Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 117

1.

Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Kosinska AD, Moeed A, Kallin N, Festag J, Su J, Steiger K, Michel ML, Protzer U, Knolle PA.

Sci Rep. 2019 Jul 25;9(1):10808. doi: 10.1038/s41598-019-47149-w.

2.

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D.

Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17.

PMID:
31207605
3.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.

PMID:
30936549
4.

The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production.

Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp LC, Knolle PA, Kolanus W, Diehl L.

Sci Rep. 2018 Oct 31;8(1):16123. doi: 10.1038/s41598-018-34522-4.

5.

[Histopathological research laboratories in translational research : Conception and integration into the infrastructure of pathological institutes].

Steiger K, Ballke S, Yen HY, Seelbach O, Alkhamas A, Boxberg M, Schwamborn K, Knolle PA, Weichert W, Mogler C.

Pathologe. 2019 Mar;40(2):172-178. doi: 10.1007/s00292-018-0458-2. German.

PMID:
30027333
6.

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D.

Hepatology. 2018 Dec;68(6):2089-2105. doi: 10.1002/hep.30080. Epub 2018 Sep 27.

7.

Interfering with Kupffer cell replenishment: New insights into liver injury.

Alazawi W, Knolle PA.

J Hepatol. 2018 Apr;68(4):635-637. doi: 10.1016/j.jhep.2018.01.011. Epub 2018 Feb 17. No abstract available.

PMID:
29463431
8.

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.

Cell Rep. 2017 Oct 17;21(3):578-586. doi: 10.1016/j.celrep.2017.09.082.

9.

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination.

Heine A, Flores C, Gevensleben H, Diehl L, Heikenwalder M, Ringelhan M, Janssen KP, Nitsche U, Garbi N, Brossart P, Knolle PA, Kurts C, Höchst B.

Oncoimmunology. 2017 Jun 16;6(8):e1338995. doi: 10.1080/2162402X.2017.1338995. eCollection 2017.

10.

Liver macrophages in healthy and diseased liver.

Abdullah Z, Knolle PA.

Pflugers Arch. 2017 Apr;469(3-4):553-560. doi: 10.1007/s00424-017-1954-6. Epub 2017 Mar 14. Review.

PMID:
28293730
11.

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.

12.

Checkpoint Inhibition in Head and Neck Cancer: Immune Therapeutic Options, Limitations, and Beyond.

Höchst B, Knolle PA.

ORL J Otorhinolaryngol Relat Spec. 2017;79(1-2):24-33. doi: 10.1159/000455810. Epub 2017 Feb 24. Review.

PMID:
28231588
13.

Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction.

Beuke K, Schildberg FA, Pinna F, Albrecht U, Liebe R, Bissinger M, Schirmacher P, Dooley S, Bode JG, Knolle PA, Kummer U, Breuhahn K, Sahle S.

FEBS J. 2017 Mar;284(5):796-813. doi: 10.1111/febs.14022. Epub 2017 Feb 17.

14.

The role of liver sinusoidal cells in local hepatic immune surveillance.

Wohlleber D, Knolle PA.

Clin Transl Immunology. 2016 Dec 9;5(12):e117. doi: 10.1038/cti.2016.74. eCollection 2016 Dec. Review.

15.

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle PA, Wohlleber D.

J Hepatol. 2017 May;66(5):978-986. doi: 10.1016/j.jhep.2016.12.015. Epub 2016 Dec 23.

PMID:
28025060
16.

Hitting the right button: MAVS-mediated defense against HAV infection.

Knolle PA.

Cell Res. 2017 Jan;27(1):7-8. doi: 10.1038/cr.2016.139. Epub 2016 Nov 25.

17.

Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. Epub 2016 Sep 6.

18.

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.

Bauernfeind F, Niepmann S, Knolle PA, Hornung V.

J Immunol. 2016 Oct 1;197(7):2900-8. doi: 10.4049/jimmunol.1501336. Epub 2016 Aug 26.

19.

Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z.

Gut. 2017 Mar;66(3):507-518. doi: 10.1136/gutjnl-2015-311224. Epub 2016 Jul 18.

PMID:
27432540
20.

Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.

Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M.

EMBO J. 2016 Aug 15;35(16):1730-44. doi: 10.15252/embj.201693801. Epub 2016 Jul 13.

21.

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.

Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.

Kidney Int. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035. Epub 2016 Jun 2.

PMID:
27262364
22.

Immunological functions of liver sinusoidal endothelial cells.

Knolle PA, Wohlleber D.

Cell Mol Immunol. 2016 May;13(3):347-53. doi: 10.1038/cmi.2016.5. Epub 2016 Apr 4. Review.

23.

Staying local-antigen presentation in the liver.

Knolle PA.

Curr Opin Immunol. 2016 Jun;40:36-42. doi: 10.1016/j.coi.2016.02.009. Epub 2016 Mar 12. Review.

PMID:
26974478
24.

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.

Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.

PMID:
26950238
25.

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity.

Rietscher R, Schröder M, Janke J, Czaplewska J, Gottschaldt M, Scherließ R, Hanefeld A, Schubert US, Schneider M, Knolle PA, Lehr CM.

Eur J Pharm Biopharm. 2016 May;102:20-31. doi: 10.1016/j.ejpb.2016.02.014. Epub 2016 Mar 2.

PMID:
26940132
26.

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.

Siegmund SV, Schlosser M, Schildberg FA, Seki E, De Minicis S, Uchinami H, Kuntzen C, Knolle PA, Strassburg CP, Schwabe RF.

PLoS One. 2016 Mar 3;11(3):e0150893. doi: 10.1371/journal.pone.0150893. eCollection 2016.

27.

Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.

Siegmund SV, Wojtalla A, Schlosser M, Schildberg FA, Knolle PA, Nüsing RM, Zimmer A, Strassburg CP, Singer MV.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):678-684. doi: 10.1016/j.bbrc.2016.01.083. Epub 2016 Jan 20.

PMID:
26801558
28.

Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA.

Nat Commun. 2015 Sep 25;6:8306. doi: 10.1038/ncomms9306.

29.

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice.

Kobuch J, Cui H, Grünwald B, Saftig P, Knolle PA, Krüger A.

Haematologica. 2015 Aug;100(8):1005-13. doi: 10.3324/haematol.2014.121590. Epub 2015 May 22.

30.

Global transcriptional characterization of CD8+ T cell memory.

Böttcher J, Knolle PA.

Semin Immunol. 2015 Feb;27(1):4-9. doi: 10.1016/j.smim.2015.03.001. Epub 2015 Apr 2. Review.

PMID:
25841628
31.

IAP antagonization promotes inflammatory destruction of vascular endothelium.

Witt A, Seeger JM, Coutelle O, Zigrino P, Broxtermann P, Andree M, Brinkmann K, Jüngst C, Schauss AC, Schüll S, Wohlleber D, Knolle PA, Krönke M, Mauch C, Kashkar H.

EMBO Rep. 2015 Jun;16(6):719-27. doi: 10.15252/embr.201439616. Epub 2015 Mar 30.

32.

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

Zeisel MB, Lucifora J, Mason WS, Sureau C, Beck J, Levrero M, Kann M, Knolle PA, Benkirane M, Durantel D, Michel ML, Autran B, Cosset FL, Strick-Marchand H, Trépo C, Kao JH, Carrat F, Lacombe K, Schinazi RF, Barré-Sinoussi F, Delfraissy JF, Zoulim F.

Gut. 2015 Aug;64(8):1314-26. doi: 10.1136/gutjnl-2014-308943. Epub 2015 Feb 10. Review.

PMID:
25670809
33.

The role of hepatic immune regulation in systemic immunity to viral infection.

Knolle PA, Böttcher J, Huang LR.

Med Microbiol Immunol. 2015 Feb;204(1):21-7. doi: 10.1007/s00430-014-0371-0. Epub 2014 Dec 19. Review.

PMID:
25523194
34.

Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection.

Lang PA, Meryk A, Pandyra AA, Brenner D, Brüstle A, Xu HC, Merches K, Lang F, Khairnar V, Sharma P, Funkner P, Recher M, Shaabani N, Duncan GS, Duhan V, Homey B, Ohashi PS, Häussinger D, Knolle PA, Honke N, Mak TW, Lang KS.

Cell Death Differ. 2015 Jan;22(1):164-73. doi: 10.1038/cdd.2014.138. Epub 2014 Sep 26.

35.

Scaling of immune responses against intracellular bacterial infection.

Abdullah Z, Knolle PA.

EMBO J. 2014 Oct 16;33(20):2283-94. doi: 10.15252/embj.201489055. Epub 2014 Sep 15. Review.

36.

IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function.

Böttcher JP, Schanz O, Garbers C, Zaremba A, Hegenbarth S, Kurts C, Beyer M, Schultze JL, Kastenmüller W, Rose-John S, Knolle PA.

Cell Rep. 2014 Sep 11;8(5):1318-27. doi: 10.1016/j.celrep.2014.07.008. Epub 2014 Sep 4.

37.

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Seubert B, Grünwald B, Kobuch J, Cui H, Schelter F, Schaten S, Siveke JT, Lim NH, Nagase H, Simonavicius N, Heikenwalder M, Reinheckel T, Sleeman JP, Janssen KP, Knolle PA, Krüger A.

Hepatology. 2015 Jan;61(1):238-48. doi: 10.1002/hep.27378. Epub 2014 Nov 24.

38.

Liver sinusoidal endothelial cell-mediated CD8 T cell priming depends on co-inhibitory signal integration over time.

Kaczmarek J, Homsi Y, van Üüm J, Metzger C, Knolle PA, Kolanus W, Lang T, Diehl L.

PLoS One. 2014 Jun 12;9(6):e99574. doi: 10.1371/journal.pone.0099574. eCollection 2014.

39.

Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance.

Schölzel K, Schildberg FA, Welz M, Börner C, Geiger S, Kurts C, Heikenwälder M, Knolle PA, Wohlleber D.

J Hepatol. 2014 Sep;61(3):600-8. doi: 10.1016/j.jhep.2014.04.028. Epub 2014 May 4.

PMID:
24798625
40.

Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium.

Schiwon M, Weisheit C, Franken L, Gutweiler S, Dixit A, Meyer-Schwesinger C, Pohl JM, Maurice NJ, Thiebes S, Lorenz K, Quast T, Fuhrmann M, Baumgarten G, Lohse MJ, Opdenakker G, Bernhagen J, Bucala R, Panzer U, Kolanus W, Gröne HJ, Garbi N, Kastenmüller W, Knolle PA, Kurts C, Engel DR.

Cell. 2014 Jan 30;156(3):456-68. doi: 10.1016/j.cell.2014.01.006.

41.

Hepatic immune regulation and its involvement in viral hepatitis infection.

Knolle PA, Thimme R.

Gastroenterology. 2014 May;146(5):1193-207. doi: 10.1053/j.gastro.2013.12.036. Epub 2014 Jan 8. Review.

PMID:
24412289
42.

Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression.

Hochheiser K, Heuser C, Krause TA, Teteris S, Ilias A, Weisheit C, Hoss F, Tittel AP, Knolle PA, Panzer U, Engel DR, Tharaux PL, Kurts C.

J Clin Invest. 2013 Oct;123(10):4242-54. doi: 10.1172/JCI70143. Epub 2013 Sep 3.

43.

Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion.

Höchst B, Schildberg FA, Sauerborn P, Gäbel YA, Gevensleben H, Goltz D, Heukamp LC, Türler A, Ballmaier M, Gieseke F, Müller I, Kalff J, Kurts C, Knolle PA, Diehl L.

J Hepatol. 2013 Sep;59(3):528-35. doi: 10.1016/j.jhep.2013.04.033. Epub 2013 May 9.

PMID:
23665041
44.

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection.

Huang LR, Wohlleber D, Reisinger F, Jenne CN, Cheng RL, Abdullah Z, Schildberg FA, Odenthal M, Dienes HP, van Rooijen N, Schmitt E, Garbi N, Croft M, Kurts C, Kubes P, Protzer U, Heikenwalder M, Knolle PA.

Nat Immunol. 2013 Jun;14(6):574-83. doi: 10.1038/ni.2573. Epub 2013 Apr 14.

PMID:
23584070
45.

Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity.

Böttcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A, Höchst B, Hegenbarth S, Grell J, Limmer A, Atreya I, Neurath MF, Busch DH, Schmitt E, van Endert P, Kolanus W, Kurts C, Schultze JL, Diehl L, Knolle PA.

Cell Rep. 2013 Mar 28;3(3):779-95. doi: 10.1016/j.celrep.2013.02.008. Epub 2013 Mar 14.

46.

Batf3-dependent dendritic cells in the renal lymph node induce tolerance against circulating antigens.

Gottschalk C, Damuzzo V, Gotot J, Kroczek RA, Yagita H, Murphy KM, Knolle PA, Ludwig-Portugall I, Kurts C.

J Am Soc Nephrol. 2013 Mar;24(4):543-9. doi: 10.1681/ASN.2012101022. Epub 2013 Feb 14.

47.

Antiproliferative effects of selective adenosine receptor agonists and antagonists on human lymphocytes: evidence for receptor-independent mechanisms.

Schiedel AC, Lacher SK, Linnemann C, Knolle PA, Müller CE.

Purinergic Signal. 2013 Sep;9(3):351-65. doi: 10.1007/s11302-013-9354-7. Epub 2013 Jan 29.

48.

RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids.

Abdullah Z, Schlee M, Roth S, Mraheil MA, Barchet W, Böttcher J, Hain T, Geiger S, Hayakawa Y, Fritz JH, Civril F, Hopfner KP, Kurts C, Ruland J, Hartmann G, Chakraborty T, Knolle PA.

EMBO J. 2012 Nov 5;31(21):4153-64. doi: 10.1038/emboj.2012.274. Epub 2012 Oct 12.

49.

NLRP3 inflammasome activity is negatively controlled by miR-223.

Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V.

J Immunol. 2012 Oct 15;189(8):4175-81. doi: 10.4049/jimmunol.1201516. Epub 2012 Sep 14.

50.

TNF-induced target cell killing by CTL activated through cross-presentation.

Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA.

Cell Rep. 2012 Sep 27;2(3):478-87. doi: 10.1016/j.celrep.2012.08.001. Epub 2012 Aug 30.

Supplemental Content

Loading ...
Support Center