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Items: 1 to 50 of 416

1.

Synthesis and Pharmacological Evaluation of [11C]4-Methoxy-N-[2-(thiophen-2-yl)imidazo[1,2-a]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors.

L'Estrade ET, Hansen HD, Falk-Petersen C, Haugaard A, Griem-Krey N, Jung S, Lüddens H, Schirmeister T, Erlandsson M, Ohlsson T, Knudsen GM, Herth MM, Wellendorph P, Frølund B.

ACS Omega. 2019 May 22;4(5):8846-8851. doi: 10.1021/acsomega.9b00434. eCollection 2019 May 31.

2.

Human biodistribution and radiation dosimetry of the 5-HT2A receptor agonist Cimbi-36 labeled with carbon-11 in two positions.

Johansen A, Holm S, Dall B, Keller S, Kristensen JL, Knudsen GM, Hansen HD.

EJNMMI Res. 2019 Jul 31;9(1):71. doi: 10.1186/s13550-019-0527-4.

3.

In vivo PET Imaging of [11C]CIMBI-5, a 5-HT2AR Agonist Radiotracer in Nonhuman Primates.

Prabhakaran J, DeLorenzo C, Zanderigo F, Knudsen GM, Gilling N, Pratap M, Jorgensen MJ, Daunais J, Kaplan JR, Parsey RV, Mann JJ, Kumar D.

J Pharm Pharm Sci. 2019;22(1):352-364. doi: 10.18433/jpps30329.

4.

Microdosing psychedelics: More questions than answers? An overview and suggestions for future research.

Kuypers KP, Ng L, Erritzoe D, Knudsen GM, Nichols CD, Nichols DE, Pani L, Soula A, Nutt D.

J Psychopharmacol. 2019 Jul 14:269881119857204. doi: 10.1177/0269881119857204. [Epub ahead of print]

PMID:
31303095
5.

Imaging HDACs In Vivo: Cross-Validation of the [11C]Martinostat Radioligand in the Pig Brain.

Donovan LL, Magnussen JH, Dyssegaard A, Lehel S, Hooker JM, Knudsen GM, Hansen HD.

Mol Imaging Biol. 2019 Jul 9. doi: 10.1007/s11307-019-01403-9. [Epub ahead of print]

PMID:
31290052
6.

Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis.

Mandel-Brehm C, Retallack H, Knudsen GM, Yamana A, Hajj-Ali RA, Calabrese LH, Tihan T, Sample HA, Zorn KC, Gorman MP, Madan Cohen J, Sreih AG, Marcus JF, Josephson SA, Douglas VC, Gelfand JM, Wilson MR, DeRisi JL.

Neurology. 2019 Jul 30;93(5):e433-e444. doi: 10.1212/WNL.0000000000007850. Epub 2019 Jul 3.

PMID:
31270218
7.

The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.

Ivry SL, Knudsen GM, Caiazza F, Sharib JM, Jaradeh K, Ravalin M, O'Donoghue AJ, Kirkwood KS, Craik CS.

Biol Chem. 2019 Jul 19. pii: /j/bchm.ahead-of-print/hsz-2019-0103/hsz-2019-0103.xml. doi: 10.1515/hsz-2019-0103. [Epub ahead of print]

PMID:
31256057
8.

Optimization of preprocessing strategies in Positron Emission Tomography (PET) neuroimaging: A [11C]DASB PET study.

Nørgaard M, Ganz M, Svarer C, Frokjaer VG, Greve DN, Strother SC, Knudsen GM.

Neuroimage. 2019 Oct 1;199:466-479. doi: 10.1016/j.neuroimage.2019.05.055. Epub 2019 Jun 1.

PMID:
31158479
9.

Automated pupillometry to detect command following in neurological patients: a proof-of-concept study.

Vassilieva A, Olsen MH, Peinkhofer C, Knudsen GM, Kondziella D.

PeerJ. 2019 May 13;7:e6929. doi: 10.7717/peerj.6929. eCollection 2019.

10.

Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding.

Deen M, Hougaard A, Hansen HD, Schain M, Dyssegaard A, Knudsen GM, Ashina M.

JAMA Neurol. 2019 Jul 1;76(7):834-840. doi: 10.1001/jamaneurol.2019.0755.

PMID:
31135819
11.

Cortical modulation of pupillary function: systematic review.

Peinkhofer C, Knudsen GM, Moretti R, Kondziella D.

PeerJ. 2019 May 7;7:e6882. doi: 10.7717/peerj.6882. eCollection 2019.

12.

Molecular imaging of neuroinflammation in patients after mild traumatic brain injury: a longitudinal 123 I-CLINDE single photon emission computed tomography study.

Ebert SE, Jensen P, Ozenne B, Armand S, Svarer C, Stenbaek DS, Moeller K, Dyssegaard A, Thomsen G, Steinmetz J, Forchhammer BH, Knudsen GM, Pinborg LH.

Eur J Neurol. 2019 Apr 19. doi: 10.1111/ene.13971. [Epub ahead of print]

PMID:
31002206
13.

Measuring endogenous changes in serotonergic neurotransmission with [11C]Cimbi-36 positron emission tomography in humans.

da Cunha-Bang S, Ettrup A, Mc Mahon B, Skibsted AP, Schain M, Lehel S, Dyssegaard A, Jørgensen LM, Møller K, Gillings N, Svarer C, Knudsen GM.

Transl Psychiatry. 2019 Apr 11;9(1):134. doi: 10.1038/s41398-019-0468-8.

14.

Development and Evaluation of Two Potential 5-HT7 Receptor PET Tracers: [18F]ENL09 and [18F]ENL10.

Tampio L'Estrade E, Xiong M, Shalgunov V, Edgar FG, Volk B, Baerentzen SL, Palner M, Erlandsson M, Ohlsson T, Knudsen GM, Herth MM.

ACS Chem Neurosci. 2019 Apr 22. doi: 10.1021/acschemneuro.9b00132. [Epub ahead of print]

PMID:
30973705
15.

Mapping Post-Translational Modifications of de Novo Purine Biosynthetic Enzymes: Implications for Pathway Regulation.

Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ.

J Proteome Res. 2019 May 3;18(5):2078-2087. doi: 10.1021/acs.jproteome.8b00969. Epub 2019 Apr 18.

PMID:
30964683
16.

Correction to: Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.

Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW.

Trials. 2019 Apr 8;20(1):201. doi: 10.1186/s13063-019-3289-4.

17.

Correction: Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.

Madsen MK, Fisher PM, Burmester D, Dyssegaard A, Stenbæk DS, Kristiansen S, Johansen SS, Lehel S, Linnet K, Svarer C, Erritzoe D, Ozenne B, Knudsen GM.

Neuropsychopharmacology. 2019 Jun;44(7):1336-1337. doi: 10.1038/s41386-019-0360-5.

PMID:
30846853
18.

Recreational use of psychedelics is associated with elevated personality trait openness: Exploration of associations with brain serotonin markers.

Erritzoe D, Smith J, Fisher PM, Carhart-Harris R, Frokjaer VG, Knudsen GM.

J Psychopharmacol. 2019 Feb 28:269881119827891. doi: 10.1177/0269881119827891. [Epub ahead of print]

PMID:
30816797
19.

Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging.

Stéen EJL, Jørgensen JT, Petersen IN, Nørregaard K, Lehel S, Shalgunov V, Birke A, Edem PE, L'Estrade ET, Hansen HD, Villadsen J, Erlandsson M, Ohlsson T, Yazdani A, Valliant JF, Kristensen JL, Barz M, Knudsen GM, Kjær A, Herth MM.

Bioorg Med Chem Lett. 2019 Apr 15;29(8):986-990. doi: 10.1016/j.bmcl.2019.02.014. Epub 2019 Feb 13.

20.

Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.

Madsen MK, Fisher PM, Burmester D, Dyssegaard A, Stenbæk DS, Kristiansen S, Johansen SS, Lehel S, Linnet K, Svarer C, Erritzoe D, Ozenne B, Knudsen GM.

Neuropsychopharmacology. 2019 Jun;44(7):1328-1334. doi: 10.1038/s41386-019-0324-9. Epub 2019 Jan 26. Erratum in: Neuropsychopharmacology. 2019 Mar 8;:.

PMID:
30685771
21.

Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study.

Stenbaek DS, Kristiansen S, Burmester D, Madsen MK, Frokjaer VG, Knudsen GM, Fisher PM.

Hum Brain Mapp. 2019 May;40(7):2117-2124. doi: 10.1002/hbm.24511. Epub 2019 Jan 11.

PMID:
30633430
22.

Three weeks of SSRI administration enhances the visual perceptual threshold - a randomized placebo-controlled study.

Lansner J, Jensen CG, Petersen A, Fisher PM, Frokjaer VG, Vangkilde S, Knudsen GM.

Psychopharmacology (Berl). 2019 Jun;236(6):1759-1769. doi: 10.1007/s00213-018-5158-3. Epub 2019 Jan 8.

PMID:
30623228
23.

Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex.

Hornboll B, Macoveanu J, Nejad A, Rowe J, Elliott R, Knudsen GM, Siebner HR, Paulson OB.

Sci Rep. 2018 Dec 17;8(1):17889. doi: 10.1038/s41598-018-36350-y.

24.

Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG (CONNECT-ME): Protocol for a Longitudinal Prospective Study and a Tertiary Clinical Care Service.

Skibsted AP, Amiri M, Fisher PM, Sidaros A, Hribljan MC, Larsen VA, Højgaard JLS, Nikolic M, Hauerberg J, Fabricius ME, Knudsen GM, Møller K, Kondziella D.

Front Neurol. 2018 Nov 27;9:1012. doi: 10.3389/fneur.2018.01012. eCollection 2018.

25.

Influence of Strategic Cortical Infarctions on Pupillary Function.

Peinkhofer C, Martens P, Grand J, Truelsen T, Knudsen GM, Kjaergaard J, Kondziella D.

Front Neurol. 2018 Oct 29;9:916. doi: 10.3389/fneur.2018.00916. eCollection 2018.

26.

Evaluation of [18 F]2FP3 in pigs and non-human primates.

Hansen HD, Constantinescu CC, Barret O, Herth MM, Magnussen JH, Lehel S, Dyssegaard A, Colomb J, Billard T, Zimmer L, Tamagnan G, Knudsen GM.

J Labelled Comp Radiopharm. 2019 Jan;62(1):34-42. doi: 10.1002/jlcr.3692. Epub 2018 Dec 6.

PMID:
30414212
27.

Effects of recombinant human erythropoietin on cognition and neural activity in remitted patients with mood disorders and first-degree relatives of patients with psychiatric disorders: a study protocol for a randomized controlled trial.

Petersen JZ, Schmidt LS, Vinberg M, Jørgensen MB, Hageman I, Ehrenreich H, Knudsen GM, Kessing LV, Miskowiak KW.

Trials. 2018 Nov 6;19(1):611. doi: 10.1186/s13063-018-2995-7.

28.

Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome.

Beekman C, Jiang Z, Suzuki BM, Palmer JM, Lindner DL, O'Donoghue AJ, Knudsen GM, Bennett RJ.

Biol Chem. 2018 Nov 27;399(12):1375-1388. doi: 10.1515/hsz-2018-0240.

PMID:
30367778
29.

Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD.

Deco G, Cruzat J, Cabral J, Knudsen GM, Carhart-Harris RL, Whybrow PC, Logothetis NK, Kringelbach ML.

Curr Biol. 2018 Oct 8;28(19):3065-3074.e6. doi: 10.1016/j.cub.2018.07.083. Epub 2018 Sep 27.

PMID:
30270185
30.

Pre-intervention test-retest reliability of EEG and ERP over four recording intervals.

Ip CT, Ganz M, Ozenne B, Sluth LB, Gram M, Viardot G, l'Hostis P, Danjou P, Knudsen GM, Christensen SR.

Int J Psychophysiol. 2018 Dec;134:30-43. doi: 10.1016/j.ijpsycho.2018.09.007. Epub 2018 Sep 22.

31.

Effect of action-based cognitive remediation on cognition and neural activity in bipolar disorder: study protocol for a randomized controlled trial.

Ott CV, Vinberg M, Bowie CR, Christensen EM, Knudsen GM, Kessing LV, Miskowiak KW.

Trials. 2018 Sep 12;19(1):487. doi: 10.1186/s13063-018-2860-8. Erratum in: Trials. 2019 Apr 8;20(1):201.

32.

Low on energy? An energy supply-demand perspective on stress and depression.

Østergaard L, Jørgensen MB, Knudsen GM.

Neurosci Biobehav Rev. 2018 Nov;94:248-270. doi: 10.1016/j.neubiorev.2018.08.007. Epub 2018 Aug 23. Review.

PMID:
30145282
33.

Migraine is associated with high brain 5-HT levels as indexed by 5-HT4 receptor binding.

Deen M, Hougaard A, Hansen HD, Svarer C, Eiberg H, Lehel S, Knudsen GM, Ashina M.

Cephalalgia. 2019 Apr;39(4):526-532. doi: 10.1177/0333102418793642. Epub 2018 Aug 8.

PMID:
30089402
34.

Seasonality-resilient individuals downregulate their cerebral 5-HT transporter binding in winter - A longitudinal combined 11C-DASB and 11C-SB207145 PET study.

Mc Mahon B, Nørgaard M, Svarer C, Andersen SB, Madsen MK, Baaré WFC, Madsen J, Frokjaer VG, Knudsen GM.

Eur Neuropsychopharmacol. 2018 Oct;28(10):1151-1160. doi: 10.1016/j.euroneuro.2018.06.004. Epub 2018 Aug 1.

PMID:
30077433
35.

Does glucagon-like peptide-1 (GLP-1) receptor agonist stimulation reduce alcohol intake in patients with alcohol dependence: study protocol of a randomised, double-blinded, placebo-controlled clinical trial.

Antonsen KK, Klausen MK, Brunchmann AS, le Dous N, Jensen ME, Miskowiak KW, Fisher PM, Thomsen GK, Rindom H, Fahmy TP, Vollstaedt-Klein S, Benveniste H, Volkow ND, Becker U, Ekstrøm C, Knudsen GM, Vilsbøll T, Fink-Jensen A.

BMJ Open. 2018 Jul 16;8(7):e019562. doi: 10.1136/bmjopen-2017-019562.

36.

Classics in Neuroimaging: The Serotonergic 2A Receptor System-from Discovery to Modern Molecular Imaging.

T L'Estrade E, Hansen HD, Erlandsson M, Ohlsson TG, Knudsen GM, Herth MM.

ACS Chem Neurosci. 2018 Jun 20;9(6):1226-1229. doi: 10.1021/acschemneuro.8b00176. Epub 2018 May 15. Review.

PMID:
29763291
37.

Cerebral serotonin transporter measurements with [11C]DASB: A review on acquisition and preprocessing across 21 PET centres.

Nørgaard M, Ganz M, Svarer C, Feng L, Ichise M, Lanzenberger R, Lubberink M, Parsey RV, Politis M, Rabiner EA, Slifstein M, Sossi V, Suhara T, Talbot PS, Turkheimer F, Strother SC, Knudsen GM.

J Cereb Blood Flow Metab. 2019 Feb;39(2):210-222. doi: 10.1177/0271678X18770107. Epub 2018 Apr 13.

PMID:
29651896
38.

Comparative genomic, transcriptomic, and proteomic reannotation of human herpesvirus 6.

Greninger AL, Knudsen GM, Roychoudhury P, Hanson DJ, Sedlak RH, Xie H, Guan J, Nguyen T, Peddu V, Boeckh M, Huang ML, Cook L, Depledge DP, Zerr DM, Koelle DM, Gantt S, Yoshikawa T, Caserta M, Hill JA, Jerome KR.

BMC Genomics. 2018 Mar 20;19(1):204. doi: 10.1186/s12864-018-4604-2.

39.

Self-perceived personality characteristics in seasonal affective disorder and their implications for severity of depression.

Hjordt LV, Dam VH, Ozenne B, Hageman I, Mc Mahon B, Mortensen EL, Knudsen GM, Stenbæk DS.

Psychiatry Res. 2018 Apr;262:108-114. doi: 10.1016/j.psychres.2018.02.015. Epub 2018 Feb 6.

PMID:
29428773
40.

High brain serotonin levels in migraine between attacks: A 5-HT4 receptor binding PET study.

Deen M, Hansen HD, Hougaard A, Nørgaard M, Eiberg H, Lehel S, Ashina M, Knudsen GM.

Neuroimage Clin. 2018 Jan 28;18:97-102. doi: 10.1016/j.nicl.2018.01.016. eCollection 2018.

41.

Amygdala response to emotional faces in seasonal affective disorder.

Borgsted C, Ozenne B, Mc Mahon B, Madsen MK, Hjordt LV, Hageman I, Baaré WFC, Knudsen GM, Fisher PM.

J Affect Disord. 2018 Mar 15;229:288-295. doi: 10.1016/j.jad.2017.12.097. Epub 2018 Jan 3.

PMID:
29329062
42.

Amygdala reactivity to fearful faces correlates positively with impulsive aggression.

da Cunha-Bang S, Fisher PM, Hjordt LV, Holst K, Knudsen GM.

Soc Neurosci. 2019 Apr;14(2):162-172. doi: 10.1080/17470919.2017.1421262. Epub 2018 Jan 7.

PMID:
29271284
43.

The importance of small polar radiometabolites in molecular neuroimaging: A PET study with [11C]Cimbi-36 labeled in two positions.

Johansen A, Hansen HD, Svarer C, Lehel S, Leth-Petersen S, Kristensen JL, Gillings N, Knudsen GM.

J Cereb Blood Flow Metab. 2018 Apr;38(4):659-668. doi: 10.1177/0271678X17746179. Epub 2017 Dec 7.

44.

Global substrate specificity profiling of post-translational modifying enzymes.

Ivry SL, Meyer NO, Winter MB, Bohn MF, Knudsen GM, O'Donoghue AJ, Craik CS.

Protein Sci. 2018 Mar;27(3):584-594. doi: 10.1002/pro.3352. Epub 2017 Dec 8. Review.

45.

Brain Networks Implicated in Seasonal Affective Disorder: A Neuroimaging PET Study of the Serotonin Transporter.

Nørgaard M, Ganz M, Svarer C, Fisher PM, Churchill NW, Beliveau V, Grady C, Strother SC, Knudsen GM.

Front Neurosci. 2017 Nov 3;11:614. doi: 10.3389/fnins.2017.00614. eCollection 2017.

46.

Automatic delineation of brain regions on MRI and PET images from the pig.

Villadsen J, Hansen HD, Jørgensen LM, Keller SH, Andersen FL, Petersen IN, Knudsen GM, Svarer C.

J Neurosci Methods. 2018 Jan 15;294:51-58. doi: 10.1016/j.jneumeth.2017.11.008. Epub 2017 Nov 13.

PMID:
29146191
47.

Men with high serotonin 1B receptor binding respond to provocations with heightened amygdala reactivity.

da Cunha-Bang S, Fisher PM, Hjordt LV, Perfalk E, Beliveau V, Holst K, Knudsen GM.

Neuroimage. 2018 Feb 1;166:79-85. doi: 10.1016/j.neuroimage.2017.10.032. Epub 2017 Oct 20.

PMID:
29061526
48.

Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females.

Tuominen L, Miettunen J, Cannon DM, Drevets WC, Frokjaer VG, Hirvonen J, Ichise M, Jensen PS, Keltikangas-Järvinen L, Klaver JM, Knudsen GM, Takano A, Suhara T, Hietala J.

Int J Neuropsychopharmacol. 2017 Dec 1;20(12):963-970. doi: 10.1093/ijnp/pyx071.

49.

Functional Characterization of 5-HT1B Receptor Drugs in Nonhuman Primates Using Simultaneous PET-MR.

Hansen HD, Mandeville JB, Sander CY, Hooker JM, Catana C, Rosen BR, Knudsen GM.

J Neurosci. 2017 Nov 1;37(44):10671-10678. doi: 10.1523/JNEUROSCI.1971-17.2017. Epub 2017 Oct 2.

50.

Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany.

Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I, Morris JC, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L, Beyer T.

Mol Imaging Biol. 2018 Feb;20(1):4-20. doi: 10.1007/s11307-017-1123-5.

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