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The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop.

Abdusselamoglu MD, Eroglu E, Burkard TR, Knoblich JA.

Elife. 2019 Jul 22;8. pii: e46566. doi: 10.7554/eLife.46566.


Broad applicability of a streamlined ethyl cinnamate-based clearing procedure.

Masselink W, Reumann D, Murawala P, Pasierbek P, Taniguchi Y, Bonnay F, Meixner K, Knoblich JA, Tanaka EM.

Development. 2019 Feb 1;146(3). pii: dev166884. doi: 10.1242/dev.166884.


Human blood vessel organoids as a model of diabetic vasculopathy.

Wimmer RA, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, Taubenschmid J, Hämmerle M, Esk C, Bagley JA, Lindenhofer D, Chen G, Boehm M, Agu CA, Yang F, Fu B, Zuber J, Knoblich JA, Kerjaschki D, Penninger JM.

Nature. 2019 Jan;565(7740):505-510. doi: 10.1038/s41586-018-0858-8. Epub 2019 Jan 16.


Publisher Correction: Guided self-organization and cortical plate formation in human brain organoids.

Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, Otani T, Livesey FJ, Knoblich JA.

Nat Biotechnol. 2018 Oct 11;36(10):1016. doi: 10.1038/nbt1018-1016a.


Author Correction: Genetically engineered cerebral organoids model brain tumor formation.

Bian S, Repic M, Guo Z, Kavirayani A, Burkard T, Bagley JA, Krauditsch C, Knoblich JA.

Nat Methods. 2018 Sep;15(9):748. doi: 10.1038/s41592-018-0118-8.


Genetically engineered cerebral organoids model brain tumor formation.

Bian S, Repic M, Guo Z, Kavirayani A, Burkard T, Bagley JA, Krauditsch C, Knoblich JA.

Nat Methods. 2018 Aug;15(8):631-639. doi: 10.1038/s41592-018-0070-7. Epub 2018 Jul 23. Erratum in: Nat Methods. 2018 Sep;15(9):748.


Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop.

Wissel S, Harzer H, Bonnay F, Burkard TR, Neumüller RA, Knoblich JA.

J Cell Biol. 2018 Sep 3;217(9):3285-3300. doi: 10.1083/jcb.201711167. Epub 2018 Jun 29.


Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation.

Corsini NS, Peer AM, Moeseneder P, Roiuk M, Burkard TR, Theussl HC, Moll I, Knoblich JA.

Cell Stem Cell. 2018 Apr 5;22(4):543-558.e12. doi: 10.1016/j.stem.2018.03.002.


The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells.

Landskron L, Steinmann V, Bonnay F, Burkard TR, Steinmann J, Reichardt I, Harzer H, Laurenson AS, Reichert H, Knoblich JA.

Elife. 2018 Mar 27;7. pii: e31347. doi: 10.7554/eLife.31347.


Tracing Stem Cell Division in Adult Neurogenesis.

Corsini NS, Knoblich JA.

Cell Stem Cell. 2018 Feb 1;22(2):143-145. doi: 10.1016/j.stem.2018.01.012.


The tumor suppressor Brat controls neuronal stem cell lineages by inhibiting Deadpan and Zelda.

Reichardt I, Bonnay F, Steinmann V, Loedige I, Burkard TR, Meister G, Knoblich JA.

EMBO Rep. 2018 Jan;19(1):102-117. doi: 10.15252/embr.201744188. Epub 2017 Nov 30.


The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells.

Abramczuk MK, Burkard TR, Rolland V, Steinmann V, Duchek P, Jiang Y, Wissel S, Reichert H, Knoblich JA.

Development. 2017 Nov 1;144(21):3932-3945. doi: 10.1242/dev.152199. Epub 2017 Sep 21.


Guided self-organization and cortical plate formation in human brain organoids.

Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, Otani T, Livesey FJ, Knoblich JA.

Nat Biotechnol. 2017 Jul;35(7):659-666. doi: 10.1038/nbt.3906. Epub 2017 May 31. Erratum in: Nat Biotechnol. 2018 Oct 11;36(10):1016.


Fused cerebral organoids model interactions between brain regions.

Bagley JA, Reumann D, Bian S, Lévi-Strauss J, Knoblich JA.

Nat Methods. 2017 Jul;14(7):743-751. doi: 10.1038/nmeth.4304. Epub 2017 May 10.


The hope and the hype of organoid research.

Huch M, Knoblich JA, Lutolf MP, Martinez-Arias A.

Development. 2017 Mar 15;144(6):938-941. doi: 10.1242/dev.150201. Review.


Self-organized developmental patterning and differentiation in cerebral organoids.

Renner M, Lancaster MA, Bian S, Choi H, Ku T, Peer A, Chung K, Knoblich JA.

EMBO J. 2017 May 15;36(10):1316-1329. doi: 10.15252/embj.201694700. Epub 2017 Mar 10.


Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding.

Falk S, Bugeon S, Ninkovic J, Pilz GA, Postiglione MP, Cremer H, Knoblich JA, Götz M.

Neuron. 2017 Feb 22;93(4):777-791.e3. doi: 10.1016/j.neuron.2017.02.009.


Human tissues in a dish: The research and ethical implications of organoid technology.

Bredenoord AL, Clevers H, Knoblich JA.

Science. 2017 Jan 20;355(6322). pii: eaaf9414. doi: 10.1126/science.aaf9414. Review.


Induction of Expansion and Folding in Human Cerebral Organoids.

Li Y, Muffat J, Omer A, Bosch I, Lancaster MA, Sur M, Gehrke L, Knoblich JA, Jaenisch R.

Cell Stem Cell. 2017 Mar 2;20(3):385-396.e3. doi: 10.1016/j.stem.2016.11.017. Epub 2016 Dec 29.


Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain.

Luo C, Lancaster MA, Castanon R, Nery JR, Knoblich JA, Ecker JR.

Cell Rep. 2016 Dec 20;17(12):3369-3384. doi: 10.1016/j.celrep.2016.12.001.


Lab-Built Brains.

Knoblich JA.

Sci Am. 2016 Dec 20;316(1):26-31. doi: 10.1038/scientificamerican0117-26. No abstract available.


MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development.

Fededa JP, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich JA, Gerlich DW.

EMBO J. 2016 Nov 15;35(22):2386-2398. Epub 2016 Oct 5.


A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.

Wissel S, Kieser A, Yasugi T, Duchek P, Roitinger E, Gokcezade J, Steinmann V, Gaul U, Mechtler K, Förstemann K, Knoblich JA, Neumüller RA.

G3 (Bethesda). 2016 Aug 9;6(8):2467-78. doi: 10.1534/g3.116.028571.


You Are What You Eat: Linking Metabolic Asymmetry and Cell Fate Choice.

Landskron L, Knoblich JA.

Dev Cell. 2016 May 9;37(3):206-8. doi: 10.1016/j.devcel.2016.04.017.


Human cerebral organoids recapitulate gene expression programs of fetal neocortex development.

Camp JG, Badsha F, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, Lewitus E, Sykes A, Hevers W, Lancaster M, Knoblich JA, Lachmann R, Pääbo S, Huttner WB, Treutlein B.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15672-7. doi: 10.1073/pnas.1520760112. Epub 2015 Dec 7.


Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC.

Ballard MS, Zhu A, Iwai N, Stensrud M, Mapps A, Postiglione MP, Knoblich JA, Hinck L.

Cell Rep. 2015 Oct 13;13(2):290-301. doi: 10.1016/j.celrep.2015.09.006. Epub 2015 Oct 1.


Proliferation control in neural stem and progenitor cells.

Homem CC, Repic M, Knoblich JA.

Nat Rev Neurosci. 2015 Nov;16(11):647-59. doi: 10.1038/nrn4021. Epub 2015 Sep 30. Review.


The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression.

Marchetti G, Reichardt I, Knoblich JA, Besse F.

J Neurosci. 2014 Oct 8;34(41):13855-64. doi: 10.1523/JNEUROSCI.3285-13.2014.


Generation of cerebral organoids from human pluripotent stem cells.

Lancaster MA, Knoblich JA.

Nat Protoc. 2014 Oct;9(10):2329-40. doi: 10.1038/nprot.2014.158. Epub 2014 Sep 4.


Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells.

Homem CCF, Steinmann V, Burkard TR, Jais A, Esterbauer H, Knoblich JA.

Cell. 2014 Aug 14;158(4):874-888. doi: 10.1016/j.cell.2014.06.024.


The conserved discs-large binding partner Banderuola regulates asymmetric cell division in Drosophila.

Mauri F, Reichardt I, Mummery-Widmer JL, Yamazaki M, Knoblich JA.

Curr Biol. 2014 Aug 18;24(16):1811-25. doi: 10.1016/j.cub.2014.06.059. Epub 2014 Jul 31.


Organogenesis in a dish: modeling development and disease using organoid technologies.

Lancaster MA, Knoblich JA.

Science. 2014 Jul 18;345(6194):1247125. doi: 10.1126/science.1247125. Epub 2014 Jul 17. Review.


Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.

Williams SE, Ratliff LA, Postiglione MP, Knoblich JA, Fuchs E.

Nat Cell Biol. 2014 Aug;16(8):758-69. doi: 10.1038/ncb3001. Epub 2014 Jul 13.


Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila.

Ayukawa T, Akiyama M, Mummery-Widmer JL, Stoeger T, Sasaki J, Knoblich JA, Senoo H, Sasaki T, Yamazaki M.

Cell Rep. 2014 Jul 24;8(2):610-21. doi: 10.1016/j.celrep.2014.06.009. Epub 2014 Jul 3.


A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells.

Yasugi T, Fischer A, Jiang Y, Reichert H, Knoblich JA.

PLoS One. 2014 May 7;9(5):e97034. doi: 10.1371/journal.pone.0097034. eCollection 2014.


SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells.

Eroglu E, Burkard TR, Jiang Y, Saini N, Homem CCF, Reichert H, Knoblich JA.

Cell. 2014 Mar 13;156(6):1259-1273. doi: 10.1016/j.cell.2014.01.053.


A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.

Hagelkruys A, Lagger S, Krahmer J, Leopoldi A, Artaker M, Pusch O, Zezula J, Weissmann S, Xie Y, Schöfer C, Schlederer M, Brosch G, Matthias P, Selfridge J, Lassmann H, Knoblich JA, Seiser C.

Development. 2014 Feb;141(3):604-616. doi: 10.1242/dev.100487.


Analysis and modeling of mitotic spindle orientations in three dimensions.

Jüschke C, Xie Y, Postiglione MP, Knoblich JA.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1014-9. doi: 10.1073/pnas.1314984111. Epub 2013 Dec 31.


Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation.

Jüschke C, Dohnal I, Pichler P, Harzer H, Swart R, Ammerer G, Mechtler K, Knoblich JA.

Genome Biol. 2013 Nov 30;14(11):r133. doi: 10.1186/gb-2013-14-11-r133.


Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages.

Homem CC, Reichardt I, Berger C, Lendl T, Knoblich JA.

PLoS One. 2013 Nov 8;8(11):e79588. doi: 10.1371/journal.pone.0079588. eCollection 2013.


Cerebral organoids model human brain development and microcephaly.

Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA.

Nature. 2013 Sep 19;501(7467):373-9. doi: 10.1038/nature12517. Epub 2013 Aug 28.


Identification of transcription factor binding sites from ChIP-seq data at high resolution.

Bardet AF, Steinmann J, Bafna S, Knoblich JA, Zeitlinger J, Stark A.

Bioinformatics. 2013 Nov 1;29(21):2705-13. doi: 10.1093/bioinformatics/btt470. Epub 2013 Aug 24.


The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex.

Xie Y, Jüschke C, Esk C, Hirotsune S, Knoblich JA.

Neuron. 2013 Jul 24;79(2):254-65. doi: 10.1016/j.neuron.2013.05.027. Epub 2013 Jul 3.


FACS purification of Drosophila larval neuroblasts for next-generation sequencing.

Harzer H, Berger C, Conder R, Schmauss G, Knoblich JA.

Nat Protoc. 2013 Jun;8(6):1088-1099. doi: 10.1038/nprot.2013.062. Epub 2013 May 9.


The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

Sparmann A, Xie Y, Verhoeven E, Vermeulen M, Lancini C, Gargiulo G, Hulsman D, Mann M, Knoblich JA, van Lohuizen M.

EMBO J. 2013 May 29;32(11):1598-612. doi: 10.1038/emboj.2013.93. Epub 2013 Apr 26.


Cell biology: Notch recycling is numbed.

Reichardt I, Knoblich JA.

Curr Biol. 2013 Apr 8;23(7):R270-2. doi: 10.1016/j.cub.2013.03.013.


Drosophila neuroblasts: a model for stem cell biology.

Homem CC, Knoblich JA.

Development. 2012 Dec 1;139(23):4297-310. doi: 10.1242/dev.080515. Review.


The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.

Goulas S, Conder R, Knoblich JA.

Cell Stem Cell. 2012 Oct 5;11(4):529-40. doi: 10.1016/j.stem.2012.06.017.


FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal.

Berger C, Harzer H, Burkard TR, Steinmann J, van der Horst S, Laurenson AS, Novatchkova M, Reichert H, Knoblich JA.

Cell Rep. 2012 Aug 30;2(2):407-18. doi: 10.1016/j.celrep.2012.07.008. Epub 2012 Aug 9.


Spindle orientation in mammalian cerebral cortical development.

Lancaster MA, Knoblich JA.

Curr Opin Neurobiol. 2012 Oct;22(5):737-46. doi: 10.1016/j.conb.2012.04.003. Epub 2012 May 2. Review.

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