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Items: 1 to 50 of 103

1.

Immune Cells and Immunosenescence.

Bischof J, Gärtner F, Zeiser K, Kunz R, Schreiner C, Hoffer E, Burster T, Knippschild U, Zimecki M.

Folia Biol (Praha). 2019;65(2):53-63.

2.

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).

Xu P, Ianes C, Gärtner F, Liu C, Burster T, Bakulev V, Rachidi N, Knippschild U, Bischof J.

Gene. 2019 Oct 5;715:144005. doi: 10.1016/j.gene.2019.144005. Epub 2019 Jul 31. Review.

PMID:
31376410
3.

The sperm associated antigen 6 interactome and its role in spermatogenesis.

Liu Y, Zhang L, Li W, Huang Q, Yuan S, Li Y, Liu J, Zhang S, Pin G, Song S, Ray PF, Arnoult C, Cho C, Garcia-Reyes B, Knippschild U, Strauss Iii JF, Zhang Z.

Reproduction. 2019 May 1. pii: REP-18-0522.R1. doi: 10.1530/REP-18-0522. [Epub ahead of print]

PMID:
31146259
4.

Kinase activity of casein kinase 1 delta (CK1δ) is modulated by protein kinase C α (PKCα) by site-specific phosphorylation within the kinase domain of CK1δ.

Meng Z, Böhm T, Xu P, Henne-Bruns D, Peifer C, Witt L, Knippschild U, Bischof J.

Biochim Biophys Acta Proteins Proteom. 2019 Jul - Aug;1867(7-8):710-721. doi: 10.1016/j.bbapap.2019.05.004. Epub 2019 May 13.

PMID:
31096047
5.

The kinase domain of CK1δ can be phosphorylated by Chk1.

Böhm T, Meng Z, Haas P, Henne-Bruns D, Rachidi N, Knippschild U, Bischof J.

Biosci Biotechnol Biochem. 2019 Sep;83(9):1663-1675. doi: 10.1080/09168451.2019.1617105. Epub 2019 May 16.

PMID:
31094292
6.

Correction: Phosphorylation of CK1δ: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo.

Giamas G, Hirner H, Shoshiashvili L, Grothey A, Gessert S, Kühl M, Henne-Bruns D, Vorgias CE, Knippschild U.

Biochem J. 2019 Apr 18;476(8):1221-1225. doi: 10.1042/BJ-2007-0091_COR. No abstract available.

PMID:
31000625
7.

Identification and Validation of a Biomarker Signature in Patients With Resectable Pancreatic Cancer via Genome-Wide Screening for Functional Genetic Variants.

Dimitrakopoulos C, Vrugt B, Flury R, Schraml P, Knippschild U, Wild P, Hoerstrup S, Henne-Bruns D, Wuerl P, Graf R, Breitenstein S, Bond G, Beerenwinkel N, Grochola LF.

JAMA Surg. 2019 Jun 1;154(6):e190484. doi: 10.1001/jamasurg.2019.0484. Epub 2019 Jun 19.

PMID:
30942874
8.

TRAILblazing Strategies for Cancer Treatment.

Kretz AL, Trauzold A, Hillenbrand A, Knippschild U, Henne-Bruns D, von Karstedt S, Lemke J.

Cancers (Basel). 2019 Mar 30;11(4). pii: E456. doi: 10.3390/cancers11040456. Review.

9.

2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.

Schehr M, Ianes C, Weisner J, Heintze L, Müller MP, Pichlo C, Charl J, Brunstein E, Ewert J, Lehr M, Baumann U, Rauh D, Knippschild U, Peifer C, Herges R.

Photochem Photobiol Sci. 2019 Jun 12;18(6):1398-1407. doi: 10.1039/c9pp00010k.

PMID:
30924488
10.

Design, Synthesis and Biological Evaluation of Isoxazole-Based CK1 Inhibitors Modified with Chiral Pyrrolidine Scaffolds.

Luxenburger A, Schmidt D, Ianes C, Pichlo C, Krüger M, von Drathen T, Brunstein E, Gainsford GJ, Baumann U, Knippschild U, Peifer C.

Molecules. 2019 Mar 1;24(5). pii: E873. doi: 10.3390/molecules24050873.

11.

Viability of glioblastoma stem cells is effectively reduced by diisothiocyanate-derived mercapturic acids.

Cwiklowska K, Westhoff MA, Freisinger S, Dwucet A, Halatsch ME, Knippschild U, Debatin KM, Schirmbeck R, Winiarski L, Oleksyszyn J, Wirtz CR, Burster T.

Oncol Lett. 2018 Nov;16(5):6181-6187. doi: 10.3892/ol.2018.9347. Epub 2018 Aug 21.

12.

The Emerging Role of Cyclin-Dependent Kinases (CDKs) in Pancreatic Ductal Adenocarcinoma.

García-Reyes B, Kretz AL, Ruff JP, von Karstedt S, Hillenbrand A, Knippschild U, Henne-Bruns D, Lemke J.

Int J Mol Sci. 2018 Oct 18;19(10). pii: E3219. doi: 10.3390/ijms19103219. Review.

13.

Diet-Induced Obesity Affects Muscle Regeneration After Murine Blunt Muscle Trauma-A Broad Spectrum Analysis.

Xu P, Werner JU, Milerski S, Hamp CM, Kuzenko T, Jähnert M, Gottmann P, de Roy L, Warnecke D, Abaei A, Palmer A, Huber-Lang M, Dürselen L, Rasche V, Schürmann A, Wabitsch M, Knippschild U.

Front Physiol. 2018 Jun 5;9:674. doi: 10.3389/fphys.2018.00674. eCollection 2018.

14.

PKD regulates actin polymerization, neutrophil deformability, and transendothelial migration in response to fMLP and trauma.

Wille C, Eiseler T, Langenberger ST, Richter J, Mizuno K, Radermacher P, Knippschild U, Huber-Lang M, Seufferlein T, Paschke S.

J Leukoc Biol. 2018 Sep;104(3):615-630. doi: 10.1002/JLB.4A0617-251RR. Epub 2018 Apr 14.

PMID:
29656400
15.

Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) δ/ε.

García-Reyes B, Witt L, Jansen B, Karasu E, Gehring T, Leban J, Henne-Bruns D, Pichlo C, Brunstein E, Baumann U, Wesseler F, Rathmer B, Schade D, Peifer C, Knippschild U.

J Med Chem. 2018 May 10;61(9):4087-4102. doi: 10.1021/acs.jmedchem.8b00095. Epub 2018 May 1.

PMID:
29630366
16.

Should We Keep Walking along the Trail for Pancreatic Cancer Treatment? Revisiting TNF-Related Apoptosis-Inducing Ligand for Anticancer Therapy.

Kretz AL, von Karstedt S, Hillenbrand A, Henne-Bruns D, Knippschild U, Trauzold A, Lemke J.

Cancers (Basel). 2018 Mar 18;10(3). pii: E77. doi: 10.3390/cancers10030077. Review.

17.

Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury.

Werner JU, Tödter K, Xu P, Lockhart L, Jähnert M, Gottmann P, Schürmann A, Scheja L, Wabitsch M, Knippschild U.

Front Physiol. 2018 Jan 30;9:19. doi: 10.3389/fphys.2018.00019. eCollection 2018.

18.

CK1α overexpression correlates with poor survival in colorectal cancer.

Richter J, Kretz AL, Lemke J, Fauler M, Werner JU, Paschke S, Leithäuser F, Henne-Bruns D, Hillenbrand A, Knippschild U.

BMC Cancer. 2018 Feb 6;18(1):140. doi: 10.1186/s12885-018-4019-0.

19.

A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε.

Dolde C, Bischof J, Grüter S, Montada A, Halekotte J, Peifer C, Kalbacher H, Baumann U, Knippschild U, Suter B.

J Cell Sci. 2018 Jan 4;131(1). pii: jcs207316. doi: 10.1242/jcs.207316.

20.

Corrigendum to "interaction of casein kinase 1 delta (CK1<delta>) with the light chain LC2 of microtubule associated protein 1A (MAP1A)" [Biochim. Biophys. Acta 1745/2 (2005) 196-2006].

Wolff S, Xiao Z, Wittau M, Süssner N, Stöter M, Knippschild U.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1923. doi: 10.1016/j.bbamcr.2017.05.022. Epub 2017 Jun 2. No abstract available.

21.

Endogenously Expressed IL-4Rα Promotes the Malignant Phenotype of Human Pancreatic Cancer In Vitro and In Vivo.

Traub B, Sun L, Ma Y, Xu P, Lemke J, Paschke S, Henne-Bruns D, Knippschild U, Kornmann M.

Int J Mol Sci. 2017 Mar 28;18(4). pii: E716. doi: 10.3390/ijms18040716.

22.

Cancer stem cells: The potential role of autophagy, proteolysis, and cathepsins in glioblastoma stem cells.

Bischof J, Westhoff MA, Wagner JE, Halatsch ME, Trentmann S, Knippschild U, Wirtz CR, Burster T.

Tumour Biol. 2017 Mar;39(3):1010428317692227. doi: 10.1177/1010428317692227. Review.

PMID:
28347245
23.

Optimized 4,5-Diarylimidazoles as Potent/Selective Inhibitors of Protein Kinase CK1δ and Their Structural Relation to p38α MAPK.

Halekotte J, Witt L, Ianes C, Krüger M, Bührmann M, Rauh D, Pichlo C, Brunstein E, Luxenburger A, Baumann U, Knippschild U, Bischof J, Peifer C.

Molecules. 2017 Mar 24;22(4). pii: E522. doi: 10.3390/molecules22040522.

24.

CDK9 is a prognostic marker and therapeutic target in pancreatic cancer.

Kretz AL, Schaum M, Richter J, Kitzig EF, Engler CC, Leithäuser F, Henne-Bruns D, Knippschild U, Lemke J.

Tumour Biol. 2017 Feb;39(2):1010428317694304. doi: 10.1177/1010428317694304.

PMID:
28231737
25.

State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261.

Föhr KJ, Knippschild U, Herkommer A, Fauler M, Peifer C, Georgieff M, Adolph O.

Invest New Drugs. 2017 Jun;35(3):277-289. doi: 10.1007/s10637-017-0429-0. Epub 2017 Feb 6.

PMID:
28164251
26.

Comparison of Different Risk Classification Systems in 558 Patients with Gastrointestinal Stromal Tumors after R0-Resection.

Schmieder M, Henne-Bruns D, Mayer B, Knippschild U, Rolke C, Schwab M, Kramer K.

Front Pharmacol. 2016 Dec 27;7:504. doi: 10.3389/fphar.2016.00504. eCollection 2016.

27.

miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function.

Giroud M, Pisani DF, Karbiener M, Barquissau V, Ghandour RA, Tews D, Fischer-Posovszky P, Chambard JC, Knippschild U, Niemi T, Taittonen M, Nuutila P, Wabitsch M, Herzig S, Virtanen KA, Langin D, Scheideler M, Amri EZ.

Mol Metab. 2016 Jun 15;5(8):615-625. doi: 10.1016/j.molmet.2016.06.005. eCollection 2016 Aug.

28.

Circulating adipokine levels and prognostic value in septic patients.

Hillenbrand A, Xu P, Zhou S, Blatz A, Weiss M, Hafner S, Henne-Bruns D, Knippschild U.

J Inflamm (Lond). 2016 Sep 6;13(1):30. doi: 10.1186/s12950-016-0138-z. eCollection 2016.

29.

CD44 SNPrs187115: A Novel Biomarker Signature that Predicts Survival in Resectable Pancreatic Ductal Adenocarcinoma.

Stracquadanio G, Vrugt B, Flury R, Schraml P, Würl P, Müller TH, Knippschild U, Henne-Bruns D, Breitenstein S, Clavien PA, Graf R, Bond GL, Grochola LF.

Clin Cancer Res. 2016 Dec 15;22(24):6069-6077. Epub 2016 Jun 9.

30.

Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas.

Yokoyama S, Higashi M, Kitamoto S, Oeldorf M, Knippschild U, Kornmann M, Maemura K, Kurahara H, Wiest E, Hamada T, Kitazono I, Goto Y, Tasaki T, Hiraki T, Hatanaka K, Mataki Y, Taguchi H, Hashimoto S, Batra SK, Tanimoto A, Yonezawa S, Hollingsworth MA.

Oncotarget. 2016 Jul 5;7(27):42553-42565. doi: 10.18632/oncotarget.9924.

31.

New potential peptide therapeutics perturbing CK1δ/α-tubulin interaction.

Krüger M, Kalbacher H, Kastritis PL, Bischof J, Barth H, Henne-Bruns D, Vorgias C, Sarno S, Pinna LA, Knippschild U.

Cancer Lett. 2016 Jun 1;375(2):375-383. doi: 10.1016/j.canlet.2016.03.021. Epub 2016 Mar 17.

PMID:
26996302
32.

MDM2 SNP 309G Allele Is Associated With Younger Age at Surgery in Chronic Pancreatitis Patients.

Udelnow A, Henne-Bruns D, Knippschild U, Halangk W, Bruns C, Halloul Z, Würl P, Grochola LF.

Pancreas. 2016 Apr;45(4):e11-2. doi: 10.1097/MPA.0000000000000602. No abstract available.

PMID:
26954495
33.

CK1δ kinase activity is modulated by protein kinase C α (PKCα)-mediated site-specific phosphorylation.

Meng Z, Bischof J, Ianes C, Henne-Bruns D, Xu P, Knippschild U.

Amino Acids. 2016 May;48(5):1185-97. doi: 10.1007/s00726-015-2154-3. Epub 2016 Jan 23.

PMID:
26803658
34.

Decreased CK1δ expression predicts prolonged survival in colorectal cancer patients.

Richter J, Rudeck S, Kretz AL, Kramer K, Just S, Henne-Bruns D, Hillenbrand A, Leithäuser F, Lemke J, Knippschild U.

Tumour Biol. 2016 Jul;37(7):8731-9. doi: 10.1007/s13277-015-4745-8. Epub 2016 Jan 7.

PMID:
26738869
35.

CK1δ activity is modulated by CDK2/E- and CDK5/p35-mediated phosphorylation.

Ianes C, Xu P, Werz N, Meng Z, Henne-Bruns D, Bischof J, Knippschild U.

Amino Acids. 2016 Feb;48(2):579-92. doi: 10.1007/s00726-015-2114-y.

PMID:
26464264
36.

Prevalence of non-alcoholic fatty liver disease in four different weight related patient groups: association with small bowel length and risk factors.

Hillenbrand A, Kiebler B, Schwab C, Scheja L, Xu P, Henne-Bruns D, Wolf AM, Knippschild U.

BMC Res Notes. 2015 Jul 3;8:290. doi: 10.1186/s13104-015-1224-7.

37.

Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST).

Kramer K, Knippschild U, Mayer B, Bögelspacher K, Spatz H, Henne-Bruns D, Agaimy A, Schwab M, Schmieder M.

BMC Cancer. 2015 Feb 14;15:57. doi: 10.1186/s12885-015-1054-y.

38.

CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application.

Winkler BS, Oltmer F, Richter J, Bischof J, Xu P, Burster T, Leithäuser F, Knippschild U.

Front Cell Dev Biol. 2015 Feb 20;3:9. doi: 10.3389/fcell.2015.00009. eCollection 2015.

39.

Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.

Xu P, Fischer-Posovszky P, Bischof J, Radermacher P, Wabitsch M, Henne-Bruns D, Wolf AM, Hillenbrand A, Knippschild U.

Mol Cell Endocrinol. 2015 May 5;406:87-101. doi: 10.1016/j.mce.2015.02.010. Epub 2015 Feb 24.

PMID:
25724478
40.

Gastrointestinal stromal tumors of the esophagus: evaluation of a pooled case series regarding clinicopathological features and clinical outcome.

Lott S, Schmieder M, Mayer B, Henne-Bruns D, Knippschild U, Agaimy A, Schwab M, Kramer K.

Am J Cancer Res. 2014 Dec 15;5(1):333-43. eCollection 2015.

41.

Frequence, spectrum and prognostic impact of additional malignancies in patients with gastrointestinal stromal tumors.

Kramer K, Wolf S, Mayer B, Schmidt SA, Agaimy A, Henne-Bruns D, Knippschild U, Schwab M, Schmieder M.

Neoplasia. 2015 Jan;17(1):134-40. doi: 10.1016/j.neo.2014.12.001.

42.

Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.

Richter J, Ullah K, Xu P, Alscher V, Blatz A, Peifer C, Halekotte J, Leban J, Vitt D, Holzmann K, Bakulev V, Pinna LA, Henne-Bruns D, Hillenbrand A, Kornmann M, Leithäuser F, Bischof J, Knippschild U.

Int J Cancer. 2015 Jun 15;136(12):2799-810. doi: 10.1002/ijc.29346. Epub 2014 Dec 1. Erratum in: Int J Cancer. 2016 Aug 15;139(4):E5.

43.

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C.

Cell Metab. 2014 Nov 4;20(5):898-909. doi: 10.1016/j.cmet.2014.09.003. Epub 2014 Oct 9.

44.

Difluoro-dioxolo-benzoimidazol-benzamides as potent inhibitors of CK1δ and ε with nanomolar inhibitory activity on cancer cell proliferation.

Richter J, Bischof J, Zaja M, Kohlhof H, Othersen O, Vitt D, Alscher V, Pospiech I, García-Reyes B, Berg S, Leban J, Knippschild U.

J Med Chem. 2014 Oct 9;57(19):7933-46. doi: 10.1021/jm500600b. Epub 2014 Sep 17.

PMID:
25191940
45.

Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage.

Stöter M, Krüger M, Banting G, Henne-Bruns D, Knippschild U.

PLoS One. 2014 Jun 17;9(6):e100090. doi: 10.1371/journal.pone.0100090. eCollection 2014.

46.

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.

Knippschild U, Krüger M, Richter J, Xu P, García-Reyes B, Peifer C, Halekotte J, Bakulev V, Bischof J.

Front Oncol. 2014 May 19;4:96. doi: 10.3389/fonc.2014.00096. eCollection 2014. Review.

47.

The obesity paradox revisited: does increased body mass protect against circulatory shock?

Radermacher P, Huber-Lang M, Knippschild U, Thiemermann C.

Shock. 2014 Jun;41(6):554-5. doi: 10.1097/SHK.0000000000000166. No abstract available.

PMID:
24830951
48.

The obesity paradox and acute kidney injury: beneficial effects of hyper-inflammation?

Hafner S, Hillenbrand A, Knippschild U, Radermacher P.

Crit Care. 2013 Dec 10;17(6):1023. doi: 10.1186/cc13152.

49.

Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells.

Haselmann V, Kurz A, Bertsch U, Hübner S, Olempska-Müller M, Fritsch J, Häsler R, Pickl A, Fritsche H, Annewanter F, Engler C, Fleig B, Bernt A, Röder C, Schmidt H, Gelhaus C, Hauser C, Egberts JH, Heneweer C, Rohde AM, Böger C, Knippschild U, Röcken C, Adam D, Walczak H, Schütze S, Janssen O, Wulczyn FG, Wajant H, Kalthoff H, Trauzold A.

Gastroenterology. 2014 Jan;146(1):278-90. doi: 10.1053/j.gastro.2013.10.009. Epub 2013 Oct 9.

PMID:
24120475
50.

CK1δ kinase activity is modulated by Chk1-mediated phosphorylation.

Bischof J, Randoll SJ, Süßner N, Henne-Bruns D, Pinna LA, Knippschild U.

PLoS One. 2013 Jul 4;8(7):e68803. doi: 10.1371/journal.pone.0068803. Print 2013.

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