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Items: 1 to 50 of 116

1.

The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1.

Calì C, Wawrzyniak M, Becker C, Maco B, Cantoni M, Jorstad A, Nigro B, Grillo F, De Paola V, Fua P, Knott GW.

PLoS One. 2018 Jul 2;13(7):e0198131. doi: 10.1371/journal.pone.0198131. eCollection 2018.

2.

Locally coordinated synaptic plasticity of visual cortex neurons in vivo.

El-Boustani S, Ip JPK, Breton-Provencher V, Knott GW, Okuno H, Bito H, Sur M.

Science. 2018 Jun 22;360(6395):1349-1354. doi: 10.1126/science.aao0862.

PMID:
29930137
3.

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey.

Innocenti GM, Caminiti R, Rouiller EM, Knott G, Dyrby TB, Descoteaux M, Thiran JP.

Cereb Cortex. 2018 Feb 27. doi: 10.1093/cercor/bhx363. [Epub ahead of print]

PMID:
29490005
4.

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider BL.

Mol Neurodegener. 2017 Nov 3;12(1):80. doi: 10.1186/s13024-017-0220-x.

5.

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images.

Gala R, Lebrecht D, Sahlender DA, Jorstad A, Knott G, Holtmaat A, Stepanyants A.

Elife. 2017 Oct 23;6. pii: e29315. doi: 10.7554/eLife.29315.

6.

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.

Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL.

Sci Rep. 2017 Oct 19;7(1):13556. doi: 10.1038/s41598-017-13786-2.

7.

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.

Lee RFS, Riedel T, Escrig S, Maclachlan C, Knott GW, Davey CA, Johnsson K, Meibom A, Dyson PJ.

Metallomics. 2017 Oct 18;9(10):1413-1420. doi: 10.1039/c7mt00153c.

PMID:
28913538
8.

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA.

Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11.

9.

The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects.

Lee RFS, Escrig S, Maclachlan C, Knott GW, Meibom A, Sava G, Dyson PJ.

Int J Mol Sci. 2017 Aug 29;18(9). pii: E1869. doi: 10.3390/ijms18091869.

10.

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.

11.

Structures of the CRISPR genome integration complex.

Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA.

Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20.

12.

Neuron Segmentation With High-Level Biological Priors.

Krasowski NE, Beier T, Knott GW, Kothe U, Hamprecht FA, Kreshuk A.

IEEE Trans Med Imaging. 2018 Apr;37(4):829-839. doi: 10.1109/TMI.2017.2712360. Epub 2017 Jun 6.

PMID:
28600240
13.

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA.

Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008.

14.

Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii.

James AM, Jayasena AS, Zhang J, Berkowitz O, Secco D, Knott GJ, Whelan J, Bond CS, Mylne JS.

Plant Cell. 2017 Mar;29(3):461-473. doi: 10.1105/tpc.16.00831. Epub 2017 Mar 14.

15.

Multicut brings automated neurite segmentation closer to human performance.

Beier T, Pape C, Rahaman N, Prange T, Berg S, Bock DD, Cardona A, Knott GW, Plaza SM, Scheffer LK, Koethe U, Kreshuk A, Hamprecht FA.

Nat Methods. 2017 Jan 31;14(2):101-102. doi: 10.1038/nmeth.4151. No abstract available.

PMID:
28139671
16.

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL.

Hum Mol Genet. 2017 Feb 1;26(3):582-598. doi: 10.1093/hmg/ddw418.

PMID:
28053050
17.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

18.

Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii.

Ramond E, Maclachlan C, Clerc-Rosset S, Knott GW, Lemaitre B.

MBio. 2016 Jul 26;7(4). pii: e00881-16. doi: 10.1128/mBio.00881-16.

19.

A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry.

Knott GJ, Panjikar S, Thorn A, Fox AH, Conte MR, Lee M, Bond CS.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):761-9. doi: 10.1107/S2059798316005830. Epub 2016 May 25.

20.

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.

Knott GJ, Bond CS, Fox AH.

Nucleic Acids Res. 2016 May 19;44(9):3989-4004. doi: 10.1093/nar/gkw271. Epub 2016 Apr 15.

21.

Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ.

Chem Commun (Camb). 2015 Nov 28;51(92):16577. doi: 10.1039/c5cc90487k.

PMID:
26507472
22.

Multi-Modal Optical Imaging of the Cerebellum in Animals.

Allegra Mascaro AL, Sacconi L, Silvestri L, Knott G, Pavone FS.

Cerebellum. 2015 Oct 17. [Epub ahead of print]

PMID:
26476852
23.

Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.

Knott GJ, Lee M, Passon DM, Fox AH, Bond CS.

Protein Sci. 2015 Dec;24(12):2033-43. doi: 10.1002/pro.2816. Epub 2015 Oct 29.

24.

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ.

Chem Commun (Camb). 2015 Nov 28;51(92):16486-9. doi: 10.1039/c5cc06983a. Erratum in: Chem Commun (Camb). 2015 Nov 28;51(92):16577.

PMID:
26426486
25.

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose.

Takado Y, Knott G, Humbel BM, Masoodi M, Escrig S, Meibom A, Comment A.

J Chem Neuroanat. 2015 Nov;69:7-12. doi: 10.1016/j.jchemneu.2015.09.003. Epub 2015 Sep 25.

PMID:
26409162
26.

Training and Support of Sessional Staff to Improve Quality of Teaching and Learning at Universities.

Knott G, Crane L, Heslop I, Glass BD.

Am J Pharm Educ. 2015 Jun 25;79(5):72. doi: 10.5688/ajpe79572. Review.

27.

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.

Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, Knott GJ, Iyer KS, Ho D, Newcombe EA, Hosoki K, Goshima N, Kawaguchi T, Hatters D, Trinkle-Mulcahy L, Hirose T, Bond CS, Fox AH.

J Cell Biol. 2015 Aug 17;210(4):529-39. doi: 10.1083/jcb.201504117.

28.

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation.

Korogod N, Petersen CC, Knott GW.

Elife. 2015 Aug 11;4. doi: 10.7554/eLife.05793.

29.

Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits.

Barnes SJ, Cheetham CE, Liu Y, Bennett SH, Albieri G, Jorstad AA, Knott GW, Finnerty GT.

J Neurosci. 2015 Jun 17;35(24):9024-37. doi: 10.1523/JNEUROSCI.4583-14.2015.

30.

Modeling brain circuitry over a wide range of scales.

Fua P, Knott GW.

Front Neuroanat. 2015 Apr 7;9:42. doi: 10.3389/fnana.2015.00042. eCollection 2015. Review.

31.

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein.

Ciron C, Zheng L, Bobela W, Knott GW, Leone TC, Kelly DP, Schneider BL.

Acta Neuropathol Commun. 2015 Apr 1;3:16. doi: 10.1186/s40478-015-0200-8.

32.

A single epidermal stem cell strategy for safe ex vivo gene therapy.

Droz-Georget Lathion S, Rochat A, Knott G, Recchia A, Martinet D, Benmohammed S, Grasset N, Zaffalon A, Besuchet Schmutz N, Savioz-Dayer E, Beckmann JS, Rougemont J, Mavilio F, Barrandon Y.

EMBO Mol Med. 2015 Apr;7(4):380-93. doi: 10.15252/emmm.201404353.

33.

Ultrastructurally smooth thick partitioning and volume stitching for large-scale connectomics.

Hayworth KJ, Xu CS, Lu Z, Knott GW, Fetter RD, Tapia JC, Lichtman JW, Hess HF.

Nat Methods. 2015 Apr;12(4):319-22. doi: 10.1038/nmeth.3292. Epub 2015 Feb 16.

34.

Neurodegeneration: Cold shock protects the brain.

Knott G.

Nature. 2015 Feb 12;518(7538):177-8. doi: 10.1038/nature14195. Epub 2015 Jan 14. No abstract available.

PMID:
25607369
35.

Learning structured models for segmentation of 2-D and 3-D imagery.

Lucchi A, Marquez-Neila P, Becker C, Li Y, Smith K, Knott G, Fua P.

IEEE Trans Med Imaging. 2015 May;34(5):1096-110. doi: 10.1109/TMI.2014.2376274. Epub 2014 Nov 26.

PMID:
25438309
36.

SAS-1 is a C2 domain protein critical for centriole integrity in C. elegans.

von Tobel L, Mikeladze-Dvali T, Delattre M, Balestra FR, Blanchoud S, Finger S, Knott G, Müller-Reichert T, Gönczy P.

PLoS Genet. 2014 Nov 20;10(11):e1004777. doi: 10.1371/journal.pgen.1004777. eCollection 2014 Nov.

37.

Correlative in vivo 2-photon imaging and focused ion beam scanning electron microscopy: 3D analysis of neuronal ultrastructure.

Maco B, Holtmaat A, Jorstad A, Fua P, Knott GW.

Methods Cell Biol. 2014;124:339-61. doi: 10.1016/B978-0-12-801075-4.00016-1.

PMID:
25287849
38.

Imaging liver and brain glycogen metabolism at the nanometer scale.

Takado Y, Knott G, Humbel BM, Escrig S, Masoodi M, Meibom A, Comment A.

Nanomedicine. 2015 Jan;11(1):239-45. doi: 10.1016/j.nano.2014.09.007. Epub 2014 Sep 28.

PMID:
25262580
39.

NeuroMorph: a toolset for the morphometric analysis and visualization of 3D models derived from electron microscopy image stacks.

Jorstad A, Nigro B, Cali C, Wawrzyniak M, Fua P, Knott G.

Neuroinformatics. 2015 Jan;13(1):83-92. doi: 10.1007/s12021-014-9242-5.

40.

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration.

Tsika E, Kannan M, Foo CS, Dikeman D, Glauser L, Gellhaar S, Galter D, Knott GW, Dawson TM, Dawson VL, Moore DJ.

Neurobiol Dis. 2014 Nov;71:345-58. doi: 10.1016/j.nbd.2014.08.027. Epub 2014 Aug 29.

41.

Semiautomated correlative 3D electron microscopy of in vivo-imaged axons and dendrites.

Maco B, Cantoni M, Holtmaat A, Kreshuk A, Hamprecht FA, Knott GW.

Nat Protoc. 2014;9(6):1354-66. doi: 10.1038/nprot.2014.101. Epub 2014 May 15.

PMID:
24833174
42.

Connexin 30 sets synaptic strength by controlling astroglial synapse invasion.

Pannasch U, Freche D, Dallérac G, Ghézali G, Escartin C, Ezan P, Cohen-Salmon M, Benchenane K, Abudara V, Dufour A, Lübke JH, Déglon N, Knott G, Holcman D, Rouach N.

Nat Neurosci. 2014 Apr;17(4):549-58. doi: 10.1038/nn.3662. Epub 2014 Mar 2.

PMID:
24584052
43.

Flash scanning electron microscopy.

Sznitman R, Lucchi A, Cantoni M, Knott G, Fua P.

Med Image Comput Comput Assist Interv. 2013;16(Pt 3):413-20.

PMID:
24505788
44.

The relationship between PSD-95 clustering and spine stability in vivo.

Cane M, Maco B, Knott G, Holtmaat A.

J Neurosci. 2014 Feb 5;34(6):2075-86. doi: 10.1523/JNEUROSCI.3353-13.2014. Erratum in: J Neurosci. 2014 May 7;34(19):6717.

45.

FOXO3 determines the accumulation of α-synuclein and controls the fate of dopaminergic neurons in the substantia nigra.

Pino E, Amamoto R, Zheng L, Cacquevel M, Sarria JC, Knott GW, Schneider BL.

Hum Mol Genet. 2014 Mar 15;23(6):1435-52. doi: 10.1093/hmg/ddt530. Epub 2013 Oct 24.

PMID:
24158851
46.

Is EM dead?

Knott G, Genoud C.

J Cell Sci. 2013 Oct 15;126(Pt 20):4545-52. doi: 10.1242/jcs.124123. Review.

47.

In-vivo single neuron axotomy triggers axon regeneration to restore synaptic density in specific cortical circuits.

Canty AJ, Huang L, Jackson JS, Little GE, Knott G, Maco B, De Paola V.

Nat Commun. 2013;4:2038. doi: 10.1038/ncomms3038.

48.

Learning context cues for synapse segmentation.

Becker C, Ali K, Knott G, Fua P.

IEEE Trans Med Imaging. 2013 Oct;32(10):1864-77. doi: 10.1109/TMI.2013.2267747. Epub 2013 Jun 11.

PMID:
23771317
49.

In vivo single branch axotomy induces GAP-43-dependent sprouting and synaptic remodeling in cerebellar cortex.

Allegra Mascaro AL, Cesare P, Sacconi L, Grasselli G, Mandolesi G, Maco B, Knott GW, Huang L, De Paola V, Strata P, Pavone FS.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10824-9. doi: 10.1073/pnas.1219256110. Epub 2013 Jun 10.

50.

Imaging green fluorescent protein-labeled neurons using light and electron microscopy.

Knott GW.

Cold Spring Harb Protoc. 2013 Jun 1;2013(6):542-50. doi: 10.1101/pdb.prot075127.

PMID:
23734023

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