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Light-driven deracemization enabled by excited-state electron transfer.

Shin NY, Ryss JM, Zhang X, Miller SJ, Knowles RR.

Science. 2019 Oct 18;366(6463):364-369. doi: 10.1126/science.aay2204.


Anti-Markovnikov Hydroamination of Unactivated Alkenes with Primary Alkyl Amines.

Miller DC, Ganley JM, Musacchio AJ, Sherwood TC, Ewing WR, Knowles RR.

J Am Chem Soc. 2019 Oct 23;141(42):16590-16594. doi: 10.1021/jacs.9b08746. Epub 2019 Oct 14.


Understanding Chemoselectivity in Proton-Coupled Electron Transfer: A Kinetic Study of Amide and Thiol Activation.

Qiu G, Knowles RR.

J Am Chem Soc. 2019 Oct 23;141(42):16574-16578. doi: 10.1021/jacs.9b08398. Epub 2019 Oct 8.


New Insights Into Cholinergic Neuron Diversity.

Ahmed NY, Knowles R, Dehorter N.

Front Mol Neurosci. 2019 Aug 27;12:204. doi: 10.3389/fnmol.2019.00204. eCollection 2019. Review.


Exhaled Volatile Organic Compounds as Markers for Medication Use in Asthma.

Brinkman P, Ahmed WM, Gómez C, Knobel HH, Weda H, Vink TJ, Nijsen TM, Wheelock CE, Dahlen SE, Montuschi P, Knowles RG, Vijverberg SJ, Maitland-van der Zee AH, Sterk PJ, Fowler SJ; U-BIOPRED Study Group.

Eur Respir J. 2019 Sep 12. pii: 1900544. doi: 10.1183/13993003.00544-2019. [Epub ahead of print]


C-H Alkylation via Multisite-Proton-Coupled Electron Transfer of an Aliphatic C-H Bond.

Morton CM, Zhu Q, Ripberger H, Troian-Gautier L, Toa ZSD, Knowles RR, Alexanian EJ.

J Am Chem Soc. 2019 Aug 21;141(33):13253-13260. doi: 10.1021/jacs.9b06834. Epub 2019 Aug 12.


Prevalence of permanent childhood hearing loss detected at the universal newborn hearing screen: Systematic review and meta-analysis.

Butcher E, Dezateux C, Cortina-Borja M, Knowles RL.

PLoS One. 2019 Jul 11;14(7):e0219600. doi: 10.1371/journal.pone.0219600. eCollection 2019.


Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer.

Zhao K, Yamashita K, Carpenter JE, Sherwood TC, Ewing WR, Cheng PTW, Knowles RR.

J Am Chem Soc. 2019 Jun 5;141(22):8752-8757. doi: 10.1021/jacs.9b03973. Epub 2019 May 23.


Evaluation of excited state bond weakening for ammonia synthesis from a manganese nitride: stepwise proton coupled electron transfer is preferred over hydrogen atom transfer.

Loose F, Wang D, Tian L, Scholes GD, Knowles RR, Chirik PJ.

Chem Commun (Camb). 2019 May 9;55(39):5595-5598. doi: 10.1039/c9cc01046g.


Decarboxylative Intramolecular Arene Alkylation Using N-(Acyloxy)phthalimides, an Organic Photocatalyst, and Visible Light.

Sherwood TC, Xiao HY, Bhaskar RG, Simmons EM, Zaretsky S, Rauch MP, Knowles RR, Dhar TGM.

J Org Chem. 2019 Jul 5;84(13):8360-8379. doi: 10.1021/acs.joc.9b00432. Epub 2019 Mar 27.


Ethnic-specific mortality of infants undergoing congenital heart surgery in England and Wales.

Knowles RL, Ridout D, Crowe S, Bull C, Wray J, Tregay J, Franklin RCG, Barron DJ, Parslow RC, Brown K.

Arch Dis Child. 2019 Sep;104(9):844-850. doi: 10.1136/archdischild-2018-315505. Epub 2019 Mar 1.


N-H Bond Formation in a Manganese(V) Nitride Yields Ammonia by Light-Driven Proton-Coupled Electron Transfer.

Wang D, Loose F, Chirik PJ, Knowles RR.

J Am Chem Soc. 2019 Mar 27;141(12):4795-4799. doi: 10.1021/jacs.8b12957. Epub 2019 Mar 5.


Rate-Driving Force Relationships in the Multisite Proton-Coupled Electron Transfer Activation of Ketones.

Qiu G, Knowles RR.

J Am Chem Soc. 2019 Feb 13;141(6):2721-2730. doi: 10.1021/jacs.8b13451. Epub 2019 Feb 1.


A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C-C Bond Cleavage Reactions.

Ota E, Wang H, Frye NL, Knowles RR.

J Am Chem Soc. 2019 Jan 30;141(4):1457-1462. doi: 10.1021/jacs.8b12552. Epub 2019 Jan 15.


"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin.

Pavlidis S, Takahashi K, Ng Kee Kwong F, Xie J, Hoda U, Sun K, Elyasigomari V, Agapow P, Loza M, Baribaud F, Chanez P, Fowler SJ, Shaw DE, Fleming LJ, Howarth PH, Sousa AR, Corfield J, Auffray C, De Meulder B, Knowles R, Sterk PJ, Guo Y, Adcock IM, Djukanovic R, Fan Chung K; on behalf of the U-BIOPRED Study Group.

Eur Respir J. 2019 Jan 3;53(1). pii: 1800938. doi: 10.1183/13993003.00938-2018. Print 2019 Jan.


Risk factors for permanent childhood hearing impairment.

Butcher E, Dezateux C, Knowles RL.

Arch Dis Child. 2018 Nov 28. pii: archdischild-2018-315866. doi: 10.1136/archdischild-2018-315866. [Epub ahead of print]


Applications and Prospects for Triplet-Triplet Annihilation Photon Upconversion.

Rauch MP, Knowles RR.

Chimia (Aarau). 2018 Aug 22;72(7):501-507. doi: 10.2533/chimia.2018.501.


AsthmaMap: An expert-driven computational representation of disease mechanisms.

Mazein A, Knowles RG, Adcock I, Chung KF, Wheelock CE, Maitland-van der Zee AH, Sterk PJ, Auffray C; AsthmaMap Project Team.

Clin Exp Allergy. 2018 Aug;48(8):916-918. doi: 10.1111/cea.13211. No abstract available.


Newborn Screening for Primary Congenital Hypothyroidism: Estimating Test Performance at Different TSH Thresholds.

Knowles RL, Oerton J, Cheetham T, Butler G, Cavanagh C, Tetlow L, Dezateux C.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3720-3728. doi: 10.1210/jc.2018-00658.


Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy.

Knowles RB, Warner TD.

Pharmacol Ther. 2019 Jan;193:83-90. doi: 10.1016/j.pharmthera.2018.08.004. Epub 2018 Aug 4. Review.


Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976. No abstract available.


Parents' Experiences of Caring for Their Child at the Time of Discharge After Cardiac Surgery and During the Postdischarge Period: Qualitative Study Using an Online Forum.

Wray J, Brown K, Tregay J, Crowe S, Knowles R, Bull K, Gibson F.

J Med Internet Res. 2018 May 9;20(5):e155. doi: 10.2196/jmir.9104.


Issues facing families of infants discharged after cardiac surgery: the perceptions of charity helpline staff.

Wray J, Tregay J, Bull C, Knowles RL, Crowe S, Brown K.

Acta Paediatr. 2018 Aug;107(8):1418-1426. doi: 10.1111/apa.14304. Epub 2018 Mar 30.


Enantioselective Synthesis of Pyrroloindolines via Noncovalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products.

Gentry EC, Rono LJ, Hale ME, Matsuura R, Knowles RR.

J Am Chem Soc. 2018 Mar 7;140(9):3394-3402. doi: 10.1021/jacs.7b13616. Epub 2018 Feb 21.


Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.


Intermolecular Anti-Markovnikov Hydroamination of Unactivated Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer.

Zhu Q, Graff DE, Knowles RR.

J Am Chem Soc. 2018 Jan 17;140(2):741-747. doi: 10.1021/jacs.7b11144. Epub 2018 Jan 4.


Sharing and reuse of individual participant data from clinical trials: principles and recommendations.

Ohmann C, Banzi R, Canham S, Battaglia S, Matei M, Ariyo C, Becnel L, Bierer B, Bowers S, Clivio L, Dias M, Druml C, Faure H, Fenner M, Galvez J, Ghersi D, Gluud C, Groves T, Houston P, Karam G, Kalra D, Knowles RL, Krleža-Jerić K, Kubiak C, Kuchinke W, Kush R, Lukkarinen A, Marques PS, Newbigging A, O'Callaghan J, Ravaud P, Schlünder I, Shanahan D, Sitter H, Spalding D, Tudur-Smith C, van Reusel P, van Veen EB, Visser GR, Wilson J, Demotes-Mainard J.

BMJ Open. 2017 Dec 14;7(12):e018647. doi: 10.1136/bmjopen-2017-018647.


The effects of crew resource management on teamwork and safety climate at Veterans Health Administration facilities.

Schwartz ME, Welsh DE, Paull DE, Knowles RS, DeLeeuw LD, Hemphill RR, Essen KE, Sculli GL.

J Healthc Risk Manag. 2018 Jul;38(1):17-37. doi: 10.1002/jhrm.21292. Epub 2017 Nov 9.


Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties.

Knowles RB, Lawrence MJ, Ferreira PM, Hayman MA, D'Silva LA, Stanford SN, Sabra A, Tucker AT, Hawkins KM, Williams PR, Warner TD, Evans PA.

Platelets. 2018 Mar;29(2):162-170. doi: 10.1080/09537104.2017.1306039. Epub 2017 May 15.


Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation.

Sousa AR, Marshall RP, Warnock LC, Bolton S, Hastie A, Symon F, Hargadon B, Marshall H, Richardson M, Brightling CE, Haldar P, Milone R, Chalk P, Williamson R, Panettieri R Jr, Knowles R, Bleecker ER, Wardlaw AJ.

Clin Exp Allergy. 2017 Jul;47(7):890-899. doi: 10.1111/cea.12954. Epub 2017 Jun 16.


Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies.

Armstrong PC, Hoefer T, Knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):949-956. doi: 10.1161/ATVBAHA.116.308763. Epub 2017 Mar 9.


Catalytic intermolecular hydroaminations of unactivated olefins with secondary alkyl amines.

Musacchio AJ, Lainhart BC, Zhang X, Naguib SG, Sherwood TC, Knowles RR.

Science. 2017 Feb 17;355(6326):727-730. doi: 10.1126/science.aal3010.


Combining qualitative and quantitative operational research methods to inform quality improvement in pathways that span multiple settings.

Crowe S, Brown K, Tregay J, Wray J, Knowles R, Ridout DA, Bull C, Utley M.

BMJ Qual Saf. 2017 Aug;26(8):641-652. doi: 10.1136/bmjqs-2016-005636. Epub 2017 Jan 6.


Leukotriene B4 levels in sputum from asthma patients.

Higham A, Cadden P, Southworth T, Rossall M, Kolsum U, Lea S, Knowles R, Singh D.

ERJ Open Res. 2016 Oct 26;2(4). pii: 00088-2015. doi: 10.1183/23120541.00088-2015. eCollection 2016 Oct.


Ethnic and socioeconomic variation in incidence of congenital heart defects.

Knowles RL, Ridout D, Crowe S, Bull C, Wray J, Tregay J, Franklin RC, Barron DJ, Cunningham D, Parslow RC, Brown KL.

Arch Dis Child. 2017 Jun;102(6):496-502. doi: 10.1136/archdischild-2016-311143. Epub 2016 Dec 16.


Catalytic alkylation of remote C-H bonds enabled by proton-coupled electron transfer.

Choi GJ, Zhu Q, Miller DC, Gu CJ, Knowles RR.

Nature. 2016 Nov 10;539(7628):268-271. doi: 10.1038/nature19811. Epub 2016 Oct 12.


Proton-Coupled Electron Transfer in Organic Synthesis: Fundamentals, Applications, and Opportunities.

Miller DC, Tarantino KT, Knowles RR.

Top Curr Chem (Cham). 2016 Jun;374(3):30. doi: 10.1007/s41061-016-0030-6. Epub 2016 May 9. Review.


Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O-H Bonds.

Yayla HG, Wang H, Tarantino KT, Orbe HS, Knowles RR.

J Am Chem Soc. 2016 Aug 31;138(34):10794-7. doi: 10.1021/jacs.6b06517. Epub 2016 Aug 18.


Self-Reported Health Experiences of Children Living with Congenital Heart Defects: Including Patient-Reported Outcomes in a National Cohort Study.

Knowles RL, Tadic V, Hogan A, Bull C, Rahi JS, Dezateux C; UK Collaborative Study of Congenital Heart Defects (UKCSCHD).

PLoS One. 2016 Aug 3;11(8):e0159326. doi: 10.1371/journal.pone.0159326. eCollection 2016.


Synthetic Applications of Proton-Coupled Electron Transfer.

Gentry EC, Knowles RR.

Acc Chem Res. 2016 Aug 16;49(8):1546-56. doi: 10.1021/acs.accounts.6b00272. Epub 2016 Jul 29.


Catalytic Carbocation Generation Enabled by the Mesolytic Cleavage of Alkoxyamine Radical Cations.

Zhu Q, Gentry EC, Knowles RR.

Angew Chem Int Ed Engl. 2016 Aug 16;55(34):9969-73. doi: 10.1002/anie.201604619. Epub 2016 Jul 12.


Identifying improvements to complex pathways: evidence synthesis and stakeholder engagement in infant congenital heart disease.

Crowe S, Knowles R, Wray J, Tregay J, Ridout DA, Utley M, Franklin R, Bull CL, Brown KL.

BMJ Open. 2016 Jun 6;6(6):e010363. doi: 10.1136/bmjopen-2015-010363.


Infant deaths in the UK community following successful cardiac surgery: building the evidence base for optimal surveillance, a mixed-methods study.

Brown KL, Wray J, Knowles RL, Crowe S, Tregay J, Ridout D, Barron DJ, Cunningham D, Parslow R, Franklin R, Barnes N, Hull S, Bull C.

Southampton (UK): NIHR Journals Library; 2016 May.


Death and Emergency Readmission of Infants Discharged After Interventions for Congenital Heart Disease: A National Study of 7643 Infants to Inform Service Improvement.

Crowe S, Ridout DA, Knowles R, Tregay J, Wray J, Barron DJ, Cunningham D, Parslow RC, Utley M, Franklin R, Bull C, Brown KL.

J Am Heart Assoc. 2016 May 20;5(5). pii: e003369. doi: 10.1161/JAHA.116.003369.


Reaching Your Full (Over)Potential: A Novel Approach to Electrocatalytic Oxygen Reduction.

Knowles RR.

ACS Cent Sci. 2015 Aug 26;1(5):224-5. doi: 10.1021/acscentsci.5b00257. Epub 2015 Aug 6. No abstract available.


Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir.

Yayla HG, Peng F, Mangion IK, McLaughlin M, Campeau LC, Davies IW, DiRocco DA, Knowles RR.

Chem Sci. 2016 Mar 1;7(3):2066-2073. doi: 10.1039/c5sc03350k. Epub 2015 Dec 7.


The impact and efficacy of routine pulse oximetry screening for CHD in a local hospital.

Jones AJ, Howarth C, Nicholl R, Mat-Ali E, Knowles R.

Cardiol Young. 2016 Oct;26(7):1397-405. doi: 10.1017/S1047951115002784. Epub 2016 Feb 24.


"I was so worried about every drop of milk" - feeding problems at home are a significant concern for parents after major heart surgery in infancy.

Tregay J, Brown K, Crowe S, Bull C, Knowles R, Wray J.

Matern Child Nutr. 2017 Apr;13(2). doi: 10.1111/mcn.12302. Epub 2016 Feb 19.


Going home after infant cardiac surgery: a UK qualitative study.

Tregay J, Wray J, Crowe S, Knowles R, Daubeney P, Franklin R, Barron D, Hull S, Barnes N, Bull C, Brown KL.

Arch Dis Child. 2016 Apr;101(4):320-5. doi: 10.1136/archdischild-2015-308827. Epub 2016 Jan 29.


Signs of deterioration in infants discharged home following congenital heart surgery in the first year of life: a qualitative study.

Tregay J, Brown KL, Crowe S, Bull C, Knowles RL, Smith L, Wray J.

Arch Dis Child. 2016 Oct;101(10):902-8. doi: 10.1136/archdischild-2014-308092. Epub 2016 Jan 28.

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