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Items: 1 to 50 of 185

1.

Stabilization and characterization of cytotoxic Aβ40 oligomers isolated from an aggregation reaction in the presence of zinc ions.

Mannini B, Habchi J, Chia SKR, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Jul 9. doi: 10.1021/acschemneuro.8b00141. [Epub ahead of print]

PMID:
29986583
2.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Jul 6. doi: 10.1039/c8cc02204f. [Epub ahead of print]

PMID:
29978862
3.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Jun 28. doi: 10.1021/acschembio.8b00466. [Epub ahead of print]

PMID:
29953201
4.

Oligomer diversity during the aggregation of the repeat-region of tau.

Kjaergaard M, Dear AJ, Kundel F, Qamar S, Meisl G, Knowles TPJ, Klenerman D.

ACS Chem Neurosci. 2018 Jun 28. doi: 10.1021/acschemneuro.8b00250. [Epub ahead of print]

PMID:
29953200
5.

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.

Brown JWP, Meisl G, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Commun (Camb). 2018 Jul 10;54(56):7854-7857. doi: 10.1039/c8cc03002b.

PMID:
29951679
6.

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7230-7235. doi: 10.1073/pnas.1721220115. Epub 2018 Jun 25.

7.

Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.

Saar KL, Müller T, Charmet J, Challa PK, Knowles TPJ.

Anal Chem. 2018 Jul 9. doi: 10.1021/acs.analchem.8b01205. [Epub ahead of print]

PMID:
29938505
8.

Determination of Polypeptide Conformation with Nanoscale Resolution in Water.

Ramer G, Ruggeri FS, Levin A, Knowles TPJ, Centrone A.

ACS Nano. 2018 Jun 28. doi: 10.1021/acsnano.8b01425. [Epub ahead of print]

PMID:
29932670
9.

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

Yang X, Meisl G, Frohm B, Thulin E, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858. doi: 10.1073/pnas.1803539115. Epub 2018 Jun 12.

10.

Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.

PMID:
29886534
11.

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

Song Y, Michaels TCT, Ma Q, Liu Z, Yuan H, Takayama S, Knowles TPJ, Shum HC.

Nat Commun. 2018 May 29;9(1):2110. doi: 10.1038/s41467-018-04510-3.

12.

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Zhang Y, Yates EV, Hong L, Saar KL, Meisl G, Dobson CM, Knowles TPJ.

Chem Sci. 2018 Feb 9;9(14):3503-3507. doi: 10.1039/c7sc04331g. eCollection 2018 Apr 14.

13.

Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals.

Bortolini C, Klausen LH, Hoffmann SV, Jones NC, Saadeh D, Wang Z, Knowles TPJ, Dong M.

ACS Nano. 2018 May 22. doi: 10.1021/acsnano.8b00448. [Epub ahead of print]

PMID:
29771495
14.

Cooperative Assembly of Hsp70 Subdomain Clusters.

Wright MA, Aprile FA, Bellaiche MMJ, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ.

Biochemistry. 2018 Jul 3;57(26):3641-3649. doi: 10.1021/acs.biochem.8b00151. Epub 2018 May 29.

PMID:
29763298
15.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
16.

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.

Sieste S, Mack T, Synatschke CV, Schilling C, Meyer Zu Reckendorf C, Pendi L, Harvey S, Ruggeri FS, Knowles TPJ, Meier C, Ng DYW, Weil T, Knöll B.

Adv Healthc Mater. 2018 Jun;7(11):e1701485. doi: 10.1002/adhm.201701485. Epub 2018 Apr 10.

PMID:
29635761
17.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

PMID:
29581486
18.

Microfluidic approaches for probing amyloid assembly and behaviour.

Herling TW, Levin A, Saar KL, Dobson CM, Knowles TPJ.

Lab Chip. 2018 Mar 27;18(7):999-1016. doi: 10.1039/c7lc01241a. Review.

PMID:
29527600
19.

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28.

PMID:
29490200
20.

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando N, Casford S, Nollen EAA, Vendruscolo M, Dobson CM, Knowles TPJ.

J Neurosci Methods. 2018 Aug 1;306:57-67. doi: 10.1016/j.jneumeth.2018.02.005. Epub 2018 Feb 13.

PMID:
29452179
21.

Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.

Challa PK, Peter Q, Wright MA, Zhang Y, Saar KL, Carozza JA, Benesch JLP, Knowles TPJ.

Anal Chem. 2018 Mar 20;90(6):3849-3855. doi: 10.1021/acs.analchem.7b04523. Epub 2018 Feb 28.

PMID:
29451779
22.

Biophotonics of Native Silk Fibrils.

Shimanovich U, Pinotsi D, Shimanovich K, Yu N, Bolisetty S, Adamcik J, Mezzenga R, Charmet J, Vollrath F, Gazit E, Dobson CM, Schierle GK, Holland C, Kaminski CF, Knowles TPJ.

Macromol Biosci. 2018 Apr;18(4):e1700295. doi: 10.1002/mabi.201700295. Epub 2018 Jan 29.

PMID:
29377575
23.

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.

Yang J, Dear AJ, Michaels TCT, Dobson CM, Knowles TPJ, Wu S, Perrett S.

J Am Chem Soc. 2018 Feb 21;140(7):2493-2503. doi: 10.1021/jacs.7b10439. Epub 2018 Feb 7.

24.

Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

Gang H, Galvagnion C, Meisl G, Müller T, Pfammatter M, Buell AK, Levin A, Dobson CM, Mu B, Knowles TPJ.

Anal Chem. 2018 Mar 6;90(5):3284-3290. doi: 10.1021/acs.analchem.7b04820. Epub 2018 Feb 13.

PMID:
29313342
25.

Microfluidics for Protein Biophysics.

Charmet J, Arosio P, Knowles TPJ.

J Mol Biol. 2018 Mar 2;430(5):565-580. doi: 10.1016/j.jmb.2017.12.015. Epub 2017 Dec 29. Review.

PMID:
29289566
26.

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Q Rev Biophys. 2017 Jan;50:e6. doi: 10.1017/S0033583516000172.

PMID:
29233218
27.

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

Saar KL, Zhang Y, Müller T, Kumar CP, Devenish S, Lynn A, Łapińska U, Yang X, Linse S, Knowles TPJ.

Lab Chip. 2017 Dec 19;18(1):162-170. doi: 10.1039/c7lc00797c.

PMID:
29192926
28.

Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements.

Kong L, Saar KL, Jacquat R, Hong L, Levin A, Gang H, Ye R, Mu B, Knowles TPJ.

Interface Focus. 2017 Dec 6;7(6):20170013. doi: 10.1098/rsfs.2017.0013. Epub 2017 Oct 20.

PMID:
29147556
29.

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.

30.

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

Mason TO, Michaels TCT, Levin A, Dobson CM, Gazit E, Knowles TPJ, Buell AK.

J Am Chem Soc. 2017 Nov 15;139(45):16134-16142. doi: 10.1021/jacs.7b00229. Epub 2017 Oct 23.

PMID:
28994295
31.

Nanoscale click-reactive scaffolds from peptide self-assembly.

Guttenplan APM, Young LJ, Matak-Vinkovic D, Kaminski CF, Knowles TPJ, Itzhaki LS.

J Nanobiotechnology. 2017 Oct 6;15(1):70. doi: 10.1186/s12951-017-0300-7.

32.

Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.

Kartanas T, Ostanin V, Challa PK, Daly R, Charmet J, Knowles TPJ.

Anal Chem. 2017 Nov 21;89(22):11929-11936. doi: 10.1021/acs.analchem.7b01174. Epub 2017 Nov 3.

PMID:
28984439
33.

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.

Meisl G, Yang X, Dobson CM, Linse S, Knowles TPJ.

Chem Sci. 2017 Jun 1;8(6):4352-4362. doi: 10.1039/c7sc00215g. Epub 2017 Apr 26.

34.

Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.

35.

Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.

Toprakcioglu Z, Levin A, Knowles TPJ.

Biomacromolecules. 2017 Nov 13;18(11):3642-3651. doi: 10.1021/acs.biomac.7b01159. Epub 2017 Oct 19.

PMID:
28959882
36.

Kinetic constraints on self-assembly into closed supramolecular structures.

Michaels TCT, Bellaiche MMJ, Hagan MF, Knowles TPJ.

Sci Rep. 2017 Sep 25;7(1):12295. doi: 10.1038/s41598-017-12528-8.

37.

Gradient-free determination of isoelectric points of proteins on chip.

Łapińska U, Saar KL, Yates EV, Herling TW, Müller T, Challa PK, Dobson CM, Knowles TPJ.

Phys Chem Chem Phys. 2017 Aug 30;19(34):23060-23067. doi: 10.1039/c7cp01503h.

PMID:
28817152
38.

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.

Šarić A, Michaels TCT, Zaccone A, Knowles TPJ, Frenkel D.

J Chem Phys. 2016 Dec 7;145(21):211926. doi: 10.1063/1.4965040.

PMID:
28799382
39.

Sequential Release of Proteins from Structured Multishell Microcapsules.

Shimanovich U, Michaels TCT, De Genst E, Matak-Vinkovic D, Dobson CM, Knowles TPJ.

Biomacromolecules. 2017 Oct 9;18(10):3052-3059. doi: 10.1021/acs.biomac.7b00351. Epub 2017 Sep 7.

PMID:
28792742
40.

Silk micrococoons for protein stabilisation and molecular encapsulation.

Shimanovich U, Ruggeri FS, De Genst E, Adamcik J, Barros TP, Porter D, Müller T, Mezzenga R, Dobson CM, Vollrath F, Holland C, Knowles TPJ.

Nat Commun. 2017 Jul 19;8:15902. doi: 10.1038/ncomms15902.

41.

Monomeric and fibrillar α-synuclein exert opposite effects on the catalytic cycle that promotes the proliferation of Aβ42 aggregates.

Chia S, Flagmeier P, Habchi J, Lattanzi V, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8005-8010. doi: 10.1073/pnas.1700239114. Epub 2017 Jul 11.

42.

Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method.

Aprile FA, Sormanni P, Perni M, Arosio P, Linse S, Knowles TPJ, Dobson CM, Vendruscolo M.

Sci Adv. 2017 Jun 21;3(6):e1700488. doi: 10.1126/sciadv.1700488. eCollection 2017 Jun.

43.

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D.

BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6.

44.

Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication.

Munke A, Persson J, Weiffert T, De Genst E, Meisl G, Arosio P, Carnerup A, Dobson CM, Vendruscolo M, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):6444-6449. doi: 10.1073/pnas.1700407114. Epub 2017 Jun 5.

45.

Ultrasensitive Measurement of Ca2+ Influx into Lipid Vesicles Induced by Protein Aggregates.

Flagmeier P, De S, Wirthensohn DC, Lee SF, Vincke C, Muyldermans S, Knowles TPJ, Gandhi S, Dobson CM, Klenerman D.

Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7750-7754. doi: 10.1002/anie.201700966. Epub 2017 May 5.

46.

Acceleration of α-synuclein aggregation.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Amyloid. 2017 Mar;24(sup1):20-21. doi: 10.1080/13506129.2017.1292904. No abstract available.

PMID:
28434341
47.

Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers.

Varilly P, Willard AP, Kirkegaard JB, Knowles TP, Chandler D.

J Chem Phys. 2017 Apr 7;146(13):135102. doi: 10.1063/1.4977932.

PMID:
28390364
48.

Microfluidic devices fabricated using fast wafer-scale LED-lithography patterning.

Challa PK, Kartanas T, Charmet J, Knowles TP.

Biomicrofluidics. 2017 Feb 17;11(1):014113. doi: 10.1063/1.4976690. eCollection 2017 Jan.

49.

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species.

Aprile FA, Arosio P, Fusco G, Chen SW, Kumita JR, Dhulesia A, Tortora P, Knowles TP, Vendruscolo M, Dobson CM, Cremades N.

Biochemistry. 2017 Mar 7;56(9):1177-1180. doi: 10.1021/acs.biochem.6b01178. Epub 2017 Feb 23.

PMID:
28230968
50.

Physical principles of filamentous protein self-assembly kinetics.

Michaels TC, Liu LX, Meisl G, Knowles TP.

J Phys Condens Matter. 2017 Apr 20;29(15):153002. doi: 10.1088/1361-648X/aa5f10. Epub 2017 Feb 7.

PMID:
28170349

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