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Items: 12


NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation.

Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, Zueva E, Maurin M, Nadalin F, Knott GJ, Zhao B, Du F, Rio M, Amiel J, Fox AH, Li P, Etienne L, Bond CS, Colleaux L, Manel N.

Cell. 2018 Oct 4;175(2):488-501.e22. doi: 10.1016/j.cell.2018.08.062. Epub 2018 Sep 27.


CRISPR-Cas guides the future of genetic engineering.

Knott GJ, Doudna JA.

Science. 2018 Aug 31;361(6405):866-869. doi: 10.1126/science.aat5011. Review.


RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.

Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR.

Cell Rep. 2018 Jul 24;24(4):1025-1036. doi: 10.1016/j.celrep.2018.06.105.


Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA.

Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11.


A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.


Structures of the CRISPR genome integration complex.

Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA.

Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20.


RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA.

Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008.


Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii.

James AM, Jayasena AS, Zhang J, Berkowitz O, Secco D, Knott GJ, Whelan J, Bond CS, Mylne JS.

Plant Cell. 2017 Mar;29(3):461-473. doi: 10.1105/tpc.16.00831. Epub 2017 Mar 14.


A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry.

Knott GJ, Panjikar S, Thorn A, Fox AH, Conte MR, Lee M, Bond CS.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):761-9. doi: 10.1107/S2059798316005830. Epub 2016 May 25.


The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.

Knott GJ, Bond CS, Fox AH.

Nucleic Acids Res. 2016 May 19;44(9):3989-4004. doi: 10.1093/nar/gkw271. Epub 2016 Apr 15.


Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.

Knott GJ, Lee M, Passon DM, Fox AH, Bond CS.

Protein Sci. 2015 Dec;24(12):2033-43. doi: 10.1002/pro.2816. Epub 2015 Oct 29.


Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.

Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, Knott GJ, Iyer KS, Ho D, Newcombe EA, Hosoki K, Goshima N, Kawaguchi T, Hatters D, Trinkle-Mulcahy L, Hirose T, Bond CS, Fox AH.

J Cell Biol. 2015 Aug 17;210(4):529-39. doi: 10.1083/jcb.201504117.

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