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Evolution of neural processing for visual perception in vertebrates.

Knudsen EI.

J Comp Neurol. 2020 Jan 31. doi: 10.1002/cne.24871. [Epub ahead of print] Review.


p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.

Guiley KZ, Stevenson JW, Lou K, Barkovich KJ, Kumarasamy V, Wijeratne TU, Bunch KL, Tripathi S, Knudsen ES, Witkiewicz AK, Shokat KM, Rubin SM.

Science. 2019 Dec 13;366(6471). pii: eaaw2106. doi: 10.1126/science.aaw2106.


Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer.

Kumarasamy V, Ruiz A, Nambiar R, Witkiewicz AK, Knudsen ES.

Oncogene. 2019 Nov 19. doi: 10.1038/s41388-019-1102-1. [Epub ahead of print]


Glucose associated NETosis in patients with ST-elevation myocardial infarction: an observational study.

Helseth R, Knudsen EC, Eritsland J, Opstad TB, Arnesen H, Andersen GØ, Seljeflot I.

BMC Cardiovasc Disord. 2019 Oct 15;19(1):221. doi: 10.1186/s12872-019-1205-1.


Interrogating Mutant Allele Expression via Customized Reference Genomes to Define Influential Cancer Mutations.

Grant AD, Vail P, Padi M, Witkiewicz AK, Knudsen ES.

Sci Rep. 2019 Sep 4;9(1):12766. doi: 10.1038/s41598-019-48967-8.


A model-based approach for targeted neurophysiology in the behaving non-human primate.

Knudsen EB, Balewski ZZ, Wallis JD.

Int IEEE EMBS Conf Neural Eng. 2019 Mar;2019:195-198. doi: 10.1109/NER.2019.8716968. Epub 2019 May 20.


Cell Cycle and Beyond: Exploiting New RB1 Controlled Mechanisms for Cancer Therapy.

Knudsen ES, Pruitt SC, Hershberger PA, Witkiewicz AK, Goodrich DW.

Trends Cancer. 2019 May;5(5):308-324. doi: 10.1016/j.trecan.2019.03.005. Epub 2019 Apr 30. Review.


Territory location and quality, together with climate, affect the timing of breeding in the white-throated dipper.

Nilsson ALK, Slagsvold T, Røstad OW, Knudsen E, Jerstad K, Cadahía L, Reitan T, Helberg M, Walseng B, Stenseth NC.

Sci Rep. 2019 May 21;9(1):7671. doi: 10.1038/s41598-019-43792-5.


IgM antibodies against phosphorylcholine measured early after acute ST-elevation myocardial infarction in relation to atherosclerotic disease burden and long-term clinical outcome.

Knudsen EC, Seljeflot I, Aksnes TA, Eritsland J, Arnesen H, Andersen GØ.

PLoS One. 2019 Apr 19;14(4):e0215640. doi: 10.1371/journal.pone.0215640. eCollection 2019.


Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.

Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, Diehl JN, Goode GD, Chaika NV, Wang Y, Zhang GF, Witkiewicz AK, Knudsen ES, Petricoin EF 3rd, Singh PK, Macdonald JM, Tran NL, Lyssiotis CA, Ying H, Kimmelman AC, Cox AD, Der CJ.

Nat Med. 2019 Apr;25(4):628-640. doi: 10.1038/s41591-019-0368-8. Epub 2019 Mar 4.


Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.

Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM.

Cell Metab. 2019 Apr 2;29(4):966-978.e4. doi: 10.1016/j.cmet.2019.01.016. Epub 2019 Feb 14.


Correction: Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.

Jansen VM, Bhola NE, Bauer JA, Formisano L, Lee KM, Hutchinson KE, Witkiewicz AK, Moore PD, Estrada MV, Sánchez V, Ericsson PG, Sanders ME, Pohlmann PR, Pishvaian MJ, Riddle DA, Dugger TC, Wei W, Knudsen ES, Arteaga CL.

Cancer Res. 2019 Feb 15;79(4):874. doi: 10.1158/0008-5472.CAN-18-4086. No abstract available.


Cell cycle plasticity driven by MTOR signaling: integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer.

Knudsen ES, Kumarasamy V, Ruiz A, Sivinski J, Chung S, Grant A, Vail P, Chauhan SS, Jie T, Riall TS, Witkiewicz AK.

Oncogene. 2019 May;38(18):3355-3370. doi: 10.1038/s41388-018-0650-0. Epub 2019 Jan 29.


Coordinately Targeting Cell-Cycle Checkpoint Functions in Integrated Models of Pancreatic Cancer.

Chung S, Vail P, Witkiewicz AK, Knudsen ES.

Clin Cancer Res. 2019 Apr 1;25(7):2290-2304. doi: 10.1158/1078-0432.CCR-18-1620. Epub 2018 Dec 11.


KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism.

Vaseva AV, Blake DR, Gilbert TSK, Ng S, Hostetter G, Azam SH, Ozkan-Dagliyan I, Gautam P, Bryant KL, Pearce KH, Herring LE, Han H, Graves LM, Witkiewicz AK, Knudsen ES, Pecot CV, Rashid N, Houghton PJ, Wennerberg K, Cox AD, Der CJ.

Cancer Cell. 2018 Nov 12;34(5):807-822.e7. doi: 10.1016/j.ccell.2018.10.001.


The vulnerability of RB loss in breast cancer: Targeting a void in cell cycle control.

Knudsen ES, Zacksenhaus E.

Oncotarget. 2018 Jul 24;9(57):30940-30941. doi: 10.18632/oncotarget.25797. eCollection 2018 Jul 24. No abstract available.


Neural Circuits That Mediate Selective Attention: A Comparative Perspective.

Knudsen EI.

Trends Neurosci. 2018 Nov;41(11):789-805. doi: 10.1016/j.tins.2018.06.006. Epub 2018 Jul 31. Review.


Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.

Brough R, Gulati A, Haider S, Kumar R, Campbell J, Knudsen E, Pettitt SJ, Ryan CJ, Lord CJ.

Oncogene. 2018 Oct;37(43):5701-5718. doi: 10.1038/s41388-018-0368-z. Epub 2018 Jun 18.


Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer.

Witkiewicz AK, Chung S, Brough R, Vail P, Franco J, Lord CJ, Knudsen ES.

Cell Rep. 2018 Jan 30;22(5):1185-1199. doi: 10.1016/j.celrep.2018.01.022.


Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors.

Mannakee BK, Balaji U, Witkiewicz AK, Gutenkunst RN, Knudsen ES.

Bioinformatics. 2018 May 15;34(10):1713-1718. doi: 10.1093/bioinformatics/bty010.


Restoration of Hindlimb Movements after Complete Spinal Cord Injury Using Brain-Controlled Functional Electrical Stimulation.

Knudsen EB, Moxon KA.

Front Neurosci. 2017 Dec 19;11:715. doi: 10.3389/fnins.2017.00715. eCollection 2017.


Composite analysis of immunological and metabolic markers defines novel subtypes of triple negative breast cancer.

Adams TA, Vail PJ, Ruiz A, Mollaee M, McCue PA, Knudsen ES, Witkiewicz AK.

Mod Pathol. 2018 Feb;31(2):288-298. doi: 10.1038/modpathol.2017.126. Epub 2017 Oct 6.


The transcriptome of CDK4/6 inhibition.

Knudsen ES, Witkiewicz AK.

Aging (Albany NY). 2017 Aug 30;9(8):1859-1860. doi: 10.18632/aging.101285. No abstract available.


Time-of-Flight Three Dimensional Neutron Diffraction in Transmission Mode for Mapping Crystal Grain Structures.

Cereser A, Strobl M, Hall SA, Steuwer A, Kiyanagi R, Tremsin AS, Knudsen EB, Shinohara T, Willendrup PK, da Silva Fanta AB, Iyengar S, Larsen PM, Hanashima T, Moyoshi T, Kadletz PM, Krooß P, Niendorf T, Sales M, Schmahl WW, Schmidt S.

Sci Rep. 2017 Aug 25;7(1):9561. doi: 10.1038/s41598-017-09717-w.


Advancement of spring arrival in a long-term study of a passerine bird: sex, age and environmental effects.

Cadahía L, Labra A, Knudsen E, Nilsson A, Lampe HM, Slagsvold T, Stenseth NC.

Oecologia. 2017 Aug;184(4):917-929. doi: 10.1007/s00442-017-3922-4. Epub 2017 Jul 29.


Disentangling the relationship between gender and work-family conflict: An integration of theoretical perspectives using meta-analytic methods.

Shockley KM, Shen W, DeNunzio MM, Arvan ML, Knudsen EA.

J Appl Psychol. 2017 Dec;102(12):1601-1635. doi: 10.1037/apl0000246. Epub 2017 Jul 27.


Space-Specific Deficits in Visual Orientation Discrimination Caused by Lesions in the Midbrain Stimulus Selection Network.

Knudsen EI, Schwarz JS, Knudsen PF, Sridharan D.

Curr Biol. 2017 Jul 24;27(14):2053-2064.e5. doi: 10.1016/j.cub.2017.06.011. Epub 2017 Jun 29.


Whole-genome sequencing for identification of the source in hospital-acquired Legionnaires' disease.

Rosendahl Madsen AM, Holm A, Jensen TG, Knudsen E, Lundgaard H, Skov MN, Uldum SA, Kemp M.

J Hosp Infect. 2017 Aug;96(4):392-395. doi: 10.1016/j.jhin.2017.04.020. Epub 2017 Apr 27.


Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature.

Knudsen ES, Hutcheson J, Vail P, Witkiewicz AK.

Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.


Genetic assessment of the effects of streamscape succession on coho salmon Oncorhynchus kisutch colonization in recently deglaciated streams.

Scribner KT, Soiseth C, McGuire J, Sage GK, Thorsteinson L, Nielsen JL, Knudsen E.

J Fish Biol. 2017 Jul;91(1):195-218. doi: 10.1111/jfb.13337. Epub 2017 May 19.


Stratification of Pancreatic Ductal Adenocarcinoma: Combinatorial Genetic, Stromal, and Immunologic Markers.

Knudsen ES, Vail P, Balaji U, Ngo H, Botros IW, Makarov V, Riaz N, Balachandran V, Leach S, Thompson DM, Chan TA, Witkiewicz AK.

Clin Cancer Res. 2017 Aug 1;23(15):4429-4440. doi: 10.1158/1078-0432.CCR-17-0162. Epub 2017 Mar 27.


The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies.

Knudsen ES, Witkiewicz AK.

Trends Cancer. 2017 Jan;3(1):39-55. doi: 10.1016/j.trecan.2016.11.006. Review.


Species identification of Streptococcus bovis group isolates causing bacteremia: a comparison of two MALDI-TOF MS systems.

Agergaard CN, Knudsen E, Dargis R, Nielsen XC, Christensen JJ, Justesen US.

Diagn Microbiol Infect Dis. 2017 May;88(1):23-25. doi: 10.1016/j.diagmicrobio.2017.02.007. Epub 2017 Feb 20.


Kinome-Wide RNA Interference Screen Reveals a Role for PDK1 in Acquired Resistance to CDK4/6 Inhibition in ER-Positive Breast Cancer.

Jansen VM, Bhola NE, Bauer JA, Formisano L, Lee KM, Hutchinson KE, Witkiewicz AK, Moore PD, Estrada MV, Sánchez V, Ericsson PG, Sanders ME, Pohlmann PR, Pishvaian MJ, Riddle DA, Dugger TC, Wei W, Knudsen ES, Arteaga CL.

Cancer Res. 2017 May 1;77(9):2488-2499. doi: 10.1158/0008-5472.CAN-16-2653. Epub 2017 Mar 1. Erratum in: Cancer Res. 2019 Feb 15;79(4):874.


Framingham risk assessment in hidradenitis suppurativa.

Hughes R, Knudsen E, Kirthi S, Kelly G, Tobin AM, Sweeney CM, Jemec GBE, Kirby B.

Br J Dermatol. 2017 May;176(5):1404-1406. doi: 10.1111/bjd.15365. Epub 2017 Mar 27. No abstract available.


Does the Superior Colliculus Control Perceptual Sensitivity or Choice Bias during Attention? Evidence from a Multialternative Decision Framework.

Sridharan D, Steinmetz NA, Moore T, Knudsen EI.

J Neurosci. 2017 Jan 18;37(3):480-511. doi: 10.1523/JNEUROSCI.4505-14.2017.


Pancreatic cancer cell lines as patient-derived avatars: genetic characterisation and functional utility.

Knudsen ES, Balaji U, Mannakee B, Vail P, Eslinger C, Moxom C, Mansour J, Witkiewicz AK.

Gut. 2018 Mar;67(3):508-520. doi: 10.1136/gutjnl-2016-313133. Epub 2017 Jan 10.


Spatially precise visual gain control mediated by a cholinergic circuit in the midbrain attention network.

Asadollahi A, Knudsen EI.

Nat Commun. 2016 Nov 17;7:13472. doi: 10.1038/ncomms13472.


Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential.

Knudsen ES, Balaji U, Freinkman E, McCue P, Witkiewicz AK.

Oncotarget. 2016 Nov 29;7(48):78396-78411. doi: 10.18632/oncotarget.11893.


The Epi Info Viral Hemorrhagic Fever (VHF) Application: A Resource for Outbreak Data Management and Contact Tracing in the 2014-2016 West Africa Ebola Epidemic.

Schafer IJ, Knudsen E, McNamara LA, Agnihotri S, Rollin PE, Islam A.

J Infect Dis. 2016 Oct 15;214(suppl 3):S122-S136. Epub 2016 Sep 1.


Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer.

Knudsen ES, Witkiewicz AK.

Oncotarget. 2016 Oct 25;7(43):69111-69123. doi: 10.18632/oncotarget.11588.


Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer.

Witkiewicz AK, Balaji U, Eslinger C, McMillan E, Conway W, Posner B, Mills GB, O'Reilly EM, Knudsen ES.

Cell Rep. 2016 Aug 16;16(7):2017-31. doi: 10.1016/j.celrep.2016.07.023. Epub 2016 Aug 4.


Bacteremia with the bovis group streptococci: species identification and association with infective endocarditis and with gastrointestinal disease.

Marmolin ES, Hartmeyer GN, Christensen JJ, Nielsen XC, Dargis R, Skov MN, Knudsen E, Kemp M, Justesen US.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):239-42. doi: 10.1016/j.diagmicrobio.2016.02.019. Epub 2016 Feb 26.


Immunologic and Metabolic Features of Pancreatic Ductal Adenocarcinoma Define Prognostic Subtypes of Disease.

Hutcheson J, Balaji U, Porembka MR, Wachsmann MB, McCue PA, Knudsen ES, Witkiewicz AK.

Clin Cancer Res. 2016 Jul 15;22(14):3606-17. doi: 10.1158/1078-0432.CCR-15-1883. Epub 2016 Feb 8.


Evaluation of an Algorithm to Predict Menstrual-Cycle Phase at the Time of Injury.

Tourville TW, Shultz SJ, Vacek PM, Knudsen EJ, Bernstein IM, Tourville KJ, Hardy DM, Johnson RJ, Slauterbeck JR, Beynnon BD.

J Athl Train. 2016 Jan;51(1):47-56. doi: 10.4085/1062-6050-51.3.01. Epub 2016 Jan 25.


Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities.

Franco J, Balaji U, Freinkman E, Witkiewicz AK, Knudsen ES.

Cell Rep. 2016 Feb 9;14(5):979-990. doi: 10.1016/j.celrep.2015.12.094. Epub 2016 Jan 21.


Increased expression of NAMPT in PBMC from patients with acute coronary syndrome and in inflammatory M1 macrophages.

Halvorsen B, Espeland MZ, Andersen GØ, Yndestad A, Sagen EL, Rashidi A, Knudsen EC, Skjelland M, Skagen KR, Krohg-Sørensen K, Holm S, Ritschel V, Holven KB, Biessen EA, Aukrust P, Dahl TB.

Atherosclerosis. 2015 Nov;243(1):204-10. doi: 10.1016/j.atherosclerosis.2015.09.010. Epub 2015 Sep 8.


Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine.

Knudsen ES, O'Reilly EM, Brody JR, Witkiewicz AK.

Gastroenterology. 2016 Jan;150(1):48-63. doi: 10.1053/j.gastro.2015.08.056. Epub 2015 Sep 15. Review.


Interactive Effects Between Exercise and Serotonergic Pharmacotherapy on Cortical Reorganization After Spinal Cord Injury.

Foffani G, Shumsky J, Knudsen EB, Ganzer PD, Moxon KA.

Neurorehabil Neural Repair. 2016 Jun;30(5):479-89. doi: 10.1177/1545968315600523. Epub 2015 Sep 3.


[Dual-energy computer tomography can be used for gout diagnostics].

Jørgensen SH, Knudsen ET, Rasmussen C.

Ugeskr Laeger. 2015 Aug 10;177(33):V10140544. Danish.


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