi: 10.1038/nrneurol.2014.187. Epub 2014 Oct 14. Review.

PMID:
25311587
7.

Novel role of cystic fibrosis transmembrane conductance regulator in maintaining adult mouse olfactory neuronal homeostasis.

Pfister S, Weber T, Härtig W, Schwerdel C, Elsaesser R, Knuesel I, Fritschy JM.

J Comp Neurol. 2015 Feb 15;523(3):406-30. doi: 10.1002/cne.23686. Epub 2014 Oct 15.

PMID:
25271146
8.
9.

The airbag problem-a potential culprit for bench-to-bedside translational efforts: relevance for Alzheimer's disease.

Krstic D, Knuesel I.

Acta Neuropathol Commun. 2013 Sep 23;1:62. doi: 10.1186/2051-5960-1-62. Review.

10.

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

Klohs J, Politano IW, Deistung A, Grandjean J, Drewek A, Dominietto M, Keist R, Schweser F, Reichenbach JR, Nitsch RM, Knuesel I, Rudin M.

PLoS One. 2013 Jun 19;8(6):e66097. doi: 10.1371/journal.pone.0066097. Print 2013.

11.

Decisive role of Reelin signaling during early stages of Alzheimer's disease.

Krstic D, Pfister S, Notter T, Knuesel I.

Neuroscience. 2013 Aug 29;246:108-16. doi: 10.1016/j.neuroscience.2013.04.042. Epub 2013 Apr 28. Review.

12.

Deciphering the mechanism underlying late-onset Alzheimer disease.

Krstic D, Knuesel I.

Nat Rev Neurol. 2013 Jan;9(1):25-34. doi: 10.1038/nrneurol.2012.236. Epub 2012 Nov 27. Review.

13.

Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators.

Krstic D, Rodriguez M, Knuesel I.

PLoS One. 2012;7(10):e47793. doi: 10.1371/journal.pone.0047793. Epub 2012 Oct 17.

14.

Characterization and turnover of CD73/IP(3)R3-positive microvillar cells in the adult mouse olfactory epithelium.

Pfister S, Dietrich MG, Sidler C, Fritschy JM, Knuesel I, Elsaesser R.

Chem Senses. 2012 Nov;37(9):859-68. doi: 10.1093/chemse/bjs069. Epub 2012 Sep 5.

15.

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice.

Krstic D, Madhusudan A, Doehner J, Vogel P, Notter T, Imhof C, Manalastas A, Hilfiker M, Pfister S, Schwerdel C, Riether C, Meyer U, Knuesel I.

J Neuroinflammation. 2012 Jul 2;9:151. doi: 10.1186/1742-2094-9-151.

16.

Extrusion of misfolded and aggregated proteins--a protective strategy of aging neurons?

Doehner J, Genoud C, Imhof C, Krstic D, Knuesel I.

Eur J Neurosci. 2012 Jun;35(12):1938-50. doi: 10.1111/j.1460-9568.2012.08154.x.

PMID:
22708604
17.

Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout.

Muhia M, Willadt S, Yee BK, Feldon J, Paterna JC, Schwendener S, Vogt K, Kennedy MB, Knuesel I.

Learn Mem. 2012 Jun 14;19(7):268-81. doi: 10.1101/lm.026351.112.

PMID:
22700469
18.

Impact of prenatal immune system disturbances on brain development.

Madhusudan A, Vogel P, Knuesel I.

J Neuroimmune Pharmacol. 2013 Mar;8(1):79-86. doi: 10.1007/s11481-012-9374-z. Epub 2012 May 13. Review.

19.

Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice.

Klohs J, Baltes C, Princz-Kranz F, Ratering D, Nitsch RM, Knuesel I, Rudin M.

J Neurosci. 2012 Feb 1;32(5):1705-13. doi: 10.1523/JNEUROSCI.5626-11.2012.

20.

Detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis.

Klohs J, Deistung A, Schweser F, Grandjean J, Dominietto M, Waschkies C, Nitsch RM, Knuesel I, Reichenbach JR, Rudin M.

J Cereb Blood Flow Metab. 2011 Dec;31(12):2282-92. doi: 10.1038/jcbfm.2011.118. Epub 2011 Aug 17.

21.

Hippocampal pyramidal cells: the reemergence of cortical lamination.

Slomianka L, Amrein I, Knuesel I, Sørensen JC, Wolfer DP.

Brain Struct Funct. 2011 Nov;216(4):301-17. doi: 10.1007/s00429-011-0322-0. Epub 2011 May 20. Review.

22.

[Prenatal infection as driving force of aging-associated neurodegenerative diseases].

Knuesel I.

Praxis (Bern 1994). 2011 Mar 2;100(5):299-304. doi: 10.1024/1661-8157/a000451. Review. German.

PMID:
21365561
23.

Impaired reelin processing and secretion by Cajal-Retzius cells contributes to granule cell dispersion in a mouse model of temporal lobe epilepsy.

Duveau V, Madhusudan A, Caleo M, Knuesel I, Fritschy JM.

Hippocampus. 2011 Sep;21(9):935-44. doi: 10.1002/hipo.20793. Epub 2010 May 17.

PMID:
20865728
24.

Reelin-mediated Signaling during Normal and Pathological Forms of Aging.

Doehner J, Knuesel I.

Aging Dis. 2010 Aug;1(1):12-29. Epub 2010 Jun 4.

25.

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I.

J Neurosci. 2010 Jul 7;30(27):9228-40. doi: 10.1523/JNEUROSCI.0418-10.2010.

26.

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases.

Knuesel I.

Prog Neurobiol. 2010 Aug;91(4):257-74. doi: 10.1016/j.pneurobio.2010.04.002. Epub 2010 Apr 22. Review.

PMID:
20417248
27.

Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression.

Arabadzisz D, Diaz-Heijtz R, Knuesel I, Weber E, Pilloud S, Dettling AC, Feldon J, Law AJ, Harrison PJ, Pryce CR.

Biol Psychiatry. 2010 Jun 1;67(11):1106-9. doi: 10.1016/j.biopsych.2009.12.016. Epub 2010 Feb 4.

PMID:
20132928
28.

Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP.

Muhia M, Yee BK, Feldon J, Markopoulos F, Knuesel I.

Eur J Neurosci. 2010 Feb;31(3):529-43. doi: 10.1111/j.1460-9568.2010.07079.x. Epub 2010 Jan 25.

PMID:
20105235
29.

Co-localization of Reelin and proteolytic AbetaPP fragments in hippocampal plaques in aged wild-type mice.

Doehner J, Madhusudan A, Konietzko U, Fritschy JM, Knuesel I.

J Alzheimers Dis. 2010;19(4):1339-57. doi: 10.3233/JAD-2010-1333.

PMID:
20061602
30.

Chronic clozapine treatment improves prenatal infection-induced working memory deficits without influencing adult hippocampal neurogenesis.

Meyer U, Knuesel I, Nyffeler M, Feldon J.

Psychopharmacology (Berl). 2010 Mar;208(4):531-43. doi: 10.1007/s00213-009-1754-6. Epub 2009 Dec 30.

PMID:
20041229
31.

Appetitively motivated instrumental learning in SynGAP heterozygous knockout mice.

Muhia M, Feldon J, Knuesel I, Yee BK.

Behav Neurosci. 2009 Oct;123(5):1114-28. doi: 10.1037/a0017118.

32.

Accumulation of reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging.

Madhusudan A, Sidler C, Knuesel I.

Eur J Neurosci. 2009 Sep;30(6):1064-76. doi: 10.1111/j.1460-9568.2009.06884.x. Epub 2009 Sep 4.

PMID:
19735296
33.

Abnormal differentiation of newborn granule cells in age-related working memory impairments.

Nyffeler M, Yee BK, Feldon J, Knuesel I.

Neurobiol Aging. 2010 Nov;31(11):1956-74. doi: 10.1016/j.neurobiolaging.2008.10.014. Epub 2008 Dec 18.

PMID:
19100662
34.

Amphetamine sensitization in rats as an animal model of schizophrenia.

Peleg-Raibstein D, Knuesel I, Feldon J.

Behav Brain Res. 2008 Aug 22;191(2):190-201. doi: 10.1016/j.bbr.2008.03.037. Epub 2008 Apr 8.

PMID:
18486243
35.

Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice.

Meyer U, Nyffeler M, Yee BK, Knuesel I, Feldon J.

Brain Behav Immun. 2008 May;22(4):469-86. Epub 2007 Nov 26.

PMID:
18023140
36.

Age-related accumulation of Reelin in amyloid-like deposits.

Knuesel I, Nyffeler M, Mormède C, Muhia M, Meyer U, Pietropaolo S, Yee BK, Pryce CR, LaFerla FM, Marighetto A, Feldon J.

Neurobiol Aging. 2009 May;30(5):697-716. Epub 2007 Sep 27.

PMID:
17904250
37.

Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge.

Meyer U, Nyffeler M, Schwendener S, Knuesel I, Yee BK, Feldon J.

Neuropsychopharmacology. 2008 Jan;33(2):441-56. Epub 2007 Apr 18.

38.

Long-term effects of early life deprivation on brain glia in Fischer rats.

Leventopoulos M, Rüedi-Bettschen D, Knuesel I, Feldon J, Pryce CR, Opacka-Juffry J.

Brain Res. 2007 Apr 20;1142:119-26. Epub 2007 Jan 18.

PMID:
17306230
39.

Maternal immune activation during pregnancy increases limbic GABAA receptor immunoreactivity in the adult offspring: implications for schizophrenia.

Nyffeler M, Meyer U, Yee BK, Feldon J, Knuesel I.

Neuroscience. 2006 Nov 17;143(1):51-62. Epub 2006 Oct 11.

PMID:
17045750
40.

The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology.

Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I, Yee BK, Feldon J.

J Neurosci. 2006 May 3;26(18):4752-62.

41.

Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.

Yee BK, Balic E, Singer P, Schwerdel C, Grampp T, Gabernet L, Knuesel I, Benke D, Feldon J, Mohler H, Boison D.

J Neurosci. 2006 Mar 22;26(12):3169-81.

42.

Differential expression of PSD proteins in age-related spatial learning impairments.

Nyffeler M, Zhang WN, Feldon J, Knuesel I.

Neurobiol Aging. 2007 Jan;28(1):143-55. Epub 2005 Dec 28.

PMID:
16386336
43.

Postnatal ontogeny of hippocampal expression of the mineralocorticoid and glucocorticoid receptors in the common marmoset monkey.

Pryce CR, Feldon J, Fuchs E, Knuesel I, Oertle T, Sengstag C, Spengler M, Weber E, Weston A, Jongen-Rélo A.

Eur J Neurosci. 2005 Mar;21(6):1521-35.

PMID:
15845080
44.

A role for synGAP in regulating neuronal apoptosis.

Knuesel I, Elliott A, Chen HJ, Mansuy IM, Kennedy MB.

Eur J Neurosci. 2005 Feb;21(3):611-21.

PMID:
15733080
45.

SynGAP regulates spine formation.

Vazquez LE, Chen HJ, Sokolova I, Knuesel I, Kennedy MB.

J Neurosci. 2004 Oct 6;24(40):8862-72.

46.

GABAergic terminals are required for postsynaptic clustering of dystrophin but not of GABA(A) receptors and gephyrin.

Brünig I, Suter A, Knuesel I, Lüscher B, Fritschy JM.

J Neurosci. 2002 Jun 15;22(12):4805-13.

47.

Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.

Knuesel I, Riban V, Zuellig RA, Schaub MC, Grady RM, Sanes JR, Fritschy JM.

Eur J Neurosci. 2002 May;15(9):1474-84.

PMID:
12028357
48.
49.

Differential expression of utrophin and dystrophin in CNS neurons: an in situ hybridization and immunohistochemical study.

Knuesel I, Bornhauser BC, Zuellig RA, Heller F, Schaub MC, Fritschy JM.

J Comp Neurol. 2000 Jul 10;422(4):594-611.

PMID:
10861528
50.

Identification and characterisation of transcript and protein of a new short N-terminal utrophin isoform.

Zuellig RA, Bornhauser BC, Knuesel I, Heller F, Fritschy JM, Schaub MC.

J Cell Biochem. 2000 Apr;77(3):418-31.

PMID:
10760950

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