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Items: 1 to 50 of 122

1.

Two pools of IRE1α in cardiac and skeletal muscle cells.

Wang Q, Groenendyk J, Paskevicius T, Qin W, Kor KC, Liu Y, Hiess F, Knollmann BC, Chen SRW, Tang J, Chen XZ, Agellon LB, Michalak M.

FASEB J. 2019 May 3:fj201802626R. doi: 10.1096/fj.201802626R. [Epub ahead of print]

PMID:
31051095
2.

Patient-independent human induced pluripotent stem cell model: A new tool for rapid determination of genetic variant pathogenicity in long QT syndrome.

Chavali NV, Kryshtal DO, Parikh SS, Wang L, Glazer AM, Blackwell DJ, Kroncke BM, Shoemaker MB, Knollmann BC.

Heart Rhythm. 2019 Apr 18. pii: S1547-5271(19)30360-1. doi: 10.1016/j.hrthm.2019.04.031. [Epub ahead of print]

PMID:
31004778
3.

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

Walweel K, Gomez-Hurtado N, Rebbeck RT, Oo YW, Beard NA, Molenaar P, Dos Remedios C, van Helden DF, Cornea RL, Knollmann BC, Laver DR.

J Mol Cell Cardiol. 2019 May;130:96-106. doi: 10.1016/j.yjmcc.2019.03.018. Epub 2019 Mar 27.

PMID:
30928430
4.

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.

Batiste SM, Blackwell DJ, Kim K, Kryshtal DO, Gomez-Hurtado N, Rebbeck RT, Cornea RL, Johnston JN, Knollmann BC.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):4810-4815. doi: 10.1073/pnas.1816685116. Epub 2019 Feb 21.

PMID:
30792355
5.

Association of Thyroid Function Genetic Predictors With Atrial Fibrillation: A Phenome-Wide Association Study and Inverse-Variance Weighted Average Meta-analysis.

Salem JE, Shoemaker MB, Bastarache L, Shaffer CM, Glazer AM, Kroncke B, Wells QS, Shi M, Straub P, Jarvik GP, Larson EB, Velez Edwards DR, Edwards TL, Davis LK, Hakonarson H, Weng C, Fasel D, Knollmann BC, Wang TJ, Denny JC, Ellinor PT, Roden DM, Mosley JD.

JAMA Cardiol. 2019 Jan 23. doi: 10.1001/jamacardio.2018.4615. [Epub ahead of print]

PMID:
30673079
6.

Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.

Prajapati R, Fujita T, Suita K, Nakamura T, Cai W, Hidaka Y, Umemura M, Yokoyama U, Knollmann BC, Okumura S, Ishikawa Y.

Circ J. 2019 Jan 25;83(2):295-303. doi: 10.1253/circj.CJ-18-0743. Epub 2018 Dec 6.

7.

Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice.

Dieseldorff Jones KM, Koh Y, Weller RS, Turna RS, Ahmad F, Huke S, Knollmann BC, Pinto JR, Hwang HS.

Arch Biochem Biophys. 2019 Jan;661:125-131. doi: 10.1016/j.abb.2018.11.006. Epub 2018 Nov 13.

PMID:
30445044
8.

Tetrodotoxin-sensitive Navs contribute to early and delayed afterdepolarizations in long QT arrhythmia models.

Koleske M, Bonilla I, Thomas J, Zaman N, Baine S, Knollmann BC, Veeraraghavan R, Györke S, Radwański PB.

J Gen Physiol. 2018 Jul 2;150(7):991-1002. doi: 10.1085/jgp.201711909. Epub 2018 May 23.

9.

Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia.

Liu B, Walton SD, Ho HT, Belevych AE, Tikunova SB, Bonilla I, Shettigar V, Knollmann BC, Priori SG, Volpe P, Radwański PB, Davis JP, Györke S.

J Am Heart Assoc. 2018 May 2;7(10). pii: e008155. doi: 10.1161/JAHA.117.008155.

10.

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL Jr, Chazin WJ.

Structure. 2018 May 1;26(5):683-694.e3. doi: 10.1016/j.str.2018.03.005. Epub 2018 Apr 5.

11.

Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice.

Suita K, Fujita T, Cai W, Hidaka Y, Jin H, Prajapati R, Umemura M, Yokoyama U, Sato M, Knollmann BC, Okumura S, Ishikawa Y.

Pflugers Arch. 2018 Jun;470(6):923-935. doi: 10.1007/s00424-018-2121-4. Epub 2018 Feb 16.

PMID:
29453615
12.

Conditional ablation and conditional rescue models for Casq2 elucidate the role of development and of cell-type specific expression of Casq2 in the CPVT2 phenotype.

Flores DJ, Duong T, Brandenberger LO, Mitra A, Shirali A, Johnson JC, Springer D, Noguchi A, Yu ZX, Ebert SN, Ludwig A, Knollmann BC, Levin MD, Pfeifer K.

Hum Mol Genet. 2018 May 1;27(9):1533-1544. doi: 10.1093/hmg/ddy060.

13.

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

Wang L, Kim K, Parikh S, Cadar AG, Bersell KR, He H, Pinto JR, Kryshtal DO, Knollmann BC.

J Mol Cell Cardiol. 2018 Jan;114:320-327. doi: 10.1016/j.yjmcc.2017.12.002. Epub 2017 Dec 5.

14.

Myofilament Calcium-Buffering Dependent Action Potential Triangulation in Human-Induced Pluripotent Stem Cell Model of Hypertrophic Cardiomyopathy.

Wang L, Kryshtal DO, Kim K, Parikh S, Cadar AG, Bersell KR, He H, Pinto JR, Knollmann BC.

J Am Coll Cardiol. 2017 Nov 14;70(20):2600-2602. doi: 10.1016/j.jacc.2017.09.033. No abstract available.

15.

Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension.

Barbaro NR, Foss JD, Kryshtal DO, Tsyba N, Kumaresan S, Xiao L, Mernaugh RL, Itani HA, Loperena R, Chen W, Dikalov S, Titze JM, Knollmann BC, Harrison DG, Kirabo A.

Cell Rep. 2017 Oct 24;21(4):1009-1020. doi: 10.1016/j.celrep.2017.10.002.

16.

Accentuated vagal antagonism paradoxically increases ryanodine receptor calcium leak in long-term exercised Calsequestrin2 knockout mice.

Ho HT, Thambidorai S, Knollmann BC, Billman GE, Györke S, Kalyanasundaram A.

Heart Rhythm. 2018 Mar;15(3):430-441. doi: 10.1016/j.hrthm.2017.10.008. Epub 2017 Oct 10.

17.

Thyroid and Glucocorticoid Hormones Promote Functional T-Tubule Development in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Parikh SS, Blackwell DJ, Gomez-Hurtado N, Frisk M, Wang L, Kim K, Dahl CP, Fiane A, Tønnessen T, Kryshtal DO, Louch WE, Knollmann BC.

Circ Res. 2017 Dec 8;121(12):1323-1330. doi: 10.1161/CIRCRESAHA.117.311920. Epub 2017 Oct 2.

18.

Calmodulin Mutants Linked to Catecholaminergic Polymorphic Ventricular Tachycardia Fail to Inhibit Human RyR2 Channels.

Walweel K, Gomez-Hurtado N, Oo YW, Beard NA, Dos Remedios C, Johnson CN, Chazin WJ, van Helden DF, Knollmann BC, Laver DR.

J Am Coll Cardiol. 2017 Jul 4;70(1):115-117. doi: 10.1016/j.jacc.2017.04.055. No abstract available.

19.

Cardiac regulatory mechanisms: new concepts and challenges.

Knollmann BC.

J Physiol. 2017 Jun 15;595(12):3683-3684. doi: 10.1113/JP274290. No abstract available.

20.

Efficacy of Flecainide in the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia: A Randomized Clinical Trial.

Kannankeril PJ, Moore JP, Cerrone M, Priori SG, Kertesz NJ, Ro PS, Batra AS, Kaufman ES, Fairbrother DL, Saarel EV, Etheridge SP, Kanter RJ, Carboni MP, Dzurik MV, Fountain D, Chen H, Ely EW, Roden DM, Knollmann BC.

JAMA Cardiol. 2017 Jul 1;2(7):759-766. doi: 10.1001/jamacardio.2017.1320.

21.

Azithromycin Causes a Novel Proarrhythmic Syndrome.

Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL Jr, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT.

Circ Arrhythm Electrophysiol. 2017 Apr;10(4). pii: e003560. doi: 10.1161/CIRCEP.115.003560.

22.

Modelling human calmodulinopathies with induced pluripotent stem cells: progress and challenges.

Gomez-Hurtado N, Blackwell DJ, Knollmann BC.

Cardiovasc Res. 2017 Apr 1;113(5):437-439. doi: 10.1093/cvr/cvx041. No abstract available.

23.

Clinical phenotype of HCN4-related sick sinus syndrome.

Raucci FJ Jr, Shoemaker MB, Knollmann BC.

Heart Rhythm. 2017 May;14(5):725-726. doi: 10.1016/j.hrthm.2017.02.006. Epub 2017 Feb 14. No abstract available.

PMID:
28213054
24.

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart.

Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM.

J Am Heart Assoc. 2016 Nov 2;5(11). pii: e002946.

25.

Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.

Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA.

Cancer Prev Res (Phila). 2016 Nov;9(11):855-865. Epub 2016 Aug 23.

26.

Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.

Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S.

JACC Basic Transl Sci. 2016 Jun;1(4):251-266.

27.

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.

Gomez-Hurtado N, Boczek NJ, Kryshtal DO, Johnson CN, Sun J, Nitu FR, Cornea RL, Chazin WJ, Calvert ML, Tester DJ, Ackerman MJ, Knollmann BC.

Circ Arrhythm Electrophysiol. 2016 Aug;9(8). pii: e004161. doi: 10.1161/CIRCEP.116.004161.

28.

Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.

Hill AP, Perry MD, Abi-Gerges N, Couderc JP, Fermini B, Hancox JC, Knollmann BC, Mirams GR, Skinner J, Zareba W, Vandenberg JI.

J Physiol. 2016 Dec 1;594(23):6893-6908. doi: 10.1113/JP272015. Epub 2016 Jun 9.

29.

Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.

Boczek NJ, Gomez-Hurtado N, Ye D, Calvert ML, Tester DJ, Kryshtal D, Hwang HS, Johnson CN, Chazin WJ, Loporcaro CG, Shah M, Papez AL, Lau YR, Kanter R, Knollmann BC, Ackerman MJ.

Circ Cardiovasc Genet. 2016 Apr;9(2):136-146. doi: 10.1161/CIRCGENETICS.115.001323. Epub 2016 Mar 11.

30.

Human induced pluripotent stem cell (hiPSC) derived cardiomyocytes to understand and test cardiac calcium handling: A glass half full.

Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC, Knollmann BC.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):379-80. doi: 10.1016/j.yjmcc.2015.10.021. No abstract available.

PMID:
26695095
31.

In Vitro Studies Indicate Intravenous Lipid Emulsion Acts as Lipid Sink in Verapamil Poisoning.

Kryshtal DO, Dawling S, Seger D, Knollmann BC.

J Med Toxicol. 2016 Jun;12(2):165-71. doi: 10.1007/s13181-015-0511-y.

32.

Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Feaster TK, Cadar AG, Wang L, Williams CH, Chun YW, Hempel JE, Bloodworth N, Merryman WD, Lim CC, Wu JC, Knollmann BC, Hong CC.

Circ Res. 2015 Dec 4;117(12):995-1000. doi: 10.1161/CIRCRESAHA.115.307580. Epub 2015 Oct 1.

33.

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.

Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Györke S.

Cardiovasc Res. 2015 Nov 1;108(2):299-311. doi: 10.1093/cvr/cvv222. Epub 2015 Sep 25.

34.

Arrhythmia Protection in Hypokalemia: A Novel Role of Ca2+-Activated K+ Currents in the Ventricle.

Faggioni M, Knollmann BC.

Circulation. 2015 Oct 13;132(15):1371-3. doi: 10.1161/CIRCULATIONAHA.115.018874. Epub 2015 Sep 11. No abstract available.

35.
36.

Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories.

Hwang HS, Kryshtal DO, Feaster TK, Sánchez-Freire V, Zhang J, Kamp TJ, Hong CC, Wu JC, Knollmann BC.

J Mol Cell Cardiol. 2015 Aug;85:79-88. doi: 10.1016/j.yjmcc.2015.05.003. Epub 2015 May 14.

37.

Essential Role of Calmodulin in RyR Inhibition by Dantrolene.

Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR.

Mol Pharmacol. 2015 Jul;88(1):57-63. doi: 10.1124/mol.115.097691. Epub 2015 Apr 28.

38.

Impaired calcium-calmodulin-dependent inactivation of Cav1.2 contributes to loss of sarcoplasmic reticulum calcium release refractoriness in mice lacking calsequestrin 2.

Kryshtal DO, Gryshchenko O, Gomez-Hurtado N, Knollmann BC.

J Mol Cell Cardiol. 2015 May;82:75-83. doi: 10.1016/j.yjmcc.2015.02.027. Epub 2015 Mar 7.

39.

Research priorities in sarcomeric cardiomyopathies.

van der Velden J, Ho CY, Tardiff JC, Olivotto I, Knollmann BC, Carrier L.

Cardiovasc Res. 2015 Apr 1;105(4):449-56. doi: 10.1093/cvr/cvv019. Epub 2015 Jan 28. Review.

40.

Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes.

Eschenhagen T, Mummery C, Knollmann BC.

Cardiovasc Res. 2015 Apr 1;105(4):424-38. doi: 10.1093/cvr/cvv017. Epub 2015 Jan 24. Review.

41.

Alternating membrane potential/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias.

Lou Q, Belevych AE, Radwański PB, Liu B, Kalyanasundaram A, Knollmann BC, Fedorov VV, Györke S.

J Physiol. 2015 Mar 15;593(6):1443-58. doi: 10.1113/jphysiol.2014.280784. Epub 2014 Dec 2.

42.

Calcium in atrial fibrillation - pulling the trigger or not?

Gomez-Hurtado N, Knollmann BC.

J Clin Invest. 2014 Nov;124(11):4684-6. doi: 10.1172/JCI77986. Epub 2014 Oct 20.

43.

Multiple modes of ryanodine receptor 2 inhibition by flecainide.

Mehra D, Imtiaz MS, van Helden DF, Knollmann BC, Laver DR.

Mol Pharmacol. 2014 Dec;86(6):696-706. doi: 10.1124/mol.114.094623. Epub 2014 Oct 1.

44.

Sinus node dysfunction in catecholaminergic polymorphic ventricular tachycardia: risk factor and potential therapeutic target?

Faggioni M, van der Werf C, Knollmann BC.

Trends Cardiovasc Med. 2014 Oct;24(7):273-8. doi: 10.1016/j.tcm.2014.07.001. Epub 2014 Jul 10. Review.

45.

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM.

Circulation. 2014 Jul 15;130(3):224-34. doi: 10.1161/CIRCULATIONAHA.113.007765. Epub 2014 Jun 3.

46.

Divergent regulation of ryanodine receptor 2 calcium release channels by arrhythmogenic human calmodulin missense mutants.

Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, Faggioni M, Chazin WJ, Laver D, George AL Jr, Cornea RL, Bers DM, Knollmann BC.

Circ Res. 2014 Mar 28;114(7):1114-24. doi: 10.1161/CIRCRESAHA.114.303391. Epub 2014 Feb 21.

47.

Suppression of spontaneous ca elevations prevents atrial fibrillation in calsequestrin 2-null hearts.

Faggioni M, Savio-Galimberti E, Venkataraman R, Hwang HS, Kannankeril PJ, Darbar D, Knollmann BC.

Circ Arrhythm Electrophysiol. 2014 Apr;7(2):313-20. doi: 10.1161/CIRCEP.113.000994. Epub 2014 Feb 3.

48.

Genetic ablation of ryanodine receptor 2 phosphorylation at Ser-2808 aggravates Ca(2+)-dependent cardiomyopathy by exacerbating diastolic Ca2+ release.

Liu B, Ho HT, Velez-Cortes F, Lou Q, Valdivia CR, Knollmann BC, Valdivia HH, Gyorke S.

J Physiol. 2014 May 1;592(9):1957-73. doi: 10.1113/jphysiol.2013.264689. Epub 2014 Jan 20.

49.

Dantrolene: from better bacon to a treatment for ventricular fibrillation.

Roden DM, Knollmann BC.

Circulation. 2014 Feb 25;129(8):834-6. doi: 10.1161/CIRCULATIONAHA.113.007657. Epub 2014 Jan 8. No abstract available.

50.

Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.

Glukhov AV, Kalyanasundaram A, Lou Q, Hage LT, Hansen BJ, Belevych AE, Mohler PJ, Knollmann BC, Periasamy M, Györke S, Fedorov VV.

Eur Heart J. 2015 Mar 14;36(11):686-97. doi: 10.1093/eurheartj/eht452. Epub 2013 Nov 11.

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