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Items: 1 to 50 of 186

2.

New Construction Act.

Knowles R, Knowles JR.

Health Estate. 1998 Apr;52(3):6. No abstract available.

PMID:
10178141
3.

East meets West: a comparison of eastern block/western aeromedical practices.

Lyons TJ, Neel RL, Simpson CG, Moore VA, Van Syoc DL, Knowles JR, Salamanca VP.

Aviat Space Environ Med. 1997 Dec;68(12):1150-3.

PMID:
9408568
4.

Introns and the origin of protein-coding genes.

Bertolaet BL, Seidel HM, Knowles JR.

Science. 1995 Jun 2;268(5215):1367; author reply 1367-9. No abstract available.

PMID:
7761859
5.

Complementation of fragments of triosephosphate isomerase defined by exon boundaries.

Bertolaet BL, Knowles JR.

Biochemistry. 1995 May 2;34(17):5736-43.

PMID:
7727434
6.
7.

Primary and secondary kinetic isotope effects as probes of the mechanism of yeast enolase.

Anderson SR, Anderson VE, Knowles JR.

Biochemistry. 1994 Aug 30;33(34):10545-55.

PMID:
8068695
8.
10.

Crystal structure of recombinant chicken triosephosphate isomerase-phosphoglycolohydroxamate complex at 1.8-A resolution.

Zhang Z, Sugio S, Komives EA, Liu KD, Knowles JR, Petsko GA, Ringe D.

Biochemistry. 1994 Mar 15;33(10):2830-7.

PMID:
8130195
11.

Triosephosphate isomerase requires a positively charged active site: the role of lysine-12.

Lodi PJ, Chang LC, Knowles JR, Komives EA.

Biochemistry. 1994 Mar 15;33(10):2809-14.

PMID:
8130193
12.
13.

Purification, cloning, and cofactor independence of glutamate racemase from Lactobacillus.

Gallo KA, Knowles JR.

Biochemistry. 1993 Apr 20;32(15):3981-90.

PMID:
8385993
14.

Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase.

Tanner ME, Gallo KA, Knowles JR.

Biochemistry. 1993 Apr 20;32(15):3998-4006.

PMID:
8097110
15.

Mechanism of the reaction catalyzed by glutamate racemase.

Gallo KA, Tanner ME, Knowles JR.

Biochemistry. 1993 Apr 20;32(15):3991-7.

PMID:
8097109
16.

Cloning, overexpression and mechanistic studies of carboxyphosphonoenolpyruvate mutase from Streptomyces hygroscopicus.

Pollack SJ, Freeman S, Pompliano DL, Knowles JR.

Eur J Biochem. 1992 Oct 15;209(2):735-43.

17.
18.
19.

Exons as microgenes?

Seidel HM, Pompliano DL, Knowles JR.

Science. 1992 Sep 11;257(5076):1489-90. No abstract available.

PMID:
1523407
21.

Crystallographic detection of a second ligand binding site in influenza virus hemagglutinin.

Sauter NK, Glick GD, Crowther RL, Park SJ, Eisen MB, Skehel JJ, Knowles JR, Wiley DC.

Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):324-8.

22.

Ligand recognition by influenza virus. The binding of bivalent sialosides.

Glick GD, Toogood PL, Wiley DC, Skehel JJ, Knowles JR.

J Biol Chem. 1991 Dec 15;266(35):23660-9.

23.

Monovalent sialosides that bind tightly to influenza A virus.

Toogood PL, Galliker PK, Glick GD, Knowles JR.

J Med Chem. 1991 Oct;34(10):3138-40. No abstract available.

PMID:
1920363
24.

Calmer waters in the channel?

Knowles JR.

J Theor Biol. 1991 Sep 7;152(1):53-5. No abstract available.

PMID:
1753767
27.

To build an enzyme....

Knowles JR.

Philos Trans R Soc Lond B Biol Sci. 1991 May 29;332(1263):115-21.

PMID:
1678530
28.

Electrophilic catalysis in triosephosphate isomerase: the role of histidine-95.

Komives EA, Chang LC, Lolis E, Tilton RF, Petsko GA, Knowles JR.

Biochemistry. 1991 Mar 26;30(12):3011-9.

PMID:
2007138
29.

Enzyme catalysis: not different, just better.

Knowles JR.

Nature. 1991 Mar 14;350(6314):121-4. Review.

PMID:
2005961
30.
31.

Stereochemical course of the reactions catalyzed by the bacterial phosphoenolpyruvate:mannitol phosphotransferase system.

Mueller EG, Khandekar SS, Knowles JR, Jacobson GR.

Biochemistry. 1990 Jul 24;29(29):6892-6.

PMID:
2118803
32.

How can a catalytic lesion be offset? The energetics of two pseudorevertant triosephosphate isomerases.

Blacklow SC, Knowles JR.

Biochemistry. 1990 May 1;29(17):4099-108.

PMID:
2361134
33.
35.

Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme.

Hermes JD, Blacklow SC, Knowles JR.

Proc Natl Acad Sci U S A. 1990 Jan;87(2):696-700.

36.

A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers.

Hermes JD, Parekh SM, Blacklow SC, Köster H, Knowles JR.

Gene. 1989 Dec 7;84(1):143-51.

PMID:
2691332
37.
38.

Evolutionary optimization of the catalytic effectiveness of an enzyme.

Burbaum JJ, Raines RT, Albery WJ, Knowles JR.

Biochemistry. 1989 Nov 28;28(24):9293-305.

PMID:
2611230
42.

Dehydroquinate synthase: the use of substrate analogues to probe the late steps of the catalyzed reaction.

Widlanski T, Bender SL, Knowles JR.

Biochemistry. 1989 Sep 19;28(19):7572-82.

PMID:
2611201
43.

Dehydroquinate synthase: the use of substrate analogues to probe the early steps of the catalyzed reaction.

Bender SL, Widlanski T, Knowles JR.

Biochemistry. 1989 Sep 19;28(19):7560-72.

PMID:
2611200
44.

Dehydroquinate synthase: the role of divalent metal cations and of nicotinamide adenine dinucleotide in catalysis.

Bender SL, Mehdi S, Knowles JR.

Biochemistry. 1989 Sep 19;28(19):7555-60.

PMID:
2514789
45.

The mechanism of biotin-dependent enzymes.

Knowles JR.

Annu Rev Biochem. 1989;58:195-221. Review. No abstract available.

PMID:
2673009
46.

The stereochemical course of phospho group transfer catalyzed by rat liver 6-phosphofructo-2-kinase.

Kountz PD, Freeman S, Cook AG, el-Maghrabi MR, Knowles JR, Pilkis SJ.

J Biol Chem. 1988 Nov 5;263(31):16069-72.

47.

On the intermediacy of carboxyphosphate in biotin-dependent carboxylations.

Ogita T, Knowles JR.

Biochemistry. 1988 Oct 18;27(21):8028-33.

PMID:
2976600
48.

Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond.

Seidel HM, Freeman S, Seto H, Knowles JR.

Nature. 1988 Sep 29;335(6189):457-8.

PMID:
3138545
49.
50.

Malate synthase: proof of a stepwise Claisen condensation using the double-isotope fractionation test.

Clark JD, O'Keefe SJ, Knowles JR.

Biochemistry. 1988 Aug 9;27(16):5961-71.

PMID:
2847778

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