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Items: 1 to 50 of 195

1.

Observation of molecular self-assembly events in massively parallel microdroplet arrays.

Toprakcioglu Z, Challa PK, Levin A, Knowles TPJ.

Lab Chip. 2018 Oct 1. doi: 10.1039/c8lc00862k. [Epub ahead of print]

PMID:
30270398
2.

SAR by kinetics for drug discovery in protein misfolding diseases.

Chia S, Habchi J, Michaels TCT, Cohen SIA, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10245-10250. doi: 10.1073/pnas.1807884115. Epub 2018 Sep 26.

3.

Microfluidic deposition for resolving single-molecule protein architecture and heterogeneity.

Ruggeri FS, Charmet J, Kartanas T, Peter Q, Chia S, Habchi J, Dobson CM, Vendruscolo M, Knowles TPJ.

Nat Commun. 2018 Sep 24;9(1):3890. doi: 10.1038/s41467-018-06345-4.

4.

Identification of Oxidative Stress in Red Blood Cells with Nanoscale Chemical Resolution by Infrared Nanospectroscopy.

Ruggeri FS, Marcott C, Dinarelli S, Longo G, Girasole M, Dietler G, Knowles TPJ.

Int J Mol Sci. 2018 Aug 30;19(9). pii: E2582. doi: 10.3390/ijms19092582.

5.

DNA-Coated Functional Oil Droplets.

Caciagli A, Zupkauskas M, Levin A, Knowles TPJ, Mugemana C, Bruns N, O'Neill T, Frith WJ, Eiser E.

Langmuir. 2018 Aug 28;34(34):10073-10080. doi: 10.1021/acs.langmuir.8b01828. Epub 2018 Aug 17.

PMID:
30086643
6.

Self-Assembly-Mediated Release of Peptide Nanoparticles through Jets Across Microdroplet Interfaces.

Levin A, Michaels TCT, Mason TO, Müller T, Adler-Abramovich L, Mahadevan L, Cates ME, Gazit E, Knowles TPJ.

ACS Appl Mater Interfaces. 2018 Aug 22;10(33):27578-27583. doi: 10.1021/acsami.8b09511. Epub 2018 Aug 9.

PMID:
30080033
7.

Origin of metastable oligomers and their effects on amyloid fibril self-assembly.

Hasecke F, Miti T, Perez C, Barton J, Schölzel D, Gremer L, Grüning CSR, Matthews G, Meisl G, Knowles TPJ, Willbold D, Neudecker P, Heise H, Ullah G, Hoyer W, Muschol M.

Chem Sci. 2018 Jun 13;9(27):5937-5948. doi: 10.1039/c8sc01479e. eCollection 2018 Jul 21.

8.

Combining Affinity Selection and Specific Ion Mobility for Microchip Protein Sensing.

Arter WE, Charmet J, Kong J, Saar KL, Herling TW, Müller T, Keyser UF, Knowles TPJ.

Anal Chem. 2018 Sep 4;90(17):10302-10310. doi: 10.1021/acs.analchem.8b02051. Epub 2018 Aug 15.

PMID:
30070105
9.

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH.

van der Wateren IM, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Sci. 2018 May 24;9(25):5506-5516. doi: 10.1039/c8sc01109e. eCollection 2018 Jul 7.

10.

Extrinsic Amyloid-Binding Dyes for Detection of Individual Protein Aggregates in Solution.

Taylor CG, Meisl G, Horrocks MH, Zetterberg H, Knowles TPJ, Klenerman D.

Anal Chem. 2018 Sep 4;90(17):10385-10393. doi: 10.1021/acs.analchem.8b02226. Epub 2018 Aug 13.

11.

Stabilization and Characterization of Cytotoxic Aβ40 Oligomers Isolated from an Aggregation Reaction in the Presence of Zinc Ions.

Mannini B, Habchi J, Chia S, Ruggeri FS, Perni M, Knowles TPJ, Dobson CM, Vendruscolo M.

ACS Chem Neurosci. 2018 Aug 10. doi: 10.1021/acschemneuro.8b00141. [Epub ahead of print]

PMID:
29986583
12.

Secondary nucleation in amyloid formation.

Törnquist M, Michaels TCT, Sanagavarapu K, Yang X, Meisl G, Cohen SIA, Knowles TPJ, Linse S.

Chem Commun (Camb). 2018 Aug 2;54(63):8667-8684. doi: 10.1039/c8cc02204f. Review.

PMID:
29978862
13.

Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine.

Perni M, Flagmeier P, Limbocker R, Cascella R, Aprile FA, Galvagnion C, Heller GT, Meisl G, Chen SW, Kumita JR, Challa PK, Kirkegaard JB, Cohen SIA, Mannini B, Barbut D, Nollen EAA, Cecchi C, Cremades N, Knowles TPJ, Chiti F, Zasloff M, Vendruscolo M, Dobson CM.

ACS Chem Biol. 2018 Aug 17;13(8):2308-2319. doi: 10.1021/acschembio.8b00466. Epub 2018 Jun 28.

PMID:
29953201
14.

Oligomer Diversity during the Aggregation of the Repeat Region of Tau.

Kjaergaard M, Dear AJ, Kundel F, Qamar S, Meisl G, Knowles TPJ, Klenerman D.

ACS Chem Neurosci. 2018 Jul 17. doi: 10.1021/acschemneuro.8b00250. [Epub ahead of print]

PMID:
29953200
15.

Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils.

Brown JWP, Meisl G, Knowles TPJ, Buell AK, Dobson CM, Galvagnion C.

Chem Commun (Camb). 2018 Jul 10;54(56):7854-7857. doi: 10.1039/c8cc03002b.

PMID:
29951679
16.

Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid α-synuclein fibrils.

Ruggeri FS, Benedetti F, Knowles TPJ, Lashuel HA, Sekatskii S, Dietler G.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7230-7235. doi: 10.1073/pnas.1721220115. Epub 2018 Jun 25.

17.

Enhancing the Resolution of Micro Free Flow Electrophoresis through Spatially Controlled Sample Injection.

Saar KL, Müller T, Charmet J, Challa PK, Knowles TPJ.

Anal Chem. 2018 Aug 7;90(15):8998-9005. doi: 10.1021/acs.analchem.8b01205. Epub 2018 Jul 9.

PMID:
29938505
18.

Determination of Polypeptide Conformation with Nanoscale Resolution in Water.

Ramer G, Ruggeri FS, Levin A, Knowles TPJ, Centrone A.

ACS Nano. 2018 Jul 24;12(7):6612-6619. doi: 10.1021/acsnano.8b01425. Epub 2018 Jun 28.

PMID:
29932670
19.

On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations.

Yang X, Meisl G, Frohm B, Thulin E, Knowles TPJ, Linse S.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858. doi: 10.1073/pnas.1803539115. Epub 2018 Jun 12.

20.

Kinetic Analysis of Amyloid Formation.

Meisl G, Michaels TCT, Linse S, Knowles TPJ.

Methods Mol Biol. 2018;1779:181-196. doi: 10.1007/978-1-4939-7816-8_12.

PMID:
29886534
21.

Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.

Song Y, Michaels TCT, Ma Q, Liu Z, Yuan H, Takayama S, Knowles TPJ, Shum HC.

Nat Commun. 2018 May 29;9(1):2110. doi: 10.1038/s41467-018-04510-3.

22.

On-chip measurements of protein unfolding from direct observations of micron-scale diffusion.

Zhang Y, Yates EV, Hong L, Saar KL, Meisl G, Dobson CM, Knowles TPJ.

Chem Sci. 2018 Feb 9;9(14):3503-3507. doi: 10.1039/c7sc04331g. eCollection 2018 Apr 14.

23.

Rapid Growth of Acetylated Aβ(16-20) into Macroscopic Crystals.

Bortolini C, Klausen LH, Hoffmann SV, Jones NC, Saadeh D, Wang Z, Knowles TPJ, Dong M.

ACS Nano. 2018 May 22. doi: 10.1021/acsnano.8b00448. [Epub ahead of print]

PMID:
29771495
24.

Cooperative Assembly of Hsp70 Subdomain Clusters.

Wright MA, Aprile FA, Bellaiche MMJ, Michaels TCT, Müller T, Arosio P, Vendruscolo M, Dobson CM, Knowles TPJ.

Biochemistry. 2018 Jul 3;57(26):3641-3649. doi: 10.1021/acs.biochem.8b00151. Epub 2018 May 29.

PMID:
29763298
25.

Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes.

Habchi J, Chia S, Galvagnion C, Michaels TCT, Bellaiche MMJ, Ruggeri FS, Sanguanini M, Idini I, Kumita JR, Sparr E, Linse S, Dobson CM, Knowles TPJ, Vendruscolo M.

Nat Chem. 2018 Jun;10(6):673-683. doi: 10.1038/s41557-018-0031-x. Epub 2018 May 7.

PMID:
29736006
26.

Water-Dispersible Polydopamine-Coated Nanofibers for Stimulation of Neuronal Growth and Adhesion.

Sieste S, Mack T, Synatschke CV, Schilling C, Meyer Zu Reckendorf C, Pendi L, Harvey S, Ruggeri FS, Knowles TPJ, Meier C, Ng DYW, Weil T, Knöll B.

Adv Healthc Mater. 2018 Jun;7(11):e1701485. doi: 10.1002/adhm.201701485. Epub 2018 Apr 10.

PMID:
29635761
27.

Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-β peptide.

Cohen SIA, Cukalevski R, Michaels TCT, Šarić A, Törnquist M, Vendruscolo M, Dobson CM, Buell AK, Knowles TPJ, Linse S.

Nat Chem. 2018 May;10(5):523-531. doi: 10.1038/s41557-018-0023-x. Epub 2018 Mar 26.

28.

Microfluidic approaches for probing amyloid assembly and behaviour.

Herling TW, Levin A, Saar KL, Dobson CM, Knowles TPJ.

Lab Chip. 2018 Mar 27;18(7):999-1016. doi: 10.1039/c7lc01241a. Review.

PMID:
29527600
29.

Chemical Kinetics for Bridging Molecular Mechanisms and Macroscopic Measurements of Amyloid Fibril Formation.

Michaels TCT, Šarić A, Habchi J, Chia S, Meisl G, Vendruscolo M, Dobson CM, Knowles TPJ.

Annu Rev Phys Chem. 2018 Apr 20;69:273-298. doi: 10.1146/annurev-physchem-050317-021322. Epub 2018 Feb 28. Review.

PMID:
29490200
30.

Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery.

Perni M, Challa PK, Kirkegaard JB, Limbocker R, Koopman M, Hardenberg MC, Sormanni P, Müller T, Saar KL, Roode LWY, Habchi J, Vecchi G, Fernando N, Casford S, Nollen EAA, Vendruscolo M, Dobson CM, Knowles TPJ.

J Neurosci Methods. 2018 Aug 1;306:57-67. doi: 10.1016/j.jneumeth.2018.02.005. Epub 2018 Feb 13.

PMID:
29452179
31.

Real-Time Intrinsic Fluorescence Visualization and Sizing of Proteins and Protein Complexes in Microfluidic Devices.

Challa PK, Peter Q, Wright MA, Zhang Y, Saar KL, Carozza JA, Benesch JLP, Knowles TPJ.

Anal Chem. 2018 Mar 20;90(6):3849-3855. doi: 10.1021/acs.analchem.7b04523. Epub 2018 Feb 28.

PMID:
29451779
32.

Biophotonics of Native Silk Fibrils.

Shimanovich U, Pinotsi D, Shimanovich K, Yu N, Bolisetty S, Adamcik J, Mezzenga R, Charmet J, Vollrath F, Gazit E, Dobson CM, Schierle GK, Holland C, Kaminski CF, Knowles TPJ.

Macromol Biosci. 2018 Apr;18(4):e1700295. doi: 10.1002/mabi.201700295. Epub 2018 Jan 29.

PMID:
29377575
33.

Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2.

Yang J, Dear AJ, Michaels TCT, Dobson CM, Knowles TPJ, Wu S, Perrett S.

J Am Chem Soc. 2018 Feb 21;140(7):2493-2503. doi: 10.1021/jacs.7b10439. Epub 2018 Feb 7.

34.

Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.

Gang H, Galvagnion C, Meisl G, Müller T, Pfammatter M, Buell AK, Levin A, Dobson CM, Mu B, Knowles TPJ.

Anal Chem. 2018 Mar 6;90(5):3284-3290. doi: 10.1021/acs.analchem.7b04820. Epub 2018 Feb 13.

PMID:
29313342
35.

Microfluidics for Protein Biophysics.

Charmet J, Arosio P, Knowles TPJ.

J Mol Biol. 2018 Mar 2;430(5):565-580. doi: 10.1016/j.jmb.2017.12.015. Epub 2017 Dec 29. Review.

PMID:
29289566
36.

Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification.

Gaspar R, Meisl G, Buell AK, Young L, Kaminski CF, Knowles TPJ, Sparr E, Linse S.

Q Rev Biophys. 2017 Jan;50:e6. doi: 10.1017/S0033583516000172.

PMID:
29233218
37.

On-chip label-free protein analysis with downstream electrodes for direct removal of electrolysis products.

Saar KL, Zhang Y, Müller T, Kumar CP, Devenish S, Lynn A, Łapińska U, Yang X, Linse S, Knowles TPJ.

Lab Chip. 2017 Dec 19;18(1):162-170. doi: 10.1039/c7lc00797c.

PMID:
29192926
38.

Mechanism of biosurfactant adsorption to oil/water interfaces from millisecond scale tensiometry measurements.

Kong L, Saar KL, Jacquat R, Hong L, Levin A, Gang H, Ye R, Mu B, Knowles TPJ.

Interface Focus. 2017 Dec 6;7(6):20170013. doi: 10.1098/rsfs.2017.0013. Epub 2017 Oct 20.

PMID:
29147556
39.

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.

40.

Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.

Mason TO, Michaels TCT, Levin A, Dobson CM, Gazit E, Knowles TPJ, Buell AK.

J Am Chem Soc. 2017 Nov 15;139(45):16134-16142. doi: 10.1021/jacs.7b00229. Epub 2017 Oct 23.

PMID:
28994295
41.

Nanoscale click-reactive scaffolds from peptide self-assembly.

Guttenplan APM, Young LJ, Matak-Vinkovic D, Kaminski CF, Knowles TPJ, Itzhaki LS.

J Nanobiotechnology. 2017 Oct 6;15(1):70. doi: 10.1186/s12951-017-0300-7.

42.

Enhanced Quality Factor Label-free Biosensing with Micro-Cantilevers Integrated into Microfluidic Systems.

Kartanas T, Ostanin V, Challa PK, Daly R, Charmet J, Knowles TPJ.

Anal Chem. 2017 Nov 21;89(22):11929-11936. doi: 10.1021/acs.analchem.7b01174. Epub 2017 Nov 3.

PMID:
28984439
43.

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants.

Meisl G, Yang X, Dobson CM, Linse S, Knowles TPJ.

Chem Sci. 2017 Jun 1;8(6):4352-4362. doi: 10.1039/c7sc00215g. Epub 2017 Apr 26.

44.

Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.

45.

Hierarchical Biomolecular Emulsions Using 3-D Microfluidics with Uniform Surface Chemistry.

Toprakcioglu Z, Levin A, Knowles TPJ.

Biomacromolecules. 2017 Nov 13;18(11):3642-3651. doi: 10.1021/acs.biomac.7b01159. Epub 2017 Oct 19.

PMID:
28959882
46.

Kinetic constraints on self-assembly into closed supramolecular structures.

Michaels TCT, Bellaiche MMJ, Hagan MF, Knowles TPJ.

Sci Rep. 2017 Sep 25;7(1):12295. doi: 10.1038/s41598-017-12528-8.

47.

Gradient-free determination of isoelectric points of proteins on chip.

Łapińska U, Saar KL, Yates EV, Herling TW, Müller T, Challa PK, Dobson CM, Knowles TPJ.

Phys Chem Chem Phys. 2017 Aug 30;19(34):23060-23067. doi: 10.1039/c7cp01503h.

PMID:
28817152
48.

Kinetics of spontaneous filament nucleation via oligomers: Insights from theory and simulation.

Šarić A, Michaels TCT, Zaccone A, Knowles TPJ, Frenkel D.

J Chem Phys. 2016 Dec 7;145(21):211926. doi: 10.1063/1.4965040.

PMID:
28799382
49.

Sequential Release of Proteins from Structured Multishell Microcapsules.

Shimanovich U, Michaels TCT, De Genst E, Matak-Vinkovic D, Dobson CM, Knowles TPJ.

Biomacromolecules. 2017 Oct 9;18(10):3052-3059. doi: 10.1021/acs.biomac.7b00351. Epub 2017 Sep 7.

PMID:
28792742
50.

Silk micrococoons for protein stabilisation and molecular encapsulation.

Shimanovich U, Ruggeri FS, De Genst E, Adamcik J, Barros TP, Porter D, Müller T, Mezzenga R, Dobson CM, Vollrath F, Holland C, Knowles TPJ.

Nat Commun. 2017 Jul 19;8:15902. doi: 10.1038/ncomms15902.

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