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Items: 32

1.

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.

Ariës IM, Bodaar K, Karim SA, Chonghaile TN, Hinze L, Burns MA, Pfirrmann M, Degar J, Landrigan JT, Balbach S, Peirs S, Menten B, Isenhart R, Stevenson KE, Neuberg DS, Devidas M, Loh ML, Hunger SP, Teachey DT, Rabin KR, Winter SS, Dunsmore KP, Wood BL, Silverman LB, Sallan SE, Van Vlierberghe P, Orkin SH, Knoechel B, Letai AG, Gutierrez A.

J Exp Med. 2018 Nov 7. pii: jem.20180570. doi: 10.1084/jem.20180570. [Epub ahead of print]

PMID:
30404791
2.

Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma.

Mandelbaum J, Shestopalov IA, Henderson RE, Chau NG, Knoechel B, Wick MJ, Zon LI.

J Exp Med. 2018 Oct 1;215(10):2673-2685. doi: 10.1084/jem.20180939. Epub 2018 Sep 12.

PMID:
30209067
3.

Comprehensive characterization of circulating and bone marrow-derived multiple myeloma cells at minimal residual disease.

Waldschmidt JM, Anand P, Knoechel B, Lohr JG.

Semin Hematol. 2018 Jan;55(1):33-37. doi: 10.1053/j.seminhematol.2018.02.010. Epub 2018 Mar 1. Review.

PMID:
29759150
4.

Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing.

Guo G, Raje NS, Seifer C, Kloeber J, Isenhart R, Ha G, Yee AJ, O'Donnell EK, Tai YT, Richardson PG, Bianchi G, Laubach JP, Warren D, Gemme E, Voisine J, Frede J, Kokkalis A, Yun H, Dimitrova V, Vijaykumar T, Meyerson M, Munshi NC, Anderson KC, Knoechel B, Lohr JG.

Leukemia. 2018 Aug;32(8):1838-1841. doi: 10.1038/s41375-018-0115-z. Epub 2018 Mar 27. No abstract available.

PMID:
29749395
5.

Peptidomimetic blockade of MYB in acute myeloid leukemia.

Ramaswamy K, Forbes L, Minuesa G, Gindin T, Brown F, Kharas MG, Krivtsov AV, Armstrong SA, Still E, de Stanchina E, Knoechel B, Koche R, Kentsis A.

Nat Commun. 2018 Jan 9;9(1):110. doi: 10.1038/s41467-017-02618-6.

6.

Genetic interrogation of circulating multiple myeloma cells at single-cell resolution.

Lohr JG, Kim S, Gould J, Knoechel B, Drier Y, Cotton MJ, Gray D, Birrer N, Wong B, Ha G, Zhang CZ, Guo G, Meyerson M, Yee AJ, Boehm JS, Raje N, Golub TR.

Sci Transl Med. 2016 Nov 2;8(363):363ra147.

7.

Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.

Knoechel B, Bhatt A, Pan L, Pedamallu CS, Severson E, Gutierrez A, Dorfman DM, Kuo FC, Kluk M, Kung AL, Zweidler-McKay P, Meyerson M, Blacklow SC, DeAngelo DJ, Aster JC.

Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000539. doi: 10.1101/mcs.a000539.

8.

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma.

Drier Y, Cotton MJ, Williamson KE, Gillespie SM, Ryan RJ, Kluk MJ, Carey CD, Rodig SJ, Sholl LM, Afrogheh AH, Faquin WC, Queimado L, Qi J, Wick MJ, El-Naggar AK, Bradner JE, Moskaluk CA, Aster JC, Knoechel B, Bernstein BE.

Nat Genet. 2016 Mar;48(3):265-72. doi: 10.1038/ng.3502. Epub 2016 Feb 1.

9.

Metabolic Mechanisms of Drug Resistance in Leukemia.

Knoechel B, Aster JC.

Cell Metab. 2015 Nov 3;22(5):759-60. doi: 10.1016/j.cmet.2015.10.005.

10.

EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.

Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN.

Cancer Cell. 2014 Nov 10;26(5):668-681. doi: 10.1016/j.ccell.2014.10.004. Epub 2014 Oct 30.

11.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

12.

Discovery of biomarkers predictive of GSI response in triple-negative breast cancer and adenoid cystic carcinoma.

Stoeck A, Lejnine S, Truong A, Pan L, Wang H, Zang C, Yuan J, Ware C, MacLean J, Garrett-Engele PW, Kluk M, Laskey J, Haines BB, Moskaluk C, Zawel L, Fawell S, Gilliland G, Zhang T, Kremer BE, Knoechel B, Bernstein BE, Pear WS, Liu XS, Aster JC, Sathyanarayanan S.

Cancer Discov. 2014 Oct;4(10):1154-67. doi: 10.1158/2159-8290.CD-13-0830. Epub 2014 Aug 7.

13.

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia.

Knoechel B, Roderick JE, Williamson KE, Zhu J, Lohr JG, Cotton MJ, Gillespie SM, Fernandez D, Ku M, Wang H, Piccioni F, Silver SJ, Jain M, Pearson D, Kluk MJ, Ott CJ, Shultz LD, Brehm MA, Greiner DL, Gutierrez A, Stegmaier K, Kung AL, Root DE, Bradner JE, Aster JC, Kelliher MA, Bernstein BE.

Nat Genet. 2014 Apr;46(4):364-70. doi: 10.1038/ng.2913. Epub 2014 Mar 2.

14.

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.

Lohr JG, Stojanov P, Carter SL, Cruz-Gordillo P, Lawrence MS, Auclair D, Sougnez C, Knoechel B, Gould J, Saksena G, Cibulskis K, McKenna A, Chapman MA, Straussman R, Levy J, Perkins LM, Keats JJ, Schumacher SE, Rosenberg M; Multiple Myeloma Research Consortium, Getz G, Golub TR.

Cancer Cell. 2014 Jan 13;25(1):91-101. doi: 10.1016/j.ccr.2013.12.015.

15.

Genomics of lymphoid malignancies reveal major activation pathways in lymphocytes.

Knoechel B, Lohr JG.

J Autoimmun. 2013 Sep;45:15-23. doi: 10.1016/j.jaut.2013.06.012. Epub 2013 Jul 21. Review.

16.

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry.

Kluk MJ, Ashworth T, Wang H, Knoechel B, Mason EF, Morgan EA, Dorfman D, Pinkus G, Weigert O, Hornick JL, Chirieac LR, Hirsch M, Oh DJ, South AP, Leigh IM, Pourreyron C, Cassidy AJ, Deangelo DJ, Weinstock DM, Krop IE, Dillon D, Brock JE, Lazar AJ, Peto M, Cho RJ, Stoeck A, Haines BB, Sathayanrayanan S, Rodig S, Aster JC.

PLoS One. 2013 Jun 18;8(6):e67306. doi: 10.1371/journal.pone.0067306. Print 2013.

17.

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.

Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3879-84. doi: 10.1073/pnas.1121343109. Epub 2012 Feb 17.

18.

Balance of Th1 and Th17 effector and peripheral regulatory T cells.

Lohr J, Knoechel B, Caretto D, Abbas AK.

Microbes Infect. 2009 Apr;11(5):589-93. doi: 10.1016/j.micinf.2009.04.012. Epub 2009 Apr 17. Review.

19.

Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance.

Barron L, Knoechel B, Lohr J, Abbas AK.

J Immunol. 2008 Mar 1;180(5):2762-6.

20.

Balancing autoaggressive and protective T cell responses.

Abbas AK, Lohr J, Knoechel B.

J Autoimmun. 2007 Mar-May;28(2-3):59-61. Epub 2007 Mar 23. Review.

21.

Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.

Lohr J, Knoechel B, Wang JJ, Villarino AV, Abbas AK.

J Exp Med. 2006 Dec 25;203(13):2785-91. Epub 2006 Nov 27.

22.

Regulatory T cells in the periphery.

Lohr J, Knoechel B, Abbas AK.

Immunol Rev. 2006 Aug;212:149-62. Review.

PMID:
16903912
23.

Functional and molecular comparison of anergic and regulatory T lymphocytes.

Knoechel B, Lohr J, Zhu S, Wong L, Hu D, Ausubel L, Abbas AK.

J Immunol. 2006 Jun 1;176(11):6473-83.

24.

Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.

Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK.

J Exp Med. 2005 Nov 21;202(10):1375-86. Epub 2005 Nov 14.

25.
26.

T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens.

Lohr J, Knoechel B, Nagabhushanam V, Abbas AK.

Immunol Rev. 2005 Apr;204:116-27. Review.

PMID:
15790354
27.

T cell tolerance and autoimmunity.

Abbas AK, Lohr J, Knoechel B, Nagabhushanam V.

Autoimmun Rev. 2004 Nov;3(7-8):471-5.

PMID:
15546793
28.

Role of B7 in T cell tolerance.

Lohr J, Knoechel B, Kahn EC, Abbas AK.

J Immunol. 2004 Oct 15;173(8):5028-35.

29.

IL-2 induces a competitive survival advantage in T lymphocytes.

Dooms H, Kahn E, Knoechel B, Abbas AK.

J Immunol. 2004 May 15;172(10):5973-9.

30.

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens.

Lohr J, Knoechel B, Jiang S, Sharpe AH, Abbas AK.

Nat Immunol. 2003 Jul;4(7):664-9. Epub 2003 May 25.

PMID:
12766766
31.

CD69 surface expression on human lung eosinophils after segmental allergen provocation.

Julius P, Luttmann W, Knoechel B, Kroegel C, Matthys H, Virchow JC Jr.

Eur Respir J. 1999 Jun;13(6):1253-9.

32.

Activation of human eosinophils by IL-13. Induction of CD69 surface antigen, its relationship to messenger RNA expression, and promotion of cellular viability.

Luttmann W, Knoechel B, Foerster M, Matthys H, Virchow JC Jr, Kroegel C.

J Immunol. 1996 Aug 15;157(4):1678-83.

PMID:
8759755

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