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Items: 1 to 50 of 218

1.

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M.

Cancer Cell. 2019 Sep 16;36(3):250-267.e9. doi: 10.1016/j.ccell.2019.08.001.

PMID:
31526758
2.

Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection.

Kosinska AD, Moeed A, Kallin N, Festag J, Su J, Steiger K, Michel ML, Protzer U, Knolle PA.

Sci Rep. 2019 Jul 25;9(1):10808. doi: 10.1038/s41598-019-47149-w.

3.

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection.

Alfei F, Kanev K, Hofmann M, Wu M, Ghoneim HE, Roelli P, Utzschneider DT, von Hoesslin M, Cullen JG, Fan Y, Eisenberg V, Wohlleber D, Steiger K, Merkler D, Delorenzi M, Knolle PA, Cohen CJ, Thimme R, Youngblood B, Zehn D.

Nature. 2019 Jul;571(7764):265-269. doi: 10.1038/s41586-019-1326-9. Epub 2019 Jun 17.

PMID:
31207605
4.

Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.

Schneider A, Kurz S, Manske K, Janas M, Heikenwälder M, Misgeld T, Aichler M, Weissmann SF, Zischka H, Knolle P, Wohlleber D.

Sci Rep. 2019 Jun 11;9(1):8492. doi: 10.1038/s41598-019-44922-9.

5.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard BGJ, Rath D, Ali A, Wolf MJ, Drescher H, Healy ME, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O'Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A, Heikenwalder M.

Nat Med. 2019 Apr;25(4):641-655. doi: 10.1038/s41591-019-0379-5. Epub 2019 Apr 1.

PMID:
30936549
6.

Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment.

Matthias J, Maul J, Noster R, Meinl H, Chao YY, Gerstenberg H, Jeschke F, Gasparoni G, Welle A, Walter J, Nordström K, Eberhardt K, Renisch D, Donakonda S, Knolle P, Soll D, Grabbe S, Garzorz-Stark N, Eyerich K, Biedermann T, Baumjohann D, Zielinski CE.

Sci Transl Med. 2019 Feb 20;11(480). pii: eaau0683. doi: 10.1126/scitranslmed.aau0683.

PMID:
30787167
7.

Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis.

Welz M, Eickhoff S, Abdullah Z, Trebicka J, Gartlan KH, Spicer JA, Demetris AJ, Akhlaghi H, Anton M, Manske K, Zehn D, Nieswandt B, Kurts C, Trapani JA, Knolle P, Wohlleber D, Kastenmüller W.

Nat Commun. 2018 Nov 15;9(1):4805. doi: 10.1038/s41467-018-07213-x.

8.

The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production.

Tolksdorf F, Mikulec J, Geers B, Endig J, Sprezyna P, Heukamp LC, Knolle PA, Kolanus W, Diehl L.

Sci Rep. 2018 Oct 31;8(1):16123. doi: 10.1038/s41598-018-34522-4.

9.

Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity.

Knier B, Hiltensperger M, Sie C, Aly L, Lepennetier G, Engleitner T, Garg G, Muschaweckh A, Mitsdörffer M, Koedel U, Höchst B, Knolle P, Gunzer M, Hemmer B, Rad R, Merkler D, Korn T.

Nat Immunol. 2018 Dec;19(12):1341-1351. doi: 10.1038/s41590-018-0237-5. Epub 2018 Oct 29.

10.

[Histopathological research laboratories in translational research : Conception and integration into the infrastructure of pathological institutes].

Steiger K, Ballke S, Yen HY, Seelbach O, Alkhamas A, Boxberg M, Schwamborn K, Knolle PA, Weichert W, Mogler C.

Pathologe. 2019 Mar;40(2):172-178. doi: 10.1007/s00292-018-0458-2. German.

PMID:
30027333
11.

Outcome of Antiviral Immunity in the Liver Is Shaped by the Level of Antigen Expressed in Infected Hepatocytes.

Manske K, Kallin N, König V, Schneider A, Kurz S, Bosch M, Welz M, Cheng RL, Bengsch B, Steiger K, Protzer U, Thimme R, Knolle PA, Wohlleber D.

Hepatology. 2018 Dec;68(6):2089-2105. doi: 10.1002/hep.30080. Epub 2018 Sep 27.

12.

Interfering with Kupffer cell replenishment: New insights into liver injury.

Alazawi W, Knolle PA.

J Hepatol. 2018 Apr;68(4):635-637. doi: 10.1016/j.jhep.2018.01.011. Epub 2018 Feb 17. No abstract available.

PMID:
29463431
13.

Primary tumor-associated expression of CXCR4 predicts formation of local and systemic recurrency in head and neck squamous cell carcinoma.

Knopf A, Bahadori L, Fritsche K, Piontek G, Becker CC, Knolle P, Krüger A, Bier H, Li Y.

Oncotarget. 2017 Nov 20;8(68):112739-112747. doi: 10.18632/oncotarget.22562. eCollection 2017 Dec 22.

14.

Tumor Necrosis Factor-Mediated Survival of CD169+ Cells Promotes Immune Activation during Vesicular Stomatitis Virus Infection.

Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA.

J Virol. 2018 Jan 17;92(3). pii: e01637-17. doi: 10.1128/JVI.01637-17. Print 2018 Feb 1.

15.

Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells.

Heuser C, Gotot J, Piotrowski EC, Philipp MS, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C.

Cell Rep. 2017 Oct 17;21(3):578-586. doi: 10.1016/j.celrep.2017.09.082.

16.

Liver X receptor activation promotes differentiation of regulatory T cells.

Herold M, Breuer J, Hucke S, Knolle P, Schwab N, Wiendl H, Klotz L.

PLoS One. 2017 Sep 19;12(9):e0184985. doi: 10.1371/journal.pone.0184985. eCollection 2017.

17.

Targeting myeloid derived suppressor cells with all-trans retinoic acid is highly time-dependent in therapeutic tumor vaccination.

Heine A, Flores C, Gevensleben H, Diehl L, Heikenwalder M, Ringelhan M, Janssen KP, Nitsche U, Garbi N, Brossart P, Knolle PA, Kurts C, Höchst B.

Oncoimmunology. 2017 Jun 16;6(8):e1338995. doi: 10.1080/2162402X.2017.1338995. eCollection 2017.

18.

Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation.

Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N.

J Allergy Clin Immunol. 2018 Jan;141(1):416-419.e10. doi: 10.1016/j.jaci.2017.06.048. Epub 2017 Aug 19. No abstract available.

PMID:
28826775
19.

Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS.

Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, Ringelhan M, Connor TO, Stadler M, Meister M, Weber J, Öllinger R, Simonavicius N, Reisinger F, Hartmann D, Meyer R, Reich M, Seehawer M, Leone V, Höchst B, Wohlleber D, Jörs S, Prinz M, Spalding D, Protzer U, Luedde T, Terracciano L, Matter M, Longerich T, Knolle P, Ried T, Keitel V, Geisler F, Unger K, Cinnamon E, Pikarsky E, Hüser N, Davis RJ, Tschaharganeh DF, Rad R, Weber A, Zender L, Haller D, Heikenwalder M.

Cancer Cell. 2017 Jun 12;31(6):771-789.e6. doi: 10.1016/j.ccell.2017.05.006.

20.

TCF1+ hepatitis C virus-specific CD8+ T cells are maintained after cessation of chronic antigen stimulation.

Wieland D, Kemming J, Schuch A, Emmerich F, Knolle P, Neumann-Haefelin C, Held W, Zehn D, Hofmann M, Thimme R.

Nat Commun. 2017 May 3;8:15050. doi: 10.1038/ncomms15050.

21.

Liver macrophages in healthy and diseased liver.

Abdullah Z, Knolle PA.

Pflugers Arch. 2017 Apr;469(3-4):553-560. doi: 10.1007/s00424-017-1954-6. Epub 2017 Mar 14. Review.

PMID:
28293730
22.

Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.

Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Müller AJ, Gruber AD, Knolle P, Guzman CA, Bruder D.

Sci Rep. 2017 Mar 7;7:43985. doi: 10.1038/srep43985.

23.

Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.

24.

Checkpoint Inhibition in Head and Neck Cancer: Immune Therapeutic Options, Limitations, and Beyond.

Höchst B, Knolle PA.

ORL J Otorhinolaryngol Relat Spec. 2017;79(1-2):24-33. doi: 10.1159/000455810. Epub 2017 Feb 24. Review.

PMID:
28231588
25.

Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction.

Beuke K, Schildberg FA, Pinna F, Albrecht U, Liebe R, Bissinger M, Schirmacher P, Dooley S, Bode JG, Knolle PA, Kummer U, Breuhahn K, Sahle S.

FEBS J. 2017 Mar;284(5):796-813. doi: 10.1111/febs.14022. Epub 2017 Feb 17.

26.

The role of liver sinusoidal cells in local hepatic immune surveillance.

Wohlleber D, Knolle PA.

Clin Transl Immunology. 2016 Dec 9;5(12):e117. doi: 10.1038/cti.2016.74. eCollection 2016 Dec. Review.

27.

Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2.

Wittlich M, Dudek M, Böttcher JP, Schanz O, Hegenbarth S, Bopp T, Schmitt E, Kurts C, Garbers C, Rose John S, Knolle PA, Wohlleber D.

J Hepatol. 2017 May;66(5):978-986. doi: 10.1016/j.jhep.2016.12.015. Epub 2016 Dec 23.

PMID:
28025060
28.

Hitting the right button: MAVS-mediated defense against HAV infection.

Knolle PA.

Cell Res. 2017 Jan;27(1):7-8. doi: 10.1038/cr.2016.139. Epub 2016 Nov 25.

29.

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow.

Grünwald B, Vandooren J, Gerg M, Ahomaa K, Hunger A, Berchtold S, Akbareian S, Schaten S, Knolle P, Edwards DR, Opdenakker G, Krüger A.

Mol Cancer Res. 2016 Nov;14(11):1147-1158. Epub 2016 Aug 3.

30.

"To Be or Not to Be": Immune Tolerance in Chronic Hepatitis B.

Protzer U, Knolle P.

Gastroenterology. 2016 Nov;151(5):805-806. doi: 10.1053/j.gastro.2016.09.038. Epub 2016 Oct 1. No abstract available.

PMID:
27702560
31.

Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4.

Schuette V, Embgenbroich M, Ulas T, Welz M, Schulte-Schrepping J, Draffehn AM, Quast T, Koch K, Nehring M, König J, Zweynert A, Harms FL, Steiner N, Limmer A, Förster I, Berberich-Siebelt F, Knolle PA, Wohlleber D, Kolanus W, Beyer M, Schultze JL, Burgdorf S.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10649-54. doi: 10.1073/pnas.1605885113. Epub 2016 Sep 6.

32.

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances.

Bauernfeind F, Niepmann S, Knolle PA, Hornung V.

J Immunol. 2016 Oct 1;197(7):2900-8. doi: 10.4049/jimmunol.1501336. Epub 2016 Aug 26.

33.

Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver.

Grünwald B, Harant V, Schaten S, Frühschütz M, Spallek R, Höchst B, Stutzer K, Berchtold S, Erkan M, Prokopchuk O, Martignoni M, Esposito I, Heikenwalder M, Gupta A, Siveke J, Saftig P, Knolle P, Wohlleber D, Krüger A.

Gastroenterology. 2016 Nov;151(5):1011-1024.e7. doi: 10.1053/j.gastro.2016.07.043. Epub 2016 Aug 6.

PMID:
27506299
34.

Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis.

Hackstein CP, Assmus LM, Welz M, Klein S, Schwandt T, Schultze J, Förster I, Gondorf F, Beyer M, Kroy D, Kurts C, Trebicka J, Kastenmüller W, Knolle PA, Abdullah Z.

Gut. 2017 Mar;66(3):507-518. doi: 10.1136/gutjnl-2015-311224. Epub 2016 Jul 18.

PMID:
27432540
35.

Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.

Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M.

EMBO J. 2016 Aug 15;35(16):1730-44. doi: 10.15252/embj.201693801. Epub 2016 Jul 13.

36.

An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice.

Ludwig-Portugall I, Bartok E, Dhana E, Evers BD, Primiano MJ, Hall JP, Franklin BS, Knolle PA, Hornung V, Hartmann G, Boor P, Latz E, Kurts C.

Kidney Int. 2016 Sep;90(3):525-39. doi: 10.1016/j.kint.2016.03.035. Epub 2016 Jun 2.

PMID:
27262364
37.

Immunological functions of liver sinusoidal endothelial cells.

Knolle PA, Wohlleber D.

Cell Mol Immunol. 2016 May;13(3):347-53. doi: 10.1038/cmi.2016.5. Epub 2016 Apr 4. Review.

38.

Staying local-antigen presentation in the liver.

Knolle PA.

Curr Opin Immunol. 2016 Jun;40:36-42. doi: 10.1016/j.coi.2016.02.009. Epub 2016 Mar 12. Review.

PMID:
26974478
39.

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Beyer M, Abdullah Z, Chemnitz JM, Maisel D, Sander J, Lehmann C, Thabet Y, Shinde PV, Schmidleithner L, Köhne M, Trebicka J, Schierwagen R, Hofmann A, Popov A, Lang KS, Oxenius A, Buch T, Kurts C, Heikenwalder M, Fätkenheuer G, Lang PA, Hartmann P, Knolle PA, Schultze JL.

Nat Immunol. 2016 May;17(5):593-603. doi: 10.1038/ni.3399. Epub 2016 Mar 7.

PMID:
26950238
40.

Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity.

Rietscher R, Schröder M, Janke J, Czaplewska J, Gottschaldt M, Scherließ R, Hanefeld A, Schubert US, Schneider M, Knolle PA, Lehr CM.

Eur J Pharm Biopharm. 2016 May;102:20-31. doi: 10.1016/j.ejpb.2016.02.014. Epub 2016 Mar 2.

PMID:
26940132
41.

Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.

Siegmund SV, Schlosser M, Schildberg FA, Seki E, De Minicis S, Uchinami H, Kuntzen C, Knolle PA, Strassburg CP, Schwabe RF.

PLoS One. 2016 Mar 3;11(3):e0150893. doi: 10.1371/journal.pone.0150893. eCollection 2016.

42.

A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.

Weiher H, Pircher H, Jansen-Dürr P, Hegenbarth S, Knolle P, Grunau S, Vapola M, Hiltunen JK, Zwacka RM, Schmelzer E, Reumann K, Will H.

BMC Res Notes. 2016 Feb 27;9:128. doi: 10.1186/s13104-016-1939-0.

43.

Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.

Siegmund SV, Wojtalla A, Schlosser M, Schildberg FA, Knolle PA, Nüsing RM, Zimmer A, Strassburg CP, Singer MV.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):678-684. doi: 10.1016/j.bbrc.2016.01.083. Epub 2016 Jan 20.

PMID:
26801558
44.

The induction of human myeloid derived suppressor cells through hepatic stellate cells is dose-dependently inhibited by the tyrosine kinase inhibitors nilotinib, dasatinib and sorafenib, but not sunitinib.

Heine A, Schilling J, Grünwald B, Krüger A, Gevensleben H, Held SA, Garbi N, Kurts C, Brossart P, Knolle P, Diehl L, Höchst B.

Cancer Immunol Immunother. 2016 Mar;65(3):273-82. doi: 10.1007/s00262-015-1790-5. Epub 2016 Jan 19.

PMID:
26786874
45.

Functional classification of memory CD8(+) T cells by CX3CR1 expression.

Böttcher JP, Beyer M, Meissner F, Abdullah Z, Sander J, Höchst B, Eickhoff S, Rieckmann JC, Russo C, Bauer T, Flecken T, Giesen D, Engel D, Jung S, Busch DH, Protzer U, Thimme R, Mann M, Kurts C, Schultze JL, Kastenmüller W, Knolle PA.

Nat Commun. 2015 Sep 25;6:8306. doi: 10.1038/ncomms9306.

46.

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Herold M, Posevitz V, Chudyka D, Hucke S, Groß C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H.

J Immunol. 2015 Oct 15;195(8):3584-95. doi: 10.4049/jimmunol.1402746. Epub 2015 Sep 16.

47.

Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates.

Franken L, Klein M, Spasova M, Elsukova A, Wiedwald U, Welz M, Knolle P, Farle M, Limmer A, Kurts C.

Sci Rep. 2015 Aug 11;5:12940. doi: 10.1038/srep12940.

48.

NIK promotes tissue destruction independently of the alternative NF-κB pathway through TNFR1/RIP1-induced apoptosis.

Boutaffala L, Bertrand MJ, Remouchamps C, Seleznik G, Reisinger F, Janas M, Bénézech C, Fernandes MT, Marchetti S, Mair F, Ganeff C, Hupalowska A, Ricci JE, Becher B, Piette J, Knolle P, Caamano J, Vandenabeele P, Heikenwalder M, Dejardin E.

Cell Death Differ. 2015 Dec;22(12):2020-33. doi: 10.1038/cdd.2015.69. Epub 2015 Jun 5.

49.

TIMP-1 signaling via CD63 triggers granulopoiesis and neutrophilia in mice.

Kobuch J, Cui H, Grünwald B, Saftig P, Knolle PA, Krüger A.

Haematologica. 2015 Aug;100(8):1005-13. doi: 10.3324/haematol.2014.121590. Epub 2015 May 22.

50.

Global transcriptional characterization of CD8+ T cell memory.

Böttcher J, Knolle PA.

Semin Immunol. 2015 Feb;27(1):4-9. doi: 10.1016/j.smim.2015.03.001. Epub 2015 Apr 2. Review.

PMID:
25841628

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