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Items: 1 to 50 of 277

1.

Dynamic lineage priming is driven via direct enhancer regulation by ERK.

Hamilton WB, Mosesson Y, Monteiro RS, Emdal KB, Knudsen TE, Francavilla C, Barkai N, Olsen JV, Brickman JM.

Nature. 2019 Nov;575(7782):355-360. doi: 10.1038/s41586-019-1732-z. Epub 2019 Nov 6.

PMID:
31695196
2.

Identification and Profiling of Environmental Chemicals That Inhibit the TGFβ/SMAD Signaling Pathway.

Wei Z, Sakamuru S, Zhang L, Zhao J, Huang R, Kleinstreuer NC, Chen Y, Shu Y, Knudsen TB, Xia M.

Chem Res Toxicol. 2019 Nov 11. doi: 10.1021/acs.chemrestox.9b00228. [Epub ahead of print]

PMID:
31652400
3.

Molecular characterization of a toxicological tipping point during human stem cell differentiation.

Saili KS, Antonijevic T, Zurlinden TJ, Shah I, Deisenroth C, Knudsen TB.

Reprod Toxicol. 2019 Oct 7;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. [Epub ahead of print]

PMID:
31600526
4.

The impact of anti-TNFα therapy on colectomy rates and corticosteroid treatment among 3001 paediatric and adolescent patients with ulcerative colitis-a nationwide study from 1995 to 2015.

Lund K, Larsen MD, Knudsen T, Kjeldsen J, Nielsen RG, Nørgård BM.

Aliment Pharmacol Ther. 2019 Nov;50(10):1077-1085. doi: 10.1111/apt.15510. Epub 2019 Oct 3.

PMID:
31579961
5.

Characterizing cleft palate toxicants using ToxCast data, chemical structure, and the biomedical literature.

Baker NC, Sipes NS, Franzosa J, Belair DG, Abbott BD, Judson RS, Knudsen TB.

Birth Defects Res. 2019 Aug 30. doi: 10.1002/bdr2.1581. [Epub ahead of print]

PMID:
31471948
6.

Reply.

Knudsen TM, Rezwan FI, Svanes C, Holloway JW.

J Allergy Clin Immunol. 2019 Aug;144(2):624-625. doi: 10.1016/j.jaci.2019.05.018. Epub 2019 Jun 15. No abstract available.

PMID:
31213285
7.

Prophylactic administration of glycoPEGylated factor IX provides protection and joint outcome superior to recombinant factor IX after induced joint bleeding.

Sun J, Livingston EW, Broberg ML, Johansen PB, Ley CD, Knudsen T, Ezban M, Bateman T, Monahan PE, Taves S.

J Thromb Haemost. 2019 Aug;17(8):1240-1246. doi: 10.1111/jth.14527. Epub 2019 Jun 28.

PMID:
31148392
8.

Deep Parotid Lobe Abscess Presenting with Dysphagia and Trismus.

Grinnell M, Logeman A, Knudsen T, Sayed Z.

Case Rep Otolaryngol. 2019 Feb 24;2019:2931015. doi: 10.1155/2019/2931015. eCollection 2019.

9.

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency.

Thomas RS, Bahadori T, Buckley TJ, Cowden J, Deisenroth C, Dionisio KL, Frithsen JB, Grulke CM, Gwinn MR, Harrill JA, Higuchi M, Houck KA, Hughes MF, Hunter ES, Isaacs KK, Judson RS, Knudsen TB, Lambert JC, Linnenbrink M, Martin TM, Newton SR, Padilla S, Patlewicz G, Paul-Friedman K, Phillips KA, Richard AM, Sams R, Shafer TJ, Setzer RW, Shah I, Simmons JE, Simmons SO, Singh A, Sobus JR, Strynar M, Swank A, Tornero-Valez R, Ulrich EM, Villeneuve DL, Wambaugh JF, Wetmore BA, Williams AJ.

Toxicol Sci. 2019 Jun 1;169(2):317-332. doi: 10.1093/toxsci/kfz058.

PMID:
30835285
10.

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions.

Gandhi JK, Knudsen T, Hill M, Roy B, Bachman L, Pfannkoch-Andrews C, Schmidt KN, Metko MM, Ackerman MJ, Resch Z, Pulido JS, Marmorstein AD.

Stem Cells Transl Med. 2019 Jun;8(6):512-521. doi: 10.1002/sctm.18-0189. Epub 2019 Feb 15.

11.

Colon capsule endoscopy for colonic surveillance.

Kroijer R, Kobaek-Larsen M, Qvist N, Knudsen T, Baatrup G.

Colorectal Dis. 2019 May;21(5):532-537. doi: 10.1111/codi.14557. Epub 2019 Feb 5.

PMID:
30637886
12.

Decreased chance of a live born child in women with rheumatoid arthritis after assisted reproduction treatment: a nationwide cohort study.

Nørgård BM, Larsen MD, Friedman S, Knudsen T, Fedder J.

Ann Rheum Dis. 2019 Mar;78(3):328-334. doi: 10.1136/annrheumdis-2018-214619. Epub 2019 Jan 12.

PMID:
30636215
13.

Bridging blood cancers and inflammation: The reduced Cancitis model.

Ottesen JT, Pedersen RK, Sajid Z, Gudmand-Hoeyer J, Bangsgaard KO, Skov V, Kjær L, Knudsen TA, Pallisgaard N, Hasselbalch HC, Andersen M.

J Theor Biol. 2019 Mar 21;465:90-108. doi: 10.1016/j.jtbi.2019.01.001. Epub 2019 Jan 4.

PMID:
30615883
14.

Reduced skeletal-muscle perfusion and impaired ATP release during hypoxia and exercise in individuals with type 2 diabetes.

Groen MB, Knudsen TA, Finsen SH, Pedersen BK, Hellsten Y, Mortensen SP.

Diabetologia. 2019 Mar;62(3):485-493. doi: 10.1007/s00125-018-4790-0. Epub 2019 Jan 3.

PMID:
30607464
15.

JAK2V617F but not CALR mutations confer increased molecular responses to interferon-α via JAK1/STAT1 activation.

Czech J, Cordua S, Weinbergerova B, Baumeister J, Crepcia A, Han L, Maié T, Costa IG, Denecke B, Maurer A, Schubert C, Feldberg K, Gezer D, Brümmendorf TH, Müller-Newen G, Mayer J, Racil Z, Kubesova B, Knudsen T, Sørensen AL, Holmström M, Kjær L, Skov V, Larsen TS, Hasselbalch HC, Chatain N, Koschmieder S.

Leukemia. 2019 Apr;33(4):995-1010. doi: 10.1038/s41375-018-0295-6. Epub 2018 Nov 23.

PMID:
30470838
16.

Absence of functional compensation between coagulation factor VIII and plasminogen in double-knockout mice.

Stagaard R, Ley CD, Almholt K, Olsen LH, Knudsen T, Flick MJ.

Blood Adv. 2018 Nov 27;2(22):3126-3136. doi: 10.1182/bloodadvances.2018024851.

17.

Hierarchical decision-making produces persistent differences in learning performance.

Knudsen T, Marchiori D, Warglien M.

Sci Rep. 2018 Oct 25;8(1):15782. doi: 10.1038/s41598-018-34128-w.

18.

The PARIS score can reliably predict 7-day all-cause mortality for both acute medical and surgical patients: an international validation study.

Brabrand M, Knudsen T, Hallas J, Graham CA, Kellett J.

QJM. 2018 Oct 1;111(10):721-725. doi: 10.1093/qjmed/hcy174.

PMID:
30124965
19.

Effect of a medicines management model on medication-related readmissions in older patients admitted to a medical acute admission unit-A randomized controlled trial.

Graabaek T, Hedegaard U, Christensen MB, Clemmensen MH, Knudsen T, Aagaard L.

J Eval Clin Pract. 2019 Feb;25(1):88-96. doi: 10.1111/jep.13013. Epub 2018 Aug 7.

PMID:
30088321
20.

Safety and efficacy of combination therapy of interferon-α2 and ruxolitinib in polycythemia vera and myelofibrosis.

Mikkelsen SU, Kjaer L, Bjørn ME, Knudsen TA, Sørensen AL, Andersen CBL, Bjerrum OW, Brochmann N, Fassi DE, Kruse TA, Larsen TS, Mourits-Andersen HT, Nielsen CH, Pallisgaard N, Thomassen M, Skov V, Hasselbalch HC.

Cancer Med. 2018 Aug;7(8):3571-3581. doi: 10.1002/cam4.1619. Epub 2018 Jun 22.

21.

Abrogating fibrinolysis does not improve bleeding or rFVIIa/rFVIII treatment in a non-mucosal venous injury model in haemophilic rodents.

Stagaard R, Flick MJ, Bojko B, Goryński K, Goryńska PZ, Ley CD, Olsen LH, Knudsen T.

J Thromb Haemost. 2018 Jul;16(7):1369-1382. doi: 10.1111/jth.14148. Epub 2018 Jun 21.

PMID:
29758126
22.

Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD.

Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK.

Reprod Toxicol. 2018 Aug;79:16-20. doi: 10.1016/j.reprotox.2018.04.016. Epub 2018 Apr 27.

23.

Mutant Best1 Expression and Impaired Phagocytosis in an iPSC Model of Autosomal Recessive Bestrophinopathy.

Marmorstein AD, Johnson AA, Bachman LA, Andrews-Pfannkoch C, Knudsen T, Gilles BJ, Hill M, Gandhi JK, Marmorstein LY, Pulido JS.

Sci Rep. 2018 Mar 14;8(1):4487. doi: 10.1038/s41598-018-21651-z.

24.

Critical age windows in the impact of lifetime smoking exposure on respiratory symptoms and disease among ever smokers.

Erbas B, Knudsen TM, Janson C, Nilsen RM, Accordini S, Benediktdottir B, Dratva J, Heinrich J, Jarvis D, Leynaert B, Matheson MC, Norbäck D, Real FG, Raherison-Semjen C, Villani S, Dharmage SC, Svanes C.

Environ Res. 2018 Jul;164:241-247. doi: 10.1016/j.envres.2018.02.028. Epub 2018 Mar 6.

25.

Fecal Calprotectin During Pregnancy in Women With Moderate-Severe Inflammatory Bowel Disease.

Kammerlander H, Nielsen J, Kjeldsen J, Knudsen T, Gradel KO, Friedman S, Nørgård BM.

Inflamm Bowel Dis. 2018 Mar 19;24(4):839-848. doi: 10.1093/ibd/izx055.

PMID:
29506137
26.

Abstract Sifter: a comprehensive front-end system to PubMed.

Baker N, Knudsen T, Williams A.

F1000Res. 2017 Dec 21;6. pii: Chem Inf Sci-2164. doi: 10.12688/f1000research.12865.1. eCollection 2017.

27.

Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine.

Christensen R, Heitmann BL, Andersen KW, Nielsen OH, Sørensen SB, Jawhara M, Bygum A, Hvid L, Grauslund J, Wied J, Glerup H, Fredberg U, Villadsen JA, Kjær SG, Fallingborg J, Moghadd SAGR, Knudsen T, Brodersen J, Frøjk J, Dahlerup JF, Bojesen AB, Sorensen GL, Thiel S, Færgeman NJ, Brandslund I, Bennike TB, Stensballe A, Schmidt EB, Franke A, Ellinghaus D, Rosenstiel P, Raes J, Boye M, Werner L, Nielsen CL, Munk HL, Nexøe AB, Ellingsen T, Holmskov U, Kjeldsen J, Andersen V.

BMJ Open. 2018 Feb 8;8(2):e018166. doi: 10.1136/bmjopen-2017-018166.

28.

Rethinking developmental toxicity testing: Evolution or revolution?

Scialli AR, Daston G, Chen C, Coder PS, Euling SY, Foreman J, Hoberman AM, Hui J, Knudsen T, Makris SL, Morford L, Piersma AH, Stanislaus D, Thompson KE.

Birth Defects Res. 2018 Jun 1;110(10):840-850. doi: 10.1002/bdr2.1212. Epub 2018 Feb 12.

29.

Combined effects of antimony and sodium diethyldithiocarbamate on soil microbial activity and speciation change of heavy metals. Implications for contaminated lands hazardous material pollution in nonferrous metal mining areas.

Zhu X, Yao J, Wang F, Yuan Z, Liu J, Jordan G, Knudsen TŠ, Avdalović J.

J Hazard Mater. 2018 May 5;349:160-167. doi: 10.1016/j.jhazmat.2018.01.044. Epub 2018 Feb 2.

PMID:
29421352
30.

Building a developmental toxicity ontology.

Baker N, Boobis A, Burgoon L, Carney E, Currie R, Fritsche E, Knudsen T, Laffont M, Piersma AH, Poole A, Schneider S, Daston G.

Birth Defects Res. 2018 Apr 3;110(6):502-518. doi: 10.1002/bdr2.1189. Epub 2018 Jan 31. Review.

PMID:
29383852
31.

Prediction of human pharmacokinetics of activated recombinant factor VII and B-domain truncated factor VIII from animal population pharmacokinetic models of haemophilia.

Larsen MS, Juul RV, Groth AV, Simonsson USH, Kristensen AT, Knudsen T, Agersø H, Kreilgaard M.

Eur J Pharm Sci. 2018 Mar 30;115:196-203. doi: 10.1016/j.ejps.2018.01.035. Epub 2018 Jan 31.

PMID:
29369801
32.

Bitter taste masking of enzyme-treated soy protein in water and bread.

Bertelsen AS, Laursen A, Knudsen TA, Møller S, Kidmose U.

J Sci Food Agric. 2018 Aug;98(10):3860-3869. doi: 10.1002/jsfa.8903. Epub 2018 Mar 23.

PMID:
29363768
33.

Exploring Gut Microbiota Composition as an Indicator of Clinical Response to Dietary FODMAP Restriction in Patients with Irritable Bowel Syndrome.

Valeur J, Småstuen MC, Knudsen T, Lied GA, Røseth AG.

Dig Dis Sci. 2018 Feb;63(2):429-436. doi: 10.1007/s10620-017-4893-3. Epub 2018 Jan 4.

PMID:
29302878
34.

Blood-brain barrier development: Systems modeling and predictive toxicology.

Saili KS, Zurlinden TJ, Schwab AJ, Silvin A, Baker NC, Hunter ES 3rd, Ginhoux F, Knudsen TB.

Birth Defects Res. 2017 Dec 1;109(20):1680-1710. doi: 10.1002/bdr2.1180. Review.

35.

Fibrin hydrogels as a xenofree and rapidly degradable support for transplantation of retinal pigment epithelium monolayers.

Gandhi JK, Manzar Z, Bachman LA, Andrews-Pfannkoch C, Knudsen T, Hill M, Schmidt H, Iezzi R, Pulido JS, Marmorstein AD.

Acta Biomater. 2018 Feb;67:134-146. doi: 10.1016/j.actbio.2017.11.058. Epub 2017 Dec 9.

PMID:
29233750
36.

Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion.

Nguyen EH, Daly WT, Le NNT, Farnoodian M, Belair DG, Schwartz MP, Lebakken CS, Ananiev GE, Saghiri MA, Knudsen TB, Sheibani N, Murphy WL.

Nat Biomed Eng. 2017;1. pii: 0096. doi: 10.1038/s41551-017-0096. Epub 2017 Jul 11.

37.

Patients with inflammatory bowel disease have increased risk of autoimmune and inflammatory diseases.

Halling ML, Kjeldsen J, Knudsen T, Nielsen J, Hansen LK.

World J Gastroenterol. 2017 Sep 7;23(33):6137-6146. doi: 10.3748/wjg.v23.i33.6137.

38.

Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm.

Anderson KGV, Hamilton WB, Roske FV, Azad A, Knudsen TE, Canham MA, Forrester LM, Brickman JM.

Nat Cell Biol. 2017 Oct;19(10):1164-1177. doi: 10.1038/ncb3617. Epub 2017 Sep 25.

PMID:
28945231
39.

Anti-TNF-α Use During the Third Trimester of Pregnancy in Women with Moderate-severe Inflammatory Bowel Disease and the Risk of Preterm Birth and Low Birth Weight.

Kammerlander H, Nielsen J, Knudsen T, Kjeldsen J, Friedman S, Nørgård BM.

Inflamm Bowel Dis. 2017 Nov;23(11):1916-1923. doi: 10.1097/MIB.0000000000001234.

PMID:
28858070
40.

Programming microphysiological systems for children's health protection.

Knudsen TB, Klieforth B, Slikker W Jr.

Exp Biol Med (Maywood). 2017 Oct;242(16):1586-1592. doi: 10.1177/1535370217717697. Epub 2017 Jun 28.

41.

Embryonic vascular disruption adverse outcomes: Linking high throughput signaling signatures with functional consequences.

Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.

Reprod Toxicol. 2017 Jun;70:82-96. doi: 10.1016/j.reprotox.2017.05.005. Epub 2017 May 17.

42.

A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine.

Andersen V, Holmskov U, Sørensen SB, Jawhara M, Andersen KW, Bygum A, Hvid L, Grauslund J, Wied J, Glerup H, Fredberg U, Villadsen JA, Kjær SG, Fallingborg J, Moghadd SAGR, Knudsen T, Brodersen J, Frøjk J, Dahlerup JF, Nielsen OH, Christensen R, Bojesen AB, Sorensen GL, Thiel S, Færgeman NJ, Brandslund I, Stensballe A, Schmidt EB, Franke A, Ellinghaus D, Rosenstiel P, Raes J, Heitmann B, Boye M, Nielsen CL, Werner L, Kjeldsen J, Ellingsen T.

Nutrients. 2017 May 15;9(5). pii: E499. doi: 10.3390/nu9050499.

43.

Embryonic vascular disruption adverse outcomes: Linking high-throughput signaling signatures with functional consequences.

Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.

Reprod Toxicol. 2017 Aug;71:16-31. doi: 10.1016/j.reprotox.2017.04.003. Epub 2017 Apr 13.

PMID:
28414088
44.

The Effect of Disease Activity on Birth Outcomes in a Nationwide Cohort of Women with Moderate to Severe Inflammatory Bowel Disease.

Kammerlander H, Nielsen J, Kjeldsen J, Knudsen T, Friedman S, Nørgård B.

Inflamm Bowel Dis. 2017 Jun;23(6):1011-1018. doi: 10.1097/MIB.0000000000001102.

PMID:
28346274
45.

Soluble CD163 predicts incident chronic lung, kidney and liver disease in HIV infection.

Kirkegaard-Klitbo DM, Mejer N, Knudsen TB, Møller HJ, Moestrup SK, Poulsen SD, Kronborg G, Benfield T.

AIDS. 2017 Apr 24;31(7):981-988. doi: 10.1097/QAD.0000000000001432. Erratum in: AIDS. 2018 Mar 13;32(5):679.

PMID:
28252527
46.

Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".

Houck KA, Judson RS, Knudsen TB, Martin MT, Richard AM, Crofton KM, Simeonov A, Paules RS, Bucher JR, Thomas RS.

Environ Health Perspect. 2017 Jan 1;125(1):A8-A11. doi: 10.1289/EHP881. No abstract available.

47.

Data for the size of cholesterol-fat micelles as a function of bile salt concentration and the physico-chemical properties of six liquid experimental pine-derived phytosterol formulations in a cholesterol-containing artificial intestine fluid.

Yi J, Knudsen TA, Nielsen AL, Duelund L, Christensen M, Hervella P, Needham D, Mouritsen OG.

Data Brief. 2016 Dec 21;10:478-481. doi: 10.1016/j.dib.2016.12.027. eCollection 2017 Feb.

48.

Computational Model of Secondary Palate Fusion and Disruption.

Hutson MS, Leung MCK, Baker NC, Spencer RM, Knudsen TB.

Chem Res Toxicol. 2017 Apr 17;30(4):965-979. doi: 10.1021/acs.chemrestox.6b00350. Epub 2017 Jan 20.

49.

Screening for angiogenic inhibitors in zebrafish to evaluate a predictive model for developmental vascular toxicity.

Tal T, Kilty C, Smith A, LaLone C, Kennedy B, Tennant A, McCollum CW, Bondesson M, Knudsen T, Padilla S, Kleinstreuer N.

Reprod Toxicol. 2017 Jun;70:70-81. doi: 10.1016/j.reprotox.2016.12.004. Epub 2016 Dec 19.

50.

Increased Age-Dependent Risk of Death Associated With lukF-PV-Positive Staphylococcus aureus Bacteremia.

Knudsen TA, Skov R, Petersen A, Larsen AR, Benfield T; Danish Staphylococcal Bacteremia Study Group.

Open Forum Infect Dis. 2016 Dec 5;3(4):ofw220. eCollection 2016 Oct.

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