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Items: 1 to 50 of 72

1.

Enzymatic activity in single cells.

Keller JG, Stougaard M, Knudsen BR.

Methods Enzymol. 2019;628:43-57. doi: 10.1016/bs.mie.2019.07.003. Epub 2019 Jul 25.

PMID:
31668235
2.

A new DNA sensor system for specific and quantitative detection of mycobacteria.

Franch O, Han X, Marcussen LB, Givskov A, Andersen MB, Godbole AA, Harmsen C, Nørskov-Lauritsen N, Thomsen J, Pedersen FS, Wang Y, Shi D, Wejse C, Pødenphant L, Nagaraja V, Bertl J, Stougaard M, Ho YP, Hede MS, Labouriau R, Knudsen BR.

Nanoscale. 2019 Jan 3;11(2):587-597. doi: 10.1039/c8nr07850e.

PMID:
30556557
3.

Detection of the Malaria causing Plasmodium Parasite in Saliva from Infected Patients using Topoisomerase I Activity as a Biomarker.

Hede MS, Fjelstrup S, Lötsch F, Zoleko RM, Klicpera A, Groger M, Mischlinger J, Endame L, Veletzky L, Neher R, Simonsen AKW, Petersen E, Mombo-Ngoma G, Stougaard M, Ho YP, Labouriau R, Ramharter M, Knudsen BR.

Sci Rep. 2018 Mar 7;8(1):4122. doi: 10.1038/s41598-018-22378-7.

4.

Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5.

Kjeldsen E, Nielsen CJF, Roy A, Tesauro C, Jakobsen AK, Stougaard M, Knudsen BR.

Cancer Genomics Proteomics. 2018 Mar-Apr;15(2):91-114.

5.

On-slide detection of enzymatic activities in selected single cells.

Keller JG, Tesauro C, Coletta A, Graversen AD, Ho YP, Kristensen P, Stougaard M, Knudsen BR.

Nanoscale. 2017 Sep 21;9(36):13546-13553. doi: 10.1039/c7nr05125e.

PMID:
28872165
6.

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.

Kristoffersen EL, Givskov A, Jørgensen LA, Jensen PW, W Byl JA, Osheroff N, Andersen AH, Stougaard M, Ho YP, Knudsen BR.

Nucleic Acids Res. 2017 Jul 27;45(13):7855-7869. doi: 10.1093/nar/gkx480.

7.

The Effects of Dithiothreitol on DNA.

Fjelstrup S, Andersen MB, Thomsen J, Wang J, Stougaard M, Pedersen FS, Ho YP, Hede MS, Knudsen BR.

Sensors (Basel). 2017 May 24;17(6). pii: E1201. doi: 10.3390/s17061201.

8.

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.

Andersen MB, Tesauro C, Gonzalez M, Kristoffersen EL, Alonso C, Rubiales G, Coletta A, Frøhlich R, Stougaard M, Ho YP, Palacios F, Knudsen BR.

Nanoscale. 2017 Feb 2;9(5):1886-1895. doi: 10.1039/c6nr06848k.

PMID:
28094391
9.

Novel DNA sensor system for highly sensitive and quantitative retrovirus detection using virus encoded integrase as a biomarker.

Wang J, Liu J, Thomsen J, Selnihhin D, Hede MS, Kirsebom FC, Franch O, Fjelstrup S, Stougaard M, Ho YP, Pedersen FS, Knudsen BR.

Nanoscale. 2017 Jan 7;9(1):440-448. doi: 10.1039/c6nr07428f. Epub 2016 Dec 9.

PMID:
27934981
10.

Optimized Detection of Plasmodium falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons.

Givskov A, Kristoffersen EL, Vandsø K, Ho YP, Stougaard M, Knudsen BR.

Sensors (Basel). 2016 Nov 15;16(11). pii: E1916.

11.

Reducing the risk of another Aliso Canyon.

Knudsen BR.

Science. 2016 Aug 26;353(6302):878. doi: 10.1126/science.aah3833. No abstract available.

PMID:
27563088
12.

DNA hairpins promote temperature controlled cargo encapsulation in a truncated octahedral nanocage structure family.

Franch O, Iacovelli F, Falconi M, Juul S, Ottaviani A, Benvenuti C, Biocca S, Ho YP, Knudsen BR, Desideri A.

Nanoscale. 2016 Jul 21;8(27):13333-41. doi: 10.1039/c6nr01806h. Epub 2016 Jun 24.

PMID:
27341703
13.

Receptor-Mediated Entry of Pristine Octahedral DNA Nanocages in Mammalian Cells.

Vindigni G, Raniolo S, Ottaviani A, Falconi M, Franch O, Knudsen BR, Desideri A, Biocca S.

ACS Nano. 2016 Jun 28;10(6):5971-9. doi: 10.1021/acsnano.6b01402. Epub 2016 May 26.

PMID:
27214742
14.

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations.

Jensen NF, Agama K, Roy A, Smith DH, Pfister TD, Rømer MU, Zhang HL, Doroshow JH, Knudsen BR, Stenvang J, Brünner N, Pommier Y.

J Exp Clin Cancer Res. 2016 Mar 31;35:56. doi: 10.1186/s13046-016-0335-x.

15.

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.

Alonso C, Fuertes M, González M, Rubiales G, Tesauro C, Knudsen BR, Palacios F.

Eur J Med Chem. 2016 Jun 10;115:179-90. doi: 10.1016/j.ejmech.2016.03.031. Epub 2016 Mar 14.

PMID:
27017547
16.

Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.

Jandu H, Aluzaite K, Fogh L, Thrane SW, Noer JB, Proszek J, Do KN, Hansen SN, Damsgaard B, Nielsen SL, Stougaard M, Knudsen BR, Moreira J, Hamerlik P, Gajjar M, Smid M, Martens J, Foekens J, Pommier Y, Brünner N, Schrohl AS, Stenvang J.

BMC Cancer. 2016 Jan 22;16:34. doi: 10.1186/s12885-016-2071-1.

17.

Specific detection of the cleavage activity of mycobacterial enzymes using a quantum dot based DNA nanosensor.

Jepsen ML, Harmsen C, Godbole AA, Nagaraja V, Knudsen BR, Ho YP.

Nanoscale. 2016 Jan 7;8(1):358-64. doi: 10.1039/c5nr06326d.

PMID:
26616006
18.

Microfluidics-Enabled Enzyme Activity Measurement in Single Cells.

Tesauro C, Frøhlich R, Stougaard M, Ho YP, Knudsen BR.

Methods Mol Biol. 2015;1346:209-19. doi: 10.1007/978-1-4939-2987-0_14.

PMID:
26542724
19.

Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene.

Zuccaro L, Tesauro C, Kurkina T, Fiorani P, Yu HK, Knudsen BR, Kern K, Desideri A, Balasubramanian K.

ACS Nano. 2015 Nov 24;9(11):11166-76. doi: 10.1021/acsnano.5b05709. Epub 2015 Oct 12.

PMID:
26445172
20.

Correlation between topoisomerase I and tyrosyl-DNA phosphodiesterase 1 activities in non-small cell lung cancer tissue.

Jakobsen AK, Lauridsen KL, Samuel EB, Proszek J, Knudsen BR, Hager H, Stougaard M.

Exp Mol Pathol. 2015 Aug;99(1):56-64. doi: 10.1016/j.yexmp.2015.05.006. Epub 2015 May 16.

PMID:
25987486
21.

Real-time investigation of human topoisomerase I reaction kinetics using an optical sensor: a fast method for drug screening and determination of active enzyme concentrations.

Kristoffersen EL, Jørgensen LA, Franch O, Etzerodt M, Frøhlich R, Bjergbæk L, Stougaard M, Ho YP, Knudsen BR.

Nanoscale. 2015 Jun 7;7(21):9825-34. doi: 10.1039/c5nr01474c.

PMID:
25963854
22.

NanoCluster Beacons as reporter probes in rolling circle enhanced enzyme activity detection.

Juul S, Obliosca JM, Liu C, Liu YL, Chen YA, Imphean DM, Knudsen BR, Ho YP, Leong KW, Yeh HC.

Nanoscale. 2015 May 14;7(18):8332-7. doi: 10.1039/c5nr01705j.

23.

Decreased camptothecin sensitivity of the stem-cell-like fraction of Caco2 cells correlates with an altered phosphorylation pattern of topoisomerase I.

Roy A, Tesauro C, Frøhlich R, Hede MS, Nielsen MJ, Kjeldsen E, Bonven B, Stougaard M, Gromova I, Knudsen BR.

PLoS One. 2014 Jun 24;9(6):e99628. doi: 10.1371/journal.pone.0099628. eCollection 2014.

24.

Synthesis of fluorosurfactants for emulsion-based biological applications.

Chiu YL, Chan HF, Phua KK, Zhang Y, Juul S, Knudsen BR, Ho YP, Leong KW.

ACS Nano. 2014 Apr 22;8(4):3913-20. doi: 10.1021/nn500810n. Epub 2014 Mar 25.

25.

Rolling circle amplification-based detection of human topoisomerase I activity on magnetic beads.

Zuccaro L, Tesauro C, Cerroni B, Ottaviani A, Knudsen BR, Balasubramanian K, Desideri A.

Anal Biochem. 2014 Apr 15;451:42-4. doi: 10.1016/j.ab.2014.02.003. Epub 2014 Feb 11.

PMID:
24525043
26.

Topoisomerase I as a biomarker: detection of activity at the single molecule level.

Proszek J, Roy A, Jakobsen AK, Frøhlich R, Knudsen BR, Stougaard M.

Sensors (Basel). 2014 Jan 10;14(1):1195-207. doi: 10.3390/s140101195.

27.

Temperature-controlled encapsulation and release of an active enzyme in the cavity of a self-assembled DNA nanocage.

Juul S, Iacovelli F, Falconi M, Kragh SL, Christensen B, Frøhlich R, Franch O, Kristoffersen EL, Stougaard M, Leong KW, Ho YP, Sørensen ES, Birkedal V, Desideri A, Knudsen BR.

ACS Nano. 2013 Nov 26;7(11):9724-34. doi: 10.1021/nn4030543. Epub 2013 Nov 1.

PMID:
24168393
28.

Real-time detection of TDP1 activity using a fluorophore-quencher coupled DNA-biosensor.

Jensen PW, Falconi M, Kristoffersen EL, Simonsen AT, Cifuentes JB, Marcussen LB, Frøhlich R, Vagner J, Harmsen C, Juul S, Ho YP, Withers MA, Lupski JR, Koch J, Desideri A, Knudsen BR, Stougaard M.

Biosens Bioelectron. 2013 Oct 15;48:230-7. doi: 10.1016/j.bios.2013.04.019. Epub 2013 Apr 25.

PMID:
23693093
29.

Quantum dot-based nanosensors for diagnosis via enzyme activity measurement.

Knudsen BR, Jepsen ML, Ho YP.

Expert Rev Mol Diagn. 2013 May;13(4):367-75. doi: 10.1586/erm.13.17. Review.

PMID:
23638819
30.

DNA-based sensor for real-time measurement of the enzymatic activity of human topoisomerase I.

Marcussen LB, Jepsen ML, Kristoffersen EL, Franch O, Proszek J, Ho YP, Stougaard M, Knudsen BR.

Sensors (Basel). 2013 Mar 25;13(4):4017-28. doi: 10.3390/s130404017.

31.

Specific detection of topoisomerase I from the malaria causing P. falciparum parasite using isothermal rolling circle amplification.

Tesauro C, Juul S, Arnò B, Nielsen CJ, Fiorani P, Frøhlich RF, Andersen FF, Desideri A, Stougaard M, Petersen E, Knudsen BR.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2416-9. doi: 10.1109/EMBC.2012.6346451.

PMID:
23366412
32.

Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement.

Juul S, Nielsen CJ, Labouriau R, Roy A, Tesauro C, Jensen PW, Harmsen C, Kristoffersen EL, Chiu YL, Frøhlich R, Fiorani P, Cox-Singh J, Tordrup D, Koch J, Bienvenu AL, Desideri A, Picot S, Petersen E, Leong KW, Ho YP, Stougaard M, Knudsen BR.

ACS Nano. 2012 Dec 21;6(12):10676-83. doi: 10.1021/nn3038594. Epub 2012 Nov 7.

33.

Microfluidics-mediated isothermal detection of enzyme activity at the single molecule level.

Juul S, Ho YP, Stougaard M, Koch J, Andersen FF, Leong KW, Knudsen BR.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:3258-61. doi: 10.1109/IEMBS.2011.6090885.

PMID:
22255034
34.

Peptide Inhibition of Topoisomerase IB from Plasmodium falciparum.

Roy A, D'Annessa I, Nielsen CJ, Tordrup D, Laursen RR, Knudsen BR, Desideri A, Andersen FF.

Mol Biol Int. 2011;2011:854626. doi: 10.4061/2011/854626. Epub 2011 May 4.

35.

Detection of single enzymatic events in rare or single cells using microfluidics.

Juul S, Ho YP, Koch J, Andersen FF, Stougaard M, Leong KW, Knudsen BR.

ACS Nano. 2011 Oct 25;5(10):8305-10. doi: 10.1021/nn203012q. Epub 2011 Sep 28.

36.

Strategies for highly sensitive biomarker detection by Rolling Circle Amplification of signals from nucleic acid composed sensors.

Stougaard M, Juul S, Andersen FF, Knudsen BR.

Integr Biol (Camb). 2011 Oct;3(10):982-92. doi: 10.1039/c1ib00049g. Epub 2011 Sep 19. Review.

PMID:
21927767
37.

Evidences of a natively unfolded state for the human topoisomerase IB N-terminal domain.

Vassallo O, Castelli S, D'Annessa I, della Rocca BM, Stella L, Knudsen BR, Desideri A.

Amino Acids. 2011 Oct;41(4):945-53. doi: 10.1007/s00726-010-0794-x. Epub 2010 Nov 3.

PMID:
21046176
38.

Topoisomerase I deficiency results in chromosomal alterations in cervical cancer cells.

Kjeldsen E, Tordrup D, Hübner GM, Knudsen BR, Andersen FF.

Anticancer Res. 2010 Sep;30(9):3257-65.

PMID:
20944095
39.

The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I.

Gentry AC, Juul S, Veigaard C, Knudsen BR, Osheroff N.

Nucleic Acids Res. 2011 Feb;39(3):1014-22. doi: 10.1093/nar/gkq822. Epub 2010 Sep 19.

40.

A novel secondary DNA binding site in human topoisomerase I unravelled by using a 2D DNA origami platform.

Subramani R, Juul S, Rotaru A, Andersen FF, Gothelf KV, Mamdouh W, Besenbacher F, Dong M, Knudsen BR.

ACS Nano. 2010 Oct 26;4(10):5969-77. doi: 10.1021/nn101662a.

PMID:
20828215
41.

Structure of nanoscale truncated octahedral DNA cages: variation of single-stranded linker regions and influence on assembly yields.

Oliveira CL, Juul S, Jørgensen HL, Knudsen B, Tordrup D, Oteri F, Falconi M, Koch J, Desideri A, Pedersen JS, Andersen FF, Knudsen BR.

ACS Nano. 2010 Mar 23;4(3):1367-76. doi: 10.1021/nn901510v.

PMID:
20146442
42.

Multiplexed detection of site specific recombinase and DNA topoisomerase activities at the single molecule level.

Andersen FF, Stougaard M, Jørgensen HL, Bendsen S, Juul S, Hald K, Andersen AH, Koch J, Knudsen BR.

ACS Nano. 2009 Dec 22;3(12):4043-54. doi: 10.1021/nn9012912.

PMID:
19950974
43.

Deciphering the structural properties that confer stability to a DNA nanocage.

Falconi M, Oteri F, Chillemi G, Andersen FF, Tordrup D, Oliveira CL, Pedersen JS, Knudsen BR, Desideri A.

ACS Nano. 2009 Jul 28;3(7):1813-22. doi: 10.1021/nn900468y. Epub 2009 Jun 22.

PMID:
19545161
44.

The QTK loop is essential for the communication between the N-terminal atpase domain and the central cleavage--ligation region in human topoisomerase IIalpha.

Bendsen S, Oestergaard VH, Skouboe C, Brinch M, Knudsen BR, Andersen AH.

Biochemistry. 2009 Jul 14;48(27):6508-15. doi: 10.1021/bi9005978.

PMID:
19485418
45.

Single-molecule detection of human topoisomerase I cleavage-ligation activity.

Stougaard M, Lohmann JS, Mancino A, Celik S, Andersen FF, Koch J, Knudsen BR.

ACS Nano. 2009 Jan 27;3(1):223-33. doi: 10.1021/nn800509b.

PMID:
19206270
46.

Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase IIalpha.

Jonstrup AT, Thomsen T, Wang Y, Knudsen BR, Koch J, Andersen AH.

Nucleic Acids Res. 2008 Nov;36(19):6165-74. doi: 10.1093/nar/gkn640. Epub 2008 Sep 29.

47.

Assembly and structural analysis of a covalently closed nano-scale DNA cage.

Andersen FF, Knudsen B, Oliveira CL, Frøhlich RF, Krüger D, Bungert J, Agbandje-McKenna M, McKenna R, Juul S, Veigaard C, Koch J, Rubinstein JL, Guldbrandtsen B, Hede MS, Karlsson G, Andersen AH, Pedersen JS, Knudsen BR.

Nucleic Acids Res. 2008 Mar;36(4):1113-9. Epub 2007 Dec 20.

48.

Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal.

Frøhlich RF, Veigaard C, Andersen FF, McClendon AK, Gentry AC, Andersen AH, Osheroff N, Stevnsner T, Knudsen BR.

Nucleic Acids Res. 2007;35(18):6170-80. Epub 2007 Sep 7.

49.

Resolution of Holliday junction substrates by human topoisomerase I.

Hede MS, Petersen RL, Frøhlich RF, Krüger D, Andersen FF, Andersen AH, Knudsen BR.

J Mol Biol. 2007 Jan 26;365(4):1076-92. Epub 2006 Oct 21.

PMID:
17101150
50.

Dissecting the cell-killing mechanism of the topoisomerase II-targeting drug ICRF-193.

Oestergaard VH, Knudsen BR, Andersen AH.

J Biol Chem. 2004 Jul 2;279(27):28100-5. Epub 2004 Apr 28.

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