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Items: 1 to 50 of 222

1.

Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid.

Frankel R, Törnquist M, Meisl G, Hansson O, Andreasson U, Zetterberg H, Blennow K, Frohm B, Cedervall T, Knowles TPJ, Leiding T, Linse S.

Commun Biol. 2019 Oct 8;2:365. doi: 10.1038/s42003-019-0612-2. eCollection 2019.

PMID:
31602414
2.

Modulating the Mechanical Performance of Macroscale Fibers through Shear-Induced Alignment and Assembly of Protein Nanofibrils.

Kamada A, Levin A, Toprakcioglu Z, Shen Y, Lutz-Bueno V, Baumann KN, Mohammadi P, Linder MB, Mezzenga R, Knowles TPJ.

Small. 2019 Oct 9:e1904190. doi: 10.1002/smll.201904190. [Epub ahead of print]

PMID:
31595701
3.

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy.

Ruggeri FS, Šneideris T, Chia S, Vendruscolo M, Knowles TPJ.

J Vis Exp. 2019 Sep 12;(151). doi: 10.3791/60108.

PMID:
31566623
4.

RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, Musteikyte G, Gachechiladze MA, Stephens CA, Pasolli HA, Forrest LR, St George-Hyslop P, Lippincott-Schwartz J, Ward ME.

Cell. 2019 Sep 19;179(1):147-164.e20. doi: 10.1016/j.cell.2019.08.050.

5.

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.

Lindstedt PR, Aprile FA, Matos MJ, Perni M, Bertoldo JB, Bernardim B, Peter Q, Jiménez-Osés G, Knowles TPJ, Dobson CM, Corzana F, Vendruscolo M, Bernardes GJL.

ACS Cent Sci. 2019 Aug 28;5(8):1417-1424. doi: 10.1021/acscentsci.9b00467. Epub 2019 Jul 19.

6.

Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.

De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D.

Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4.

7.

Universality of filamentous aggregation phenomena.

Michaels TCT, Dear AJ, Knowles TPJ.

Phys Rev E. 2019 Jun;99(6-1):062415. doi: 10.1103/PhysRevE.99.062415.

PMID:
31330719
8.

Analysis of αB-crystallin polydispersity in solution through native microfluidic electrophoresis.

Wright MA, Ruggeri FS, Saar KL, Challa PK, Benesch JLP, Knowles TPJ.

Analyst. 2019 Jul 21;144(14):4413-4424. doi: 10.1039/c9an00382g. Epub 2019 Jun 19.

PMID:
31215547
9.

Programmable On-Chip Artificial Cell Producing Post-Translationally Modified Ubiquitinated Protein.

Zilberzwige-Tal S, Levin A, Toprakcioglu Z, Knowles TPJ, Gazit E, Elbaz J.

Small. 2019 Aug;15(31):e1901780. doi: 10.1002/smll.201901780. Epub 2019 Jun 17.

PMID:
31207024
10.

Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species.

Sang JC, Lee JE, Dear AJ, De S, Meisl G, Thackray AM, Bujdoso R, Knowles TPJ, Klenerman D.

Chem Sci. 2019 Mar 25;10(17):4588-4597. doi: 10.1039/c8sc05627g. eCollection 2019 May 7.

11.

Secondary nucleation and elongation occur at different sites on Alzheimer's amyloid-β aggregates.

Scheidt T, Łapińska U, Kumita JR, Whiten DR, Klenerman D, Wilson MR, Cohen SIA, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ, Arosio P.

Sci Adv. 2019 Apr 17;5(4):eaau3112. doi: 10.1126/sciadv.aau3112. eCollection 2019 Apr.

12.

Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms.

De S, Wirthensohn DC, Flagmeier P, Hughes C, Aprile FA, Ruggeri FS, Whiten DR, Emin D, Xia Z, Varela JA, Sormanni P, Kundel F, Knowles TPJ, Dobson CM, Bryant C, Vendruscolo M, Klenerman D.

Nat Commun. 2019 Apr 4;10(1):1541. doi: 10.1038/s41467-019-09477-3.

13.

The Amyloid Phenomenon and Its Significance in Biology and Medicine.

Dobson CM, Knowles TPJ, Vendruscolo M.

Cold Spring Harb Perspect Biol. 2019 Apr 1. pii: a033878. doi: 10.1101/cshperspect.a033878. [Epub ahead of print]

PMID:
30936117
14.

Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation.

Matos MJ, Navo CD, Hakala T, Ferhati X, Guerreiro A, Hartmann D, Bernardim B, Saar KL, Compañón I, Corzana F, Knowles TPJ, Jiménez-Osés G, Bernardes GJL.

Angew Chem Int Ed Engl. 2019 May 13;58(20):6640-6644. doi: 10.1002/anie.201901405. Epub 2019 Apr 9.

15.

A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli.

Sanagavarapu K, Nüske E, Nasir I, Meisl G, Immink JN, Sormanni P, Vendruscolo M, Knowles TPJ, Malmendal A, Cabaleiro-Lago C, Linse S.

Sci Rep. 2019 Mar 6;9(1):3680. doi: 10.1038/s41598-019-39216-z.

16.

Fabrication and Characterization of Reconstituted Silk Microgels for the Storage and Release of Small Molecules.

Liu X, Toprakcioglu Z, Dear AJ, Levin A, Ruggeri FS, Taylor CG, Hu M, Kumita JR, Andreasen M, Dobson CM, Shimanovich U, Knowles TPJ.

Macromol Rapid Commun. 2019 Apr;40(8):e1800898. doi: 10.1002/marc.201800898. Epub 2019 Mar 6.

PMID:
30840348
17.

Increased Secondary Nucleation Underlies Accelerated Aggregation of the Four-Residue N-Terminally Truncated Aβ42 Species Aβ5-42.

Weiffert T, Meisl G, Flagmeier P, De S, Dunning CJR, Frohm B, Zetterberg H, Blennow K, Portelius E, Klenerman D, Dobson CM, Knowles TPJ, Linse S.

ACS Chem Neurosci. 2019 May 15;10(5):2374-2384. doi: 10.1021/acschemneuro.8b00676. Epub 2019 Mar 8.

PMID:
30793584
18.

Atomic force microscopy for single molecule characterisation of protein aggregation.

Ruggeri FS, Šneideris T, Vendruscolo M, Knowles TPJ.

Arch Biochem Biophys. 2019 Mar 30;664:134-148. doi: 10.1016/j.abb.2019.02.001. Epub 2019 Feb 8. Review.

19.

Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.

Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM.

Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5.

20.

Physical Determinants of Amyloid Assembly in Biofilm Formation.

Andreasen M, Meisl G, Taylor JD, Michaels TCT, Levin A, Otzen DE, Chapman MR, Dobson CM, Matthews SJ, Knowles TPJ.

MBio. 2019 Jan 8;10(1). pii: e02279-18. doi: 10.1128/mBio.02279-18.

21.

Automated Behavioral Analysis of Large C. elegans Populations Using a Wide Field-of-view Tracking Platform.

Perni M, Casford S, Aprile FA, Nollen EA, Knowles TPJ, Vendruscolo M, Dobson CM.

J Vis Exp. 2018 Nov 28;(141). doi: 10.3791/58643.

PMID:
30582580
22.

Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism.

Bortolini C, Kartanas T, Copic D, Condado Morales I, Zhang Y, Challa PK, Peter Q, Jávorfi T, Hussain R, Dong M, Siligardi G, Knowles TPJ, Charmet J.

Lab Chip. 2018 Dec 18;19(1):50-58. doi: 10.1039/c8lc00757h.

PMID:
30515508
23.

Mechanobiology of Protein Droplets: Force Arises from Disorder.

Welsh TJ, Shen Y, Levin A, Knowles TPJ.

Cell. 2018 Nov 29;175(6):1457-1459. doi: 10.1016/j.cell.2018.11.020.

PMID:
30500530
24.

Quantifying Co-Oligomer Formation by α-Synuclein.

Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D.

ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29.

25.

Direct Observation of Murine Prion Protein Replication in Vitro.

Sang JC, Meisl G, Thackray AM, Hong L, Ponjavic A, Knowles TPJ, Bujdoso R, Klenerman D.

J Am Chem Soc. 2018 Nov 7;140(44):14789-14798. doi: 10.1021/jacs.8b08311. Epub 2018 Oct 23.

26.

Statistical Mechanics of Globular Oligomer Formation by Protein Molecules.

Dear AJ, Šarić A, Michaels TCT, Dobson CM, Knowles TPJ.

J Phys Chem B. 2018 Dec 13;122(49):11721-11730. doi: 10.1021/acs.jpcb.8b07805. Epub 2018 Oct 31.

PMID:
30336667
27.

Observation of molecular self-assembly events in massively parallel microdroplet arrays.

Toprakcioglu Z, Challa PK, Levin A, Knowles TPJ.

Lab Chip. 2018 Oct 23;18(21):3303-3309. doi: 10.1039/c8lc00862k.

PMID:
30270398
28.

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26.

29.

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.

Ruggeri FS, Charmet J, Kartanas T, Peter Q, Chia S, Habchi J, Dobson CM, Vendruscolo M, Knowles TPJ.

Nat Commun. 2018 Sep 24;9(1):3890. doi: 10.1038/s41467-018-06345-4.

30.

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy.

Ruggeri FS, Marcott C, Dinarelli S, Longo G, Girasole M, Dietler G, Knowles TPJ.

Int J Mol Sci. 2018 Aug 30;19(9). pii: E2582. doi: 10.3390/ijms19092582.

31.

DNA-Coated Functional Oil Droplets.

Caciagli A, Zupkauskas M, Levin A, Knowles TPJ, Mugemana C, Bruns N, O'Neill T, Frith WJ, Eiser E.

Langmuir. 2018 Aug 28;34(34):10073-10080. doi: 10.1021/acs.langmuir.8b01828. Epub 2018 Aug 17.

PMID:
30086643
32.

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces.

Levin A, Michaels TCT, Mason TO, Müller T, Adler-Abramovich L, Mahadevan L, Cates ME, Gazit E, Knowles TPJ.

ACS Appl Mater Interfaces. 2018 Aug 22;10(33):27578-27583. doi: 10.1021/acsami.8b09511. Epub 2018 Aug 9.

PMID:
30080033
33.

Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M.

Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21.

34.

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.

Arter WE, Charmet J, Kong J, Saar KL, Herling TW, Müller T, Keyser UF, Knowles TPJ.

Anal Chem. 2018 Sep 4;90(17):10302-10310. doi: 10.1021/acs.analchem.8b02051. Epub 2018 Aug 15.

PMID:
30070105
35.

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH.

van der Wateren IM, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Sci. 2018 May 24;9(25):5506-5516. doi: 10.1039/c8sc01109e. eCollection 2018 Jul 7.

36.

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D.

Anal Chem. 2018 Sep 4;90(17):10385-10393. doi: 10.1021/acs.analchem.8b02226. Epub 2018 Aug 13.

37.

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

Mannini B, Habchi J, Chia S, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Dec 19;9(12):2959-2971. doi: 10.1021/acschemneuro.8b00141. Epub 2018 Aug 10.

PMID:
29986583
38.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684. doi: 10.1039/c8cc02204f. Review.

PMID:
29978862
39.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28.

PMID:
29953201
40.

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

Kjaergaard M, Dear AJ, Kundel F, Qamar S, Meisl G, Knowles TPJ, Klenerman D.

ACS Chem Neurosci. 2018 Dec 19;9(12):3060-3071. doi: 10.1021/acschemneuro.8b00250. Epub 2018 Jul 17.

41.

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.

Brown JWP, Meisl G, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Commun (Camb). 2018 Jul 10;54(56):7854-7857. doi: 10.1039/c8cc03002b.

PMID:
29951679
42.

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7230-7235. doi: 10.1073/pnas.1721220115. Epub 2018 Jun 25.

43.

Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.

Saar KL, Müller T, Charmet J, Challa PK, Knowles TPJ.

Anal Chem. 2018 Aug 7;90(15):8998-9005. doi: 10.1021/acs.analchem.8b01205. Epub 2018 Jul 9.

PMID:
29938505
44.

Determination of Polypeptide Conformation with Nanoscale Resolution in Water.

Ramer G, Ruggeri FS, Levin A, Knowles TPJ, Centrone A.

ACS Nano. 2018 Jul 24;12(7):6612-6619. doi: 10.1021/acsnano.8b01425. Epub 2018 Jun 28.

PMID:
29932670
45.

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

Yang X, Meisl G, Frohm B, Thulin E, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858. doi: 10.1073/pnas.1803539115. Epub 2018 Jun 12.

46.

Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.

PMID:
29886534
47.

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

Song Y, Michaels TCT, Ma Q, Liu Z, Yuan H, Takayama S, Knowles TPJ, Shum HC.

Nat Commun. 2018 May 29;9(1):2110. doi: 10.1038/s41467-018-04510-3.

48.

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Zhang Y, Yates EV, Hong L, Saar KL, Meisl G, Dobson CM, Knowles TPJ.

Chem Sci. 2018 Feb 9;9(14):3503-3507. doi: 10.1039/c7sc04331g. eCollection 2018 Apr 14.

49.

Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals.

Bortolini C, Klausen LH, Hoffmann SV, Jones NC, Saadeh D, Wang Z, Knowles TPJ, Dong M.

ACS Nano. 2018 Jun 26;12(6):5408-5416. doi: 10.1021/acsnano.8b00448. Epub 2018 May 22.

PMID:
29771495
50.

Cooperative Assembly of Hsp70 Subdomain Clusters.

Wright MA, Aprile FA, Bellaiche MMJ, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ.

Biochemistry. 2018 Jul 3;57(26):3641-3649. doi: 10.1021/acs.biochem.8b00151. Epub 2018 May 29.

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