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Items: 36


The C-terminal tail of the bacterial translocation ATPase SecA modulates its activity.

Jamshad M, Knowles TJ, White SA, Ward DG, Mohammed F, Rahman KF, Wynne M, Hughes GW, Kramer G, Bukau B, Huber D.

Elife. 2019 Jun 27;8. pii: e48385. doi: 10.7554/eLife.48385.


Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system.

Hughes GW, Hall SCL, Laxton CS, Sridhar P, Mahadi AH, Hatton C, Piggot TJ, Wotherspoon PJ, Leney AC, Ward DG, Jamshad M, Spana V, Cadby IT, Harding C, Isom GL, Bryant JA, Parr RJ, Yakub Y, Jeeves M, Huber D, Henderson IR, Clifton LA, Lovering AL, Knowles TJ.

Nat Microbiol. 2019 Oct;4(10):1692-1705. doi: 10.1038/s41564-019-0481-y. Epub 2019 Jun 24.


Structural Investigations of Protein-Lipid Complexes Using Neutron Scattering.

Clifton LA, Hall SCL, Mahmoudi N, Knowles TJ, Heinrich F, Lakey JH.

Methods Mol Biol. 2019;2003:201-251. doi: 10.1007/978-1-4939-9512-7_11.


SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.

Pollock NL, Rai M, Simon KS, Hesketh SJ, Teo ACK, Parmar M, Sridhar P, Collins R, Lee SC, Stroud ZN, Bakker SE, Muench SP, Barton CH, Hurlbut G, Roper DI, Smith CJI, Knowles TJ, Spickett CM, East JM, Postis VLG, Dafforn TR.

Biochim Biophys Acta Biomembr. 2019 Aug 1;1861(8):1437-1445. doi: 10.1016/j.bbamem.2019.05.011. Epub 2019 May 28.


YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium.

Morris FC, Wells TJ, Bryant JA, Schager AE, Sevastsyanovich YR, Squire DJP, Marshall J, Isom GL, Rooke J, Maderbocus R, Knowles TJ, Overduin M, Rossiter AE, Cunningham AF, Henderson IR.

Infect Immun. 2018 Oct 25;86(11). pii: e00829-17. doi: 10.1128/IAI.00829-17. Print 2018 Nov.


Image-Assisted Microvessel-on-a-Chip Platform for Studying Cancer Cell Transendothelial Migration Dynamics.

Bertulli C, Gerigk M, Piano N, Liu Y, Zhang D, Müller T, Knowles TJ, Huang YYS.

Sci Rep. 2018 Aug 20;8(1):12480. doi: 10.1038/s41598-018-30776-0.


Minichaperone (GroEL191-345) mediated folding of MalZ proceeds by binding and release of native and functional intermediates.

Jain N, Knowles TJ, Lund PA, Chaudhuri TK.

Biochim Biophys Acta Proteins Proteom. 2018 Sep;1866(9):941-951. doi: 10.1016/j.bbapap.2018.05.015. Epub 2018 Jun 2.


An acid-compatible co-polymer for the solubilization of membranes and proteins into lipid bilayer-containing nanoparticles.

Hall SCL, Tognoloni C, Charlton J, Bragginton ÉC, Rothnie AJ, Sridhar P, Wheatley M, Knowles TJ, Arnold T, Edler KJ, Dafforn TR.

Nanoscale. 2018 Jun 7;10(22):10609-10619. doi: 10.1039/c8nr01322e.


Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading.

Kundel F, Hong L, Falcon B, McEwan WA, Michaels TCT, Meisl G, Esteras N, Abramov AY, Knowles TJP, Goedert M, Klenerman D.

ACS Chem Neurosci. 2018 Jun 20;9(6):1276-1282. doi: 10.1021/acschemneuro.8b00094. Epub 2018 Apr 8.


BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain.

Salim M, Knowles TJ, Baker AT, Davey MS, Jeeves M, Sridhar P, Wilkie J, Willcox CR, Kadri H, Taher TE, Vantourout P, Hayday A, Mehellou Y, Mohammed F, Willcox BE.

ACS Chem Biol. 2017 Oct 20;12(10):2631-2643. doi: 10.1021/acschembio.7b00694. Epub 2017 Sep 14.


MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis.

Isom GL, Davies NJ, Chong ZS, Bryant JA, Jamshad M, Sharif M, Cunningham AF, Knowles TJ, Chng SS, Cole JA, Henderson IR.

Sci Rep. 2017 Aug 17;7(1):8608. doi: 10.1038/s41598-017-09111-6.


Membrane protein extraction and purification using styrene-maleic acid (SMA) copolymer: effect of variations in polymer structure.

Morrison KA, Akram A, Mathews A, Khan ZA, Patel JH, Zhou C, Hardy DJ, Moore-Kelly C, Patel R, Odiba V, Knowles TJ, Javed MU, Chmel NP, Dafforn TR, Rothnie AJ.

Biochem J. 2016 Dec 1;473(23):4349-4360. Epub 2016 Sep 30.


Secondary structure and (1)H, (13)C and (15)N resonance assignments of Skint-1: a selecting ligand for a murine γδ T cell subset implicated in tumour suppression.

Salim M, Willcox CR, Mohammed F, Hayday AC, Overduin M, Willcox BE, Knowles TJ.

Biomol NMR Assign. 2016 Oct;10(2):357-60. doi: 10.1007/s12104-016-9700-0. Epub 2016 Aug 4.


A method for detergent-free isolation of membrane proteins in their local lipid environment.

Lee SC, Knowles TJ, Postis VL, Jamshad M, Parslow RA, Lin YP, Goldman A, Sridhar P, Overduin M, Muench SP, Dafforn TR.

Nat Protoc. 2016 Jul;11(7):1149-62. doi: 10.1038/nprot.2016.070. Epub 2016 Jun 2.


Encapsulated membrane proteins: A simplified system for molecular simulation.

Lee SC, Khalid S, Pollock NL, Knowles TJ, Edler K, Rothnie AJ, R T Thomas O, Dafforn TR.

Biochim Biophys Acta. 2016 Oct;1858(10):2549-2557. doi: 10.1016/j.bbamem.2016.02.039. Epub 2016 Mar 3. Review.


Mechanism of intermediate filament recognition by plakin repeat domains revealed by envoplakin targeting of vimentin.

Fogl C, Mohammed F, Al-Jassar C, Jeeves M, Knowles TJ, Rodriguez-Zamora P, White SA, Odintsova E, Overduin M, Chidgey M.

Nat Commun. 2016 Mar 3;7:10827. doi: 10.1038/ncomms10827.


Characterization of a Putative Receptor Binding Surface on Skint-1, a Critical Determinant of Dendritic Epidermal T Cell Selection.

Salim M, Knowles TJ, Hart R, Mohammed F, Woodward MJ, Willcox CR, Overduin M, Hayday AC, Willcox BE.

J Biol Chem. 2016 Apr 22;291(17):9310-21. doi: 10.1074/jbc.M116.722066. Epub 2016 Feb 25.


Expression, Purification, and Screening of BamE, a Component of the BAM Complex, for Structural Characterization.

Jeeves M, Sridhar P, Knowles TJ.

Methods Mol Biol. 2015;1329:245-58. doi: 10.1007/978-1-4939-2871-2_19.


A novel pathway for outer membrane protein biogenesis in Gram-negative bacteria.

Jeeves M, Knowles TJ.

Mol Microbiol. 2015 Aug;97(4):607-11. doi: 10.1111/mmi.13082. Epub 2015 Jul 17.


Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion.

Browning DF, Bavro VN, Mason JL, Sevastsyanovich YR, Rossiter AE, Jeeves M, Wells TJ, Knowles TJ, Cunningham AF, Donald JW, Palmer T, Overduin M, Henderson IR.

Mol Microbiol. 2015 Aug;97(4):646-59. doi: 10.1111/mmi.13052. Epub 2015 Jun 6.


Structural analysis of a nanoparticle containing a lipid bilayer used for detergent-free extraction of membrane proteins.

Jamshad M, Grimard V, Idini I, Knowles TJ, Dowle MR, Schofield N, Sridhar P, Lin YP, Finka R, Wheatley M, Thomas OR, Palmer RE, Overduin M, Govaerts C, Ruysschaert JM, Edler KJ, Dafforn TR.

Nano Res. 2015 Mar;8(3):774-789. doi: 10.1007/s12274-014-0560-6. Epub 2014 Oct 23.


G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

Jamshad M, Charlton J, Lin YP, Routledge SJ, Bawa Z, Knowles TJ, Overduin M, Dekker N, Dafforn TR, Bill RM, Poyner DR, Wheatley M.

Biosci Rep. 2015 Apr 16;35(2). pii: e00188. doi: 10.1042/BSR20140171.


Detergent-free purification of ABC (ATP-binding-cassette) transporters.

Gulati S, Jamshad M, Knowles TJ, Morrison KA, Downing R, Cant N, Collins R, Koenderink JB, Ford RC, Overduin M, Kerr ID, Dafforn TR, Rothnie AJ.

Biochem J. 2014 Jul 15;461(2):269-78. doi: 10.1042/BJ20131477.


Mutational and topological analysis of the Escherichia coli BamA protein.

Browning DF, Matthews SA, Rossiter AE, Sevastsyanovich YR, Jeeves M, Mason JL, Wells TJ, Wardius CA, Knowles TJ, Cunningham AF, Bavro VN, Overduin M, Henderson IR.

PLoS One. 2013 Dec 23;8(12):e84512. doi: 10.1371/journal.pone.0084512. eCollection 2013.


A generalised module for the selective extracellular accumulation of recombinant proteins.

Sevastsyanovich YR, Leyton DL, Wells TJ, Wardius CA, Tveen-Jensen K, Morris FC, Knowles TJ, Cunningham AF, Cole JA, Henderson IR.

Microb Cell Fact. 2012 May 28;11:69. doi: 10.1186/1475-2859-11-69.


Evolutionary history of copy-number-variable locus for the low-affinity Fcγ receptor: mutation rate, autoimmune disease, and the legacy of helminth infection.

Machado LR, Hardwick RJ, Bowdrey J, Bogle H, Knowles TJ, Sironi M, Hollox EJ.

Am J Hum Genet. 2012 Jun 8;90(6):973-85. doi: 10.1016/j.ajhg.2012.04.018. Epub 2012 May 17.


The essential β-barrel assembly machinery complex components BamD and BamA are required for autotransporter biogenesis.

Rossiter AE, Leyton DL, Tveen-Jensen K, Browning DF, Sevastsyanovich Y, Knowles TJ, Nichols KB, Cunningham AF, Overduin M, Schembri MA, Henderson IR.

J Bacteriol. 2011 Aug;193(16):4250-3. doi: 10.1128/JB.00192-11. Epub 2011 Jun 10.


Surfactant-free purification of membrane proteins with intact native membrane environment.

Jamshad M, Lin YP, Knowles TJ, Parslow RA, Harris C, Wheatley M, Poyner DR, Bill RM, Thomas OR, Overduin M, Dafforn TR.

Biochem Soc Trans. 2011 Jun;39(3):813-8. doi: 10.1042/BST0390813. Review.


Structure and function of BamE within the outer membrane and the β-barrel assembly machine.

Knowles TJ, Browning DF, Jeeves M, Maderbocus R, Rajesh S, Sridhar P, Manoli E, Emery D, Sommer U, Spencer A, Leyton DL, Squire D, Chaudhuri RR, Viant MR, Cunningham AF, Henderson IR, Overduin M.

EMBO Rep. 2011 Feb;12(2):123-8. doi: 10.1038/embor.2010.202. Epub 2011 Jan 7.


Secondary structure and 1H, 13C and 15N resonance assignments of BamE, a component of the outer membrane protein assembly machinery in Escherichia coli.

Knowles TJ, Sridhar P, Rajesh S, Manoli E, Overduin M, Henderson IR.

Biomol NMR Assign. 2010 Oct;4(2):179-81. doi: 10.1007/s12104-010-9236-7. Epub 2010 Jun 5.


Secondary structure and (1)H, (13)C and (15)N backbone resonance assignments of BamC, a component of the outer membrane protein assembly machinery in Escherichia coli.

Knowles TJ, McClelland DM, Rajesh S, Henderson IR, Overduin M.

Biomol NMR Assign. 2009 Dec;3(2):203-6. doi: 10.1007/s12104-009-9175-3. Epub 2009 Jun 24.


Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer.

Knowles TJ, Finka R, Smith C, Lin YP, Dafforn T, Overduin M.

J Am Chem Soc. 2009 Jun 10;131(22):7484-5. doi: 10.1021/ja810046q.


Membrane protein architects: the role of the BAM complex in outer membrane protein assembly.

Knowles TJ, Scott-Tucker A, Overduin M, Henderson IR.

Nat Rev Microbiol. 2009 Mar;7(3):206-14. doi: 10.1038/nrmicro2069. Epub 2009 Feb 2. Review.


Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

Conner M, Hicks MR, Dafforn T, Knowles TJ, Ludwig C, Staddon S, Overduin M, Günther UL, Thome J, Wheatley M, Poyner DR, Conner AC.

Biochemistry. 2008 Aug 12;47(32):8434-44. doi: 10.1021/bi8004126. Epub 2008 Jul 18.


Fold and function of polypeptide transport-associated domains responsible for delivering unfolded proteins to membranes.

Knowles TJ, Jeeves M, Bobat S, Dancea F, McClelland D, Palmer T, Overduin M, Henderson IR.

Mol Microbiol. 2008 Jun;68(5):1216-27. doi: 10.1111/j.1365-2958.2008.06225.x. Epub 2008 Apr 21.


Secondary structure and 1H, 13C and 15N resonance assignments of the Escherichia coli YaeT POTRA domain.

Knowles TJ, Bobat S, Jeeves M, Henderson IR, Overduin M.

Biomol NMR Assign. 2007 Jul;1(1):113-5. doi: 10.1007/s12104-007-9032-1. Epub 2007 Jul 21.


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