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Items: 14

1.

Serum-free culture of primary human hepatocytes in a miniaturized hollow-fibre membrane bioreactor for pharmacological in vitro studies.

Lübberstedt M, Müller-Vieira U, Biemel KM, Darnell M, Hoffmann SA, Knöspel F, Wönne EC, Knobeloch D, Nüssler AK, Gerlach JC, Andersson TB, Zeilinger K.

J Tissue Eng Regen Med. 2015 Sep;9(9):1017-26. doi: 10.1002/term.1652. Epub 2012 Nov 20.

PMID:
23165723
2.

Analysis of drug metabolism activities in a miniaturized liver cell bioreactor for use in pharmacological studies.

Hoffmann SA, Müller-Vieira U, Biemel K, Knobeloch D, Heydel S, Lübberstedt M, Nüssler AK, Andersson TB, Gerlach JC, Zeilinger K.

Biotechnol Bioeng. 2012 Dec;109(12):3172-81. doi: 10.1002/bit.24573. Epub 2012 Jun 27.

PMID:
22688505
3.

Human hepatocytes: isolation, culture, and quality procedures.

Knobeloch D, Ehnert S, Schyschka L, Büchler P, Schoenberg M, Kleeff J, Thasler WE, Nussler NC, Godoy P, Hengstler J, Nussler AK.

Methods Mol Biol. 2012;806:99-120. doi: 10.1007/978-1-61779-367-7_8.

PMID:
22057448
4.

Hepatotropic growth factors protect hepatocytes during inflammation by upregulation of antioxidative systems.

Glanemann M, Knobeloch D, Ehnert S, Culmes M, Seeliger C, Seehofer D, Nussler AK.

World J Gastroenterol. 2011 May 7;17(17):2199-205. doi: 10.3748/wjg.v17.i17.2199.

5.

Further characterization of autologous NeoHepatocytes for in vitro toxicity testing.

Ehnert S, Schyschka L, Noss A, Knobeloch D, Kleeff J, Büchler P, Gillen S, Stöckle U, Burkhart J, Fabian E, Nussler AK.

Toxicol In Vitro. 2011 Sep;25(6):1203-8. doi: 10.1016/j.tiv.2011.05.013. Epub 2011 May 20.

PMID:
21621600
6.

In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor.

Mueller D, Tascher G, Müller-Vieira U, Knobeloch D, Nuessler AK, Zeilinger K, Heinzle E, Noor F.

J Tissue Eng Regen Med. 2011 Aug;5(8):e207-18. doi: 10.1002/term.418. Epub 2011 Mar 27.

PMID:
21442764
7.

Scaling down of a clinical three-dimensional perfusion multicompartment hollow fiber liver bioreactor developed for extracorporeal liver support to an analytical scale device useful for hepatic pharmacological in vitro studies.

Zeilinger K, Schreiter T, Darnell M, Söderdahl T, Lübberstedt M, Dillner B, Knobeloch D, Nüssler AK, Gerlach JC, Andersson TB.

Tissue Eng Part C Methods. 2011 May;17(5):549-56. doi: 10.1089/ten.TEC.2010.0580. Epub 2011 Feb 16.

PMID:
21210724
8.

Profiling induction of cytochrome p450 enzyme activity by statins using a new liquid chromatography-tandem mass spectrometry cocktail assay in human hepatocytes.

Feidt DM, Klein K, Hofmann U, Riedmaier S, Knobeloch D, Thasler WE, Weiss TS, Schwab M, Zanger UM.

Drug Metab Dispos. 2010 Sep;38(9):1589-97. doi: 10.1124/dmd.110.033886. Epub 2010 Jun 15.

PMID:
20551241
9.

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.

Lübberstedt M, Müller-Vieira U, Mayer M, Biemel KM, Knöspel F, Knobeloch D, Nüssler AK, Gerlach JC, Zeilinger K.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):59-68. doi: 10.1016/j.vascn.2010.04.013. Epub 2010 May 9.

PMID:
20460162
10.

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: a comparison of primary human hepatocytes and OATP-transfected HEK293 cells.

Fischer A, Hoeger SJ, Stemmer K, Feurstein DJ, Knobeloch D, Nussler A, Dietrich DR.

Toxicol Appl Pharmacol. 2010 May 15;245(1):9-20. doi: 10.1016/j.taap.2010.02.006. Epub 2010 Feb 17.

PMID:
20171238
11.

Neohepatocytes from alcoholics and controls express hepatocyte markers and display reduced fibrogenic TGF-ß/Smad3 signaling: advantage for cell transplantation?

Ehnert S, Knobeloch D, Blankenstein A, Müller A, Böcker U, Gillen S, Friess H, Thasler WE, Dooley S, Nussler AK.

Alcohol Clin Exp Res. 2010 Apr;34(4):708-18. doi: 10.1111/j.1530-0277.2009.01140.x. Epub 2010 Jan 26.

PMID:
20102559
12.

Protective role of HO-1 for alcohol-dependent liver damage.

Nussler AK, Hao L, Knobeloch D, Yao P, Nussler NC, Wang Z, Liu L, Ehnert S.

Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.

PMID:
21525764
13.

A coleopteran triosephosphate isomerase: X-ray structure and phylogenetic impact of insect sequences.

Knobeloch D, Schmidt A, Scheerer P, Krauss N, Wessner H, Scholz Ch, Küttner G, von Rintelen T, Wessel A, Höhne W.

Insect Mol Biol. 2010 Feb;19(1):35-48. doi: 10.1111/j.1365-2583.2009.00928.x. Epub 2009 Oct 22.

PMID:
19849721
14.

Evaluation and optimization of hepatocyte culture media factors by design of experiments (DoE) methodology.

Dong J, Mandenius CF, Lübberstedt M, Urbaniak T, Nüssler AK, Knobeloch D, Gerlach JC, Zeilinger K.

Cytotechnology. 2008 Jul;57(3):251-61. doi: 10.1007/s10616-008-9168-6. Epub 2008 Oct 7.

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