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Items: 29


Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Knuepfer E, Wright KE, Kumar Prajapati S, Rawlinson TA, Mohring F, Koch M, Lyth OR, Howell SA, Villasis E, Snijders AP, Moon RW, Draper SJ, Rosanas-Urgell A, Higgins MK, Baum J, Holder AA.

PLoS Pathog. 2019 Jun 11;15(6):e1007809. doi: 10.1371/journal.ppat.1007809. [Epub ahead of print]


Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA.

Cell Chem Biol. 2019 Apr 9. pii: S2451-9456(19)30111-4. doi: 10.1016/j.chembiol.2019.03.015. [Epub ahead of print]


Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA.

J Biol Chem. 2017 Oct 27;292(43):17857-17875. doi: 10.1074/jbc.M117.802769. Epub 2017 Sep 11.


Generating conditional gene knockouts in Plasmodium - a toolkit to produce stable DiCre recombinase-expressing parasite lines using CRISPR/Cas9.

Knuepfer E, Napiorkowska M, van Ooij C, Holder AA.

Sci Rep. 2017 Jun 20;7(1):3881. doi: 10.1038/s41598-017-03984-3.


The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake.

Sherling ES, Knuepfer E, Brzostowski JA, Miller LH, Blackman MJ, van Ooij C.

Elife. 2017 Mar 2;6. pii: e23239. doi: 10.7554/eLife.23239.


Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites.

Hill RJ, Ringel A, Knuepfer E, Moon RW, Blackman MJ, van Ooij C.

J Biol Chem. 2016 Nov 11;291(46):24280-24292. Epub 2016 Oct 2.


Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi.

Moon RW, Sharaf H, Hastings CH, Ho YS, Nair MB, Rchiad Z, Knuepfer E, Ramaprasad A, Mohring F, Amir A, Yusuf NA, Hall J, Almond N, Lau YL, Pain A, Blackman MJ, Holder AA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7231-6. doi: 10.1073/pnas.1522469113. Epub 2016 Jun 14.


Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.

Crosnier C, Iqbal Z, Knuepfer E, Maciuca S, Perrin AJ, Kamuyu G, Goulding D, Bustamante LY, Miles A, Moore SC, Dougan G, Holder AA, Kwiatkowski DP, Rayner JC, Pleass RJ, Wright GJ.

J Biol Chem. 2016 Jul 1;291(27):14285-99. doi: 10.1074/jbc.M116.722074. Epub 2016 May 12.


The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA.

J Biol Chem. 2015 May 8;290(19):12147-64. doi: 10.1074/jbc.M115.637694. Epub 2015 Mar 23.


Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ.

Mol Microbiol. 2015 Apr;96(2):368-87. doi: 10.1111/mmi.12941. Epub 2015 Feb 11.


Plasmodium falciparum Rab5B is an N-terminally myristoylated Rab GTPase that is targeted to the parasite's plasma and food vacuole membranes.

Ezougou CN, Ben-Rached F, Moss DK, Lin JW, Black S, Knuepfer E, Green JL, Khan SM, Mukhopadhyay A, Janse CJ, Coppens I, Yera H, Holder AA, Langsley G.

PLoS One. 2014 Feb 3;9(2):e87695. doi: 10.1371/journal.pone.0087695. eCollection 2014.


Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.

Douglas AD, Williams AR, Knuepfer E, Illingworth JJ, Furze JM, Crosnier C, Choudhary P, Bustamante LY, Zakutansky SE, Awuah DK, Alanine DG, Theron M, Worth A, Shimkets R, Rayner JC, Holder AA, Wright GJ, Draper SJ.

J Immunol. 2014 Jan 1;192(1):245-58. doi: 10.4049/jimmunol.1302045. Epub 2013 Nov 29.


Inducible knockdown of Plasmodium gene expression using the glmS ribozyme.

Prommana P, Uthaipibull C, Wongsombat C, Kamchonwongpaisan S, Yuthavong Y, Knuepfer E, Holder AA, Shaw PJ.

PLoS One. 2013 Aug 30;8(8):e73783. doi: 10.1371/journal.pone.0073783. eCollection 2013.


RON12, a novel Plasmodium-specific rhoptry neck protein important for parasite proliferation.

Knuepfer E, Suleyman O, Dluzewski AR, Straschil U, O'Keeffe AH, Ogun SA, Green JL, Grainger M, Tewari R, Holder AA.

Cell Microbiol. 2014 May;16(5):657-72. doi: 10.1111/cmi.12181. Epub 2013 Aug 28.


Population genomic scan for candidate signatures of balancing selection to guide antigen characterization in malaria parasites.

Amambua-Ngwa A, Tetteh KK, Manske M, Gomez-Escobar N, Stewart LB, Deerhake ME, Cheeseman IH, Newbold CI, Holder AA, Knuepfer E, Janha O, Jallow M, Campino S, Macinnis B, Kwiatkowski DP, Conway DJ.

PLoS Genet. 2012;8(11):e1002992. doi: 10.1371/journal.pgen.1002992. Epub 2012 Nov 1.


Subcellular location, phosphorylation and assembly into the motor complex of GAP45 during Plasmodium falciparum schizont development.

Ridzuan MA, Moon RW, Knuepfer E, Black S, Holder AA, Green JL.

PLoS One. 2012;7(3):e33845. doi: 10.1371/journal.pone.0033845. Epub 2012 Mar 30.


Targeted disruption of py235ebp-1: invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein.

Ogun SA, Tewari R, Otto TD, Howell SA, Knuepfer E, Cunningham DA, Xu Z, Pain A, Holder AA.

PLoS Pathog. 2011 Feb;7(2):e1001288. doi: 10.1371/journal.ppat.1001288. Epub 2011 Feb 17.


Novel putative glycosylphosphatidylinositol-anchored micronemal antigen of Plasmodium falciparum that binds to erythrocytes.

Hinds L, Green JL, Knuepfer E, Grainger M, Holder AA.

Eukaryot Cell. 2009 Dec;8(12):1869-79. doi: 10.1128/EC.00218-09. Epub 2009 Oct 9.


A multifunctional serine protease primes the malaria parasite for red blood cell invasion.

Koussis K, Withers-Martinez C, Yeoh S, Child M, Hackett F, Knuepfer E, Juliano L, Woehlbier U, Bujard H, Blackman MJ.

EMBO J. 2009 Mar 18;28(6):725-35. doi: 10.1038/emboj.2009.22. Epub 2009 Feb 12.


The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase.

Green JL, Rees-Channer RR, Howell SA, Martin SR, Knuepfer E, Taylor HM, Grainger M, Holder AA.

J Biol Chem. 2008 Nov 7;283(45):30980-9. doi: 10.1074/jbc.M803129200. Epub 2008 Sep 3.


Plasmodium thrombospondin related apical merozoite protein (PTRAMP) is shed from the surface of merozoites by PfSUB2 upon invasion of erythrocytes.

Green JL, Hinds L, Grainger M, Knuepfer E, Holder AA.

Mol Biochem Parasitol. 2006 Nov;150(1):114-7. Epub 2006 Jul 17. No abstract available.


Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains.

Frankland S, Adisa A, Horrocks P, Taraschi TF, Schneider T, Elliott SR, Rogerson SJ, Knuepfer E, Cowman AF, Newbold CI, Tilley L.

Eukaryot Cell. 2006 May;5(5):849-60.


Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane.

Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF.

Mol Microbiol. 2005 Nov;58(4):1039-53. Erratum in: Mol Microbiol. 2006 Jan;59(2):722.


Function of the plasmodium export element can be blocked by green fluorescent protein.

Knuepfer E, Rug M, Cowman AF.

Mol Biochem Parasitol. 2005 Aug;142(2):258-62. No abstract available.


Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes.

Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF.

Blood. 2005 May 15;105(10):4078-87. Epub 2005 Feb 3.


Targeting malaria virulence and remodeling proteins to the host erythrocyte.

Marti M, Good RT, Rug M, Knuepfer E, Cowman AF.

Science. 2004 Dec 10;306(5703):1930-3.


Phenotypic changes associated with deletion and overexpression of a stage-regulated gene family in Leishmania.

McKean PG, Denny PW, Knuepfer E, Keen JK, Smith DF.

Cell Microbiol. 2001 Aug;3(8):511-23.


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