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Items: 1 to 50 of 68

1.

Strategies to Target ISG15 and USP18 Toward Therapeutic Applications.

Jiménez Fernández D, Hess S, Knobeloch KP.

Front Chem. 2020 Jan 21;7:923. doi: 10.3389/fchem.2019.00923. eCollection 2019. Review.

2.

Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing.

Fan JB, Miyauchi S, Xu HZ, Liu D, Kim LJY, Burkart C, Cheng H, Arimoto KI, Yan M, Zhou Y, Győrffy B, Knobeloch KP, Rich JN, Cang H, Fu XD, Zhang DE.

Cancer Discov. 2020 Jan 23. doi: 10.1158/2159-8290.CD-19-0608. [Epub ahead of print]

PMID:
31974171
3.

Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions.

Dufner A, Knobeloch KP.

Biochem Soc Trans. 2019 Dec 20;47(6):1867-1879. doi: 10.1042/BST20190527.

4.

The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection.

Zhang Y, Thery F, Wu NC, Luhmann EK, Dussurget O, Foecke M, Bredow C, Jiménez-Fernández D, Leandro K, Beling A, Knobeloch KP, Impens F, Cossart P, Radoshevich L.

Nat Commun. 2019 Nov 26;10(1):5383. doi: 10.1038/s41467-019-13393-x.

5.

Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties.

Xin BT, Gan J, Fernandez DJ, Knobeloch KP, Geurink PP, Ovaa H.

Org Biomol Chem. 2019 Dec 28;17(48):10148-10152. doi: 10.1039/c9ob02127b. Epub 2019 Nov 11.

PMID:
31710063
6.

Loss of USP18 in microglia induces white matter pathology.

Schwabenland M, Mossad O, Peres AG, Kessler F, Maron FJM, Harsan LA, Bienert T, von Elverfeldt D, Knobeloch KP, Staszewski O, Heppner FL, Meuwissen MEC, Mancini GMS, Prinz M, Blank T.

Acta Neuropathol Commun. 2019 Jul 4;7(1):106. doi: 10.1186/s40478-019-0757-8. No abstract available.

7.

DC Respond to Cognate T Cell Interaction in the Antigen-Challenged Lymph Node.

Curato C, Bernshtein B, Zupancič E, Dufner A, Jaitin D, Giladi A, David E, Chappell-Maor L, Leshkowitz D, Knobeloch KP, Amit I, Florindo HF, Jung S.

Front Immunol. 2019 Apr 25;10:863. doi: 10.3389/fimmu.2019.00863. eCollection 2019.

8.

The probacterial effect of type I interferon signaling requires its own negative regulator USP18.

Shaabani N, Honke N, Nguyen N, Huang Z, Arimoto KI, Lazar D, Loe TK, Lang KS, Prinz M, Knobeloch KP, Zhang DE, Teijaro JR.

Sci Immunol. 2018 Sep 28;3(27). pii: eaau2125. doi: 10.1126/sciimmunol.aau2125.

9.

USP18 - a multifunctional component in the interferon response.

Basters A, Knobeloch KP, Fritz G.

Biosci Rep. 2018 Nov 15;38(6). pii: BSR20180250. doi: 10.1042/BSR20180250. Print 2018 Dec 21. Review.

10.

Cysteine-Reactive Free ISG15 Generates IL-1β-Producing CD8α+ Dendritic Cells at the Site of Infection.

Napolitano A, van der Veen AG, Bunyan M, Borg A, Frith D, Howell S, Kjaer S, Beling A, Snijders AP, Knobeloch KP, Frickel EM.

J Immunol. 2018 Jul 15;201(2):604-614. doi: 10.4049/jimmunol.1701322. Epub 2018 Jun 11.

11.

How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease.

Basters A, Knobeloch KP, Fritz G.

FEBS J. 2018 Mar;285(6):1024-1029. doi: 10.1111/febs.14260. Epub 2017 Sep 21. Review.

12.

Post-translational control of T cell development by the ESCRT protein CHMP5.

Adoro S, Park KH, Bettigole SE, Lis R, Shin HR, Seo H, Kim JH, Knobeloch KP, Shim JH, Glimcher LH.

Nat Immunol. 2017 Jul;18(7):780-790. doi: 10.1038/ni.3764. Epub 2017 May 29.

PMID:
28553951
13.

Structural basis of the specificity of USP18 toward ISG15.

Basters A, Geurink PP, Röcker A, Witting KF, Tadayon R, Hess S, Semrau MS, Storici P, Ovaa H, Knobeloch KP, Fritz G.

Nat Struct Mol Biol. 2017 Mar;24(3):270-278. doi: 10.1038/nsmb.3371. Epub 2017 Feb 6.

14.

Erratum: USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479c. No abstract available.

PMID:
27849203
15.

USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

Torre S, Polyak MJ, Langlais D, Fodil N, Kennedy JM, Radovanovic I, Berghout J, Leiva-Torres GA, Krawczyk CM, Ilangumaran S, Mossman K, Liang C, Knobeloch KP, Healy LM, Antel J, Arbour N, Prat A, Majewski J, Lathrop M, Vidal SM, Gros P.

Nat Immunol. 2017 Jan;18(1):54-63. doi: 10.1038/ni.3581. Epub 2016 Oct 10. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479.

PMID:
27721430
16.

Correction: ISG15 Regulates Peritoneal Macrophages Functionality against Viral Infection.

Yángüez E, García-Culebras A, Frau A, Llompart C, Knobeloch KP, Gutierrez-Erlandsson S, García-Sastre A, Esteban M, Nieto A, Guerra S.

PLoS Pathog. 2016 Oct 13;12(10):e1005969. doi: 10.1371/journal.ppat.1005969. eCollection 2016 Oct.

17.

Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.

Cerikan B, Shaheen R, Colo GP, Gläßer C, Hata S, Knobeloch KP, Alkuraya FS, Fässler R, Schiebel E.

Dev Cell. 2016 Oct 10;39(1):28-43. doi: 10.1016/j.devcel.2016.08.020. Epub 2016 Sep 29.

18.

Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.

Peschke K, Achleitner M, Frenzel K, Gerbaulet A, Ada SR, Zeller N, Lienenklaus S, Lesche M, Poulet C, Naumann R, Dahl A, Ravens U, Günther C, Müller W, Knobeloch KP, Prinz M, Roers A, Behrendt R.

J Immunol. 2016 Sep 15;197(6):2157-66. doi: 10.4049/jimmunol.1600722. Epub 2016 Aug 10.

19.

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development.

Klein-Hessling S, Rudolf R, Muhammad K, Knobeloch KP, Maqbool MA, Cauchy P, Andrau JC, Avots A, Talora C, Ellenrieder V, Screpanti I, Serfling E, Patra AK.

Nat Commun. 2016 Jun 17;7:11841. doi: 10.1038/ncomms11841.

20.

USP8--Another DUB in the T cell club.

Dufner A, Knobeloch KP.

Cell Cycle. 2015;14(24):3775-6. doi: 10.1080/15384101.2015.1105698. No abstract available.

21.

NFATc1 releases BCL6-dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice.

Busch R, Murti K, Liu J, Patra AK, Muhammad K, Knobeloch KP, Lichtinger M, Bonifer C, Wörtge S, Waisman A, Reifenberg K, Ellenrieder V, Serfling E, Avots A.

Eur J Immunol. 2016 Mar;46(3):634-46. doi: 10.1002/eji.201545925. Epub 2016 Jan 8.

22.

The A-kinase Anchoring Protein GSKIP Regulates GSK3β Activity and Controls Palatal Shelf Fusion in Mice.

Deák VA, Skroblin P, Dittmayer C, Knobeloch KP, Bachmann S, Klussmann E.

J Biol Chem. 2016 Jan 8;291(2):681-90. doi: 10.1074/jbc.M115.701177. Epub 2015 Nov 18.

23.

ISG15 counteracts Listeria monocytogenes infection.

Radoshevich L, Impens F, Ribet D, Quereda JJ, Nam Tham T, Nahori MA, Bierne H, Dussurget O, Pizarro-Cerdá J, Knobeloch KP, Cossart P.

Elife. 2015 Aug 11;4. doi: 10.7554/eLife.06848.

24.

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.

Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP.

Nat Immunol. 2015 Sep;16(9):950-60. doi: 10.1038/ni.3230. Epub 2015 Jul 27.

PMID:
26214742
25.

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function.

Albert GI, Schell C, Kirschner KM, Schäfer S, Naumann R, Müller A, Kretz O, Kuropka B, Girbig M, Hübner N, Krause E, Scholz H, Huber TB, Knobeloch KP, Freund C.

J Mol Cell Biol. 2015 Oct;7(5):402-14. doi: 10.1093/jmcb/mjv039. Epub 2015 Jun 16.

PMID:
26082520
26.

USP18 lack in microglia causes destructive interferonopathy of the mouse brain.

Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M.

EMBO J. 2015 Jun 12;34(12):1612-29. doi: 10.15252/embj.201490791. Epub 2015 Apr 20.

27.

ISG15 uncut: Dissecting enzymatic and non-enzymatic functions of USP18 in vivo.

Ketscher L, Knobeloch KP.

Cytokine. 2015 Dec;76(2):569-571. doi: 10.1016/j.cyto.2015.03.006. Epub 2015 Mar 21.

PMID:
25805508
28.

Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance.

Ketscher L, Hannß R, Morales DJ, Basters A, Guerra S, Goldmann T, Hausmann A, Prinz M, Naumann R, Pekosz A, Utermöhlen O, Lenschow DJ, Knobeloch KP.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1577-82. doi: 10.1073/pnas.1412881112. Epub 2015 Jan 20.

29.

Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy.

Rahnefeld A, Klingel K, Schuermann A, Diny NL, Althof N, Lindner A, Bleienheuft P, Savvatis K, Respondek D, Opitz E, Ketscher L, Sauter M, Seifert U, Tschöpe C, Poller W, Knobeloch KP, Voigt A.

Circulation. 2014 Oct 28;130(18):1589-600. doi: 10.1161/CIRCULATIONAHA.114.009847. Epub 2014 Aug 27.

PMID:
25165091
30.

Genetic targeting of microglia.

Wieghofer P, Knobeloch KP, Prinz M.

Glia. 2015 Jan;63(1):1-22. doi: 10.1002/glia.22727. Epub 2014 Aug 8. Review.

PMID:
25132502
31.

Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15.

Basters A, Geurink PP, El Oualid F, Ketscher L, Casutt MS, Krause E, Ovaa H, Knobeloch KP, Fritz G.

FEBS J. 2014 Apr;281(7):1918-28. doi: 10.1111/febs.12754. Epub 2014 Mar 3.

32.

STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.

Begitt A, Droescher M, Meyer T, Schmid CD, Baker M, Antunes F, Knobeloch KP, Owen MR, Naumann R, Decker T, Vinkemeier U.

Nat Immunol. 2014 Feb;15(2):168-76. doi: 10.1038/ni.2794. Epub 2014 Jan 12. Erratum in: Nat Immunol. 2014 Nov;15(11):1090.

PMID:
24413774
33.

HIF1α deubiquitination by USP8 is essential for ciliogenesis in normoxia.

Troilo A, Alexander I, Muehl S, Jaramillo D, Knobeloch KP, Krek W.

EMBO Rep. 2014 Jan;15(1):77-85. doi: 10.1002/embr.201337688. Epub 2013 Dec 30.

34.

ISG15 regulates peritoneal macrophages functionality against viral infection.

Yángüez E, García-Culebras A, Frau A, Llompart C, Knobeloch KP, Gutierrez-Erlandsson S, García-Sastre A, Esteban M, Nieto A, Guerra S.

PLoS Pathog. 2013;9(10):e1003632. doi: 10.1371/journal.ppat.1003632. Epub 2013 Oct 10. Erratum in: PLoS Pathog. 2013 Oct;9(10). doi: 10.1371/annotation/64a20cef-bf55-4d84-983e-b914eb09b1ee. PLoS Pathog. 2016 Oct 13;12 (10 ):e1005969.

35.

High yield expression of catalytically active USP18 (UBP43) using a Trigger Factor fusion system.

Basters A, Ketscher L, Deuerling E, Arkona C, Rademann J, Knobeloch KP, Fritz G.

BMC Biotechnol. 2012 Aug 23;12:56. doi: 10.1186/1472-6750-12-56.

36.

Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system.

Prinz M, Knobeloch KP.

Front Immunol. 2012 Apr 9;3:67. doi: 10.3389/fimmu.2012.00067. eCollection 2012.

37.

mHERC6 is the essential ISG15 E3 ligase in the murine system.

Ketscher L, Basters A, Prinz M, Knobeloch KP.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):135-40. doi: 10.1016/j.bbrc.2011.11.071. Epub 2011 Nov 23.

PMID:
22138649
38.

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Dann A, Poeck H, Croxford AL, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth SG, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.

Nat Neurosci. 2011 Dec 4;15(1):98-106. doi: 10.1038/nn.2964.

PMID:
22138643
39.

ISG15 modulates development of the erythroid lineage.

Maragno AL, Pironin M, Alcalde H, Cong X, Knobeloch KP, Tangy F, Zhang DE, Ghysdael J, Quang CT.

PLoS One. 2011;6(10):e26068. doi: 10.1371/journal.pone.0026068. Epub 2011 Oct 12.

40.

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ.

Begitt A, Droescher M, Knobeloch KP, Vinkemeier U.

Blood. 2011 Jul 28;118(4):1002-7. doi: 10.1182/blood-2011-04-347930. Epub 2011 Jun 2.

PMID:
21636857
41.

Control of bone formation by the serpentine receptor Frizzled-9.

Albers J, Schulze J, Beil FT, Gebauer M, Baranowsky A, Keller J, Marshall RP, Wintges K, Friedrich FW, Priemel M, Schilling AF, Rueger JM, Cornils K, Fehse B, Streichert T, Sauter G, Jakob F, Insogna KL, Pober B, Knobeloch KP, Francke U, Amling M, Schinke T.

J Cell Biol. 2011 Mar 21;192(6):1057-72. doi: 10.1083/jcb.201008012. Epub 2011 Mar 14.

42.

IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system.

Raasch J, Zeller N, van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, Del Turco D, Deller T, Blank T, Priller J, Brück W, Pasparakis M, Prinz M.

Brain. 2011 Apr;134(Pt 4):1184-98. doi: 10.1093/brain/awq359. Epub 2011 Feb 10.

43.

In vivo functions of isgylation.

Knobeloch KP.

Subcell Biochem. 2010;54:215-27. doi: 10.1007/978-1-4419-6676-6_17.

PMID:
21222285
44.

Cone versus rod disease in a mutant Rpgr mouse caused by different genetic backgrounds.

Brunner S, Skosyrski S, Kirschner-Schwabe R, Knobeloch KP, Neidhardt J, Feil S, Glaus E, Luhmann UF, Rüther K, Berger W.

Invest Ophthalmol Vis Sci. 2010 Feb;51(2):1106-15. doi: 10.1167/iovs.08-2742. Epub 2009 Dec 10.

45.

Vaccinia virus E3 protein prevents the antiviral action of ISG15.

Guerra S, Cáceres A, Knobeloch KP, Horak I, Esteban M.

PLoS Pathog. 2008 Jul 4;4(7):e1000096. doi: 10.1371/journal.ppat.1000096.

46.

Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system.

Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Brück W, Kalinke U.

Immunity. 2008 May;28(5):675-86. doi: 10.1016/j.immuni.2008.03.011.

47.

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.

Niendorf S, Oksche A, Kisser A, Löhler J, Prinz M, Schorle H, Feller S, Lewitzky M, Horak I, Knobeloch KP.

Mol Cell Biol. 2007 Jul;27(13):5029-39. Epub 2007 Apr 23.

48.

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition.

Fischer A, Steidl C, Wagner TU, Lang E, Jakob PM, Friedl P, Knobeloch KP, Gessler M.

Circ Res. 2007 Mar 30;100(6):856-63. Epub 2007 Feb 15.

PMID:
17303760
49.

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.

Lenschow DJ, Lai C, Frias-Staheli N, Giannakopoulos NV, Lutz A, Wolff T, Osiak A, Levine B, Schmidt RE, García-Sastre A, Leib DA, Pekosz A, Knobeloch KP, Horak I, Virgin HW 4th.

Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1371-6. Epub 2007 Jan 16.

50.

ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation.

Lu G, Reinert JT, Pitha-Rowe I, Okumura A, Kellum M, Knobeloch KP, Hassel B, Pitha PM.

Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):29-41.

PMID:
16914094

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