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Items: 1 to 50 of 136

1.

Publisher Correction: Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution.

Hayworth KJ, Peale D, Januszewski M, Knott GW, Lu Z, Xu CS, Hess HF.

Nat Methods. 2020 Jan;17(1):114. doi: 10.1038/s41592-019-0695-1.

PMID:
31802009
2.

Gas cluster ion beam SEM for imaging of large tissue samples with 10 nm isotropic resolution.

Hayworth KJ, Peale D, Januszewski M, Knott GW, Lu Z, Xu CS, Hess HF.

Nat Methods. 2020 Jan;17(1):68-71. doi: 10.1038/s41592-019-0641-2. Epub 2019 Nov 18. Erratum in: Nat Methods. 2019 Dec 4;:.

PMID:
31740820
3.

Synaptic proximity enables NMDAR signalling to promote brain metastasis.

Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, McCabe BD, Galván JA, Robinson HPC, Zlobec I, Ciriello G, Hanahan D.

Nature. 2019 Sep;573(7775):526-531. doi: 10.1038/s41586-019-1576-6. Epub 2019 Sep 18.

PMID:
31534217
4.

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a.

Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA.

Elife. 2019 Aug 9;8. pii: e49110. doi: 10.7554/eLife.49110.

5.

Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors.

Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA.

Nature. 2019 Apr;568(7752):E8-E10. doi: 10.1038/s41586-019-1084-8.

PMID:
30944483
6.

Broad-spectrum enzymatic inhibition of CRISPR-Cas12a.

Knott GJ, Thornton BW, Lobba MJ, Liu JJ, Al-Shayeb B, Watters KE, Doudna JA.

Nat Struct Mol Biol. 2019 Apr;26(4):315-321. doi: 10.1038/s41594-019-0208-z. Epub 2019 Apr 1.

7.

Differential effect on myelination through abolition of activity-dependent synaptic vesicle release or reduction of overall electrical activity of selected cortical projections in the mouse.

Korrell KV, Disser J, Parley K, Vadisiute A, Requena-Komuro MC, Fodder H, Pollart C, Knott G, Molnár Z, Hoerder-Suabedissen A.

J Anat. 2019 Sep;235(3):452-467. doi: 10.1111/joa.12974. Epub 2019 Mar 22.

8.

CasX enzymes comprise a distinct family of RNA-guided genome editors.

Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA.

Nature. 2019 Feb;566(7743):218-223. doi: 10.1038/s41586-019-0908-x. Epub 2019 Feb 4. Erratum in: Nature. 2019 Apr;568(7752):E8-E10.

9.

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging.

D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J.

Mol Cell. 2019 Feb 21;73(4):775-787.e10. doi: 10.1016/j.molcel.2018.11.034. Epub 2019 Jan 11.

PMID:
30642763
10.

Block Face Scanning Electron Microscopy of Fluorescently Labeled Axons Without Using Near Infra-Red Branding.

Maclachlan C, Sahlender DA, Hayashi S, Molnár Z, Knott G.

Front Neuroanat. 2018 Nov 6;12:88. doi: 10.3389/fnana.2018.00088. eCollection 2018.

11.

Cellular Uptake and Intracellular Trafficking of Poly( N-(2-Hydroxypropyl) Methacrylamide).

Battistella C, Guiet R, Burri O, Seitz A, Escrig S, Knott GW, Meibom A, Klok HA.

Biomacromolecules. 2019 Jan 14;20(1):231-242. doi: 10.1021/acs.biomac.8b01372. Epub 2018 Nov 14.

PMID:
30395472
12.

In vivo modeling of human neuron dynamics and Down syndrome.

Real R, Peter M, Trabalza A, Khan S, Smith MA, Dopp J, Barnes SJ, Momoh A, Strano A, Volpi E, Knott G, Livesey FJ, De Paola V.

Science. 2018 Nov 16;362(6416). pii: eaau1810. doi: 10.1126/science.aau1810. Epub 2018 Oct 11.

13.

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation.

Lahaye X, Gentili M, Silvin A, Conrad C, Picard L, Jouve M, Zueva E, Maurin M, Nadalin F, Knott GJ, Zhao B, Du F, Rio M, Amiel J, Fox AH, Li P, Etienne L, Bond CS, Colleaux L, Manel N.

Cell. 2018 Oct 4;175(2):488-501.e22. doi: 10.1016/j.cell.2018.08.062. Epub 2018 Sep 27.

14.

CRISPR-Cas guides the future of genetic engineering.

Knott GJ, Doudna JA.

Science. 2018 Aug 31;361(6405):866-869. doi: 10.1126/science.aat5011. Review.

15.

Molecular insights into Vibrio cholerae's intra-amoebal host-pathogen interactions.

Van der Henst C, Vanhove AS, Drebes Dörr NC, Stutzmann S, Stoudmann C, Clerc S, Scrignari T, Maclachlan C, Knott G, Blokesch M.

Nat Commun. 2018 Aug 27;9(1):3460. doi: 10.1038/s41467-018-05976-x.

16.

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.

Mol Psychiatry. 2018 Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print]

17.

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency.

Bacq A, Astori S, Gebara E, Tang W, Silva BA, Sanchez-Mut J, Grosse J, Guillot de Suduiraut I, Zanoletti O, Maclachlan C, Knott GW, Gräff J, Sandi C.

Mol Psychiatry. 2018 Aug 8. doi: 10.1038/s41380-018-0132-3. [Epub ahead of print]

PMID:
30089788
18.

NeuroMorph: A Software Toolset for 3D Analysis of Neurite Morphology and Connectivity.

Jorstad A, Blanc J, Knott G.

Front Neuroanat. 2018 Jul 23;12:59. doi: 10.3389/fnana.2018.00059. eCollection 2018.

19.

Ultrastructural basis of strong unitary inhibition in a binaural neuron.

Gjoni E, Aguet C, Sahlender DA, Knott G, Schneggenburger R.

J Physiol. 2018 Oct;596(20):4969-4982. doi: 10.1113/JP276015. Epub 2018 Sep 2.

20.

RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a.

Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR.

Cell Rep. 2018 Jul 24;24(4):1025-1036. doi: 10.1016/j.celrep.2018.06.105.

21.

The effects of aging on neuropil structure in mouse somatosensory cortex-A 3D electron microscopy analysis of layer 1.

Calì C, Wawrzyniak M, Becker C, Maco B, Cantoni M, Jorstad A, Nigro B, Grillo F, De Paola V, Fua P, Knott GW.

PLoS One. 2018 Jul 2;13(7):e0198131. doi: 10.1371/journal.pone.0198131. eCollection 2018.

22.

Locally coordinated synaptic plasticity of visual cortex neurons in vivo.

El-Boustani S, Ip JPK, Breton-Provencher V, Knott GW, Okuno H, Bito H, Sur M.

Science. 2018 Jun 22;360(6395):1349-1354. doi: 10.1126/science.aao0862.

23.

Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey.

Innocenti GM, Caminiti R, Rouiller EM, Knott G, Dyrby TB, Descoteaux M, Thiran JP.

Cereb Cortex. 2019 Feb 1;29(2):788-801. doi: 10.1093/cercor/bhx363.

PMID:
29490005
24.

Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider BL.

Mol Neurodegener. 2017 Nov 3;12(1):80. doi: 10.1186/s13024-017-0220-x.

25.

Computer assisted detection of axonal bouton structural plasticity in in vivo time-lapse images.

Gala R, Lebrecht D, Sahlender DA, Jorstad A, Knott G, Holtmaat A, Stepanyants A.

Elife. 2017 Oct 23;6. pii: e29315. doi: 10.7554/eLife.29315.

26.

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.

Lathuilière A, Valdés P, Papin S, Cacquevel M, Maclachlan C, Knott GW, Muhs A, Paganetti P, Schneider BL.

Sci Rep. 2017 Oct 19;7(1):13556. doi: 10.1038/s41598-017-13786-2.

27.

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.

Lee RFS, Riedel T, Escrig S, Maclachlan C, Knott GW, Davey CA, Johnsson K, Meibom A, Dyson PJ.

Metallomics. 2017 Oct 18;9(10):1413-1420. doi: 10.1039/c7mt00153c.

PMID:
28913538
28.

Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme.

Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA.

Nat Struct Mol Biol. 2017 Oct;24(10):825-833. doi: 10.1038/nsmb.3466. Epub 2017 Sep 11.

29.

The Differential Distribution of RAPTA-T in Non-Invasive and Invasive Breast Cancer Cells Correlates with Its Anti-Invasive and Anti-Metastatic Effects.

Lee RFS, Escrig S, Maclachlan C, Knott GW, Meibom A, Sava G, Dyson PJ.

Int J Mol Sci. 2017 Aug 29;18(9). pii: E1869. doi: 10.3390/ijms18091869.

30.

A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.

31.

Structures of the CRISPR genome integration complex.

Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA.

Science. 2017 Sep 15;357(6356):1113-1118. doi: 10.1126/science.aao0679. Epub 2017 Jul 20.

32.

Neuron Segmentation With High-Level Biological Priors.

Krasowski NE, Beier T, Knott GW, Kothe U, Hamprecht FA, Kreshuk A.

IEEE Trans Med Imaging. 2018 Apr;37(4):829-839. doi: 10.1109/TMI.2017.2712360. Epub 2017 Jun 6.

PMID:
28600240
33.

RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes.

East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA.

Mol Cell. 2017 May 4;66(3):373-383.e3. doi: 10.1016/j.molcel.2017.04.008.

34.

Evidence for Ancient Origins of Bowman-Birk Inhibitors from Selaginella moellendorffii.

James AM, Jayasena AS, Zhang J, Berkowitz O, Secco D, Knott GJ, Whelan J, Bond CS, Mylne JS.

Plant Cell. 2017 Mar;29(3):461-473. doi: 10.1105/tpc.16.00831. Epub 2017 Mar 14.

35.

Multicut brings automated neurite segmentation closer to human performance.

Beier T, Pape C, Rahaman N, Prange T, Berg S, Bock DD, Cardona A, Knott GW, Plaza SM, Scheffer LK, Koethe U, Kreshuk A, Hamprecht FA.

Nat Methods. 2017 Jan 31;14(2):101-102. doi: 10.1038/nmeth.4151. No abstract available.

PMID:
28139671
36.

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL.

Hum Mol Genet. 2017 Feb 1;26(3):582-598. doi: 10.1093/hmg/ddw418.

PMID:
28053050
37.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

38.

Cell Division by Longitudinal Scission in the Insect Endosymbiont Spiroplasma poulsonii.

Ramond E, Maclachlan C, Clerc-Rosset S, Knott GW, Lemaitre B.

mBio. 2016 Jul 26;7(4). pii: e00881-16. doi: 10.1128/mBio.00881-16.

39.

A crystallographic study of human NONO (p54(nrb)): overcoming pathological problems with purification, data collection and noncrystallographic symmetry.

Knott GJ, Panjikar S, Thorn A, Fox AH, Conte MR, Lee M, Bond CS.

Acta Crystallogr D Struct Biol. 2016 Jun;72(Pt 6):761-9. doi: 10.1107/S2059798316005830. Epub 2016 May 25.

40.

The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold.

Knott GJ, Bond CS, Fox AH.

Nucleic Acids Res. 2016 May 19;44(9):3989-4004. doi: 10.1093/nar/gkw271. Epub 2016 Apr 15.

41.

Correction: NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ.

Chem Commun (Camb). 2015 Nov 28;51(92):16577. doi: 10.1039/c5cc90487k.

PMID:
26507472
42.

Multi-Modal Optical Imaging of the Cerebellum in Animals.

Allegra Mascaro AL, Sacconi L, Silvestri L, Knott G, Pavone FS.

Cerebellum. 2016 Feb;15(1):18-20. doi: 10.1007/s12311-015-0730-4. Review.

PMID:
26476852
43.

Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function.

Knott GJ, Lee M, Passon DM, Fox AH, Bond CS.

Protein Sci. 2015 Dec;24(12):2033-43. doi: 10.1002/pro.2816. Epub 2015 Oct 29.

44.

NanoSIMS analysis of an isotopically labelled organometallic ruthenium(II) drug to probe its distribution and state in vitro.

Lee RF, Escrig S, Croisier M, Clerc-Rosset S, Knott GW, Meibom A, Davey CA, Johnsson K, Dyson PJ.

Chem Commun (Camb). 2015 Nov 28;51(92):16486-9. doi: 10.1039/c5cc06983a. Erratum in: Chem Commun (Camb). 2015 Nov 28;51(92):16577.

PMID:
26426486
45.

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose.

Takado Y, Knott G, Humbel BM, Masoodi M, Escrig S, Meibom A, Comment A.

J Chem Neuroanat. 2015 Nov;69:7-12. doi: 10.1016/j.jchemneu.2015.09.003. Epub 2015 Sep 25.

PMID:
26409162
46.

Training and Support of Sessional Staff to Improve Quality of Teaching and Learning at Universities.

Knott G, Crane L, Heslop I, Glass BD.

Am J Pharm Educ. 2015 Jun 25;79(5):72. doi: 10.5688/ajpe79572. Review.

47.

Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles.

Hennig S, Kong G, Mannen T, Sadowska A, Kobelke S, Blythe A, Knott GJ, Iyer KS, Ho D, Newcombe EA, Hosoki K, Goshima N, Kawaguchi T, Hatters D, Trinkle-Mulcahy L, Hirose T, Bond CS, Fox AH.

J Cell Biol. 2015 Aug 17;210(4):529-39. doi: 10.1083/jcb.201504117.

48.

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation.

Korogod N, Petersen CC, Knott GW.

Elife. 2015 Aug 11;4. doi: 10.7554/eLife.05793.

49.

Delayed and Temporally Imprecise Neurotransmission in Reorganizing Cortical Microcircuits.

Barnes SJ, Cheetham CE, Liu Y, Bennett SH, Albieri G, Jorstad AA, Knott GW, Finnerty GT.

J Neurosci. 2015 Jun 17;35(24):9024-37. doi: 10.1523/JNEUROSCI.4583-14.2015.

50.

Modeling brain circuitry over a wide range of scales.

Fua P, Knott GW.

Front Neuroanat. 2015 Apr 7;9:42. doi: 10.3389/fnana.2015.00042. eCollection 2015. Review.

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