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Increasing Mortality Among Patients With Diabetes and Chronic Liver Disease From 2007 Through 2017.

Kim D, Cholankeril G, Kim SH, Abbasi F, Knowles JW, Ahmed A.

Clin Gastroenterol Hepatol. 2019 Jun 17. pii: S1542-3565(19)30649-4. doi: 10.1016/j.cgh.2019.06.011. [Epub ahead of print] No abstract available.


Impact of race/ethnicity on insulin resistance and hypertriglyceridaemia.

Raygor V, Abbasi F, Lazzeroni LC, Kim S, Ingelsson E, Reaven GM, Knowles JW.

Diab Vasc Dis Res. 2019 Mar;16(2):153-159. doi: 10.1177/1479164118813890.


Trends in overall, cardiovascular and cancer-related mortality among individuals with diabetes reported on death certificates in the United States between 2007 and 2017.

Kim D, Li AA, Cholankeril G, Kim SH, Ingelsson E, Knowles JW, Harrington RA, Ahmed A.

Diabetologia. 2019 Jul;62(7):1185-1194. doi: 10.1007/s00125-019-4870-9. Epub 2019 Apr 22.


Polygenic risk scores in coronary artery disease.

Rao AS, Knowles JW.

Curr Opin Cardiol. 2019 Jul;34(4):435-440. doi: 10.1097/HCO.0000000000000629.


No evidence of a causal association of type 2 diabetes and glucose metabolism with atrial fibrillation.

Harati H, Zanetti D, Rao A, Gustafsson S, Perez M, Ingelsson E, Knowles JW.

Diabetologia. 2019 May;62(5):800-804. doi: 10.1007/s00125-019-4836-y. Epub 2019 Feb 27.


Genetic Testing and Risk Scores: Impact on Familial Hypercholesterolemia.

Sarraju A, Knowles JW.

Front Cardiovasc Med. 2019 Jan 29;6:5. doi: 10.3389/fcvm.2019.00005. eCollection 2019. Review.


Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease.

Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA.

JAMA Cardiol. 2019 Feb 13. doi: 10.1001/jamacardio.2018.4936. [Epub ahead of print]


Body composition and atrial fibrillation: a Mendelian randomization study.

Tikkanen E, Gustafsson S, Knowles JW, Perez M, Burgess S, Ingelsson E.

Eur Heart J. 2019 Apr 21;40(16):1277-1282. doi: 10.1093/eurheartj/ehz003.


Safety and Efficacy of PCSK9 Inhibitors After Heart Transplantation.

Moayedi Y, Kozuszko S, Knowles JW, Chih S, Oro G, Lee R, Fearon WF, Ross HJ, Teuteberg JJ, Khush KK.

Can J Cardiol. 2019 Jan;35(1):104.e1-104.e3. doi: 10.1016/j.cjca.2018.11.004. Epub 2018 Nov 14.


ClinVar database of global familial hypercholesterolemia-associated DNA variants.

Iacocca MA, Chora JR, Carrié A, Freiberger T, Leigh SE, Defesche JC, Kurtz CL, DiStefano MT, Santos RD, Humphries SE, Mata P, Jannes CE, Hooper AJ, Wilemon KA, Benlian P, O'Connor R, Garcia J, Wand H, Tichy L, Sijbrands EJ, Hegele RA, Bourbon M, Knowles JW; ClinGen FH Variant Curation Expert Panel.

Hum Mutat. 2018 Nov;39(11):1631-1640. doi: 10.1002/humu.23634.


Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel.

Sturm AC, Knowles JW, Gidding SS, Ahmad ZS, Ahmed CD, Ballantyne CM, Baum SJ, Bourbon M, Carrié A, Cuchel M, de Ferranti SD, Defesche JC, Freiberger T, Hershberger RE, Hovingh GK, Karayan L, Kastelein JJP, Kindt I, Lane SR, Leigh SE, Linton MF, Mata P, Neal WA, Nordestgaard BG, Santos RD, Harada-Shiba M, Sijbrands EJ, Stitziel NO, Yamashita S, Wilemon KA, Ledbetter DH, Rader DJ; Convened by the Familial Hypercholesterolemia Foundation.

J Am Coll Cardiol. 2018 Aug 7;72(6):662-680. doi: 10.1016/j.jacc.2018.05.044. Review.


Frequency of Statin Use in Patients With Low-Density Lipoprotein Cholesterol ≥190 mg/dl from the Veterans Affairs Health System.

Rodriguez F, Knowles JW, Maron DJ, Virani SS, Heidenreich PA.

Am J Cardiol. 2018 Sep 1;122(5):756-761. doi: 10.1016/j.amjcard.2018.05.008. Epub 2018 Jun 7.


Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke.

Rao AS, Lindholm D, Rivas MA, Knowles JW, Montgomery SB, Ingelsson E.

Circ Genom Precis Med. 2018 Jul;11(7):e002162. doi: 10.1161/CIRCGEN.118.002162.


Large Q and S waves in lead III on the electrocardiogram distinguish patients with hypertrophic cardiomyopathy from athletes.

Chen AS, Bent RE, Wheeler M, Knowles JW, Haddad F, Froelicher V, Ashley E, Perez MV.

Heart. 2018 Nov;104(22):1871-1877. doi: 10.1136/heartjnl-2017-312647. Epub 2018 Apr 21.


Short-Term Repeatability of Insulin Resistance Indexes in Older Adults: The Atherosclerosis Risk in Communities Study.

Poon AK, Meyer ML, Reaven G, Knowles JW, Selvin E, Pankow JS, Couper D, Loehr L, Heiss G.

J Clin Endocrinol Metab. 2018 Jun 1;103(6):2175-2181. doi: 10.1210/jc.2017-02437.


Cardiovascular disease: The rise of the genetic risk score.

Knowles JW, Ashley EA.

PLoS Med. 2018 Mar 30;15(3):e1002546. doi: 10.1371/journal.pmed.1002546. eCollection 2018 Mar.


Genome-wide scan for circulating vascular adhesion protein-1 levels: MACROD2 as a potential transcriptional regulator of adipogenesis.

Chang YC, Hee SW, Lee WJ, Li HY, Chang TJ, Lin MW, Hung YJ, Lee IT, Hung KY, Assimes T, Knowles JW, Nong JY, Lee PC, Chiu YF, Chuang LM.

J Diabetes Investig. 2018 Sep;9(5):1067-1074. doi: 10.1111/jdi.12805. Epub 2018 Feb 26.


First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring.

Helle EIT, Biegley P, Knowles JW, Leader JB, Pendergrass S, Yang W, Reaven GR, Shaw GM, Ritchie M, Priest JR.

J Pediatr. 2018 Apr;195:275-278. doi: 10.1016/j.jpeds.2017.10.046. Epub 2017 Dec 15.


Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry.

Amrock SM, Duell PB, Knickelbine T, Martin SS, O'Brien EC, Watson KE, Mitri J, Kindt I, Shrader P, Baum SJ, Hemphill LC, Ahmed CD, Andersen RL, Kullo IJ, McCann D, Larry JA, Murray MF, Fishberg R, Guyton JR, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Underberg JA, Thompson P, Duffy D, Linton MF, Shapiro MD, Moriarty PM, Knowles JW, Ahmad ZS.

Atherosclerosis. 2017 Dec;267:19-26. doi: 10.1016/j.atherosclerosis.2017.10.006. Epub 2017 Oct 6.


Is ACS in Young Patients a "Canary in the Coal Mine" for Familial Hypercholesterolemia?

Knowles JW, Sarraju A.

J Am Coll Cardiol. 2017 Oct 3;70(14):1741-1743. doi: 10.1016/j.jacc.2017.08.019. No abstract available.


Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study.

Knowles JW, Zarafshar S, Pavlovic A, Goldstein BA, Tsai S, Li J, McConnell MV, Absher D, Ashley EA, Kiernan M, Ioannidis JPA, Assimes TL.

Front Cardiovasc Med. 2017 Aug 14;4:53. doi: 10.3389/fcvm.2017.00053. eCollection 2017.


Cascade Screening for Familial Hypercholesterolemia and the Use of Genetic Testing.

Knowles JW, Rader DJ, Khoury MJ.

JAMA. 2017 Jul 25;318(4):381-382. doi: 10.1001/jama.2017.8543. No abstract available.


Induced Pluripotent Stem Cell-Derived Endothelial Cells in Insulin Resistance and Metabolic Syndrome.

Carcamo-Orive I, Huang NF, Quertermous T, Knowles JW.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2038-2042. doi: 10.1161/ATVBAHA.117.309291. Epub 2017 Jul 20. Review.


Relationship between simple markers of insulin resistance and coronary artery calcification.

Reaven GM, Knowles JW, Leonard D, Barlow CE, Willis BL, Haskell WL, Maron DJ.

J Clin Lipidol. 2017 Jul - Aug;11(4):1007-1012. doi: 10.1016/j.jacl.2017.05.013. Epub 2017 Jun 6.


Leveraging Human Genetics to Understand the Relation of LDL Cholesterol with Type 2 Diabetes.

Ingelsson E, Knowles JW.

Clin Chem. 2017 Jul;63(7):1187-1189. doi: 10.1373/clinchem.2016.268565. Epub 2017 May 17. No abstract available.


Access to Nonstatin Lipid-Lowering Therapies in Patients at High Risk of Atherosclerotic Cardiovascular Disease.

Knowles JW, Howard WB, Karayan L, Baum SJ, Wilemon KA, Ballantyne CM, Myers KD.

Circulation. 2017 May 30;135(22):2204-2206. doi: 10.1161/CIRCULATIONAHA.117.027705. Epub 2017 Apr 26. No abstract available.


The role of registries and genetic databases in familial hypercholesterolemia.

Kindt I, Mata P, Knowles JW.

Curr Opin Lipidol. 2017 Apr;28(2):152-160. doi: 10.1097/MOL.0000000000000398. Review.


Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D'Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MYR, Zhu K, Wang S, Roussos P, Schadt EE, Pandey G, Chang R, Quertermous T, Lemischka I.

Cell Stem Cell. 2017 Apr 6;20(4):518-532.e9. doi: 10.1016/j.stem.2016.11.005. Epub 2016 Dec 22.


Familial Hypercholesterolemia.

Youngblom E, Pariani M, Knowles JW.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2014 Jan 2 [updated 2016 Dec 8].


Use of high-intensity statins for patients with atherosclerotic cardiovascular disease in the Veterans Affairs Health System: Practice impact of the new cholesterol guidelines.

Rodriguez F, Lin S, Maron DJ, Knowles JW, Virani SS, Heidenreich PA.

Am Heart J. 2016 Dec;182:97-102. doi: 10.1016/j.ahj.2016.09.007. Epub 2016 Sep 29.


Association Between Intensity of Statin Therapy and Mortality in Patients With Atherosclerotic Cardiovascular Disease.

Rodriguez F, Maron DJ, Knowles JW, Virani SS, Lin S, Heidenreich PA.

JAMA Cardiol. 2017 Jan 1;2(1):47-54. doi: 10.1001/jamacardio.2016.4052.


Metabolic Markers to Predict Incident Diabetes Mellitus in Statin-Treated Patients (from the Treating to New Targets and the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trials).

Kohli P, Knowles JW, Sarraju A, Waters DD, Reaven G.

Am J Cardiol. 2016 Nov 1;118(9):1275-1281. doi: 10.1016/j.amjcard.2016.07.054. Epub 2016 Aug 12.


Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.

Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW.

Cell Rep. 2016 Oct 4;17(2):527-540. doi: 10.1016/j.celrep.2016.09.005.


US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry.

Ahmad ZS, Andersen RL, Andersen LH, O'Brien EC, Kindt I, Shrader P, Vasandani C, Newman CB, deGoma EM, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Kullo IJ, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW.

J Clin Lipidol. 2016 Sep-Oct;10(5):1223-9. doi: 10.1016/j.jacl.2016.07.011. Epub 2016 Aug 6.


Novel Therapies for Familial Hypercholesterolemia.

Parizo J, Sarraju A, Knowles JW.

Curr Treat Options Cardiovasc Med. 2016 Nov;18(11):64. doi: 10.1007/s11936-016-0486-2. Review.


Hypertriglyceridemia: A simple approach to identify insulin resistance and enhanced cardio-metabolic risk in patients with prediabetes.

Abbasi F, Kohli P, Reaven GM, Knowles JW.

Diabetes Res Clin Pract. 2016 Oct;120:156-61. doi: 10.1016/j.diabres.2016.07.024. Epub 2016 Aug 6.


Standards of Evidence and Mechanistic Inference in Autosomal Recessive Hypercholesterolemia.

Priest JR, Knowles JW.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1465-6. doi: 10.1161/ATVBAHA.116.307714. No abstract available.


Statins in Familial Hypercholesterolemia: Translating Evidence to Action.

Knowles JW.

J Am Coll Cardiol. 2016 Jul 19;68(3):261-264. doi: 10.1016/j.jacc.2016.05.024. No abstract available.


Enough Evidence, Time to Act!

Rodriguez F, Knowles JW.

Circulation. 2016 Jul 5;134(1):20-3. doi: 10.1161/CIRCULATIONAHA.116.023010. No abstract available.


Interdisciplinary psychosocial care for families with inherited cardiovascular diseases.

Caleshu C, Kasparian NA, Edwards KS, Yeates L, Semsarian C, Perez M, Ashley E, Turner CJ, Knowles JW, Ingles J.

Trends Cardiovasc Med. 2016 Oct;26(7):647-53. doi: 10.1016/j.tcm.2016.04.010. Epub 2016 Apr 28. Review.


Usual Blood Pressure and New-Onset Diabetes Risk: Evidence From 4.1 Million Adults and a Meta-Analysis.

Knowles JW, Reaven G.

J Am Coll Cardiol. 2016 Apr 5;67(13):1656-1657. doi: 10.1016/j.jacc.2015.12.065. No abstract available.


Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.

Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC.

Nat Med. 2016 May;22(5):547-56. doi: 10.1038/nm.4087. Epub 2016 Apr 18.


Treatment Gaps in Adults With Heterozygous Familial Hypercholesterolemia in the United States: Data From the CASCADE-FH Registry.

deGoma EM, Ahmad ZS, O'Brien EC, Kindt I, Shrader P, Newman CB, Pokharel Y, Baum SJ, Hemphill LC, Hudgins LC, Ahmed CD, Gidding SS, Duffy D, Neal W, Wilemon K, Roe MT, Rader DJ, Ballantyne CM, Linton MF, Duell PB, Shapiro MD, Moriarty PM, Knowles JW.

Circ Cardiovasc Genet. 2016 Jun;9(3):240-9. doi: 10.1161/CIRCGENETICS.116.001381. Epub 2016 Mar 24.


Impact of Septal Reduction on Left Atrial Size and Diastole in Hypertrophic Cardiomyopathy.

Finocchiaro G, Haddad F, Kobayashi Y, Lee D, Pavlovic A, Schnittger I, Sinagra G, Magavern E, Myers J, Froelicher V, Knowles JW, Ashley E.

Echocardiography. 2016 May;33(5):686-94. doi: 10.1111/echo.13158. Epub 2016 Mar 1.


Cardiometabolic Effects of Glucagon-Like Peptide-1 Agonists.

Sarraju A, Kim SH, Knowles JW.

Curr Atheroscler Rep. 2016 Feb;18(2):7. doi: 10.1007/s11883-016-0558-5. Review.


Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.

Knowles JW, Xie W, Zhang Z, Chennamsetty I, Assimes TL, Paananen J, Hansson O, Pankow J, Goodarzi MO, Carcamo-Orive I, Morris AP, Chen YD, Mäkinen VP, Ganna A, Mahajan A, Guo X, Abbasi F, Greenawalt DM, Lum P, Molony C, Lind L, Lindgren C, Raffel LJ, Tsao PS; RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium; EUGENE (European Network on Functional Genomics of Type Diabetes) Study; GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium; SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study, Schadt EE, Rotter JI, Sinaiko A, Reaven G, Yang X, Hsiung CA, Groop L, Cordell HJ, Laakso M, Hao K, Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T.

J Clin Invest. 2016 Jan;126(1):403. doi: 10.1172/JCI85921. Epub 2016 Jan 4. No abstract available.


The Agenda for Familial Hypercholesterolemia: A Scientific Statement From the American Heart Association.

Gidding SS, Champagne MA, de Ferranti SD, Defesche J, Ito MK, Knowles JW, McCrindle B, Raal F, Rader D, Santos RD, Lopes-Virella M, Watts GF, Wierzbicki AS; American Heart Association Atherosclerosis, Hypertension, and Obesity in Young Committee of Council on Cardiovascular Disease in Young, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, and Council on Lifestyle and Cardiometabolic Health.

Circulation. 2015 Dec 1;132(22):2167-92. doi: 10.1161/CIR.0000000000000297. Epub 2015 Oct 28. Review. No abstract available. Erratum in: Circulation. 2015 Dec 22;132(25):e397.


Maternal Midpregnancy Glucose Levels and Risk of Congenital Heart Disease in Offspring.

Priest JR, Yang W, Reaven G, Knowles JW, Shaw GM.

JAMA Pediatr. 2015 Dec;169(12):1112-6. doi: 10.1001/jamapediatrics.2015.2831.


Corrigendum: Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example.

Goldstein BA, Knowles JW, Salfati E, Ioannidis JP, Assimes TL.

Front Genet. 2015 Jul 7;6:231. doi: 10.3389/fgene.2015.00231. eCollection 2015.


Systematic Comparison of Digital Electrocardiograms From Healthy Athletes and Patients With Hypertrophic Cardiomyopathy.

Bent RE, Wheeler MT, Hadley D, Knowles JW, Pavlovic A, Finocchiaro G, Haddad F, Salisbury H, Race S, Shmargad Y, Matheson GO, Kumar N, Saini D, Froelicher V, Ashley E, Perez MV.

J Am Coll Cardiol. 2015 Jun 9;65(22):2462-3. doi: 10.1016/j.jacc.2015.03.559. No abstract available.

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