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Items: 28

1.

The development and characterization of a chemical probe targeting PRMT1 over PRMT5.

Mann SA, Salsburg A, Causey CP, Knuckley B.

Bioorg Med Chem. 2019 Jan 1;27(1):224-229. doi: 10.1016/j.bmc.2018.12.001. Epub 2018 Dec 4.

PMID:
30529151
2.

Mechanistic studies of the agmatine deiminase from Listeria monocytogenes.

Soares CA, Knuckley B.

Biochem J. 2016 Jun 1;473(11):1553-61. doi: 10.1042/BCJ20160221. Epub 2016 Mar 31.

3.

Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product.

James ED, Knuckley B, Alqahtani N, Porwal S, Ban J, Karty JA, Viswanathan R, Lane AL.

ACS Synth Biol. 2016 Jul 15;5(7):547-53. doi: 10.1021/acssynbio.5b00120. Epub 2015 Dec 9.

PMID:
26641496
4.

Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes.

Nguyen HC, Wang M, Salsburg A, Knuckley B.

ACS Comb Sci. 2015 Sep 14;17(9):500-5. doi: 10.1021/acscombsci.5b00070. Epub 2015 Aug 13.

PMID:
26252756
5.

Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases.

Marchenko M, Thomson A, Ellis TN, Knuckley B, Causey CP.

Bioorg Med Chem. 2015 May 1;23(9):2159-67. doi: 10.1016/j.bmc.2015.03.013. Epub 2015 Mar 9.

PMID:
25819331
6.

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases.

Thomson A, O'Connor S, Knuckley B, Causey CP.

Bioorg Med Chem. 2014 Sep 1;22(17):4602-8. doi: 10.1016/j.bmc.2014.07.028. Epub 2014 Jul 25.

PMID:
25127464
7.

Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism.

Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR.

Biochemistry. 2014 Jul 15;53(27):4426-33. doi: 10.1021/bi500554b. Epub 2014 Jul 3.

8.

Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor.

Dreyton CJ, Jones JE, Knuckley BA, Subramanian V, Anderson ED, Brown SJ, Fernandez-Vega V, Eberhart C, Spicer T, Zuhl AM, Ferguson J, Speers AE, Wang C, Boger DL, Thompson P, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Apr 5].

9.

Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates.

Lewallen DM, Steckler CJ, Knuckley B, Chalmers MJ, Thompson PR.

Mol Biosyst. 2012 Jun;8(6):1701-6. doi: 10.1039/c2mb25053e. Epub 2012 Mar 28.

PMID:
22456874
10.

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps.

Dwivedi N, Upadhyay J, Neeli I, Khan S, Pattanaik D, Myers L, Kirou KA, Hellmich B, Knuckley B, Thompson PR, Crow MK, Mikuls TR, Csernok E, Radic M.

Arthritis Rheum. 2012 Apr;64(4):982-92. doi: 10.1002/art.33432. Epub 2011 Oct 27.

11.

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR.

J Med Chem. 2011 Oct 13;54(19):6919-35. doi: 10.1021/jm2008985. Epub 2011 Sep 16. Erratum in: J Med Chem. 2011 Nov 24;54(22):7942.

12.

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.

Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G929-38. doi: 10.1152/ajpgi.00435.2010. Epub 2011 Mar 17.

13.

N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.

Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM.

J Immunol. 2011 Apr 1;186(7):4396-404. doi: 10.4049/jimmunol.1001620. Epub 2011 Feb 23.

14.

A fluopol-ABPP HTS assay to identify PAD inhibitors.

Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR.

Chem Commun (Camb). 2010 Oct 14;46(38):7175-7. doi: 10.1039/c0cc02634d. Epub 2010 Aug 25.

15.

Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3.

Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR.

Biochemistry. 2010 Jun 15;49(23):4852-63. doi: 10.1021/bi100363t.

16.

Characterization and inactivation of an agmatine deiminase from Helicobacter pylori.

Jones JE, Causey CP, Lovelace L, Knuckley B, Flick H, Lebioda L, Thompson PR.

Bioorg Chem. 2010 Apr;38(2):62-73. doi: 10.1016/j.bioorg.2009.11.004. Epub 2009 Nov 29.

17.

Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation.

Knuckley B, Causey CP, Pellechia PJ, Cook PF, Thompson PR.

Chembiochem. 2010 Jan 25;11(2):161-5. doi: 10.1002/cbic.200900698.

18.

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential.

Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR.

Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27. Review.

19.

Prefrontal control of trace eyeblink conditioning in rabbits (Oryctolagus cuniculus) II: effects of type of unconditioned stimulus (airpuff vs. periorbital shock) and unconditioned stimulus intensity.

Oswald BB, Knuckley B, Mahan K, Sanders C, Powell DA.

Physiol Behav. 2009 Jan 8;96(1):67-72. doi: 10.1016/j.physbeh.2008.08.013. Epub 2008 Aug 24.

PMID:
18793661
20.

Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.

Knuckley B, Luo Y, Thompson PR.

Bioorg Med Chem. 2008 Jan 15;16(2):739-45. Epub 2007 Oct 13.

21.

Protein arginine deiminase 4: evidence for a reverse protonation mechanism.

Knuckley B, Bhatia M, Thompson PR.

Biochemistry. 2007 Jun 5;46(22):6578-87. Epub 2007 May 12.

22.

Ibotenic acid lesions to ventrolateral thalamic nuclei disrupts trace and delay eyeblink conditioning in rabbits.

Oswald BB, Knuckley B, Maddox SA, Powell DA.

Behav Brain Res. 2007 Apr 16;179(1):111-7. Epub 2007 Jan 31.

PMID:
17335917
23.
24.

Prefrontal control of trace versus delay eyeblink conditioning: role of the unconditioned stimulus in rabbits (Oryctolagus cuniculus).

Oswald B, Knuckley B, Mahan K, Sanders C, Powell DA.

Behav Neurosci. 2006 Oct;120(5):1033-42.

PMID:
17014255
25.

Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.

Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR.

Biochemistry. 2006 Oct 3;45(39):11727-36.

26.

A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation.

Luo Y, Knuckley B, Lee YH, Stallcup MR, Thompson PR.

J Am Chem Soc. 2006 Feb 1;128(4):1092-3.

27.
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