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Items: 47

1.

Refractory focal epilepsy in a paediatric patient with primary familial brain calcification.

Knowles JK, Santoro JD, Porter BE, Baumer FM.

Seizure. 2018 Mar;56:50-52. doi: 10.1016/j.seizure.2018.02.001. Epub 2018 Feb 6.

2.

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.

PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.

3.

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.

Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.

4.

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.

J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009.

5.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.

PLoS One. 2008;3(11):e3604. doi: 10.1371/journal.pone.0003604. Epub 2008 Nov 3.

6.

Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms.

Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM.

Curr Alzheimer Res. 2007 Dec;4(5):503-6. Review.

PMID:
18220511
7.

Jonathan K. C. Knowles discusses the impact of pharmacogenomics on market segmentation.

Knowles JK.

Nat Rev Drug Discov. 2004 Oct;3(10):822. No abstract available.

PMID:
15497246
8.

Diagnostics and the future of medicine.

Knowles JK.

Clin Chem Lab Med. 2000 Sep;38(9):804. No abstract available.

PMID:
11097331
9.

The three-dimensional crystal structure of the catalytic core of cellobiohydrolase I from Trichoderma reesei.

Divne C, Ståhlberg J, Reinikainen T, Ruohonen L, Pettersson G, Knowles JK, Teeri TT, Jones TA.

Science. 1994 Jul 22;265(5171):524-8.

PMID:
8036495
10.

Characterization of a birch (Betula pendula Roth.) embryogenic gene, BP8.

Puupponen-Pimiä R, Saloheimo M, Vasara T, Ra R, Gaugecz J, Kurtén U, Knowles JK, Keränen S, Kauppinen V.

Plant Mol Biol. 1993 Oct;23(2):423-8.

PMID:
8219076
11.

Efficient secretion of murine Fab fragments by Escherichia coli is determined by the first constant domain of the heavy chain.

Alfthan K, Takkinen K, Sizmann D, Seppälä I, Immonen T, Vanne L, Keränen S, Kaartinen M, Knowles JK, Teeri TT.

Gene. 1993 Jun 30;128(2):203-9.

PMID:
8514187
12.

Efficient production of antibody fragments by the filamentous fungus Trichoderma reesei.

Nyyssönen E, Penttilä M, Harkki A, Saloheimo A, Knowles JK, Keränen S.

Biotechnology (N Y). 1993 May;11(5):591-5.

PMID:
7763606
13.

A Ca(2+)-independent protein kinase C from fission yeast.

Mazzei GJ, Schmid EM, Knowles JK, Payton MA, Maundrell KG.

J Biol Chem. 1993 Apr 5;268(10):7401-6.

14.
15.

Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes.

Blomqvist K, Nikkola M, Lehtovaara P, Suihko ML, Airaksinen U, Stråby KB, Knowles JK, Penttilä ME.

J Bacteriol. 1993 Mar;175(5):1392-404.

16.

Modelling of the lignin peroxidase LIII of Phlebia radiata: use of a sequence template generated from a 3-D structure.

Hoffrén AM, Saloheimo M, Thomas P, Overington JP, Johnson MS, Knowles JK, Blundell TL.

Protein Eng. 1993 Feb;6(2):177-82.

PMID:
8386362
17.

Investigation of the function of mutated cellulose-binding domains of Trichoderma reesei cellobiohydrolase I.

Reinikainen T, Ruohonen L, Nevanen T, Laaksonen L, Kraulis P, Jones TA, Knowles JK, Teeri TT.

Proteins. 1992 Dec;14(4):475-82.

PMID:
1438185
18.

Structure, function, and genetics of cellulases.

Teeri TT, Penttilä M, Keränen S, Nevalainen H, Knowles JK.

Biotechnology. 1992;21:417-45. Review. No abstract available.

PMID:
1576482
19.

Saccharomyces cerevisiae cells secreting an Aspergillus niger beta-galactosidase grow on whey permeate.

Kumar V, Ramakrishnan S, Teeri TT, Knowles JK, Hartley BS.

Biotechnology (N Y). 1992 Jan;10(1):82-5.

PMID:
1368193
20.

An active single-chain antibody containing a cellulase linker domain is secreted by Escherichia coli.

Takkinen K, Laukkanen ML, Sizmann D, Alfthan K, Immonen T, Vanne L, Kaartinen M, Knowles JK, Teeri TT.

Protein Eng. 1991 Oct;4(7):837-41.

PMID:
1798707
21.

Production of functional IgM Fab fragments by Saccharomyces cerevisiae.

Edqvist J, Keränen S, Penttilä M, Stråby KB, Knowles JK.

J Biotechnol. 1991 Oct;20(3):291-300.

PMID:
1367574
22.

Promoter structure and expression of the 3-phosphoglycerate kinase-encoding gene (pgk1) of Trichoderma reesei.

Vanhanen S, Saloheimo A, Ilmén M, Knowles JK, Penttilä M.

Gene. 1991 Sep 30;106(1):129-33.

PMID:
1937034
23.

Isolation and structural analysis of the laccase gene from the lignin-degrading fungus Phlebia radiata.

Saloheimo M, Niku-Paavola ML, Knowles JK.

J Gen Microbiol. 1991 Jul;137(7):1537-44.

PMID:
1955850
24.

Enzyme production by recombinant Trichoderma reesei strains.

Uusitalo JM, Nevalainen KM, Harkki AM, Knowles JK, Penttilä ME.

J Biotechnol. 1991 Jan;17(1):35-49.

PMID:
1367015
25.

Site-directed mutagenesis of the putative catalytic residues of Trichoderma reesei cellobiohydrolase I and endoglucanase I.

Mitsuishi Y, Nitisinprasert S, Saloheimo M, Biese I, Reinikainen T, Claeyssens M, Keränen S, Knowles JK, Teeri TT.

FEBS Lett. 1990 Nov 26;275(1-2):135-8.

26.

Three-dimensional structure of cellobiohydrolase II from Trichoderma reesei.

Rouvinen J, Bergfors T, Teeri T, Knowles JK, Jones TA.

Science. 1990 Jul 27;249(4967):380-6. Erratum in: Science 1990 Sep 21;249(4975):1359.

PMID:
2377893
27.
28.

Random mutagenesis used to probe the structure and function of Bacillus stearothermophilus alpha-amylase.

Holm L, Koivula AK, Lehtovaara PM, Hemminki A, Knowles JK.

Protein Eng. 1990 Jan;3(3):181-91.

PMID:
2330367
29.

Structural homology among the peroxidase enzyme family revealed by hydrophobic cluster analysis.

Henrissat B, Saloheimo M, Lavaitte S, Knowles JK.

Proteins. 1990;8(3):251-7.

PMID:
2177893
30.

A lignin peroxidase-encoding cDNA from the white-rot fungus Phlebia radiata: characterization and expression in Trichoderma reesei.

Saloheimo M, Barajas V, Niku-Paavola ML, Knowles JK.

Gene. 1989 Dec 28;85(2):343-51.

PMID:
2628172
31.

Treatment of severe anaemia in children in a rural hospital.

Dorward JA, Knowles JK, Dorward IM.

Trop Doct. 1989 Oct;19(4):155-8.

PMID:
2815301
32.

Molecular analysis of a Phanerochaete chrysosporium lignin peroxidase gene.

Walther I, Kälin M, Reiser J, Suter F, Fritsche B, Saloheimo M, Leisola M, Teeri T, Knowles JK, Fiechter A.

Gene. 1988 Oct 15;70(1):127-37.

PMID:
3240864
33.

A new method for random mutagenesis of complete genes: enzymatic generation of mutant libraries in vitro.

Lehtovaara PM, Koivula AK, Bamford J, Knowles JK.

Protein Eng. 1988 Apr;2(1):63-8.

PMID:
3151018
34.

EGIII, a new endoglucanase from Trichoderma reesei: the characterization of both gene and enzyme.

Saloheimo M, Lehtovaara P, Penttilä M, Teeri TT, Ståhlberg J, Johansson G, Pettersson G, Claeyssens M, Tomme P, Knowles JK.

Gene. 1988;63(1):11-22.

PMID:
3384334
35.

Efficient secretion of two fungal cellobiohydrolases by Saccharomyces cerevisiae.

Penttilä ME, André L, Lehtovaara P, Bailey M, Teeri TT, Knowles JK.

Gene. 1988;63(1):103-12.

PMID:
3290051
36.

A shelter that saves mothers' lives.

Knowles JK.

World Health Forum. 1988;9(3):387-8. No abstract available.

PMID:
3252829
37.

Expression of two Trichoderma reesei endoglucanases in the yeast Saccharomyces cerevisiae.

Penttilä ME, André L, Saloheimo M, Lehtovaara P, Knowles JK.

Yeast. 1987 Sep;3(3):175-85.

PMID:
3332972
38.

Efficient secretion of Bacillus amyloliquefaciens alpha-amylase by [corrected] its own signal peptide from Saccharomyces cerevisiae host cells [corrected].

Ruohonen L, Hackman P, Lehtovaara P, Knowles JK, Keränen S.

Gene. 1987;59(2-3):161-70. Erratum in: Gene 1988 Apr 29;64(2):327.

PMID:
2830166
39.

A case of visceral leishmaniasis in Malawi.

Knowles JK, Paul B, Hutt MS, Lucas S.

Trans R Soc Trop Med Hyg. 1981;75(3):474-5. No abstract available.

PMID:
7324120
40.

Absence of detectable mitochondrial recombination in Paramecium.

Adoutte A, Knowles JK, Sainsard-Chanet A.

Genetics. 1979 Dec;93(4):797-831.

41.

Translation of homologous RNA injected into the ciliate Stylonychia mytilus.

Knowles JK, Lipps HJ, Nock A.

Biochem Biophys Res Commun. 1978 Feb 28;80(4):897-904. No abstract available.

PMID:
416826
42.
43.

Interspecies transfer of mitochondria in Paramecium aurelia.

Beale GH, Knowles JK.

Mol Gen Genet. 1976 Jan 16;143(2):197-201.

PMID:
1250220
44.
45.

Mitochondrial genetics in Paramecium.

Beale GH, Knowles JK, Tait A.

Nature. 1972 Feb 18;235(5338):396-7. No abstract available.

PMID:
4551647
46.

A new method for studying the genetic control of specific mitochondrial proteins in Paramecium aurelia.

Knowles JK, Tait A.

Mol Gen Genet. 1972;117(1):53-9. No abstract available.

PMID:
5069431
47.

Observations on two mitochondrial phenotypes in single paramecium cells.

Knowles JK.

Exp Cell Res. 1972 Jan;70(1):223-6. No abstract available.

PMID:
5008400

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